Research Topics
Genomes and Genes | Hossein ArdehaliSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Endomyocardial biopsy plays a role in diagnosing patients with unexplained cardiomyopathyHossein Ardehali
Division of Cardiology, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, USA
Am Heart J 147:919-23. 2004..This study was undertaken to evaluate the utility of EMBx in confirming or excluding a clinically suspected diagnosis...- Role of the mitochondrial ATP-sensitive K+ channels in cardioprotectionHossein Ardehali
Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
Acta Biochim Pol 51:379-90. 2004..This review attempts to provide an up-to-date overview of the role of mitoK(ATP) in cardioprotection... - A positive endomyocardial biopsy result for sarcoid is associated with poor prognosis in patients with initially unexplained cardiomyopathyHossein Ardehali
Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
Am Heart J 150:459-63. 2005..In patients with cardiomyopathy, the diagnosis of sarcoidosis has important treatment implications. We studied the prognostic implications of a cardiac biopsy diagnosis of sarcoidosis in patients with unexplained cardiomyopathy... 
Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS productionRongxue Wu
Division of Cardiology, Department of Medicine, Northwestern University School of Medicine, Chicago, IL, USA
EMBO Mol Med 4:633-46. 2012..Overall, these data suggest that HKII and its mitochondrial binding negatively regulate cardiac hypertrophy by decreasing ROS production via mitochondrial permeability...- Regulation and cytoprotective role of hexokinase IIIEugene Wyatt
Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
PLoS ONE 5:e13823. 2010..HKIII does not bind mitochondria, and little is known about its regulation or cytoprotective effects. We studied the regulation of HKIII at the transcriptional and protein levels and investigated its role in cellular protection... - Diagnostic approach to the patient with cardiomyopathy: whom to biopsyHossein Ardehali
Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
Am Heart J 149:7-12. 2005..However, our experience and recent evidence suggests that EMBx may be a valuable diagnostic modality and should be included in the evaluation of patients with initially unexplained cardiomyopathy... - Blockade of the erbB2 receptor induces cardiomyocyte death through mitochondrial and reactive oxygen species-dependent pathwaysLeo I Gordon
Division of Hematology Oncology, Department of Medicine, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA
J Biol Chem 284:2080-7. 2009..Manipulation of redox signaling may be beneficial in cancer patients receiving trastuzumab... - Reduction in hexokinase II levels results in decreased cardiac function and altered remodeling after ischemia/reperfusion injuryRongxue Wu
Department of Medicine, Northwestern University School of Medicine, Chicago, IL, USA
Circ Res 108:60-9. 2011..Hexokinase (HK)II is a HK isoform that is expressed in the heart and can bind to the mitochondrial outer membrane... - Mitochondrial K(ATP) channels in cell survival and deathHossein Ardehali
Institute of Molecular Cardiobiology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205-2195, USA
J Mol Cell Cardiol 39:7-16. 2005..In this review, we attempt to highlight the recent advances in the physiological role of mitoK(ATP) and discuss the controversies and unanswered questions... - Targeting myocardial substrate metabolism in heart failure: potential for new therapiesHossein Ardehali
Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Eur J Heart Fail 14:120-9. 2012..We propose that cardiac energetics should be considered as a potential target for therapy in heart failure and more research should be done in this area... 
The sulfonylurea receptor, an atypical ATP-binding cassette protein, and its regulation of the KATP channelMichael A Burke
Division of Cardiology, Feinberg Cardiovascular Institute, Northwestern University, Chicago, Ill, USA
Circ Res 102:164-76. 2008..Here, we review the structure and function of ABC proteins and discuss SUR, its regulation of the K(ATP) channel, and its role in cardiovascular disease...- Comparison of survival among patients with connective tissue disease and cardiomyopathy (systemic sclerosis, systemic lupus erythematosus, and undifferentiated disease)Ilya Leyngold
Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
Am J Cardiol 100:513-7. 2007..Patients with systemic lupus erythematosus and cardiomyopathy have a similar prognosis to those with idiopathic DCM. Finally, the presence of myocarditis does not alter the survival of patients with CTD and cardiomyopathy... - Mitochondrial ATP-binding cassette proteinsMichael A Burke
Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
Transl Res 150:73-80. 2007..In this review, we will discuss the structure, function, physiology, and pathophysiology of these mitochondrial ABC proteins... - Cardioprotective role of the mitochondrial ATP-binding cassette protein 1Hossein Ardehali
Division of Cardiology, Feinberg Cardiovascular Institute, Northwestern University, Chicago, Ill, USA
Circ Res 97:740-2. 2005..These results support the notion that mABC1 protein plays a major role in cellular protection against oxidant stress, identifying mABC1 as a novel target for cardioprotective therapeutics... - Multiprotein complex containing succinate dehydrogenase confers mitochondrial ATP-sensitive K+ channel activityHossein Ardehali
Institute of Molecular Cardiobiology and Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 101:11880-5. 2004..The findings also provide a tangible clue as to the structural basis of mitoK(ATP) channels... - Signaling mechanisms in ischemic preconditioning: interaction of PKCepsilon and MitoK(ATP) in the inner membrane of mitochondriaHossein Ardehali
Circ Res 99:798-800. 2006 - Targeting of the mitochondrial membrane proteins to the cell surface for functional studiesHossein Ardehali
Feinberg Cardiovascular Institute, Northwestern University, Chicago, IL 60611, USA
Biochem Biophys Res Commun 338:1143-51. 2005..Our findings open new ways to study mitochondrial membrane proteins in established cell culture systems by targeting them to the cell surface, where they can more reliably be studied using various molecular and cellular techniques... - Cytoprotective channels in mitochondriaHossein Ardehali
Feinberg Cardiovascular Institute, Northwestern University, 303 E Chicago Avenue, Chicago, IL 60611, USA
J Bioenerg Biomembr 37:171-7. 2005..This review attempts to provide an updated overview of the proposed mechanism for the protective function of these membrane proteins. Controversies and unanswered questions regarding these channels will also be discussed... - TOM20 and the heartbreakers: evidence for the role of mitochondrial transport proteins in cardioprotectionMark Bowers
J Mol Cell Cardiol 41:406-9. 2006