L J Appel

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. doi request reprint Population-wide sodium reduction: the bumpy road from evidence to policy
    Lawrence J Appel
    Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD 21287, USA
    Ann Epidemiol 22:417-25. 2012
  2. doi request reprint Comparative effectiveness of weight-loss interventions in clinical practice
    Lawrence J Appel
    Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA
    N Engl J Med 365:1959-68. 2011
  3. doi request reprint Long-term effects of renin-angiotensin system-blocking therapy and a low blood pressure goal on progression of hypertensive chronic kidney disease in African Americans
    Lawrence J Appel
    Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins Institutions, Johns Hopkins University, Baltimore, MD 21205 2223, USA
    Arch Intern Med 168:832-9. 2008
  4. doi request reprint ASH Position Paper: Dietary approaches to lower blood pressure
    Lawrence J Appel
    Department of Medicine, Division of General Internal Medicine, Johns Hopkins University, Baltimore, MD 21205 2223, USA
    J Clin Hypertens (Greenwich) 11:358-68. 2009
  5. ncbi request reprint The effects of protein intake on blood pressure and cardiovascular disease
    Lawrence J Appel
    Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Curr Opin Lipidol 14:55-9. 2003
  6. pmc Intensive blood-pressure control in hypertensive chronic kidney disease
    Lawrence J Appel
    Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21205 2223, USA
    N Engl J Med 363:918-29. 2010
  7. ncbi request reprint Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial
    Lawrence J Appel
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Md 21205 2233, USA
    JAMA 289:2083-93. 2003
  8. ncbi request reprint Lifestyle modification as a means to prevent and treat high blood pressure
    Lawrence J Appel
    Professor of Medicine, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Am Soc Nephrol 14:S99-S102. 2003
  9. ncbi request reprint The rationale and design of the AASK cohort study
    Lawrence J Appel
    Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland, 21205, USA
    J Am Soc Nephrol 14:S166-72. 2003
  10. ncbi request reprint Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart randomized trial
    Lawrence J Appel
    Welch Center for Prevention, Epidemiology and Clinical Research, Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2223, USA
    JAMA 294:2455-64. 2005

Collaborators

Detail Information

Publications107 found, 100 shown here

  1. doi request reprint Population-wide sodium reduction: the bumpy road from evidence to policy
    Lawrence J Appel
    Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD 21287, USA
    Ann Epidemiol 22:417-25. 2012
    ..We highlight a number of lessons learned, many of which are germane to policy development in other domains...
  2. doi request reprint Comparative effectiveness of weight-loss interventions in clinical practice
    Lawrence J Appel
    Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA
    N Engl J Med 365:1959-68. 2011
    ..Obesity and its cardiovascular complications are extremely common medical problems, but evidence on how to accomplish weight loss in clinical practice is sparse...
  3. doi request reprint Long-term effects of renin-angiotensin system-blocking therapy and a low blood pressure goal on progression of hypertensive chronic kidney disease in African Americans
    Lawrence J Appel
    Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins Institutions, Johns Hopkins University, Baltimore, MD 21205 2223, USA
    Arch Intern Med 168:832-9. 2008
    ..A low blood pressure (BP) goal (BP, <130/80 mm Hg) is also recommended. The objective of this study was to determine the long-term effects of currently recommended BP therapy in 1094 African Americans with hypertensive CKD...
  4. doi request reprint ASH Position Paper: Dietary approaches to lower blood pressure
    Lawrence J Appel
    Department of Medicine, Division of General Internal Medicine, Johns Hopkins University, Baltimore, MD 21205 2223, USA
    J Clin Hypertens (Greenwich) 11:358-68. 2009
    ..The current challenge is designing and implementing effective clinical and public health interventions that lead to sustained dietary changes among individuals and more broadly in the general population...
  5. ncbi request reprint The effects of protein intake on blood pressure and cardiovascular disease
    Lawrence J Appel
    Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Curr Opin Lipidol 14:55-9. 2003
    ..In contrast, recent observational studies and clinical trials have suggested that increased protein intake, particularly protein from plant sources, might actually reduce blood pressure and prevent cardiovascular disease...
  6. pmc Intensive blood-pressure control in hypertensive chronic kidney disease
    Lawrence J Appel
    Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21205 2223, USA
    N Engl J Med 363:918-29. 2010
    ..Yet few trials have tested whether intensive blood-pressure control retards the progression of chronic kidney disease among black patients...
  7. ncbi request reprint Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial
    Lawrence J Appel
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Md 21205 2233, USA
    JAMA 289:2083-93. 2003
    ..The Dietary Approaches to Stop Hypertension (DASH) diet also lowers BP. To date, no trial has evaluated the effects of simultaneously implementing these lifestyle recommendations...
