Research Topics
| R R TurnerSummaryAffiliation: John Wayne Cancer Institute Country: USA Publications
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Detail Information
Publications
Newer pathologic assessment techniques for colorectal carcinomaRoderick R Turner
Department of Pathology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA 90404, USA
Clin Cancer Res 13:6871s-6s. 2007..This brief review discusses the most promising of these approaches and evidence supporting their potential clinical utility...- Histopathologic assessment of the sentinel lymph node in breast cancerR R Turner
John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, California 90404, USA
Ann Surg Oncol 8:56S-59S. 2001..Pathologic characteristics of the primary tumor and SLN metastasis determine the risk of non-SLN metastasis in the same lymphatic basin... - Colorectal carcinoma nodal staging. Frequency and nature of cytokeratin-positive cells in sentinel and nonsentinel lymph nodesRoderick R Turner
Department of Pathology, Saint John s Health Center, Santa Monica, Calif, USA
Arch Pathol Lab Med 127:673-9. 2003..Nodal staging accuracy is important for prognosis and selection of patients for chemotherapy. Sentinel lymph node (SLN) mapping improves staging accuracy in breast cancer and melanoma and is being investigated for colorectal carcinoma... - Prospective observational study of sentinel lymphadenectomy without further axillary dissection in patients with sentinel node-negative breast cancerA E Giuliano
Joyce Eisenberg Keefer Breast Center, Division of Surgical Oncology, Statistical Coordinating Unit, Department of Nuclear Medicine, Santa Monica, CA, USA
J Clin Oncol 18:2553-9. 2000..Therefore, we hypothesized that SLND alone in patients with tumor-negative sentinel nodes would achieve axillary control, with minimal complications... - Molecular staging of early colon cancer on the basis of sentinel node analysis: a multicenter phase II trialA J Bilchik
Department of Molecular Oncology, John Wayne Cancer Institute, Saint John s Health Center, Santa Monica, CA 90404, USA
J Clin Oncol 19:1128-36. 2001..We hypothesized that multimarker reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of sentinel lymph nodes (SNs) draining a primary CRC could detect micrometastases not detected by conventional histopathologic analysis... 
Prognostic relevance of occult nodal micrometastases and circulating tumor cells in colorectal cancer in a prospective multicenter trialKazuo Koyanagi
Department of Molecular Oncology, John Wayne Cancer Institute, Santa Monica, California 90404, USA
Clin Cancer Res 14:7391-6. 2008..Nodal micrometastasis and circulating tumor cells detected by multimarker quantitative real-time reverse transcription-PCR (qRT-PCR) may have prognostic importance in patients with colorectal cancer...- Aberrant hypermethylation in primary tumours and sentinel lymph node metastases in paediatric patients with cutaneous melanomaK T Huynh
Department of Molecular Oncology, John Wayne Cancer Institute, Santa Monica, CA 90404, USA
Br J Dermatol 166:1319-26. 2012..Yet, there are no molecular prognostic studies identifying these differences... - Pathologic examination of sentinel lymph node for breast carcinomaR R Turner
Department of Surgery, John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica California 90404, USA
World J Surg 25:798-805. 2001..This review discusses our current understanding of the pathologic and molecular techniques for sentinel node examination... 
