P Argani

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc MYC gene amplification is often acquired in lethal distant breast cancer metastases of unamplified primary tumors
    Aatur D Singhi
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Mod Pathol 25:378-87. 2012
  2. pmc The growth response to androgen receptor signaling in ERα-negative human breast cells is dependent on p21 and mediated by MAPK activation
    Joseph P Garay
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Breast Cancer Res 14:R27. 2012
  3. doi request reprint A broad survey of cathepsin K immunoreactivity in human neoplasms
    Gang Zheng
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA
    Am J Clin Pathol 139:151-9. 2013
  4. doi request reprint Molecular confirmation of t(6;11)(p21;q12) renal cell carcinoma in archival paraffin-embedded material using a break-apart TFEB FISH assay expands its clinicopathologic spectrum
    Pedram Argani
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 36:1516-26. 2012
  5. pmc Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9
    Dengfeng Cao
    Departments of Pathology and Immunology, Washington University, St Louis, MO, USA
    Breast Cancer Res 10:R91. 2008
  6. doi request reprint Melanotic Xp11 translocation renal cancers: a distinctive neoplasm with overlapping features of PEComa, carcinoma, and melanoma
    Pedram Argani
    Department of Pathology, The Johns Hopkins Hospital, The Johns Hopkins University, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 33:609-19. 2009
  7. ncbi request reprint Papillary renal cell carcinoma with low-grade spindle cell foci: a mimic of mucinous tubular and spindle cell carcinoma
    Pedram Argani
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 32:1353-9. 2008
  8. ncbi request reprint PRCC-TFE3 renal carcinomas: morphologic, immunohistochemical, ultrastructural, and molecular analysis of an entity associated with the t(X;1)(p11.2;q21)
    Pedram Argani
    Department of Pathology, Surgical Pathology, Johns Hopkins Hospital, Weinberg Building, Room 2242, 401 N Broadway, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 26:1553-66. 2002
  9. ncbi request reprint Xp11 translocation renal cell carcinoma in adults: expanded clinical, pathologic, and genetic spectrum
    Pedram Argani
    Department of Pathology, The Johns Hopkins University, Baltimore, MD 21231 2140, USA
    Am J Surg Pathol 31:1149-60. 2007
  10. pmc Xp11 translocation renal cell carcinoma (RCC): extended immunohistochemical profile emphasizing novel RCC markers
    Pedram Argani
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 34:1295-303. 2010

Detail Information

Publications98

  1. pmc MYC gene amplification is often acquired in lethal distant breast cancer metastases of unamplified primary tumors
    Aatur D Singhi
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Mod Pathol 25:378-87. 2012
    ..These observations underscore the importance of MYC in breast cancer progression/metastasis, as well as its relevance as a potential therapeutic target in otherwise incurable metastatic disease...
  2. pmc The growth response to androgen receptor signaling in ERα-negative human breast cells is dependent on p21 and mediated by MAPK activation
    Joseph P Garay
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Breast Cancer Res 14:R27. 2012
    ..In addition, many breast cancers co-express other steroid hormone receptors that can affect AR signaling, further obfuscating the effects of androgens on breast cancer cells...
  3. doi request reprint A broad survey of cathepsin K immunoreactivity in human neoplasms
    Gang Zheng
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA
    Am J Clin Pathol 139:151-9. 2013
    ..Cathepsin K IHC can be helpful in distinguishing ASPS and translocation RCC from some but not all of the lesions in their differential diagnosis...
  4. doi request reprint Molecular confirmation of t(6;11)(p21;q12) renal cell carcinoma in archival paraffin-embedded material using a break-apart TFEB FISH assay expands its clinicopathologic spectrum
    Pedram Argani
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 36:1516-26. 2012
    ....
  5. pmc Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9
    Dengfeng Cao
    Departments of Pathology and Immunology, Washington University, St Louis, MO, USA
    Breast Cancer Res 10:R91. 2008
    ..Global gene expression profiling of LCIS has not been performed...
  6. doi request reprint Melanotic Xp11 translocation renal cancers: a distinctive neoplasm with overlapping features of PEComa, carcinoma, and melanoma
    Pedram Argani
    Department of Pathology, The Johns Hopkins Hospital, The Johns Hopkins University, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 33:609-19. 2009
    ....
  7. ncbi request reprint Papillary renal cell carcinoma with low-grade spindle cell foci: a mimic of mucinous tubular and spindle cell carcinoma
    Pedram Argani
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 32:1353-9. 2008
    ..Fluorescence in situ hybridization analysis effectively separates these morphologically very similar yet genetically distinctive entities...
