Nishant Agrawal

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. pmc Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS
    Nishant Agrawal
    Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 98:E364-9. 2013
  2. pmc Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma
    Nishant Agrawal
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institutions, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer Discov 2:899-905. 2012
  3. pmc Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
    Nishant Agrawal
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Science 333:1154-7. 2011
  4. doi The relationship between chronic lymphocytic thyroiditis and central neck lymph node metastasis in North American patients with papillary thyroid carcinoma
    Sebastian M Jara
    Division of Head and Neck Endocrine Surgery, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD
    Surgery 154:1272-80; discussion 1280-2. 2013
  5. pmc Exomic sequencing of four rare central nervous system tumor types
    Chetan Bettegowda
    Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Oncotarget 4:572-83. 2013
  6. doi Profile of patients with completion thyroidectomy and assessment of their suitability for outpatient surgery
    Gaosong Wu
    Division of Thyroid and Parathyroid Surgery, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Otolaryngol Head Neck Surg 145:727-31. 2011
  7. pmc Lessons learned from next-generation sequencing in head and neck cancer
    Myriam Loyo
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Head Neck 35:454-63. 2013
  8. doi Primary and salvage total laryngectomy
    Nishant Agrawal
    Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 6th Floor, Baltimore, MD 21287, USA
    Otolaryngol Clin North Am 41:771-80, vii. 2008
  9. pmc Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas
    Yuchen Jiao
    Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, The Johns Hopkins Kimmel Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Oncotarget 3:709-22. 2012
  10. doi Implementation of a TORS program in an academic medical center
    Jeremy D Richmon
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland 21287 0910, USA
    Laryngoscope 121:2344-8. 2011