Nodal stage classification for breast carcinoma: improving interobserver reproducibility through standardized histologic criteria and image-based trainingRoderick R Turner
Department of Pathology, Saint John s Health Center, 1328 Twenty Second St, Santa Monica, CA 90404, USA
J Clin Oncol 26:258-63. 2008..We sought to determine whether a set of clearly defined histologic criteria could lead to reproducible nodal classification by pathologists...- Prognostic impact of micrometastases in colon cancer: interim results of a prospective multicenter trialAnton J Bilchik
Department of Gastrointestinal Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA 90404, and Michigan State University McLaren Regional Medical Center, Flint, MI, USA
Ann Surg 246:568-75; discussion 575-7. 2007..6% rate of micrometastases (MM) identified by immunohistochemical staining (IHC) of H&E-negative SNs in CC. We hypothesized that these MM have prognostic importance... - One hundred consecutive cases of sentinel lymph node mapping in early colorectal carcinoma: detection of missed micrometastasesThomas F Wood
John Wayne Cancer Institute, Santa Monica, CA 90404, USA
J Gastrointest Surg 6:322-9; discussion 229-30. 2002..Further studies are necessary to elucidate the clinical relevance of these micrometastases... - Lymphoscintigraphy and lymphatic mapping for identification of sentinel lymph nodesE C Hsueh
Joyce Eisenberg Keefer Breast Center and the Division of Surgical Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA 90404, USA
World J Surg 25:794-7. 2001.... - Peptide nucleic acid clamp PCR: a novel K-ras mutation detection assay for colorectal cancer micrometastases in lymph nodesBret Taback
Department of Molecular Oncology, John Wayne Cancer Institute, Saint John s Health Center, Santa Monica, CA 90404, USA
Int J Cancer 111:409-14. 2004..This study demonstrates the utility, specificity and sensitivity of PNA clamp PCR assay in identifying occult micrometastases in the SLN of CRC patients by single-base mutation analysis... - Human high molecular weight-melanoma-associated antigen: utility for detection of metastatic melanoma in sentinel lymph nodesYasufumi Goto
Department of Molecular Oncology, John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
Clin Cancer Res 14:3401-7. 2008..Immunohistochemical staining (IHC) using S-100p-HMB-45-, and MART-1-specific antibodies is used for detecting metastases in sentinel lymph nodes (SLN). However, improvement in IHC is needed for melanoma micrometastasis detection... - Nonsentinel node metastases in breast cancer patients with isolated tumor cells in the sentinel node: implications for completion axillary node dissectionKristine E Calhoun
The Joyce Eisenberg Keefer Breast Center, John Wayne Cancer Institute at Saint John's Health Center, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
Am J Surg 190:588-91. 2005..3% had micrometastases. When ALND was not performed, axillary recurrence was not seen. The low risk of non-SLN disease in this study fails to support the routine use of ALND for ITC-positive SLNs... - Impact of micrometastases in the sentinel node of patients with invasive breast cancerNora M Hansen
John Wayne Cancer Institute, Santa Monica, CA 90404, USA
J Clin Oncol 27:4679-84. 2009..This study is based on the new sixth edition of the American Joint Committee on Cancer (AJCC) staging criteria... - Prognostic significance of molecular upstaging of paraffin-embedded sentinel lymph nodes in melanoma patientsHiroya Takeuchi
Department of Molecular Oncology, John Wayne Cancer Institute, Saint John's Health Center, Santa Monica, CA 90404, USA
J Clin Oncol 22:2671-80. 2004..CONCLUSION: Molecular upstaging of PE histopathology-negative SLNs by multiple-marker qRT assay is a significant independent prognostic factor for long-term disease recurrence and overall survival of patients with early-stage melanoma... - Prospective multicenter trial of staging adequacy in colon cancer: preliminary resultsAnton J Bilchik
John Wayne Cancer Institute and Saint Johns Health Center, Santa Monica, CA 90404, USA
Arch Surg 141:527-33; discussion 533-4. 2006..A 25% recurrence rate in patients with node-negative CRC suggests that current staging practices are inadequate. Focused analysis of the sentinel node (SN) by multiple sectioning and immunohistochemistry improves staging accuracy... - Carbon dye histologically confirms the identity of sentinel lymph nodes in cutaneous melanomaP I Haigh
Roy E. Coats Research Laboratories, Division of Surgical Oncology, John Wayne Cancer Institute at Saint John's Health Center, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
Cancer 92:535-41. 2001..The location of carbon particles within SNs may assist the pathologist in the detection of metastases, thereby decreasing the histopathologic false-negative rate of LM/SL and subsequently reducing the same-basin recurrence rate... - Predictors of occult nodal metastasis in colon cancer: results from a prospective multicenter trialNabil Wasif
John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA, USA
Surgery 147:352-7. 2010..We sought to investigate the correlation of clinicopathologic features of colon cancer with OMs and to identify predictors of OM... - Effect of lymphatic mapping on the new tumor-node-metastasis classification for colorectal cancerAnton J Bilchik
