Marilyn S Albert

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Changes in cognition
    Marilyn S Albert
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neurobiol Aging 32:S58-63. 2011
  2. ncbi request reprint Mild cognitive impairment and dementia
    Marilyn S Albert
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21212, USA
    Annu Rev Clin Psychol 2:379-88. 2006
  3. pmc The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    Marilyn S Albert
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Alzheimers Dement 7:270-9. 2011
  4. ncbi request reprint Longitudinal change in cognitive performance among individuals with mild cognitive impairment
    Marilyn Albert
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neuropsychology 21:158-69. 2007
  5. pmc A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
    April J Ho
    Laboratory of Neuroimaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:8404-9. 2010
  6. pmc Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairment
    Bradford C Dickerson
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Arch Gen Psychiatry 64:1443-50. 2007
  7. ncbi request reprint Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia
    Eric E Smith
    Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Arch Neurol 65:94-100. 2008
  8. pmc Evidence of altered posteromedial cortical FMRI activity in subjects at risk for Alzheimer disease
    Maija Pihlajamaki
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, MA, USA
    Alzheimer Dis Assoc Disord 24:28-36. 2010
  9. ncbi request reprint Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis
    Kim A Celone
    Memory Disorders Unit, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 26:10222-31. 2006
  10. pmc Selectivity of executive function deficits in mild cognitive impairment
    Jason Brandt
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, 21287 7218, USA
    Neuropsychology 23:607-18. 2009

