Ruben Adler

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi request reprint Cell death in age-related macular degeneration
    R Adler
    The Departments of Ophthalmology and Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 9257, USA
    Mol Vis 5:31. 1999
  2. ncbi request reprint A model of retinal cell differentiation in the chick embryo
    R Adler
    Wilmer Eye Institute, The Johns Hopkins University, School of Medicine, MD, Baltimore, USA
    Prog Retin Eye Res 19:529-57. 2000
  3. ncbi request reprint Microenvironmental regulation of visual pigment expression in the chick retina
    R Adler
    Wilmer Ophthalmological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Dev Biol 236:454-64. 2001
  4. doi request reprint Curing blindness with stem cells: hope, reality, and challenges
    Ruben Adler
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Adv Exp Med Biol 613:3-20. 2008
  5. pmc Molecular mechanisms of optic vesicle development: complexities, ambiguities and controversies
    Ruben Adler
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 9257, USA
    Dev Biol 305:1-13. 2007
  6. pmc Challenges in the study of neuronal differentiation: a view from the embryonic eye
    Ruben Adler
    Department of Ophthalmology and Neuroscience The Johns Hopkins University School of Medicine Baltimore, MD 21287 9257, USA
    Dev Dyn 234:454-63. 2005
  7. pmc Transcription factors CTCF and Pax6 are segregated to different cell types during retinal cell differentiation
    M Valeria Canto-Soler
    The Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9257, USA
    Dev Dyn 237:758-67. 2008
  8. pmc Alternative splicing of neuroligin and its protein distribution in the outer plexiform layer of the chicken retina
    Karl J Wahlin
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Comp Neurol 518:4938-62. 2010
  9. pmc Roles of cell-intrinsic and microenvironmental factors in photoreceptor cell differentiation
    Rebecca L Bradford
    The Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Dev Biol 286:31-45. 2005
  10. ncbi request reprint Optic cup and lens development requires Pax6 expression in the early optic vesicle during a narrow time window
    M Valeria Canto-Soler
    The Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Dev Biol 294:119-32. 2006

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Cell death in age-related macular degeneration
    R Adler
    The Departments of Ophthalmology and Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 9257, USA
    Mol Vis 5:31. 1999
    ..We conclude with an overview of concepts and speculation derived from our current research...
  2. ncbi request reprint A model of retinal cell differentiation in the chick embryo
    R Adler
    Wilmer Eye Institute, The Johns Hopkins University, School of Medicine, MD, Baltimore, USA
    Prog Retin Eye Res 19:529-57. 2000
    ....
  3. ncbi request reprint Microenvironmental regulation of visual pigment expression in the chick retina
    R Adler
    Wilmer Ophthalmological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Dev Biol 236:454-64. 2001
    ..Taken together, these findings suggest that red opsin expression may be constitutive for many developing photoreceptor cells in the chick...
  4. doi request reprint Curing blindness with stem cells: hope, reality, and challenges
    Ruben Adler
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Adv Exp Med Biol 613:3-20. 2008
  5. pmc Molecular mechanisms of optic vesicle development: complexities, ambiguities and controversies
    Ruben Adler
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 9257, USA
    Dev Biol 305:1-13. 2007
    ..Finally, and without attempting to be exhaustive, we will point out some important aspects of optic vesicle development that have not yet received enough attention...
  6. pmc Challenges in the study of neuronal differentiation: a view from the embryonic eye
    Ruben Adler
    Department of Ophthalmology and Neuroscience The Johns Hopkins University School of Medicine Baltimore, MD 21287 9257, USA
    Dev Dyn 234:454-63. 2005
    ..This article will describe some of these challenges, while highlighting the conceptual and methodological breakthroughs that will be necessary to overcome them...
  7. pmc Transcription factors CTCF and Pax6 are segregated to different cell types during retinal cell differentiation
    M Valeria Canto-Soler
    The Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9257, USA
    Dev Dyn 237:758-67. 2008
    ..Functional studies are now under way to further analyze the role of CTCF in retinal cell differentiation...
  8. pmc Alternative splicing of neuroligin and its protein distribution in the outer plexiform layer of the chicken retina
    Karl J Wahlin
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Comp Neurol 518:4938-62. 2010
    ..This work lays the groundwork for future studies on the functional roles of the neuroligins within the retina...