  8. ncbi request reprint PRCC-TFE3 renal carcinomas: morphologic, immunohistochemical, ultrastructural, and molecular analysis of an entity associated with the t(X;1)(p11.2;q21)
    Pedram Argani
    Department of Pathology, Surgical Pathology, Johns Hopkins Hospital, Weinberg Building, Room 2242, 401 N Broadway, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 26:1553-66. 2002
    ..Aside from their distinctive clinicopathologic features described here, there is experimental evidence suggesting that these tumors may show differential sensitivity to certain chemotherapeutic agents...
  9. ncbi request reprint Xp11 translocation renal cell carcinoma in adults: expanded clinical, pathologic, and genetic spectrum
    Pedram Argani
    Department of Pathology, The Johns Hopkins University, Baltimore, MD 21231 2140, USA
    Am J Surg Pathol 31:1149-60. 2007
    ..Although they may be uncommon on a percentage basis, given the vast predominance of RCC in adults compared with children, adult Xp11 translocation RCC may well outnumber their pediatric counterparts...
  10. pmc Xp11 translocation renal cell carcinoma (RCC): extended immunohistochemical profile emphasizing novel RCC markers
    Pedram Argani
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 34:1295-303. 2010
    ..Elevated expression of phosphorylated S6 in Xp11 translocation RCC suggests the mTOR pathway as an attractive potential therapeutic target for these neoplasms...
  11. doi request reprint A distinctive subset of PEComas harbors TFE3 gene fusions
    Pedram Argani
    Department of Pathology and Oncology, The Johns Hopkins Medical Intuitions, Baltimore, MD, USA
    Am J Surg Pathol 34:1395-406. 2010
    ..Despite significant morphologic and immunohistochemical overlap with other PEComas, PEComas harboring TFE3 gene fusions may represent a distinctive entity...
  12. ncbi request reprint Distinctive neoplasms characterised by specific chromosomal translocations comprise a significant proportion of paediatric renal cell carcinomas
    Pedram Argani
    Department of Pathology, Surgical Pathology, The Johns Hopkins Hospital, Weinberg Building Room 2242, 401 N Broadway, Baltimore, MD 21231 2410, USA
    Pathology 35:492-8. 2003
  13. pmc Primary renal neoplasms with the ASPL-TFE3 gene fusion of alveolar soft part sarcoma: a distinctive tumor entity previously included among renal cell carcinomas of children and adolescents
    P Argani
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21231 2410, USA
    Am J Pathol 159:179-92. 2001
    ..Finally, the finding of distinctive tumors being associated with balanced and unbalanced forms of the same translocation is to our knowledge, unprecedented...
  14. ncbi request reprint Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE)
    P Argani
    Department of Pathology, The Johns Hopkins Medical Institutions, 2242 Weinberg, 410 North Broadway, Baltimore, MD 21231 2410, USA
    Clin Cancer Res 7:3862-8. 2001
    ..In this study, we evaluate the potential utility of mesothelin as a tumor marker for pancreatic adenocarcinoma...
  15. ncbi request reprint Recent advances in pediatric renal neoplasia
    Pedram Argani
    The Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Adv Anat Pathol 10:243-60. 2003
    ..Together, these last two translocation-associated tumors represent a significant proportion of pediatric renal cell carcinomas. This review highlights each of these recent advances...
  16. ncbi request reprint Metanephric neoplasms: the hyperdifferentiated, benign end of the Wilms tumor spectrum?
    Pedram Argani
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231 2410, USA
    Clin Lab Med 25:379-92. 2005
    ..Although this concept implies that the more active lesions (Wilms tumor) mature with time into inactive ones (usual MAFs or MA), the converse (that an active Wilms tumor can arise within an inactive usual MAF or MA) remains possible...
  17. ncbi request reprint Translocation carcinomas of the kidney
    Pedram Argani
    Department of Surgical Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231 2410, USA
    Clin Lab Med 25:363-78. 2005
    ..The clinical behavior of these neoplasms relative to conventional, adult-type renal carcinomas remains to be determined, and will be an important area of future investigation...
  18. ncbi request reprint Discovery of new markers of cancer through serial analysis of gene expression: prostate stem cell antigen is overexpressed in pancreatic adenocarcinoma
    P Argani
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Cancer Res 61:4320-4. 2001
    ..PSCA is a novel tumor marker for pancreatic carcinoma that has potential diagnostic and therapeutic implications. These results establish the validity of analyses of SAGE databases to identify novel tumor markers...
  19. ncbi request reprint Differing rates of loss of DPC4 expression and of p53 overexpression among carcinomas of the proximal and distal bile ducts
    P Argani
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Cancer 91:1332-41. 2001
    ..Biliary tract carcinomas are clinically heterogeneous. It is not known if molecular heterogeneity underlies the clinical differences...
