Research Topics
| A J BilchikSummaryAffiliation: John Wayne Cancer Institute Country: USA Publications
| Collaborators
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Detail Information
Publications
Colorectal carcinoma nodal staging. Frequency and nature of cytokeratin-positive cells in sentinel and nonsentinel lymph nodesRoderick R Turner
Department of Pathology, Saint John s Health Center, Santa Monica, Calif, USA
Arch Pathol Lab Med 127:673-9. 2003..Nodal staging accuracy is important for prognosis and selection of patients for chemotherapy. Sentinel lymph node (SLN) mapping improves staging accuracy in breast cancer and melanoma and is being investigated for colorectal carcinoma...- Aberrant drainage and missed micrometastases: the value of lymphatic mapping and focused analysis of sentinel lymph nodes in gastrointestinal neoplasmsA J Bilchik
John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, California 90404, USA
Ann Surg Oncol 8:82S-85S. 2001..Our cumulative experience indicates that focused analysis of the SLNs draining GI neoplasms can increase the detection of micrometastases and may improve selection of patients for adjuvant treatment... - Prospective multicenter trial of staging adequacy in colon cancer: preliminary resultsAnton J Bilchik
John Wayne Cancer Institute and Saint Johns Health Center, Santa Monica, CA 90404, USA
Arch Surg 141:527-33; discussion 533-4. 2006..A 25% recurrence rate in patients with node-negative CRC suggests that current staging practices are inadequate. Focused analysis of the sentinel node (SN) by multiple sectioning and immunohistochemistry improves staging accuracy... - Lymphatic mapping and sentinel node analysis to optimize laparoscopic resection and staging of colorectal cancer: an updateAnton J Bilchik
John Wayne Cancer Institute, Saint John s Health Center, Santa Monica, CA 90404, USA
Cancer Control 10:219-23. 2003..Lymphatic mapping (LM) and sentinel lymph node (SLN) analysis can improve the accuracy of staging in open colectomy, but its utility during laparoscopic colectomy is unknown... - Effect of lymphatic mapping on the new tumor-node-metastasis classification for colorectal cancerAnton J Bilchik
Division of Surgical Oncology, John Wayne Cancer Institute at Saint John s Health Center, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
J Clin Oncol 21:668-72. 2003..This study examined the role of lymphatic mapping (LM) in the application of the new tumor-node-metastasis (TNM) classification for MM and ITC... - Prognostic impact of micrometastases in colon cancer: interim results of a prospective multicenter trialAnton J Bilchik
Department of Gastrointestinal Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA 90404, and Michigan State University McLaren Regional Medical Center, Flint, MI, USA
Ann Surg 246:568-75; discussion 575-7. 2007..6% rate of micrometastases (MM) identified by immunohistochemical staining (IHC) of H&E-negative SNs in CC. We hypothesized that these MM have prognostic importance... - Ultrastaging of early colon cancer using lymphatic mapping and molecular analysisA J Bilchik
The John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
Eur J Cancer 38:977-85. 2002..This may have important implications when selecting patients for adjuvant treatment protocols... - Arterial chemotherapy as adjuvant and palliative treatment of hepatic colorectal metastases: an updateAnton J Bilchik
John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
Surg Oncol Clin N Am 12:193-210. 2003..Molecular analysis of the tumor may ultimately help select patients who are good candidates for regional chemotherapy... - The use of molecular profiling of early colorectal cancer to predict micrometastasesAnton J Bilchik
Department of Molecular Oncology, John Wayne Cancer Institute, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
Arch Surg 137:1377-83. 2002..Lymphatic mapping followed by focused analysis of the sentinel node is highly accurate in identifying micrometastases... - Systemic irinotecan or regional floxuridine chemotherapy prolongs survival after hepatic cryosurgery in patients with metastatic colon cancer refractory to 5-fluorouracilA J Bilchik
John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA, USA
Clin Colorectal Cancer 1:36-42. 2001..These data indicate that CSA offers an effective alternative for unresectable patients resistant to 5-FU. Systemic CPT-11 or regional FUDR may further prolong survival after CSA... - Molecular staging of early colon cancer on the basis of sentinel node analysis: a multicenter phase II trialA J Bilchik
Department of Molecular Oncology, John Wayne Cancer Institute, Saint John s Health Center, Santa Monica, CA 90404, USA