  8. ncbi request reprint Lifestyle modification as a means to prevent and treat high blood pressure
    Lawrence J Appel
    Professor of Medicine, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Am Soc Nephrol 14:S99-S102. 2003
    ..The current challenge to health care providers, researchers, government officials, and the general public is developing and implementing effective clinical and public health strategies that lead to sustained lifestyle modification...
  9. ncbi request reprint The rationale and design of the AASK cohort study
    Lawrence J Appel
    Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland, 21205, USA
    J Am Soc Nephrol 14:S166-72. 2003
    ..Such results might eventually lead to new strategies that delay or prevent ESRD...
  10. ncbi request reprint Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart randomized trial
    Lawrence J Appel
    Welch Center for Prevention, Epidemiology and Clinical Research, Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2223, USA
    JAMA 294:2455-64. 2005
    ..Reduced intake of saturated fat is widely recommended for prevention of cardiovascular disease. The type of macronutrient that should replace saturated fat remains uncertain...
  11. ncbi request reprint A primer on the design, conduct, and interpretation of clinical trials
    Lawrence J Appel
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205 2223, USA
    Clin J Am Soc Nephrol 1:1360-7. 2006
    ..The primary objective of this article is to provide an overview of the design, conduct, and interpretation of trials with an emphasis on aspects that are relevant to nephrology...
  12. ncbi request reprint Effects of reduced sodium intake on hypertension control in older individuals: results from the Trial of Nonpharmacologic Interventions in the Elderly (TONE)
    L J Appel
    Johns Hopkins University, 2024 E Monument St, Suite 2 645, Baltimore, MD 21205 2223, USA
    Arch Intern Med 161:685-93. 2001
    ..Few trials have evaluated the effects of reduced sodium intake in older individuals, and no trial has examined the effects in relevant subgroups such as African Americans...
  13. pmc Correlates of N-terminal prohormone brain natriuretic peptides in African Americans with hypertensive chronic kidney disease: the African American Study of Kidney Disease and Hypertension
    S Yi
    Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA
    Am J Nephrol 29:292-8. 2009
    ..Few correlates of NT-proBNP levels have been identified in persons with moderate chronic kidney disease (CKD), and data from those without heart failure and from African Americans are especially limited...
  14. ncbi request reprint Effect of dietary patterns on ambulatory blood pressure : results from the Dietary Approaches to Stop Hypertension (DASH) Trial. DASH Collaborative Research Group
    T J Moore
    Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
    Hypertension 34:472-7. 1999
    ..These results demonstrate that the DASH combination diet provides significant round-the-clock reduction in BP, especially in hypertensive participants...
  15. ncbi request reprint Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial
    Jackson T Wright
    Case Western Reserve University, Department of Medicine, University Hospitals of Cleveland and the Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH 44106 5014, USA
    JAMA 288:2421-31. 2002
    ..Hypertension is a leading cause of end-stage renal disease (ESRD) in the United States, with no known treatment to prevent progressive declines leading to ESRD...
  16. ncbi request reprint Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group
    F M Sacks
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 344:3-10. 2001
    ....
  17. ncbi request reprint Association between cigarette smoking and lipid peroxidation in a controlled feeding study
    E R Miller
    Welch Center for Prevention, Epidemiology and Clinical Research, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21205 2223, USA
    Circulation 96:1097-101. 1997
    ....
  18. ncbi request reprint Association of dietary protein intake and coffee consumption with serum homocysteine concentrations in an older population
    R Z Stolzenberg-Solomon
    Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD, USA
    Am J Clin Nutr 69:467-75. 1999
    ..Previous studies identified suboptimal nutritional status and dietary intake of folate, vitamin B-6, and vitamin B-12 as determinants of elevated tHcy...
  19. ncbi request reprint Effect of dietary patterns on serum homocysteine: results of a randomized, controlled feeding study
    L J Appel
    Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Circulation 102:852-7. 2000
    ..Although numerous studies have assessed the impact of vitamin supplements on homocysteine, the effect of dietary patterns on homocysteine has not been well studied...
  20. ncbi request reprint The role of diet in the prevention and treatment of hypertension
    L J Appel
    Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, 2024 East Monument Street, Suite 2 645, Baltimore, MD 21205 2223, USA
    Curr Atheroscler Rep 2:521-8. 2000
    ....
  21. ncbi request reprint Motivations for exercise and weight loss among African-American women: focus group results and their contribution towards program development
    D R Young
    Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, 2024 E, Monument Street No 2 600, Baltimore, MD 21205, USA
    Ethn Health 6:227-45. 2001
    ..To develop effective intervention strategies, we need to understand why some women are successful...