  20. ncbi request reprint The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25
    M Ladanyi
    Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    Oncogene 20:48-57. 2001
    ..Oncogene (2001) 20, 48 - 57...
  21. ncbi request reprint Immunohistochemical labeling for the Dpc4 gene product is a specific marker for adenocarcinoma in biopsy specimens of the pancreas and bile duct
    M Tascilar
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Clin Pathol 116:831-7. 2001
    ..Importantly, loss of Dpc4 expression has been reported in in situ carcinomas, suggesting that loss of expression should not be equated with invasive carcinoma...
  22. ncbi request reprint Detection of the ETV6-NTRK3 chimeric RNA of infantile fibrosarcoma/cellular congenital mesoblastic nephroma in paraffin-embedded tissue: application to challenging pediatric renal stromal tumors
    P Argani
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Mod Pathol 13:29-36. 2000
    ..These results suggest that cases morphologically defined as mixed CMN may represent a mixed group of genetically distinct entities...
  23. ncbi request reprint Primary renal synovial sarcoma: molecular and morphologic delineation of an entity previously included among embryonal sarcomas of the kidney
    P Argani
    The Johns Hopkins Hospital and National Wilms Tumor Study Group Pathology Center, Baltimore, Maryland, USA
    Am J Surg Pathol 24:1087-96. 2000
    ..Primary renal synovial sarcoma is a distinctive clinicopathologic entity confirmed by molecular detection of SYT-SSX fusion transcripts...
  24. ncbi request reprint The spectrum of metanephric adenofibroma and related lesions: clinicopathologic study of 25 cases from the National Wilms Tumor Study Group Pathology Center
    M R Arroyo
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21231-2410, USA
    Am J Surg Pathol 25:433-44. 2001
    ..A relationship to PRCC is also evident...
  25. pmc A distinctive pediatric renal neoplasm characterized by epithelioid morphology, basement membrane production, focal HMB45 immunoreactivity, and t(6;11)(p21.1;q12) chromosome translocation
    P Argani
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21231 2410, USA
    Am J Pathol 158:2089-96. 2001
    ..Cytogenetic analysis reveals the identical t(6;11)(p21.1;q12) chromosome translocation as the sole abnormality in these two tumors, confirming their identity and distinctive nature...
  26. ncbi request reprint Metanephric stromal tumor: report of 31 cases of a distinctive pediatric renal neoplasm
    P Argani
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Am J Surg Pathol 24:917-26. 2000
    ..Recognition of this entity can spare a child potentially toxic adjuvant chemotherapy that might be used for lesions in its differential diagnosis, specifically clear cell sarcoma of the kidney...
  27. ncbi request reprint Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast
    Scott L Kominsky
    Breast Cancer Program, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Oncogene 22:2021-33. 2003
    ..In summary, these studies provide insight into the potential role of CLDN-7 in the progression and ability of breast cancer cells to disseminate...
  28. ncbi request reprint Renal carcinomas with the t(6;11)(p21;q12): clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCR
    Pedram Argani
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Surg Pathol 29:230-40. 2005
    ..Finally, the special molecular features of the Alpha-TFEB gene fusion allow its molecular detection by DNA PCR as a robust alternative to RT-PCR in clinical tumor samples...
  29. ncbi request reprint Immunohistochemical and genetic analysis of non-small cell and small cell gallbladder carcinoma and their precursor lesions
    Anil V Parwani
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21231 2410, USA
    Mod Pathol 16:299-308. 2003
    ..It is noteworthy that all of these alterations occur at the level of carcinoma in situ...
  30. ncbi request reprint Very high frequency of hypermethylated genes in breast cancer metastasis to the bone, brain, and lung
    Jyoti Mehrotra
    Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Clin Cancer Res 10:3104-9. 2004
    ....
  31. ncbi request reprint DNA methylation of RASSF1A, HIN-1, RAR-beta, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma
    Mary Jo Fackler
    Breast Cancer Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 401 N Broadway, Baltimore, MD 21231 2410, USA
    Int J Cancer 107:970-5. 2003
    ..01). These results suggest that these 2 types of tumors share many common methylation patterns and some molecular differences. Additional studies might lend further understanding into the etiology and clinical behavior of this tumor type...
  32. doi request reprint Hypermethylated genes as biomarkers of cancer in women with pathologic nipple discharge
    Mary Jo Fackler
    Departments of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Clin Cancer Res 15:3802-11. 2009
    ....