  9. pmc Roles of cell-intrinsic and microenvironmental factors in photoreceptor cell differentiation
    Rebecca L Bradford
    The Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Dev Biol 286:31-45. 2005
    ....
  10. ncbi request reprint Optic cup and lens development requires Pax6 expression in the early optic vesicle during a narrow time window
    M Valeria Canto-Soler
    The Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Dev Biol 294:119-32. 2006
    ..The results, moreover, indicate that there is a critical stage during which Pax6 expression in the OV is necessary for normal lens development...
  11. ncbi request reprint Developmental regulation of muscleblind-like (MBNL) gene expression in the chicken embryo retina
    Hu Huang
    Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Dev Dyn 237:286-96. 2008
    ....
  12. ncbi request reprint Molecular dynamics of photoreceptor synapse formation in the developing chick retina
    Karl J Wahlin
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9257, USA
    J Comp Neurol 506:822-37. 2008
    ..The identity of the signals that regulate the coordinated expression of these synaptic components remains to be investigated...
  13. ncbi request reprint A method for analysis of gene expression in isolated mouse photoreceptor and Müller cells
    Karl J Wahlin
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 9257, USA
    Mol Vis 10:366-75. 2004
    ..The purpose of this study was to develop methods to assess gene expression in single retinal cells...
  14. ncbi request reprint Effects of follistatin overexpression on cell differentiation in the chick embryo retina
    Ernesto F Moreira
    Department of Opthalmology, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287 9257, USA
    Dev Biol 298:272-84. 2006
    ..Increases in cell death were also observed in FS-treated retinas. Taken together with previous in vitro studies, our results suggest that activin is a powerful regulator of neuronal differentiation in the central nervous system...
  15. ncbi request reprint Effects of homeobox genes on the differentiation of photoreceptor and nonphotoreceptor neurons
    Jeffrey Toy
    Wilmer Ophthalmological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Invest Ophthalmol Vis Sci 43:3522-9. 2002
    ....
  16. ncbi request reprint Gene discovery in the embryonic chick retina
    Abigail S Hackam
    Guerrieri Center for Genetic Engineering and Molecular Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287 9257, USA
    Mol Vis 9:262-76. 2003
    ..The purpose of this study was to identity and characterize genes expressed in the chick embryo retina as candidate molecules involved in the development and function of photoreceptors and other retinal cell types...
  17. ncbi request reprint The role of bone morphogenetic proteins in the differentiation of the ventral optic cup
    Ruben Adler
    The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Development 129:3161-71. 2002
    ..This was frequently accompanied by abnormal growth of ganglion cell axons, which failed to enter the optic nerve. The data suggest that endogenous BMPs have significant effects on the development of ventral optic cup structures...
  18. pmc Have we achieved a unified model of photoreceptor cell fate specification in vertebrates?
    Ruben Adler
    Wilmer Institute, Johns Hopkins University, School of Medicine, 519 Maumenee, 600 N Wolfe, Baltimore, MD 21287 9257, USA
    Brain Res 1192:134-50. 2008
    ..Based on these considerations, we conclude that we are not yet ready to construct a unified model of photoreceptor cell fate specification in the developing vertebrate retina...
  19. ncbi request reprint Bone morphogenetic protein 7 increases chick photoreceptor outer segment initiation
    Rachna Sehgal
    Department of Biology, Center for Regenerative Biology and Medicine, Indiana University Purdue University, Indianapolis, 46202, USA
    Invest Ophthalmol Vis Sci 47:3625-34. 2006
    ..The purpose of this study was to investigate the regulation of photoreceptor differentiation and outer segment elongation by the growth factor BMP7...
  20. ncbi request reprint Bone morphogenetic protein signaling and the initiation of lens fiber cell differentiation
    Teri Louise Belecky-Adams
    Department of Biology, Indiana University Purdue University Indianapolis, SL306, Indianapolis, IN 46202, USA
    Development 129:3795-802. 2002
    ..These data indicate that BMPs participate in the differentiation of lens fiber cells, along with at least one additional, and still unknown factor...