  22. ncbi request reprint The effects of macronutrients on blood pressure and lipids: an overview of the DASH and OmniHeart trials
    Edgar R Miller
    National Institute on Aging, National Institutes of Health, 3001 South Hanover Street, 5th Floor, Room NM 530, Baltimore, MD 21225, USA
    Curr Atheroscler Rep 8:460-5. 2006
    ..Furthermore, these results also document substantial flexibility that should enhance the ability of individuals to consume a heart-healthy diet...
  23. ncbi request reprint The PREMIER intervention helps participants follow the Dietary Approaches to Stop Hypertension dietary pattern and the current Dietary Reference Intakes recommendations
    Pao Hwa Lin
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Am Diet Assoc 107:1541-51. 2007
    ..To examine the influence of the PREMIER study lifestyle interventions on dietary intakes and adherence to the Dietary Approaches to Stop Hypertension (DASH) dietary pattern and the Dietary Reference Intakes (DRI)...
  24. doi request reprint The effects of dietary patterns on plasma renin activity: results from the Dietary Approaches to Stop Hypertension trial
    Q Chen
    Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Hum Hypertens 26:664-9. 2012
    ..002, P=0.98) or DASH diet (slope=-0.08, P=0.32). These data suggest that a blunted counter-regulatory response of the renin-angiotensin system is associated with the BP-lowering effect of the F/V and DASH diets...
  25. ncbi request reprint One year follow-up of overweight and obese hypertensive adults following intensive lifestyle therapy
    M L Jehn
    Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Hum Nutr Diet 19:349-54. 2006
    ..To examine the long-term effect on weight maintenance and dietary habits of participants in a clinical trial for weight loss...
  26. ncbi request reprint Results of the Diet, Exercise, and Weight Loss Intervention Trial (DEW-IT)
    Edgar R Miller
    Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, Baltimore, MD 21205 2223, USA
    Hypertension 40:612-8. 2002
    ..001), net of control. In conclusion, among hypertensive overweight adults already on antihypertensive medication, a comprehensive lifestyle intervention can substantially lower blood pressure and improve blood pressure control...
  27. pmc A behavioral weight-loss intervention for persons with serious mental illness in psychiatric rehabilitation centers
    G L Daumit
    Division of General Internal Medicine, Department of Medicine, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Int J Obes (Lond) 35:1114-23. 2011
    ..Overweight and obesity are epidemic in populations with serious mental illnesses. We developed and pilot-tested a behavioral weight-loss intervention appropriately tailored for persons with serious mental disorders...
  28. ncbi request reprint The DASH diet and sodium reduction improve markers of bone turnover and calcium metabolism in adults
    Pao Hwa Lin
    Department of Medicine, Sarah W Stedman Center for Nutritional Studies, Duke University Medical Center, Durham, NC, USA
    J Nutr 133:3130-6. 2003
    ..A reduced sodium intake reduced calcium excretion in both diet groups and serum OC in the DASH group. The DASH diet and reduced sodium intake may have complementary, beneficial effects on bone health...
  29. pmc Lifestyle interventions reduce coronary heart disease risk: results from the PREMIER Trial
    Nisa M Maruthur
    Division of General Internal Medicine and the Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Circulation 119:2026-31. 2009
    ....
  30. ncbi request reprint Vitamin-mineral supplementation and the progression of atherosclerosis: a meta-analysis of randomized controlled trials
    Joachim Bleys
    Department of Epidemiology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Am J Clin Nutr 84:880-7; quiz 954-5. 2006
    ..Although trials have not shown a benefit of these supplements on clinical cardiovascular events, it is unknown whether they affect the progression of atherosclerosis as measured by imaging techniques...
  31. pmc Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss
    S H Shah
    Department of Medicine, DUMC, Duke University Medical Center, Box 3445, Durham, NC 27710, USA
    Diabetologia 55:321-30. 2012
    ..Insulin resistance (IR) improves with weight loss, but this response is heterogeneous. We hypothesised that metabolomic profiling would identify biomarkers predicting changes in IR with weight loss...
  32. ncbi request reprint A comparison of the Yale Physical Activity Survey with other physical activity measures
    D R Young
    The Johns Hopkins University, Welch Center for Prevention, Epidemiology, and Clinical Research, 2024 E Monument Street 2 600, Baltimore, MD 21205, USA
    Med Sci Sports Exerc 33:955-61. 2001
    ..The purpose of this study was to determine associations of the Yale Physical Activity Survey (YPAS) with the Stanford 7-d physical activity recall (PAR) and several physiologic measures, both cross-sectionally and longitudinally...
  33. ncbi request reprint Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality
    Edgar R Miller
    The Johns Hopkins School of Medicine, and The Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2223, USA
    Ann Intern Med 142:37-46. 2005
    ..However, several trials of high-dosage vitamin E supplementation showed non-statistically significant increases in total mortality...
  34. pmc Changes in serum potassium mediate thiazide-induced diabetes
    Tariq Shafi
    Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD 21224 2780, USA
    Hypertension 52:1022-9. 2008
    ..Potassium supplementation might prevent thiazide-induced diabetes. This hypothesis can and should be tested in a randomized trial...