  33. ncbi request reprint Expanding the histologic spectrum of mucinous tubular and spindle cell carcinoma of the kidney
    Samson W Fine
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Am J Surg Pathol 30:1554-60. 2006
    ..Pathologists must be aware of the spectrum of histologic findings within MTSCs to ensure their accurate diagnosis...
  34. ncbi request reprint HOXB7, a homeodomain protein, is overexpressed in breast cancer and confers epithelial-mesenchymal transition
    Xinyan Wu
    Breast Cancer Program, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer Res 66:9527-34. 2006
    ..Thus, HOXB7 overexpression caused EMT in epithelial cells, accompanied by acquisition of aggressive properties of tumorigenicity, migration, and invasion...
  35. ncbi request reprint Performance characteristics of a reverse transcriptase-polymerase chain reaction assay for the detection of tumor-specific fusion transcripts from archival tissue
    Michael K Fritsch
    Department of Pathology, The Johns Hopkins Medical Institutions, 401 N Broadway, Baltimore, MD 22131 2410, USA
    Pediatr Dev Pathol 6:43-53. 2003
    ..Additional studies such as FISH may be useful in clarifying the nature of equivocal or unexpected results...
  36. pmc Telomere shortening occurs in subsets of normal breast epithelium as well as in situ and invasive carcinoma
    Alan K Meeker
    Department of Pathology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Pathol 164:925-35. 2004
    ..We postulate that such shortening is the result of hormonally driven, physiological proliferation, and may delineate a population of epithelial cells at risk for subsequent malignant transformation...
  37. doi request reprint The alternative lengthening of telomeres phenotype in breast carcinoma is associated with HER-2 overexpression
    Andrea Proctor Subhawong
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA
    Mod Pathol 22:1423-31. 2009
    ..As cancers using the ALT pathway are predicted to be resistant to therapies based on telomerase inhibition, these results may have therapeutic consequences...
  38. ncbi request reprint Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis
    Yoshiharu Miyamoto
    Departments of Surgery, Oncology, and Pathology, The Sidney Kimmel Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Cancer Cell 3:565-76. 2003
    ..These findings suggest that Notch mediates the tumor-initiating effects of TG alpha by expanding a population of undifferentiated precursor cells...
  39. ncbi request reprint Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasms
    Fikret Sahin
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mod Pathol 16:686-91. 2003
    ..Immunohistochemical analysis for Stk11 expression may be a valid surrogate for genetic analysis of STK11 gene mutations in cancers...
  40. ncbi request reprint Two-color quantitative multiplex methylation-specific PCR
    Theresa Swift-Scanlan
    Johns Hopkins University School of Medicine, Baltimore, MD 21231 1000, USA
    Biotechniques 40:210-9. 2006
    ..Our modification decreases the cost and time of each real-time experiment by allowing increased throughput of clinical samples and by doubling either the number of genes or the number of samples that can be analyzed per real-time plate...
  41. ncbi request reprint Telomere length variation in biliary tract metaplasia, dysplasia, and carcinoma
    Donna E Hansel
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Mod Pathol 19:772-9. 2006
    ..We conclude that telomere shortening is a consistent and early finding in the development of biliary tract carcinoma...
  42. ncbi request reprint Anthracotic and anthracosilicotic spindle cell pseudotumors of mediastinal lymph nodes: report of five cases of a reactive lesion that stimulates malignancy
    P Argani
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Hum Pathol 29:851-5. 1998
    ..The differential diagnosis includes a variety of spindle cell neoplasms, including malignant fibrous histiocytoma, follicular dendritic cell tumor, spindle cell melanoma, and Kaposi's sarcoma...
  43. ncbi request reprint Adult presentation of metanephric stromal tumor
    R Bluebond-Langner
    James Buchanan Brady Urological Institute and Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 168:1482-3. 2002
  44. ncbi request reprint Wnt signaling in human development: beta-catenin nuclear translocation in fetal lung, kidney, placenta, capillaries, adrenal, and cartilage
    C G Eberhart
    Department of Pathology, Johns Hopkins School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA
    Pediatr Dev Pathol 4:351-7. 2001
    ..These investigations suggest a defined role for Wnt signaling in human fetal development and provide a catalogue of non-neoplastic tissues with nuclear beta-catenin staining...
  45. ncbi request reprint Role of the DPC4 tumor suppressor gene in adenocarcinoma of the ampulla of Vater: analysis of 140 cases
    Denis M McCarthy
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Mod Pathol 16:272-8. 2003
    ..Although ampullary and pancreatic adenocarcinomas share histologic and molecular features, ampullary carcinomas are less likely to show loss of Dpc4 expression or K-ras gene mutations...