Research Grants

Detail Information

Publications33

  1. pmc Changes in cognition
    Marilyn S Albert
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neurobiol Aging 32:S58-63. 2011
    ..There are recent reports that amyloid accumulation may also be associated with memory performance in cognitively normal individuals...
  2. ncbi request reprint Mild cognitive impairment and dementia
    Marilyn S Albert
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21212, USA
    Annu Rev Clin Psychol 2:379-88. 2006
    ....
  3. pmc The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    Marilyn S Albert
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Alzheimers Dement 7:270-9. 2011
    ..Considerable work is needed to validate the criteria that use biomarkers and to standardize biomarker analysis for use in community settings...
  4. ncbi request reprint Longitudinal change in cognitive performance among individuals with mild cognitive impairment
    Marilyn Albert
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neuropsychology 21:158-69. 2007
    ..Individuals with an APOE epsilon4 allele scored lower on the episodic memory and executive function factors at baseline...
  5. pmc A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
    April J Ho
    Laboratory of Neuroimaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:8404-9. 2010
    ..These brain maps reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly...
  6. pmc Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairment
    Bradford C Dickerson
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Arch Gen Psychiatry 64:1443-50. 2007
    ....
  7. ncbi request reprint Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia
    Eric E Smith
    Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Arch Neurol 65:94-100. 2008
    ..To determine whether magnetic resonance imaging (MRI) white matter hyperintensities (WMH), whole-brain atrophy, and cardiovascular risk factors predict the development of cognitive decline and dementia...
  8. pmc Evidence of altered posteromedial cortical FMRI activity in subjects at risk for Alzheimer disease
    Maija Pihlajamaki
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, MA, USA
    Alzheimer Dis Assoc Disord 24:28-36. 2010
    ..Altered fMRI activity of the posteromedial areas of the brain default network may be an early indicator of risk for AD...
  9. ncbi request reprint Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis
    Kim A Celone
    Memory Disorders Unit, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 26:10222-31. 2006
    ..These data may also provide functional evidence of the interaction between neocortical and medial temporal lobe pathology in early AD...
  10. pmc Selectivity of executive function deficits in mild cognitive impairment
    Jason Brandt
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, 21287 7218, USA
    Neuropsychology 23:607-18. 2009
    ..Multiple-domain MCI patients had more severe impairments in planning/problem solving and working memory than single-domain patients, leading to the supposition that they, not pure amnestic MCIs, are at highest risk of imminent dementia...
  11. pmc Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment
    Arnold Bakker
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    Neuron 74:467-74. 2012
    ....
  12. pmc Cerebrospinal fluid profiles and prospective course and outcome in patients with amnestic mild cognitive impairment
    Ozioma C Okonkwo
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Arch Neurol 68:113-9. 2011
    ..To examine the effect of specific cerebrospinal fluid (CSF) profiles on the rate of cognitive decline, disease progression, and risk of conversion to Alzheimer disease (AD) dementia in patients with amnestic mild cognitive impairment (MCI)...
  13. ncbi request reprint Medial temporal lobe function and structure in mild cognitive impairment
    Bradford C Dickerson
    Department of Neurology, Gerontology Research Unit, Massachusetts General Hospital, MGH East 149 2691, 149 13th Street, Charlestown, MA 02129, USA
    Ann Neurol 56:27-35. 2004
    ..We hypothesize that increased activation in MTL regions reflects a compensatory response to accumulating AD pathology and may serve as a marker for impending clinical decline...
  14. pmc The SIST-M: predictive validity of a brief structured clinical dementia rating interview
    Olivia I Okereke
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Alzheimer Dis Assoc Disord 26:225-31. 2012
    ....
  15. pmc The relation of patient dependence to home health aide use in Alzheimer's disease
    Rachel K Scherer
    Cognitive Neuroscience Division, Taub Institute for Research in Alzheimer s Disease and the Aging Brain, Gertrude H Sergievsky Center, Department of Neurology, Columbia University Medical Center, 630 West 168th St, P and S Box 16, New York, NY 10032, USA
    J Gerontol A Biol Sci Med Sci 63:1005-9. 2008
    ..The objective of this study was to examine whether the Dependence Scale can predict home health aide (HHA) use...
  16. ncbi request reprint Hippocampal and neocortical activation during repetitive encoding in older persons
    Erin Rand-Giovannetti
    Gerontology Research Unit, Department of Psychiatry, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, and Johns Hopkins University, Baltimore, MD 21205, USA
    Neurobiol Aging 27:173-82. 2006
    ..Our findings suggest that hippocampal function is preserved in normal aging and that repetition-based memory enhancing techniques may engage primarily neocortical attentional networks...
  17. ncbi request reprint Changing the trajectory of cognitive decline?
    Marilyn S Albert
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, USA
    N Engl J Med 357:502-3. 2007
  18. pmc Voxelwise genome-wide association study (vGWAS)
    Jason L Stein
