M A Aon

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi GSH or palmitate preserves mitochondrial energetic/redox balance, preventing mechanical dysfunction in metabolically challenged myocytes/hearts from type 2 diabetic mice
    Carlo G Tocchetti
    Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Diabetes 61:3094-105. 2012
  2. ncbi Mitochondrial network energetics in the heart
    Miguel A Aon
    Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA
    Wiley Interdiscip Rev Syst Biol Med 4:599-613. 2012
  3. ncbi The scale-free dynamics of eukaryotic cells
    Miguel A Aon
    The Johns Hopkins University Institute of Molecular Cardiobiology, Baltimore, MD, USA
    PLoS ONE 3:e3624. 2008
  4. ncbi Control and regulation of integrated mitochondrial function in metabolic and transport networks
    Sonia Cortassa
    Johns Hopkins University, School of Medicine, Division of Cardiology 720 Rutland Ave, 1059 Ross Bldg, Baltimore, MD 21205, USA E Mails B O R M A
    Int J Mol Sci 10:1500-13. 2009
  5. ncbi From mitochondrial dynamics to arrhythmias
    M A Aon
    Johns Hopkins University, School of Medicine, Division of Cardiology, 720 Rutland Ave, 1059 Ross Bldg, Baltimore, MD 21205, USA
    Int J Biochem Cell Biol 41:1940-8. 2009
  6. ncbi Redox-optimized ROS balance: a unifying hypothesis
    M A Aon
    The Johns Hopkins University, School of Medicine, Institute of Molecular Cardiobiology, Baltimore, MD 21205 2195, USA
    Biochim Biophys Acta 1797:865-77. 2010

Research Grants

  1. Mechanisms Underlying Mitrochondrial Dysfunction in the Diabetic Heart
    Nazareno Paolocci; Fiscal Year: 2009
  2. Mechanisms Underlying Mitrochondrial Dysfunction in the Diabetic Heart
    Nazareno Paolocci; Fiscal Year: 2010

Collaborators

Detail Information

Publications6

  1. ncbi GSH or palmitate preserves mitochondrial energetic/redox balance, preventing mechanical dysfunction in metabolically challenged myocytes/hearts from type 2 diabetic mice
    Carlo G Tocchetti
    Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Diabetes 61:3094-105. 2012
    ....
  2. ncbi Mitochondrial network energetics in the heart
    Miguel A Aon
    Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA
    Wiley Interdiscip Rev Syst Biol Med 4:599-613. 2012
    ..Under severe energy crises, the network behavior of mitochondria and associated glycolytic and other metabolic networks collapse, thereby triggering fatal arrhythmias...
  3. ncbi The scale-free dynamics of eukaryotic cells
    Miguel A Aon
    The Johns Hopkins University Institute of Molecular Cardiobiology, Baltimore, MD, USA
    PLoS ONE 3:e3624. 2008
    ..We argue that the operation of scale-free bioenergetic dynamics plays a fundamental role to integrate cellular function, while providing a framework for robust, yet flexible, responses to the environment...
  4. ncbi Control and regulation of integrated mitochondrial function in metabolic and transport networks
    Sonia Cortassa
    Johns Hopkins University, School of Medicine, Division of Cardiology 720 Rutland Ave, 1059 Ross Bldg, Baltimore, MD 21205, USA E Mails B O R M A
    Int J Mol Sci 10:1500-13. 2009
    ..The approach we have used demonstrates how properties of integrated systems may be understood through applications of computational modeling and control analysis...
  5. ncbi From mitochondrial dynamics to arrhythmias
    M A Aon
    Johns Hopkins University, School of Medicine, Division of Cardiology, 720 Rutland Ave, 1059 Ross Bldg, Baltimore, MD 21205, USA
    Int J Biochem Cell Biol 41:1940-8. 2009
    ....
  6. ncbi Redox-optimized ROS balance: a unifying hypothesis
    M A Aon
    The Johns Hopkins University, School of Medicine, Institute of Molecular Cardiobiology, Baltimore, MD 21205 2195, USA
    Biochim Biophys Acta 1797:865-77. 2010
    ..The continuum described by the model has the potential to account for many disparate experimental observations and also provides a rationale for graded physiological ROS signaling at redox potentials near the minimum...

Research Grants2

  1. Mechanisms Underlying Mitrochondrial Dysfunction in the Diabetic Heart
    Nazareno Paolocci; Fiscal Year: 2009
    ....
  2. Mechanisms Underlying Mitrochondrial Dysfunction in the Diabetic Heart
    Nazareno Paolocci; Fiscal Year: 2010
    ....