  46. pmc Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation
    Christophe Rosty
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2196, USA
    Am J Pathol 160:45-50. 2002
    ..Because most pancreatic carcinomas express S100A4, it may be a useful target for early detection strategies...
  47. doi request reprint Pseudoangiomatous stromal hyperplasia (PASH) of the breast with foci of morphologic malignancy: a case of PASH with malignant transformation?
    Hind Nassar
    Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Int J Surg Pathol 18:564-9. 2010
    ..This is perhaps the first case of PASH with foci of malignant histologic features reported in the literature and represents a rare sarcoma derived from specialized hormonally responsive mammary stroma...
  48. ncbi request reprint A novel CLTC-TFE3 gene fusion in pediatric renal adenocarcinoma with t(X;17)(p11.2;q23)
    Pedram Argani
    The Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Oncogene 22:5374-8. 2003
    ..Further analysis of the shared features of CLTC and other TFE3 fusion partners may shed light on the essential biology of TFE3 fusion proteins...
  49. pmc Carbonic anhydrase IX expression in renal neoplasms: correlation with tumor type and grade
    Elizabeth M Genega
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Am J Clin Pathol 134:873-9. 2010
    ..01) cases. An association between CAIX expression and grade (P < .01) in primary clear cell carcinomas was found. CAIX expression is more common in clear cell RCC than other renal tumor types and is associated with grade...
  50. ncbi request reprint MUC4 expression increases progressively in pancreatic intraepithelial neoplasia
    Michael J Swartz
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Clin Pathol 117:791-6. 2002
    ..Our data help establish the patterns of MUC4 expression in neoplastic precursors in the pancreas and add further support to the progression model for pancreatic adenocarcinoma...
  51. doi request reprint Heterogeneity of Bcl-2 expression in metastatic breast carcinoma
    Andrea Proctor Subhawong
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Mod Pathol 23:1089-96. 2010
    ..Instead, downregulation of bcl-2 expression may occur in the setting of hormone therapy resistance. Our findings call into question the potential utility of anti-bcl-2 therapy in metastatic breast cancer...
  52. ncbi request reprint Distinguishing benign dissecting mucin (stromal mucin pools) from invasive mucinous carcinoma
    Diana Molavi
    Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
    Adv Anat Pathol 15:1-17. 2008
    ....
  53. ncbi request reprint Intraductal spread by metastatic islet cell tumor (well-differentiated pancreatic endocrine neoplasm) involving the breast of a child, mimicking a primary mammary carcinoma
    Kara Judson
    Department of Pathology, The Johns Hopkins Medical Institutions, 401 North Broadway, Baltimore, MD 21287, USA
    Am J Surg Pathol 30:912-8. 2006
    ..To our knowledge, this is the second case of islet cell tumor reported to metastasize to the breast, and the first report of a metastasis proven to have grown within existing ducts of the breast by immunohistochemistry...
  54. pmc Promoter hypermethylation in sentinel lymph nodes as a marker for breast cancer recurrence
    Hetty E Carraway
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Breast Cancer Res Treat 114:315-25. 2009
    ..This study evaluates the methylation frequency and pattern in HNSN to determine if detection of hypermethylation of one or more genes is associated with an increased recurrence risk in node negative breast cancer...
  55. ncbi request reprint Novel markers of pancreatic adenocarcinoma in fine-needle aspiration: mesothelin and prostate stem cell antigen labeling increases accuracy in cytologically borderline cases
    Denis M McCarthy
    Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland 21287, U S A
    Appl Immunohistochem Mol Morphol 11:238-43. 2003
    ..In this study, immunohistochemical labeling for 2 of these markers, PSCA and mesothelin, appears highly specific for pancreatic adenocarcinoma in FNA specimens and useful in categorizing cytologically suspicious lesions...
  56. ncbi request reprint Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray
    Anirban Maitra
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mod Pathol 16:902-12. 2003
    ....
  57. ncbi request reprint Homozygous deletion of the MTAP gene in invasive adenocarcinoma of the pancreas and in periampullary cancer: a potential new target for therapy
    Steven R Hustinx
    Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Cancer Biol Ther 4:83-6. 2005
    ..Thus, pancreatic cancer is a promising cancer type in which to explore novel chemotherapeutic strategies to exploit the selective loss of MTAP function...