Collaborators

Detail Information

Publications22

  1. pmc Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS
    Nishant Agrawal
    Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 98:E364-9. 2013
    ..Objective: To explore the genetic origin of MTC, we sequenced the protein coding exons of approximately 21,000 genes in 17 sporadic MTCs...
  2. pmc Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma
    Nishant Agrawal
    Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institutions, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer Discov 2:899-905. 2012
    ..Finally, we provide a genetic basis for the evolution of EACs from Barrett esophagus...
  3. pmc Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
    Nishant Agrawal
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Science 333:1154-7. 2011
    ..Nearly 40% of the 28 mutations identified in NOTCH1 were predicted to truncate the gene product, suggesting that NOTCH1 may function as a tumor suppressor gene rather than an oncogene in this tumor type...
  4. doi The relationship between chronic lymphocytic thyroiditis and central neck lymph node metastasis in North American patients with papillary thyroid carcinoma
    Sebastian M Jara
    Division of Head and Neck Endocrine Surgery, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD
    Surgery 154:1272-80; discussion 1280-2. 2013
    ..We sought to assess the incidence of central nodal metastasis (CNM) in patients with PTC and concurrent CLT...
  5. pmc Exomic sequencing of four rare central nervous system tumor types
    Chetan Bettegowda
    Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Oncotarget 4:572-83. 2013
    ..Our study supports the hypothesis that pathologically similar tumors arising in different age groups and from different compartments may represent distinct disease processes with varied genetic composition...
  6. doi Profile of patients with completion thyroidectomy and assessment of their suitability for outpatient surgery
    Gaosong Wu
    Division of Thyroid and Parathyroid Surgery, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Otolaryngol Head Neck Surg 145:727-31. 2011
    ..The authors sought to evaluate postoperative complications associated with completion thyroidectomy in their institution to determine if it would be safe and feasible to perform as an outpatient procedure...
  7. pmc Lessons learned from next-generation sequencing in head and neck cancer
    Myriam Loyo
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Head Neck 35:454-63. 2013
    ..Emphasis is placed on the involved cellular pathways, clinical correlations, and potential therapeutic interventions. Additionally, the implications of human papillomavirus on mutation patterns are discussed...
  8. doi Primary and salvage total laryngectomy
    Nishant Agrawal
    Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 6th Floor, Baltimore, MD 21287, USA
    Otolaryngol Clin North Am 41:771-80, vii. 2008
    ..Nevertheless, total laryngectomy is not extinct and still plays an important role in primary therapy for advanced stage laryngeal cancers and as salvage therapy for failures of organ preservation strategies...
  9. pmc Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas
    Yuchen Jiao
    Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, The Johns Hopkins Kimmel Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Oncotarget 3:709-22. 2012
    ....
  10. doi Implementation of a TORS program in an academic medical center
    Jeremy D Richmon
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland 21287 0910, USA
    Laryngoscope 121:2344-8. 2011
    ..Various obstacles exist to efficiently implement this novel surgical technique in a busy academic center. We present our experience to illustrate one approach to initiating a TORS program...
  11. doi Detection of circulating tumor DNA in early- and late-stage human malignancies
    Chetan Bettegowda
    Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Sci Transl Med 6:224ra24. 2014
    ..Together, these data suggest that ctDNA is a broadly applicable, sensitive, and specific biomarker that can be used for a variety of clinical and research purposes in patients with multiple different types of cancer. ..
  12. pmc Mutations in CIC and FUBP1 contribute to human oligodendroglioma
    Chetan Bettegowda
    Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287, USA
    Science 333:1453-5. 2011
    ..These results suggest a critical role for these genes in the biology and pathology of oligodendrocytes...
  13. doi Image-guided transnasal endoscopic resection of an orbital solitary fibrous tumor
    Neil R Miller
    Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Ophthal Plast Reconstr Surg 24:65-7. 2008
    ..This approach should be added to the armamentarium of surgical approaches to orbital lesions...
  14. pmc Volumetric change of human papillomavirus-related neck lymph nodes before, during, and shortly after intensity-modulated radiation therapy
    Giuseppe Sanguineti
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, MD, USA
    Head Neck 34:1640-7. 2012
    ..To assess volumetric changes of human papillomavirus (HPV)-related lymph nodes (LN) before, during, and after a course of intensity-modulated radiation therapy (IMRT) ± chemotherapy...
  15. ncbi Use of fibrin sealant in closing mucocutaneous fistulas following head and neck cancer surgery
    Tarik Y Farrag
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0910, USA
    Otolaryngol Head Neck Surg 137:159-61. 2007
  16. doi Management of early-stage laryngeal cancer
    Nishant Agrawal
    Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 6th Floor, Baltimore, MD 21287, USA
    Otolaryngol Clin North Am 41:757-69, vi-vii. 2008
    ..Tumor factors, patient factors, and physician and patient preferences should dictate the choice of therapy...
  17. doi Does prosthesis diameter matter? The relationship between voice prosthesis diameter and complications
    Heather M Starmer
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    Otolaryngol Head Neck Surg 144:740-6. 2011
    ..To assess the impact of tracheoesophageal voice prosthesis diameter and treatment status on prosthesis-related complications...
  18. ncbi Laryngeal lipoma associated with diffuse lipomatosis: case report and literature review
    Megan L Durr
    Johns Hopkins Head and Neck Surgery at GBMC, 6569 N Charles St, PPW Suite 401, Baltimore, MD 21204, USA
    Ear Nose Throat J 89:34-7. 2010
    ..To the best of our knowledge, this is only the second case of laryngeal lipoma associated with lipomatosis to be reported in the English-language literature. We also review the literature on head and neck lipomas...
  19. pmc Evaluation of DNA from the Papanicolaou test to detect ovarian and endometrial cancers
    Isaac Kinde
    The Ludwig Center for Cancer Genetics and Therapeutics, The Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21287, USA
    Sci Transl Med 5:167ra4. 2013
    ..Although improvements need to be made before applying this test in a routine clinical manner, it represents a promising step toward a broadly applicable screening methodology for the early detection of gynecologic malignancies...
  20. pmc Oral cavity and oropharyngeal squamous cell carcinoma genomics
    Marietta Tan
    Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University School of Medicine, 601 North Caroline Street, Baltimore, MD 21287, USA
    Otolaryngol Clin North Am 46:545-66. 2013
    ..A discussion of the implications of these data on treatment and future goals for cancer genomics is included. ..
  21. pmc A large nonmetastatic anaplastic thyroid cancer with complete thyroidal confinement
    Jeffrey C Xing
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0910, USA
    Case Report Med 2011:583978. 2011
    ..This is an unusual case of ATC in that it is one of the largest ATC tumors reported to display mild pathologic behavior and relatively long-term patient survival...
  22. ncbi Algorithm for safe and effective reoperative thyroid bed surgery for recurrent/persistent papillary thyroid carcinoma
    Tarik Y Farrag
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Head Neck 29:1069-74. 2007
    ..The aim of this study was to review our experience with reoperative thyroid bed surgery (RTBS) for recurrent/persistent papillary thyroid cancer (PTC), and present an algorithm for safe and effective RTBS...