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles School of Medicine, Neuroscience Research Building 225E, 635 Charles Young Drive, Los Angeles, CA 90095 1769, USA
    Neuroimage 53:1160-74. 2010
    ..These genes have high relevance to brain structure. This is the first voxelwise genome wide association study to our knowledge, and offers a novel method to discover genetic influences on brain structure...
  19. ncbi request reprint Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin
    Aleister J Saunders
    Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Hum Mol Genet 12:2765-76. 2003
    ..However, the negative case - control studies suggest that any underlying pathogenic polymorphisms have a modest effect, and may operate primarily among individuals with a family history of AD...
  20. pmc Measuring cerebral atrophy and white matter hyperintensity burden to predict the rate of cognitive decline in Alzheimer disease
    Adam M Brickman
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 630 W 168th St, Campus Box 16, New York, NY 10032, USA
    Arch Neurol 65:1202-8. 2008
    ..To determine if baseline measurements of cerebral atrophy and severity of white matter hyperintensity (WMH) predict the rate of future cognitive decline in patients with Alzheimer disease (AD)...
  21. ncbi request reprint Exploring candidate gene associations with neuropsychological performance
    Matthew B McQueen
    Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, Colorado 80309 0447, USA
    Am J Med Genet B Neuropsychiatr Genet 144:987-91. 2007
    ....
  22. ncbi request reprint Structural magnetic resonance imaging in established and prodromal Alzheimer disease: a review
    Monika Atiya
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston University, Boston, Massachusetts 02129, USA
    Alzheimer Dis Assoc Disord 17:177-95. 2003
  23. ncbi request reprint An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest
    Rahul S Desikan
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, W701, Boston, MA 02118, USA
    Neuroimage 31:968-80. 2006
    ....
  24. ncbi request reprint Achieving and maintaining cognitive vitality with aging
    Howard M Fillit
    Institute for the Study of Aging, Inc, New York, NY 10153, USA
    Mayo Clin Proc 77:681-96. 2002
    ..The data presented in this review should interest physicians who provide preventive care management to middle-aged and older individuals who seek to maintain cognitive vitality with aging...
  25. ncbi request reprint Predicting cognitive impairment in high-functioning community-dwelling older persons: MacArthur Studies of Successful Aging
    Joshua Chodosh
    Division of Geriatrics, UCLA School of Medicine, 10945 Le Conte Avenue, Los Angeles, CA 90095, USA
    J Am Geriatr Soc 50:1051-60. 2002
    ..To examine whether simple cognitive tests, when applied to cognitively intact older persons, are useful predictors of cognitive impairment 7 years later...
  26. ncbi request reprint Results of a high-resolution genome screen of 437 Alzheimer's disease families
    Deborah Blacker
    Massachusetts General Hospital, Charlestown, MA, USA
    Hum Mol Genet 12:23-32. 2003
    ..Although some of these will surely prove to be false positives, these linkage signals should provide a valuable framework for future studies aimed at identifying additional susceptibility genes for late-onset AD...
  27. ncbi request reprint Detection of very early Alzheimer disease through neuroimaging
    Marilyn S Albert
    Department of Psychiatry, Harvard Medical School, Massachusetts Geneal Hospital, Charlestown, Massachusetts, USA
    Alzheimer Dis Assoc Disord 17:S63-5. 2003
  28. ncbi request reprint MRI-guided SPECT perfusion measures and volumetric MRI in prodromal Alzheimer disease
    Georges El Fakhri
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arch Neurol 60:1066-72. 2003
    ....
  29. pmc Spatial distribution of white-matter hyperintensities in Alzheimer disease, cerebral amyloid angiopathy, and healthy aging
    Christopher M Holland
    Center for Neurological Imaging, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Stroke 39:1127-33. 2008
    ..We sought to determine whether the spatial distribution of WMHs discriminates between different disease groups and healthy aging individuals and whether these distributions are related to local cerebral perfusion patterns...
  30. ncbi request reprint Quantitative SPECT leads to improved performance in discrimination tasks related to prodromal Alzheimer's disease
    Georges El Fakhri
    Department of Radiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Nucl Med 45:2026-31. 2004
    ....
  31. ncbi request reprint Differential amygdala habituation to neutral faces in young and elderly adults
    Michelle M Wedig
    Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Harvard Medical School, 13th Street, Building 149, 2nd Floor, Charlestown, MA 02129, USA
    Neurosci Lett 385:114-9. 2005
    ..We conclude that, in healthy elderly adults, the amygdala retains its adaptive habituation response, but speculate that intrinsic changes in amygdala anatomy during aging may modulate its laterality...
  32. ncbi request reprint Association between mind-body and cardiovascular exercises and memory in older adults
    Agnes S Chan
    Department of Psychology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    J Am Geriatr Soc 53:1754-60. 2005
    ..Older adults who engaged in both types of exercise were also included to examine the combined effects...
  33. ncbi request reprint Memory decline: the boundary between aging and age-related disease
    Marilyn S Albert
    Ann Neurol 51:282-4. 2002

Research Grants2

  1. Research Training in Age-Related Cognitive Disorders
    Marilyn Albert; Fiscal Year: 2007
    ....
  2. Research Training in Age-Related Cognitive Disorders
    Marilyn Albert; Fiscal Year: 2008
    ....