  58. ncbi request reprint Missed it by that much
    Andrea Proctor Subhawong
    Department of Pathology, The Johns Hopkins Hospital, 401 N Broadway, Baltimore, MD 21231 2410, USA
    Int J Surg Pathol 15:384. 2007
  59. ncbi request reprint Analysis of novel tumor markers in pancreatic and biliary carcinomas using tissue microarrays
    Sharon L Swierczynski
    Department of Pathology, The Johns Hopkinds University School of Medicine, Baltimore, MD 21231, USA
    Hum Pathol 35:357-66. 2004
    ..Therefore, these markers are potentially useful in developing diagnostic tests and treatment paradigms for tumors involving the biliary system...
  60. ncbi request reprint Expression of the caudal-type homeodomain transcription factors CDX 1/2 and outcome in carcinomas of the ampulla of Vater
    Donna E Hansel
    MBBS, Department of Surgery, The Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross 771, Baltimore, MD 21205, USA
    J Clin Oncol 23:1811-8. 2005
    ..We assessed the expression of these putative intestinal epithelial-specific transcription factors and their influence on patient outcome...
  61. ncbi request reprint Telomere shortening occurs early during breast tumorigenesis: a cause of chromosome destabilization underlying malignant transformation?
    Alan K Meeker
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Mammary Gland Biol Neoplasia 9:285-96. 2004
    ..Telomere shortening is therefore a strong candidate for the cause of structural chromosome defects that contribute to breast cancer development...
  62. ncbi request reprint Quantitative multiplex methylation-specific PCR assay for the detection of promoter hypermethylation in multiple genes in breast cancer
    Mary Jo Fackler
    Breast Cancer Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231 1000, USA
    Cancer Res 64:4442-52. 2004
    ..Such an approach could be used in a variety of small samples derived from different tissues, with these or different biomarkers to enhance detection of malignancy...
  63. ncbi request reprint Estrogen receptor/progesterone receptor-negative breast cancers of young African-American women have a higher frequency of methylation of multiple genes than those of Caucasian women
    Jyoti Mehrotra
    Breast Cancer Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
    Clin Cancer Res 10:2052-7. 2004
    ....
  64. ncbi request reprint Epigenetic suppression of secreted frizzled related protein 1 (SFRP1) expression in human breast cancer
    Pang Kuo Lo
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 5:281-6. 2006
    ..Based on the frequency of tumor-specific hypermethylation in this gene, SFRP1 could provide a valuable marker for breast cancer...
  65. pmc Telomere lengths of translocation-associated and nontranslocation-associated sarcomas differ dramatically
    Elizabeth Montgomery
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231 1000, USA
    Am J Pathol 164:1523-9. 2004
    ....
  66. ncbi request reprint Global expression analysis of well-differentiated pancreatic endocrine neoplasms using oligonucleotide microarrays
    Anirban Maitra
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Clin Cancer Res 9:5988-95. 2003
    ..Global expression microarrays can document abnormal pathways that impact on tumorigenesis and disease progression...
  67. ncbi request reprint Low-grade myxoid renal epithelial neoplasms with distal nephron differentiation
    A V Parwani
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231-2410, USA
    Hum Pathol 32:506-12. 2001
    ..Similar tumors probably have been reported among low-grade collecting duct carcinomas or tumors "possibly related to the loop of Henle."..
  68. pmc Heterogeneity of breast cancer metastases: comparison of therapeutic target expression and promoter methylation between primary tumors and their multifocal metastases
    Julie M Wu
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Clin Cancer Res 14:1938-46. 2008
    ..A comprehensive comparison of biomarker expression between patients' primary breast carcinoma (PBC) and their metastatic breast carcinomas (MBC) has not been done...
  69. ncbi request reprint Microsatellite instability in intraductal papillary neoplasms of the biliary tract
    Susan C Abraham
    Division of Gastrointestinal Liver Pathology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Mod Pathol 15:1309-17. 2002
    ....
  70. ncbi request reprint Mucinous tubular and spindle cell carcinoma of the kidney: cytopathologic findings
    Christopher L Owens
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Diagn Cytopathol 35:593-6. 2007
    ..Subsequent nephrectomy was performed and the surgical pathology specimen showed a mucinous tubular and spindle cell carcinoma of the kidney. The patient has done well post-operatively with 10 months of benign follow-up...
  71. ncbi request reprint Aberrant nuclear immunoreactivity for TFE3 in neoplasms with TFE3 gene fusions: a sensitive and specific immunohistochemical assay
    Pedram Argani
    Department of Pathology, John Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Surg Pathol 27:750-61. 2003
    ..Carcinomas associated with TFE3 gene fusions may account for a significant proportion of pediatric renal carcinomas, and this immunohistochemistry assay may help to clarify their true prevalence...