  35. pmc Reduction in consumption of sugar-sweetened beverages is associated with weight loss: the PREMIER trial
    Liwei Chen
    Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Am J Clin Nutr 89:1299-306. 2009
    ..Consumption of liquid calories from beverages has increased in parallel with the obesity epidemic in the US population, but their causal relation remains unclear...
  36. ncbi request reprint A dietary pattern that lowers oxidative stress increases antibodies to oxidized LDL: results from a randomized controlled feeding study
    Edgar R Miller
    Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, 2024 East Monument Street, Suite 2 624, Baltimore, MD 21205 2223, USA
    Atherosclerosis 183:175-82. 2005
    ..We tested the hypothesis that consumption of a healthy diet rich in fruits and vegetables and reduced in saturated fat, total fat, and cholesterol will concomitantly reduce oxidative stress and Ab-oxLDL...
  37. pmc The effect of n-3 long-chain polyunsaturated fatty acid supplementation on urine protein excretion and kidney function: meta-analysis of clinical trials
    Edgar R Miller
    Johns Hopkins School of Medicine, The Johns Hopkins Bloomberg School of Public Health, and The Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Am J Clin Nutr 89:1937-45. 2009
    ..Although epidemiologic and experimental studies suggest that n-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) supplementation may prevent or slow the progression of kidney disease, evidence from clinical trials is inconsistent...
  38. pmc Racial differences in urinary potassium excretion
    Sharon Turban
    Division of Nephrology, Johns Hopkins University School of Medicine, 1830 E Monument Street, Suite 416, Baltimore, MD 21205, USA
    J Am Soc Nephrol 19:1396-402. 2008
    ..39), and 903 mg/d in the DASH group (P < 0.001). Racial differences in urinary K excretion seem to reflect more than intake differences; further studies are needed to understand their potential impact on clinical outcomes...
  39. ncbi request reprint Inflammation modifies the effects of a reduced-fat low-cholesterol diet on lipids: results from the DASH-sodium trial
    Thomas P Erlinger
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circulation 108:150-4. 2003
    ..Inflammatory mediators regulate key aspects of lipid metabolism. We hypothesized that inflammation could diminish the cholesterol-lowering effect of a reduced-fat/low-cholesterol diet...
  40. ncbi request reprint The potential impact of nonpharmacologic population-wide blood pressure reduction on coronary heart disease events: pronounced benefits in African-Americans and hypertensives
    Thomas P Erlinger
    Welch Center for Prevention, Epidemiology and Clinical Research, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Prev Med 37:327-33. 2003
    ..However, several nonpharmacologic interventions reduce BP to a greater degree in hypertensives and African-Americans...
  41. ncbi request reprint ASH position paper: dietary approaches to lower blood pressure
    Lawrence J Appel
    Department of Medicine, Division of General Internal Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    J Am Soc Hypertens 4:79-89. 2010
    ..The current challenge is designing and implementing effective clinical and public health interventions that lead to sustained dietary changes among individuals and more broadly in the general population...
  42. ncbi request reprint Leukocytosis, hypoalbuminemia, and the risk for chronic kidney disease in US adults
    Thomas P Erlinger
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Kidney Dis 42:256-63. 2003
    ..Atherosclerosis and chronic kidney disease (CKD) share several common antecedents. However, the association between inflammatory markers and incident CKD is unknown...
  43. doi request reprint Meta-analysis of folic acid supplementation trials on risk of cardiovascular disease and risk interaction with baseline homocysteine levels
    Edgar R Miller
    The Johns Hopkins School of Medicine, Baltimore, MD, USA
    Am J Cardiol 106:517-27. 2010
    ..This interaction may have important implications for recommendations of FA supplement use. In the meantime, FA supplementation should not be recommended as a means to prevent or treat CVD or stroke...
  44. pmc Rate of ESRD exceeds mortality among African Americans with hypertensive nephrosclerosis
    Tahira P Alves
    Department of Medicine, Division of Nephrology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Am Soc Nephrol 21:1361-9. 2010
    ..In conclusion, AASK participants were more likely to reach ESRD than to die...
  45. pmc Independent but coordinated trials: insights from the practice-based Opportunities for Weight Reduction Trials Collaborative Research Group
    Hsin Chieh Yeh
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    Clin Trials 7:322-32. 2010
    ..Still, efforts were made to coordinate and standardize several aspects of the trials. The three trials formed a collaborative group, the 'Practice-based Opportunities for Weight Reduction (POWER) Trials Collaborative Research Group.'..