Division of Surgical Oncology, John Wayne Cancer Institute at Saint John s Health Center, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
J Clin Oncol 21:668-72. 2003..This study examined the role of lymphatic mapping (LM) in the application of the new tumor-node-metastasis (TNM) classification for MM and ITC... - Lymphatic mapping and sentinel lymphadenectomy for early-stage melanoma: therapeutic utility and implications of nodal microanatomy and molecular staging for improving the accuracy of detection of nodal micrometastasesDonald L Morton
Roy E Coats Research Laboratories of the John Wayne Cancer Insstitute at Saint John s Health Center, Santa Monica, CA 90404, USA
Ann Surg 238:538-49; discussion 549-50. 2003.... - Lymphatic mapping establishes the role of BRAF gene mutation in papillary thyroid carcinomaJoseph Kim
Department of Molecular Oncology, John Wayne Cancer Institute at Saint Johns Hospital, Santa Monica, CA 90404, USA
Ann Surg 244:799-804. 2006..To define the role of BRAF gene mutation in the progression of papillary thyroid carcinoma... - Molecular diagnosis of micrometastasis in the sentinel lymph nodeHiroya Takeuchi
Department of Molecular Oncology, John Wayne Cancer Institute, Saint John's Health Center, Santa Monica, California 90404, USA
Cancer Treat Res 127:221-52. 2005 - Proteomic profiling of primary breast cancer predicts axillary lymph node metastasisTaku Nakagawa
Department of Molecular Oncology, Division of Biostatistics, and Joyce Eisenberg Keefer Breast Center, John Wayne Cancer Institute, Santa Monica, CA 90404, USA
Cancer Res 66:11825-30. 2006..016 and 0.0083, respectively). ProteinChip array analysis identified differential protein peaks in primary breast cancers that predict the presence and number of ALN metastases and non-SLN status... - Melanoma recurrence patterns after negative sentinel lymphadenectomyTheresa G Zogakis
Roy E. Coats Research Laboratories, John Wayne Cancer Institute, Saint John's Health Center, Santa Monica, CA 90404, USA
Arch Surg 140:865-71; discussion 871-2. 2005..The low incidence (1.7%) of regional basin recurrence in patients with negative SNs supports the accuracy of our current method of lymphatic mapping and sentinel lymphadenectomy to identify occult regional nodal basin metastasis... - Quantitative analysis of methylation of genomic loci in early-stage rectal cancer predicts distant recurrenceMichiel F G de Maat
Department of Molecular Oncology, John Wayne Cancer Institute, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
J Clin Oncol 26:2327-35. 2008..We then explored in a different clinical patient group whether these epigenetic changes could be correlated with clinical outcome... - Chemokine receptor CXCR4 expression in patients with melanoma and colorectal cancer liver metastases and the association with disease outcomeJoseph Kim
Department of Molecular Oncology, Gastrointestinal Cancer Section, John Wayne Cancer Institute, Saint John's Health Center, Santa Monica, CA 90404, USA
Ann Surg 244:113-20. 2006..Quantitative analysis of CXCR4 gene expression in patients with liver metastases has prognostic significance for disease outcome... - Isolated tumor cells in the sentinel node affect long-term prognosis of patients with melanomaRandall P Scheri
Department of Surgical Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA, USA
Ann Surg Oncol 14:2861-6. 2007..The clinical significance of isolated tumor cells (ITCs) in the melanoma-draining sentinel nodes (SNs) is unclear... - Importance of sentinel lymph node biopsy in patients with thin melanomaByron E Wright
Department of Surgical Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, California 90404, USA
Arch Surg 143:892-9; discussion 899-900. 2008..The status of the sentinel node (SN) confers important prognostic information for patients with thin melanoma... - Chemokine receptor CXCR4 expression in colorectal cancer patients increases the risk for recurrence and for poor survivalJoseph Kim
Department of Molecular Oncology, John Wayne Cancer Institute, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
J Clin Oncol 23:2744-53. 2005..The CXCR4-CXCL12 signaling mechanism may be clinically relevant for patients with CRC and represents a potential novel target for disease-directed therapy... - Assessment of methylation events during colorectal tumor progression by absolute quantitative analysis of methylated allelesMichiel F G de Maat
Department of Molecular Oncology, John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
Mol Cancer Res 5:461-71. 2007.... - American Society of Clinical Oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancerGary H Lyman
University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
J Clin Oncol 23:7703-20. 2005..To develop a guideline for the use of sentinel node biopsy (SNB) in early stage breast cancer... - Outcomes for women with ductal carcinoma-in-situ and a positive sentinel node: a multi-institutional auditKatrina H Moore
Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, MRI 1026, New York, NY 10021, USA
Ann Surg Oncol 14:2911-7. 2007..Although it is well established that nodal status for invasive disease is prognostically important, the clinical relevance of a positive SLN in patients with DCIS remains undetermined...