Hossein Ardehali

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Endomyocardial biopsy plays a role in diagnosing patients with unexplained cardiomyopathy
    Hossein Ardehali
    Division of Cardiology, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, USA
    Am Heart J 147:919-23. 2004
  2. ncbi request reprint Role of the mitochondrial ATP-sensitive K+ channels in cardioprotection
    Hossein Ardehali
    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Acta Biochim Pol 51:379-90. 2004
  3. ncbi request reprint A positive endomyocardial biopsy result for sarcoid is associated with poor prognosis in patients with initially unexplained cardiomyopathy
    Hossein Ardehali
    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Am Heart J 150:459-63. 2005
  4. pmc Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production
    Rongxue Wu
    Division of Cardiology, Department of Medicine, Northwestern University School of Medicine, Chicago, IL, USA
    EMBO Mol Med 4:633-46. 2012
  5. pmc Blockade of the erbB2 receptor induces cardiomyocyte death through mitochondrial and reactive oxygen species-dependent pathways
    Leo I Gordon
    Division of Hematology Oncology, Department of Medicine, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA
    J Biol Chem 284:2080-7. 2009
  6. pmc Regulation and cytoprotective role of hexokinase III
    Eugene Wyatt
    Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
    PLoS ONE 5:e13823. 2010
  7. ncbi request reprint Diagnostic approach to the patient with cardiomyopathy: whom to biopsy
    Hossein Ardehali
    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Am Heart J 149:7-12. 2005
  8. pmc Reduction in hexokinase II levels results in decreased cardiac function and altered remodeling after ischemia/reperfusion injury
    Rongxue Wu
    Department of Medicine, Northwestern University School of Medicine, Chicago, IL, USA
    Circ Res 108:60-9. 2011
  9. pmc Mitochondrial K(ATP) channels in cell survival and death
    Hossein Ardehali
    Institute of Molecular Cardiobiology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205 2195, USA
    J Mol Cell Cardiol 39:7-16. 2005
  10. pmc Translating the basic knowledge of mitochondrial functions to metabolic therapy: role of L-carnitine
    Santica M Marcovina
    Department of Medicine, University of Washington, Seattle, WA, USA
    Transl Res 161:73-84. 2013

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Endomyocardial biopsy plays a role in diagnosing patients with unexplained cardiomyopathy
    Hossein Ardehali
    Division of Cardiology, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, USA
    Am Heart J 147:919-23. 2004
    ..This study was undertaken to evaluate the utility of EMBx in confirming or excluding a clinically suspected diagnosis...
  2. ncbi request reprint Role of the mitochondrial ATP-sensitive K+ channels in cardioprotection
    Hossein Ardehali
    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Acta Biochim Pol 51:379-90. 2004
    ..This review attempts to provide an up-to-date overview of the role of mitoK(ATP) in cardioprotection...
  3. ncbi request reprint A positive endomyocardial biopsy result for sarcoid is associated with poor prognosis in patients with initially unexplained cardiomyopathy
    Hossein Ardehali
    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Am Heart J 150:459-63. 2005
    ..In patients with cardiomyopathy, the diagnosis of sarcoidosis has important treatment implications. We studied the prognostic implications of a cardiac biopsy diagnosis of sarcoidosis in patients with unexplained cardiomyopathy...
  4. pmc Hexokinase II knockdown results in exaggerated cardiac hypertrophy via increased ROS production
    Rongxue Wu
    Division of Cardiology, Department of Medicine, Northwestern University School of Medicine, Chicago, IL, USA
    EMBO Mol Med 4:633-46. 2012
    ..Overall, these data suggest that HKII and its mitochondrial binding negatively regulate cardiac hypertrophy by decreasing ROS production via mitochondrial permeability...
  5. pmc Blockade of the erbB2 receptor induces cardiomyocyte death through mitochondrial and reactive oxygen species-dependent pathways
    Leo I Gordon
    Division of Hematology Oncology, Department of Medicine, Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA
    J Biol Chem 284:2080-7. 2009
    ..Manipulation of redox signaling may be beneficial in cancer patients receiving trastuzumab...
  6. pmc Regulation and cytoprotective role of hexokinase III
    Eugene Wyatt
    Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
    PLoS ONE 5:e13823. 2010
    ..HKIII does not bind mitochondria, and little is known about its regulation or cytoprotective effects. We studied the regulation of HKIII at the transcriptional and protein levels and investigated its role in cellular protection...
  7. ncbi request reprint Diagnostic approach to the patient with cardiomyopathy: whom to biopsy
    Hossein Ardehali
    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Am Heart J 149:7-12. 2005
    ..However, our experience and recent evidence suggests that EMBx may be a valuable diagnostic modality and should be included in the evaluation of patients with initially unexplained cardiomyopathy...
