Research Topics
Genomes and GenesSpecies | Nishant AgrawalSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Exomic Sequencing of Medullary Thyroid Cancer Reveals Dominant and Mutually Exclusive Oncogenic Mutations in RET and RASNishant Agrawal
MD, AssociateJohns Hopkins University School of Medicine, Department of Otolaryngology Head and Neck Surgery, 601 North Caroline Street, JHOC 6, Baltimore, Maryland 21287
J Clin Endocrinol Metab 98:E364-9. 2013..Relatively few mutations overall and no commonly recurrent driver mutations other than RET, HRAS, and KRAS were seen in the MTC exome...- Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinomaNishant Agrawal
Ludwig Center for Cancer Genetics and Therapeutics and Howard Hughes Medical Institutions, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Cancer Discov 2:899-905. 2012..Finally, we provide a genetic basis for the evolution of EACs from Barrett esophagus... - Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1Nishant Agrawal
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA
Science 333:1154-7. 2011..Nearly 40% of the 28 mutations identified in NOTCH1 were predicted to truncate the gene product, suggesting that NOTCH1 may function as a tumor suppressor gene rather than an oncogene in this tumor type... 
Profile of patients with completion thyroidectomy and assessment of their suitability for outpatient surgeryGaosong Wu
Division of Thyroid and Parathyroid Surgery, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Otolaryngol Head Neck Surg 145:727-31. 2011..The authors sought to evaluate postoperative complications associated with completion thyroidectomy in their institution to determine if it would be safe and feasible to perform as an outpatient procedure...
Exomic sequencing of four rare central nervous system tumor typesChetan Bettegowda
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Oncotarget 4:572-83. 2013..Our study supports the hypothesis that pathologically similar tumors arising in different age groups and from different compartments may represent distinct disease processes with varied genetic composition...- Primary and salvage total laryngectomyNishant Agrawal
Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 6th Floor, Baltimore, MD 21287, USA
Otolaryngol Clin North Am 41:771-80, vii. 2008..Nevertheless, total laryngectomy is not extinct and still plays an important role in primary therapy for advanced stage laryngeal cancers and as salvage therapy for failures of organ preservation strategies... - Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomasYuchen Jiao
Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, The Johns Hopkins Kimmel Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Oncotarget 3:709-22. 2012.... - Implementation of a TORS program in an academic medical centerJeremy D Richmon
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland 21287 0910, USA
Laryngoscope 121:2344-8. 2011..Various obstacles exist to efficiently implement this novel surgical technique in a busy academic center. We present our experience to illustrate one approach to initiating a TORS program... - Mutations in CIC and FUBP1 contribute to human oligodendrogliomaChetan Bettegowda
Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21287, USA
Science 333:1453-5. 2011..These results suggest a critical role for these genes in the biology and pathology of oligodendrocytes... - Lessons learned from next-generation sequencing in head and neck cancerMyriam Loyo
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Head Neck 35:454-63. 2013..Emphasis is placed on the involved cellular pathways, clinical correlations, and potential therapeutic interventions. Additionally, the implications of human papillomavirus on mutation patterns are discussed... - Image-guided transnasal endoscopic resection of an orbital solitary fibrous tumorNeil R Miller
Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Ophthal Plast Reconstr Surg 24:65-7. 2008..This approach should be added to the armamentarium of surgical approaches to orbital lesions... - Volumetric change of human papillomavirus-related neck lymph nodes before, during, and shortly after intensity-modulated radiation therapyGiuseppe Sanguineti
Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, MD, USA
Head Neck 34:1640-7. 2012..To assess volumetric changes of human papillomavirus (HPV)-related lymph nodes (LN) before, during, and after a course of intensity-modulated radiation therapy (IMRT) ± chemotherapy... - Use of fibrin sealant in closing mucocutaneous fistulas following head and neck cancer surgeryTarik Y Farrag
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287-0910, USA
Otolaryngol Head Neck Surg 137:159-61. 2007 - Laryngeal lipoma associated with diffuse lipomatosis: case report and literature reviewMegan L Durr
Johns Hopkins Head and Neck Surgery at GBMC, 6569 N Charles St, PPW Suite 401, Baltimore, MD 21204, USA
Ear Nose Throat J 89:34-7. 2010..To the best of our knowledge, this is only the second case of laryngeal lipoma associated with lipomatosis to be reported in the English-language literature. We also review the literature on head and neck lipomas... - Management of early-stage laryngeal cancerNishant Agrawal
Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University School of Medicine, 601 North Caroline Street, JHOC 6th Floor, Baltimore, MD 21287, USA
Otolaryngol Clin North Am 41:757-69, vi-vii. 2008..Tumor factors, patient factors, and physician and patient preferences should dictate the choice of therapy... - Does prosthesis diameter matter? The relationship between voice prosthesis diameter and complicationsHeather M Starmer
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Otolaryngol Head Neck Surg 144:740-6. 2011..To assess the impact of tracheoesophageal voice prosthesis diameter and treatment status on prosthesis-related complications... - Evaluation of DNA from the Papanicolaou test to detect ovarian and endometrial cancersIsaac Kinde
The Ludwig Center for Cancer Genetics and Therapeutics, The Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21287, USA
Sci Transl Med 5:167ra4. 2013..Although improvements need to be made before applying this test in a routine clinical manner, it represents a promising step toward a broadly applicable screening methodology for the early detection of gynecologic malignancies... - A large nonmetastatic anaplastic thyroid cancer with complete thyroidal confinementJeffrey C Xing
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0910, USA
Case Report Med 2011:583978. 2011..This is an unusual case of ATC in that it is one of the largest ATC tumors reported to display mild pathologic behavior and relatively long-term patient survival... - Algorithm for safe and effective reoperative thyroid bed surgery for recurrent/persistent papillary thyroid carcinomaTarik Y Farrag
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Head Neck 29:1069-74. 2007..The aim of this study was to review our experience with reoperative thyroid bed surgery (RTBS) for recurrent/persistent papillary thyroid cancer (PTC), and present an algorithm for safe and effective RTBS...