  72. doi request reprint Xp11 translocation renal cell carcinoma
    Hillary Ross
    Departments of Pathology, Johns Hopkins Hospital, 401 North Broadway, Weinberg 2242, Baltimore, Maryland 21231, USA
    Pathology 42:369-73. 2010
    ..Regardless, the tumour can metastasise decades after its initial presentation, so long-term follow-up is necessary. A recently reported melanotic neoplasm with overt melanin pigment may represent a new subset of TFE3 related cancers...
  73. doi request reprint Complex rearrangement of chromosomes 1, 7, 21, 22 in Ewing sarcoma
    Natini Jinawath
    Institute of Genetic Medicine, Johns Hopkins Medical Institutions, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Cancer Genet Cytogenet 201:42-7. 2010
    ..This case adds to the spectrum of genetic rearrangements identified in ES tumors...
  74. pmc Identification of novel cellular targets in biliary tract cancers using global gene expression technology
    Donna E Hansel
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21212, USA
    Am J Pathol 163:217-29. 2003
    ..The majority of genes identified in the present study has not been previously reported in biliary cancers, and represent novel potential screening and therapeutic targets of this cancer type...
  75. ncbi request reprint Nephrogenic rests mimicking Wilms' tumor on CT
    Naveen Subhas
    Russell H Morgan Department of Radiology, The Johns Hopkins Hospital and School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
    Pediatr Radiol 34:152-5. 2004
    ..One of the NR grew on serial imaging studies mimicking a WT, but after resection was confirmed to be a benign hyperplastic NR on pathologic examination...
  76. ncbi request reprint Xp11 translocation renal cell carcinoma: delayed but massive and lethal metastases of a chemotherapy-associated secondary malignancy
    Soroush Rais-Bahrami
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Urology 70:178.e3-6. 2007
    ....
  77. ncbi request reprint Translocation carcinomas of the kidney after chemotherapy in childhood
    Pedram Argani
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA
    J Clin Oncol 24:1529-34. 2006
    ..Renal cell carcinoma (RCC) occurring as a secondary malignancy is uncommon. Translocation RCC, bearing TFE3 or TFEB gene fusions, are recently recognized entities for which risk factors have not been identified...
  78. ncbi request reprint Primary alveolar soft part sarcoma (ASPS) of the breast: report of a deceptive case with xanthomatous features confirmed by TFE3 immunohistochemistry and electron microscopy
    Julie Wu
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231 2410, USA
    Int J Surg Pathol 13:81-5. 2005
    ..With this report, we confirm the utility of a novel immunohistochmical technique for the identification of an ASPS presenting in an unusual locale...
  79. pmc Polymorphisms in estrogen-metabolizing and estrogen receptor genes and the risk of developing breast cancer among a cohort of women with benign breast disease
    Lisa Gallicchio
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    BMC Cancer 6:173. 2006
    ....
  80. ncbi request reprint Progression of gene hypermethylation in gallstone disease leading to gallbladder cancer
    Michael G House
    Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231 1000, USA
    Ann Surg Oncol 10:882-9. 2003
    ..Aberrant methylation of tumor-suppressor genes is associated with a loss of gene function that can afford selective growth advantages to sporadic neoplastic cells arising during gallbladder inflammation...
  81. pmc Intratumoral heterogeneity of HER-2 gene amplification and protein overexpression in breast cancer
    Julie M Wu
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Hum Pathol 41:914-7. 2010
    ....
  82. doi request reprint Fat-predominant mixed epithelial stromal tumor (MEST): report of a unique case mimicking angiomyolipoma
    Anthony N Sireci
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Int J Surg Pathol 16:73-7. 2008
    ..Melanocytic markers HMB45 and Melan A, typically positive in angiomyolipoma, were nonreactive. This case expands the morphologic spectrum of MEST to include mimics of angiomyolipoma...
  83. ncbi request reprint Inverted (Hobnail) high-grade prostatic intraepithelial neoplasia (PIN): report of 15 cases of a previously undescribed pattern of high-grade PIN
    P Argani
    Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland 21231-2410, USA
    Am J Surg Pathol 25:1534-9. 2001
    ..Inverted HGPIN is a morphologically distinctive form of HGPIN that shares the association with carcinoma and peripheral zone localization with other recognized forms of HGPIN...
  84. ncbi request reprint Interleukin-1 alpha mediates the growth proliferative effects of transforming growth factor-beta in p21 null MCF-10A human mammary epithelial cells
    B Karakas
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Oncogene 25:5561-9. 2006
    ....
  85. ncbi request reprint The desmoplastic response to infiltrating breast carcinoma: gene expression at the site of primary invasion and implications for comparisons between tumor types
    Christine A Iacobuzio-Donahue
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Cancer Res 62:5351-7. 2002
    ..Some of the genes presented are novel markers of the invasive process, imply communication at the host/tumor interface, and suggest potential therapeutic targets...