Research Grants27

  1. VISUAL NEURONS: DEVELOPMENTAL AND REGENERATION IN VITRO
    Ruben Adler; Fiscal Year: 1993
    ..Results from these studies should help us to understand not only normal photoreceptor development and function, but also the mechanisms leading to their disease and degeneration...
  2. VISUAL NEURONS--DEVELOPMENT AND REGENERATION IN VITRO
    Ruben Adler; Fiscal Year: 2000
    ..These studies are expected to shed light on cellular and molecular mechanisms of normal retinal development and function, and to contribute to the search for therapeutic approaches for retinal degenerative disorders. ..
  3. VISUAL NEURONS--DEVELOPMENT AND REGENERATION IN VITRO
    Ruben Adler; Fiscal Year: 2001
    ..The information derived from these studies is expected to further our understanding of the mechanisms of retinal development, and may also be relevant for some therapeutic approaches to retinal degenerations. ..
  4. VISUAL NEURONS--DEVELOPMENT AND REGENERATION IN VITRO
    Ruben Adler; Fiscal Year: 2002
    ..The information derived from these studies is expected to further our understanding of the mechanisms of retinal development, and may also be relevant for some therapeutic approaches to retinal degenerations. ..
  5. VISUAL NEURONS--DEVELOPMENT AND REGENERATION IN VITRO
    Ruben Adler; Fiscal Year: 2003
    ..The information derived from these studies is expected to further our understanding of the mechanisms of retinal development, and may also be relevant for some therapeutic approaches to retinal degenerations. ..
  6. VISUAL NEURONS--DEVELOPMENT AND REGENERATION IN VITRO
    Ruben Adler; Fiscal Year: 2004
    ..The information derived from these studies is expected to further our understanding of the mechanisms of retinal development, and may also be relevant for some therapeutic approaches to retinal degenerations. ..
  7. Gene Expression Analysis in Microcaptured Retinal Cells
    Ruben Adler; Fiscal Year: 2005
    ..The potential impact of the identification of these molecules is clear, since they could offer new avenues for the treatment of these devastating diseases. ..
  8. VISUAL NEURONS--DEVELOPMENT AND REGENERATION IN VITRO
    Ruben Adler; Fiscal Year: 2005
    ..The information derived from these studies is expected to further our understanding of the mechanisms of retinal development, and may also be relevant for some therapeutic approaches to retinal degenerations. ..
  9. VISUAL NEURONS--DEVELOPMENT AND REGENERATION IN VITRO
    Ruben Adler; Fiscal Year: 2006
    ....
  10. VISUAL NEUROSCIENCE TRAINING PROGRAM
    Ruben Adler; Fiscal Year: 2007
    ..State- of-the-art laboratories, study space for students, seminar rooms and libraries are located in adjacent buildings in the Medical School complex, and at the Mind/Brain Institute. ..
  11. VISUAL NEURONS: DEVELOPMENT AND REGENERATION IN VITRO
    Ruben Adler; Fiscal Year: 1992
    ..Results from these studies should help us to understand not only normal photoreceptor development and function, but also the mechanisms leading to their disease and degeneration...
  12. VISUAL NEURONS: DEVELOPMENT AND REGENERATION IN VITRO
    Ruben Adler; Fiscal Year: 1990
    ..Results from these studies should help us to understand not only normal photoreceptor development and function, but also the mechanisms leading to their disease and degeneration...
  13. VISUAL NEURONS--DEVELOPMENT AND REGENERATION IN VITRO
    Ruben Adler; Fiscal Year: 1999
    ..These studies are expected to shed light on cellular and molecular mechanisms of normal retinal development and function, and to contribute to the search for therapeutic approaches for retinal degenerative disorders. ..
  14. VISUAL NEURONS: DEVELOPMENT AND REGENERATION IN VITRO
    Ruben Adler; Fiscal Year: 1991
    ..Results from these studies should help us to understand not only normal photoreceptor development and function, but also the mechanisms leading to their disease and degeneration...
  15. VISUAL NEURONS--DEVELOPMENT AND REGENERATION IN VITRO
    Donald Zack; Fiscal Year: 2007
    ....