  46. ncbi request reprint The impact of angiotensin II receptor blockade and the DASH diet on markers of endogenous fibrinolysis
    T P Erlinger
    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    J Hum Hypertens 16:391-7. 2002
    ..In contrast, the DASH diet had no significant effect on markers of fibrinolysis in whites or African-Americans...
  47. doi request reprint N-terminal prohormone brain natriuretic peptide as a predictor of cardiovascular disease and mortality in blacks with hypertensive kidney disease: the African American Study of Kidney Disease and Hypertension (AASK)
    B C Astor
    Welch Center for Prevention, Epidemiology and Clinical Research, 2024 E Monument St, Suite 2 600, Baltimore, MD 21205, USA
    Circulation 117:1685-92. 2008
    ..Higher levels of N-terminal prohormone brain-type natriuretic peptide (NT-proBNP) predict cardiovascular disease (CVD) in several disease states, but few data are available in patients with chronic kidney disease or in blacks...
  48. ncbi request reprint Effect of dietary patterns on measures of lipid peroxidation: results from a randomized clinical trial
    E R Miller
    Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Circulation 98:2390-5. 1998
    ..Although previous studies have demonstrated a beneficial impact of antioxidant vitamin supplements on lipid peroxidation, the effect of dietary patterns on lipid peroxidation is unknown...
  49. doi request reprint Impacts of measurement protocols on blood pressure tracking from childhood into adulthood: a metaregression analysis
    Xiaoli Chen
    Center for Human Nutrition, Department of International Health, Bloomberg School of Public Health, Hopkins University, Baltimore, Johns Hopkins University, 615 N Wolfe St, Baltimore, MD 21205, USA
    Hypertension 51:642-9. 2008
    ..In general, Korotkoff phase 4 seems to be different from Korotkoff phase 5, and automated device is a promising approach for BP assessment in childhood...
  50. ncbi request reprint Relationship between systemic markers of inflammation and serum beta-carotene levels
    T P Erlinger
    Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, 2024 E Monument St, Suite 2 600, Baltimore, MD 21205, USA
    Arch Intern Med 161:1903-8. 2001
    ..This pattern of findings raises the possibility that confounding by other factors might explain the association between serum beta-carotene level and disease risk...
  51. ncbi request reprint Patient characteristics related to intensity of weight reduction care in a university medical clinic
    F L Brancati
    Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Health Institutions, Baltimore, MD 21205
    J Gen Intern Med 7:609-14. 1992
    ..Heightened awareness of being overweight may enhance the provision of weight reduction care. Prospective studies are required to confirm these findings...
  52. pmc Serum vitamin D, parathyroid hormone levels, and carotid atherosclerosis
    Jared P Reis
    Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Atherosclerosis 207:585-90. 2009
    ..Additional research is needed to determine whether vitamin D may influence the progression of atherosclerosis, including the effects of supplementation on the atherosclerotic process...
  53. pmc Aortic pulse pressure is associated with carotid IMT in chronic kidney disease: report from Chronic Renal Insufficiency Cohort
    Stephanie S DeLoach
    Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Am J Hypertens 22:1235-41. 2009
    ....
  54. ncbi request reprint Impact of pill organizers and blister packs on adherence to pill taking in two vitamin supplementation trials
    H Y Huang
    Department of Epidemiology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, MD 21205 2223, USA
    Am J Epidemiol 152:780-7. 2000
    ..In summary, use of blister packs, but not pill organizers, improved adherence as measured by pill counts among those with lower adherence. Neither pill delivery system improved adherence as measured by serum vitamin levels...
  55. ncbi request reprint Effects of vitamin C and vitamin E on in vivo lipid peroxidation: results of a randomized controlled trial
    Han Yao Huang
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore 21205 2223, USA
    Am J Clin Nutr 76:549-55. 2002
    ..Evidence predominantly from in vitro studies suggests that antioxidant vitamins can prevent lipid peroxidation and that vitamin C and vitamin E have synergistic effects. However, in vivo evidence in support of these hypotheses is sparse...
  56. ncbi request reprint The effect of ambient temperature and barometric pressure on ambulatory blood pressure variability
    Megan Jehn
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 2024 E Monument Street, Baltimore, MD 21205 2223, USA
    Am J Hypertens 15:941-5. 2002
    ..The effect of ambient temperature on cardiovascular disease has previously been studied. Less known are the effects of climate on blood pressure (BP) regulation, specifically, the role of temperature on BP variability...
  57. pmc Effects of folic acid supplementation on serum folate and plasma homocysteine concentrations in older adults: a dose-response trial
    Cheryl A M Anderson
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Am J Epidemiol 172:932-41. 2010
    ..However, for older adults with low serum folate levels, supplementation will improve folate status and may be beneficial for lowering homocysteine concentrations...