  86. ncbi request reprint Pathologic quiz case: a 77-year-old woman with bilateral breast masses. Amyloidosis involving the breast
    Aisling M Fleury
    School of Medicine, University College, Cork, Ireland
    Arch Pathol Lab Med 128:e67-9. 2004
  87. pmc Epithelial and stromal cathepsin K and CXCL14 expression in breast tumor progression
    Celina G Kleer
    Department of Pathology, University of Michigan Cancer Center, Ann Arbor, Michigan, USA
    Clin Cancer Res 14:5357-67. 2008
    ..To evaluate the expression of cathepsin K (CTSK) and CXCL14 in stromal and epithelial cells in human breast tumor progression...
  88. ncbi request reprint PRCC-TFE3 renal cell carcinoma in a boy with a history of contralateral mesoblastic nephroma
    Ali Mirza Onder
    Department of Pediatrics, Division of Pediatric Nephrology, Miller School of Medicine, University of Miami, Miami, FL, USA
    Pediatr Nephrol 21:1471-5. 2006
    ..He has been on hemodialysis, is tumor free, and has not been receiving chemotherapy for 24 months. This is the first report of a RCC as a second malignant neoplasm in a child treated for a congenital mesoblastic nephroma...
  89. ncbi request reprint The evolving story of renal translocation carcinomas
    Pedram Argani
    Am J Clin Pathol 126:332-4. 2006
  90. ncbi request reprint Bilateral Wilms' tumor with anaplasia: lessons from the National Wilms' Tumor Study
    Thomas E Hamilton
    Division of Pediatric Surgery, Maine Medical Center, Portland, ME 04102, USA
    J Pediatr Surg 41:1641-4. 2006
    ..We hypothesized that delay in diagnosis of anaplasia could affect time to appropriate surgery and intensive multimodality therapy...
  91. ncbi request reprint Molecular definition of breast tumor heterogeneity
    Michail Shipitsin
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cancer Cell 11:259-73. 2007
    ..Our data suggest prognostic relevance of CD44+ cells and therapeutic targeting of distinct tumor cell populations...
  92. pmc Retinoblastoma pathway dysregulation causes DNA methyltransferase 1 overexpression in cancer via MAD2-mediated inhibition of the anaphase-promoting complex
    Agoston T Agoston
    Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Am J Pathol 170:1585-93. 2007
    ..37 (P<0.001). This suggests that RB pathway inactivation, a common dysfunction in cancer cells, may be the underlying cause of DNMT1 dysregulation...
  93. ncbi request reprint Xp11 translocation carcinoma of the kidney presenting with multilocular cystic renal cell carcinoma-like features
    Sueli Suzigan
    Laborclin Lab, School of Medicine, Sao Jose do Rio Preto, SP, Brazil
    Int J Surg Pathol 15:199-203. 2007
    ..A similar case has not been found in the literature. The example emphasizes the high index of suspicion needed for an accurate diagnosis of renal carcinomas...
  94. ncbi request reprint Anaplastic nephrogenic rest
    Pedram Argani
    Am J Surg Pathol 30:1339-41. 2006
  95. pmc Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation
    Ian J Davis
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:6051-6. 2003
    ..Alpha-TFEB is thus identified as a fusion gene in a subset of pediatric renal neoplasms...
  96. doi request reprint Pediatric renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion
    Ni Wayan Winarti
    Department of Pathology, Medical Faculty of Udayana University, Denpasar, Bali, Indonesia
    Int J Surg Pathol 16:66-72. 2008
    ..Immunohistochemically, the cells showed strong nuclear immunoreactivity for TFE3. We concluded that this case was an RCC associated with Xp11.2 translocation/TFE3 fusion, Fuhrman grade 3, stage IV...
  97. doi request reprint Translocation renal cell carcinoma: lack of negative impact due to lymph node spread
    James I Geller
    Department of Hematology Oncology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Cancer 112:1607-16. 2008
    ..Pediatric renal cell carcinoma (RCC) is clinically distinct from adult RCC. Characterization of the unique biological and clinical features of pediatric RCC are required...
  98. ncbi request reprint Bilateral Wilms' tumors with progressive or nonresponsive disease
    Robert C Shamberger
    Department of Surgery, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    J Pediatr Surg 41:652-7; discussion 652-7. 2006
    ..To provide guidelines for future cooperative group trials, we reviewed the outcomes of children with bilateral Wilms' tumors (BWTs) treated on National Wilms Tumor Study-4 (NWTS-4) who had progressive or nonresponsive disease (PNRD)...