  8. pmc Reduction in hexokinase II levels results in decreased cardiac function and altered remodeling after ischemia/reperfusion injury
    Rongxue Wu
    Department of Medicine, Northwestern University School of Medicine, Chicago, IL, USA
    Circ Res 108:60-9. 2011
    ..Hexokinase (HK)II is a HK isoform that is expressed in the heart and can bind to the mitochondrial outer membrane...
  9. pmc Mitochondrial K(ATP) channels in cell survival and death
    Hossein Ardehali
    Institute of Molecular Cardiobiology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205 2195, USA
    J Mol Cell Cardiol 39:7-16. 2005
    ..In this review, we attempt to highlight the recent advances in the physiological role of mitoK(ATP) and discuss the controversies and unanswered questions...
  10. pmc Translating the basic knowledge of mitochondrial functions to metabolic therapy: role of L-carnitine
    Santica M Marcovina
    Department of Medicine, University of Washington, Seattle, WA, USA
    Transl Res 161:73-84. 2013
    ..Thus, L-carnitine and its derivatives show promise in the treatment of chronic conditions and diseases associated with mitochondrial dysfunction but further translational studies are needed to fully explore their potential...
  11. pmc Targeting myocardial substrate metabolism in heart failure: potential for new therapies
    Hossein Ardehali
    Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Eur J Heart Fail 14:120-9. 2012
    ..We propose that cardiac energetics should be considered as a potential target for therapy in heart failure and more research should be done in this area...
  12. doi request reprint The sulfonylurea receptor, an atypical ATP-binding cassette protein, and its regulation of the KATP channel
    Michael A Burke
    Division of Cardiology, Feinberg Cardiovascular Institute, Northwestern University, Chicago, Ill, USA
    Circ Res 102:164-76. 2008
    ..Here, we review the structure and function of ABC proteins and discuss SUR, its regulation of the K(ATP) channel, and its role in cardiovascular disease...
  13. ncbi request reprint Mitochondrial ATP-binding cassette proteins
    Michael A Burke
    Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Transl Res 150:73-80. 2007
    ..In this review, we will discuss the structure, function, physiology, and pathophysiology of these mitochondrial ABC proteins...
  14. ncbi request reprint Comparison of survival among patients with connective tissue disease and cardiomyopathy (systemic sclerosis, systemic lupus erythematosus, and undifferentiated disease)
    Ilya Leyngold
    Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Cardiol 100:513-7. 2007
    ..Patients with systemic lupus erythematosus and cardiomyopathy have a similar prognosis to those with idiopathic DCM. Finally, the presence of myocarditis does not alter the survival of patients with CTD and cardiomyopathy...
  15. pmc Cardioprotective role of the mitochondrial ATP-binding cassette protein 1
    Hossein Ardehali
    Division of Cardiology, Feinberg Cardiovascular Institute, Northwestern University, Chicago, Ill, USA
    Circ Res 97:740-2. 2005
    ..These results support the notion that mABC1 protein plays a major role in cellular protection against oxidant stress, identifying mABC1 as a novel target for cardioprotective therapeutics...
  16. pmc Multiprotein complex containing succinate dehydrogenase confers mitochondrial ATP-sensitive K+ channel activity
    Hossein Ardehali
    Institute of Molecular Cardiobiology and Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 101:11880-5. 2004
    ..The findings also provide a tangible clue as to the structural basis of mitoK(ATP) channels...
  17. ncbi request reprint TOM20 and the heartbreakers: evidence for the role of mitochondrial transport proteins in cardioprotection
    Mark Bowers
    J Mol Cell Cardiol 41:406-9. 2006
  18. ncbi request reprint Cytoprotective channels in mitochondria
    Hossein Ardehali
    Feinberg Cardiovascular Institute, Northwestern University, 303 E Chicago Avenue, Chicago, IL 60611, USA
    J Bioenerg Biomembr 37:171-7. 2005
    ..This review attempts to provide an updated overview of the proposed mechanism for the protective function of these membrane proteins. Controversies and unanswered questions regarding these channels will also be discussed...
  19. ncbi request reprint Targeting of the mitochondrial membrane proteins to the cell surface for functional studies
    Hossein Ardehali
    Feinberg Cardiovascular Institute, Northwestern University, Chicago, IL 60611, USA
    Biochem Biophys Res Commun 338:1143-51. 2005
    ..Our findings open new ways to study mitochondrial membrane proteins in established cell culture systems by targeting them to the cell surface, where they can more reliably be studied using various molecular and cellular techniques...
  20. ncbi request reprint Signaling mechanisms in ischemic preconditioning: interaction of PKCepsilon and MitoK(ATP) in the inner membrane of mitochondria
    Hossein Ardehali
    Circ Res 99:798-800. 2006