  58. doi request reprint Dietary sources of sodium in China, Japan, the United Kingdom, and the United States, women and men aged 40 to 59 years: the INTERMAP study
    Cheryl A M Anderson
    Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
    J Am Diet Assoc 110:736-45. 2010
    ..To avoid excess sodium intake in Japan, the United Kingdom, and the United States, salt must be reduced in commercially processed foods...
  59. ncbi request reprint Lifestyle modification: is it achievable and durable? The argument for
    Lawrence J Appel
    Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Clin Hypertens (Greenwich) 6:578-81. 2004
  60. doi request reprint Comparison of strategies for sustaining weight loss: the weight loss maintenance randomized controlled trial
    Laura P Svetkey
    Division of Nephrology, Department of Medicine, Duke Hypertension Center and Sarah W Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    JAMA 299:1139-48. 2008
    ..Behavioral weight loss interventions achieve short-term success, but re-gain is common...
  61. pmc Characteristics associated with fasting appetite hormones (obestatin, ghrelin, and leptin)
    Jeannette M Beasley
    Center for Clinical Trials, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Obesity (Silver Spring) 17:349-54. 2009
    ..Modifiable risk factors for chronic diseases, such as BMI, are associated with fasting levels of leptin, obestatin, and ghrelin...
  62. ncbi request reprint Supplementation of diets with alpha-tocopherol reduces serum concentrations of gamma- and delta-tocopherol in humans
    Han Yao Huang
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Nutr 133:3137-40. 2003
    ..In view of the potential benefits of gamma- and delta-tocopherol, the efficacy of alpha-tocopherol supplementation may be reduced due to decreases in serum gamma- and delta-tocopherol levels. Additional research is clearly warranted...
  63. ncbi request reprint Measuring blood pressure accurately: new and persistent challenges
    Daniel W Jones
    Department of Medicine, University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216 4505, USA
    JAMA 289:1027-30. 2003
  64. doi request reprint Vitamin D status and cardiometabolic risk factors in the United States adolescent population
    Jared P Reis
    Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Pediatrics 124:e371-9. 2009
    ..We examined whether low serum vitamin D levels (25-hydroxyvitamin D [25(OH)D]) are associated with cardiovascular risk factors in US adolescents aged 12 to 19 years...
  65. ncbi request reprint The effects of vitamin C supplementation on serum concentrations of uric acid: results of a randomized controlled trial
    Han Yao Huang
    Johns Hopkins University, Baltimore, Maryland 21205, USA
    Arthritis Rheum 52:1843-7. 2005
    ..Previous studies have suggested a uricosuric effect of vitamin C. Whether vitamin C reduces serum uric acid is unknown. We undertook this study to determine the effects of vitamin C supplementation on serum uric acid concentrations...
  66. ncbi request reprint Comprehensive lifestyle modification and blood pressure control: a review of the PREMIER trial
    Heather L McGuire
    Division of Nephrology, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Hypertens (Greenwich) 6:383-90. 2004
    ..001) compared with a decrease to 26% in the advice-only group. The PREMIER trial demonstrated that persons with above-optimal BP and stage 1 hypertension can make multiple lifestyle changes leading to better control of BP...
  67. ncbi request reprint Effects of omega-3 fatty acids on cardiovascular health
    Lawrence J Appel
    Am Fam Physician 70:34-5. 2004
  68. ncbi request reprint Successfully recruiting a multicultural population: the DASH-Sodium experience
    Betty M Kennedy
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Ethn Dis 15:123-9. 2005
    ..Although the most successful method of recruitment was mass mailing brochures, three times as many brochures were distributed to obtain similar success as in the initial DASH trial...
  69. ncbi request reprint A further subgroup analysis of the effects of the DASH diet and three dietary sodium levels on blood pressure: results of the DASH-Sodium Trial
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, Lousiana, USA
    Am J Cardiol 94:222-7. 2004
    ....
  70. ncbi request reprint Evidence-based guidelines for cardiovascular disease prevention in women. American Heart Association scientific statement
    Lori Mosca
    Arterioscler Thromb Vasc Biol 24:e29-50. 2004
  71. ncbi request reprint Beyond (or back to) traditional risk factors: preventing cardiovascular disease in patients with chronic kidney disease
    Lawrence J Appel
    Ann Intern Med 140:60-1. 2004
  72. ncbi request reprint Effect of dietary sodium intake on blood lipids: results from the DASH-sodium trial
    David W Harsha
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Hypertension 43:393-8. 2004
    ..There were no significant interactions between the effects of sodium and the DASH diet on serum lipids. In conclusion, changes in dietary sodium intake over the range of 50 to 150 mmol/d did not affect blood lipid concentrations...
  73. pmc Effect of protein, unsaturated fat, and carbohydrate intakes on plasma apolipoprotein B and VLDL and LDL containing apolipoprotein C-III: results from the OmniHeart Trial
    Jeremy D Furtado
    Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 87:1623-30. 2008
    ..Dietary intake affects lipoprotein concentration and composition related to those apolipoproteins...
  74. ncbi request reprint Individual blood pressure responses to changes in salt intake: results from the DASH-Sodium trial
    Eva Obarzanek
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 8136, MSC 7936, Bethesda, MD 20892 7936, USA
    Hypertension 42:459-67. 2003
    ....
  75. ncbi request reprint The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trials
    Sun Ha Jee
    Department of Epidemiology and Disease Control, Yonsei University Graduate School of Health Science and Management, Seoul, Korea
    Am J Hypertens 15:691-6. 2002
    ..An increased intake of magnesium might lower blood pressure (BP), yet evidence from clinical trials is inconsistent, perhaps as a result of small sample size or heterogeneity in study design...
  76. ncbi request reprint Association of angiotensin-converting enzyme DD genotype with blood pressure sensitivity to weight loss
    John B Kostis
    UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903 0019, USA
    Am Heart J 144:625-9. 2002
    ..Salt sensitivity--the degree of blood pressure change in response to a change in sodium load--has been extensively explored. However, the determinants of the extent of blood pressure change after weight reduction have not been evaluated...
  77. ncbi request reprint Primary prevention of hypertension: clinical and public health advisory from The National High Blood Pressure Education Program
    Paul K Whelton
    Department of Epidemiology and Medicine, Tulane University Health Sciences Center, Tulane University, New Orleans, LA, USA
    JAMA 288:1882-8. 2002
    ....
  78. ncbi request reprint Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease
    Penny M Kris-Etherton
    Circulation 106:2747-57. 2002
  79. ncbi request reprint The verdict from ALLHAT--thiazide diuretics are the preferred initial therapy for hypertension
    Lawrence J Appel
    JAMA 288:3039-42. 2002
  80. ncbi request reprint The DASH diet enhances the blood pressure response to losartan in hypertensive patients
    Paul R Conlin
    Division of Endocrinology, Diabetes and Hypertension PRC, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Hypertens 16:337-42. 2003
    ..We conducted a clinical trial to assess the BP response to the DASH diet with an antihypertensive medication, losartan, in participants with essential hypertension...
  81. ncbi request reprint The Chronic Renal Insufficiency Cohort (CRIC) Study: Design and Methods
    Harold I Feldman
    Center for Clinical Epidemiology, Philadelphia, 19104, USA
    J Am Soc Nephrol 14:S148-53. 2003
    ..Insights from CRIC should lead to the formulation of hypotheses regarding therapy that will serve as the basis for targeted interventional trials focused on reducing the burden of CRI and CVD...
  82. ncbi request reprint Sodium and blood pressure: no data dredging, please!
    Frank M Sacks
    Am J Hypertens 16:614-6. 2003
  83. ncbi request reprint Premier: a clinical trial of comprehensive lifestyle modification for blood pressure control: rationale, design and baseline characteristics
    Laura P Svetkey
    Duke Hypertension Center and Sarah W Stedman Center for Nutritional Studies, Duke University Medical Center, Durham, NC, USA
    Ann Epidemiol 13:462-71. 2003
    ..To describe PREMIER, a randomized trial to determine the effects of multi-component lifestyle interventions on blood pressure (BP)...
  84. doi request reprint Dietary patterns and longevity: expanding the blue zones
    Lawrence J Appel
    Circulation 118:214-5. 2008
  85. pmc Weight loss during the intensive intervention phase of the weight-loss maintenance trial
    Jack F Hollis
    Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon 97227, USA
    Am J Prev Med 35:118-26. 2008
    ..This paper describes methods and results for the initial 6-month weight-loss program (Phase I)...
  86. pmc Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial
    Vibha Bhatnagar
    University of California San Diego, La Jolla, USA
    J Hypertens 25:2082-92. 2007
    ..It has yet to be determined whether genotyping at the angiotensin-converting enzyme (ACE) locus is predictive of blood pressure response to an ACE inhibitor...
  87. ncbi request reprint Effects of comprehensive lifestyle modification on diet, weight, physical fitness, and blood pressure control: 18-month results of a randomized trial
    Patricia J Elmer
    Kaiser Permanente Northwest, Portland, Oregon 97227, USA
    Ann Intern Med 144:485-95. 2006
    ..The main 6-month results from the PREMIER trial showed that comprehensive behavioral intervention programs improve lifestyle behaviors and lower blood pressure...
  88. ncbi request reprint Differing effects of antihypertensive drugs on the incidence of diabetes mellitus among patients with hypertensive kidney disease
    Denyse Thornley-Brown
    Division of Nephrology, University of Alabama at Birmingham, USA
    Arch Intern Med 166:797-805. 2006
    ..We compared the incidence of type 2 diabetes mellitus (DM) and the composite outcome of impaired fasting glucose or DM (IFG/DM) for the African American Study of Kidney Disease and Hypertension interventions...
  89. ncbi request reprint Effects of PREMIER lifestyle modifications on participants with and without the metabolic syndrome
    Lillian F Lien
    Division of Endocrinology, Metabolism, and Nutrition, Duke University Medical Center, Durham, NC 27710, USA
    Hypertension 50:609-16. 2007
    ..Our data suggest that strategies for lowering BP in individuals with metabolic syndrome may be enhanced by recommendations to adopt the DASH dietary pattern...
  90. ncbi request reprint Effects of individual components of multiple behavior changes: the PREMIER trial
    Eva Obarzanek
    National Heart, Lung, and Blood Institute, Bethesda, MD 20892 7936, USA
    Am J Health Behav 31:545-60. 2007
    ..To assess contributions of individual lifestyle changes on systolic blood pressure (SBP) changes...
  91. ncbi request reprint Reductions in dietary energy density are associated with weight loss in overweight and obese participants in the PREMIER trial
    Jenny H Ledikwe
    Department of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, USA
    Am J Clin Nutr 85:1212-21. 2007
    ..Dietary energy density (ED) reductions are associated with energy intake (EI) reductions. Little is known about influences on body weight (BW)...
  92. pmc Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the trials of hypertension prevention (TOHP)
    Nancy R Cook
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    BMJ 334:885-8. 2007
    ..To examine the effects of reduction in dietary sodium intake on cardiovascular events using data from two completed randomised trials, TOHP I and TOHP II...
  93. ncbi request reprint Cardiovascular outcomes in the African American Study of Kidney Disease and Hypertension (AASK) Trial
    Keith Norris
    Charles R Drew University of Medicine and Science, Lynwood, CA 90262, USA
    Am J Kidney Dis 48:739-51. 2006
    ..Patients with chronic kidney disease are at increased risk for cardiovascular (CV) events...
  94. ncbi request reprint Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee
    Alice H Lichtenstein
    Circulation 114:82-96. 2006
    ..By adhering to these diet and lifestyle recommendations, Americans can substantially reduce their risk of developing cardiovascular disease, which remains the leading cause of morbidity and mortality in the United States...
  95. ncbi request reprint Prevalence and correlates of left ventricular hypertrophy in the African American Study of Kidney Disease Cohort Study
    Gail E Peterson
    Division of Cardiology, University of Texas Southwestern Medical Center, 5909 Harry Hines Blvd, HA9 133, Dallas, TX 75235 9047, USA
    Hypertension 50:1033-9. 2007
    ....
  96. ncbi request reprint Should reducing nocturnal blood pressure be a therapeutic target in CKD? The time is ripe for a clinical outcomes trial
    Mahboob Rahman
    Am J Kidney Dis 50:901-3. 2007
  97. ncbi request reprint Baseline predictors of renal disease progression in the African American Study of Hypertension and Kidney Disease
    Keith C Norris
    Associate Dean for Research, Charles R Drew University, 1731 E 120th Street, Los Angeles, CA 90059, USA
    J Am Soc Nephrol 17:2928-36. 2006
    ..These findings identify a subset of this high-risk population that might benefit from even more aggressive treatment...
  98. pmc Characteristics of the diet patterns tested in the optimal macronutrient intake trial to prevent heart disease (OmniHeart): options for a heart-healthy diet
    Janis F Swain
    General Clinical Research Center, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Am Diet Assoc 108:257-65. 2008
    ..To describe the nutrient and food composition of the diets tested in the Optimal Macronutrient Intake Trial to Prevent Heart Disease (OmniHeart)...
  99. pmc Alternatives for macronutrient intake and chronic disease: a comparison of the OmniHeart diets with popular diets and with dietary recommendations
    Russell J de Souza
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02215, USA
    Am J Clin Nutr 88:1-11. 2008
    ..The lower carbohydrate diets improved the CVD risk factors. Several popular diets claiming health benefits emphasize carbohydrate, fat, or protein or various combined approaches...
  100. doi request reprint Effect of group racial composition on weight loss in African Americans
    Jamy D Ard
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA
    Obesity (Silver Spring) 16:306-10. 2008
    ..We tested the hypothesis that AA who participate in all AA weight loss intervention groups will lose more weight than AA who participate in mixed race groups...
  101. doi request reprint Dietary phosphorus and blood pressure: international study of macro- and micro-nutrients and blood pressure
    Paul Elliott
    Department of Epidemiology and Public Health, Faculty of Medicine, St Mary s Campus, Imperial College London, London, United Kingdom
    Hypertension 51:669-75. 2008
    ..These results indicate the potential for increased phosphorus/mineral intake to lower blood pressure as part of the recommendations for healthier eating patterns for the prevention and control of prehypertension and hypertension...