J Clin Oncol 19:1128-36. 2001..We hypothesized that multimarker reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of sentinel lymph nodes (SNs) draining a primary CRC could detect micrometastases not detected by conventional histopathologic analysis... - Radiofrequency ablation of unresectable hepatic malignancies: lessons learnedA J Bilchik
Department of Surgical Oncology, John Wayne Cancer Institute, Santa Monica, California 90404, USA
Oncologist 6:24-33. 2001..Complications may be minimized when these approaches are selectively applied... - Cryosurgical ablation and radiofrequency ablation for unresectable hepatic malignant neoplasms: a proposed algorithmA J Bilchik
John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, Calif 90404, USA
Arch Surg 135:657-62; discussion 662-4. 2000..Thermal ablation of unresectable hepatic tumors can be achieved by cryosurgical ablation (CSA) or radiofrequency ablation (RFA). The relative advantages and disadvantages of each technique have not yet been determined... - Validation of lymphatic mapping in colorectal cancer: in vivo, ex vivo, and laparoscopic techniquesT F Wood
John Wayne Cancer Institute, Santa Monica, California 90404, USA
Ann Surg Oncol 8:150-7. 2001..During LCR, colonoscopic injection can be used to mark the primary tumor and define the lymphatic drainage so that adequate resection margins are obtained. These LM techniques improve staging accuracy in CRC... - Lymphatic mapping improves staging during laparoscopic colectomy for cancerT F Wood
The John Wayne Cancer Institute, Saint John's Health Center, Department of Surgical Oncology, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
Surg Endosc 15:715-9. 2001..Focused examination of SN identifies occult micrometastases that up-stage CRC... - Laparoscopic radiofrequency ablation of unresectable hepatic malignancies. A phase 2 trialM H Chung
John Wayne Cancer Institute, Saint John's Health Center, 2200 Santa Monica Boulevard, Santa Monica, California, 90404, USA
Surg Endosc 15:1020-6. 2001..CONCLUSION: Laparoscopic RFA and intraoperative ultrasound constitute a safe and accurate method for ablation of unresectable hepatic tumors... - Repeat hepatic cryotherapy for metastatic colorectal cancerM H Chung
John Wayne Cancer Institute, Santa Monica, Calif 90404, USA
J Gastrointest Surg 5:287-93. 2001..However, a prospective trial is needed to validate the efficacy of systemic therapy and to better define the indications for repeat hepatic cryotherapy... - Systemic irinotecan and regional floxuridine after hepatic cytoreduction in 185 patients with unresectable colorectal cancer metastasesDavid A Litvak
Division of Surgical Oncology, John Wayne Cancer Institute, Saint John's Health Center, Santa Monica, California, USA
Ann Surg Oncol 9:148-55. 2002..CONCLUSIONS: Combined therapy with irinotecan/FUDR may improve the results of surgical cytoreduction for unresectable CRC hepatic metastases... 
Prognostic relevance of occult nodal micrometastases and circulating tumor cells in colorectal cancer in a prospective multicenter trialKazuo Koyanagi
Department of Molecular Oncology, John Wayne Cancer Institute, Santa Monica, California 90404, USA
Clin Cancer Res 14:7391-6. 2008..Nodal micrometastasis and circulating tumor cells detected by multimarker quantitative real-time reverse transcription-PCR (qRT-PCR) may have prognostic importance in patients with colorectal cancer...- Radiofrequency ablation of hepatic metastases from colorectal cancer: are newer generation probes better?Aziz Ahmad
John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, California 90404, USA
Am Surg 72:875-9. 2006..Newer-generation probes are associated with lower rates of margin recurrence and higher rates of disease-free survival after RFA of hepatic metastases from colorectal cancer... - CancerVax, an allogeneic tumor cell vaccine, induces specific humoral and cellular immune responses in advanced colon cancerN Habal
Sonya Valley Ghidossi Vaccine Laboratory of the Roy E. Coats Research Laboratories, Santa Monica, California 90404, USA
Ann Surg Oncol 8:389-401. 2001..These responses correlate with overall survival. This novel therapeutic regimen for patients with advanced colon cancer merits further investigation... - Thermal ablation of hepatic malignancy: useful but still not optimalM B Nicholl
Department of Gastrointestinal Surgery, John Wayne Cancer Institute at Saint John s Health Center, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
Eur J Surg Oncol 34:318-23. 2008..Although radiofrequency ablation is currently the most widely used thermal ablative technique for hepatic malignancy, microwave ablation is gaining popularity and eventually may prove to be more effective... - Role of repeated hepatectomy in the multimodal treatment of hepatic colorectal metastasesAziz Ahmad
John Wayne Cancer Institute at Saint John s Health Center, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
Arch Surg 142:526-31; discussion 531-2. 2007..Multimodal treatment consisting of repeated hepatectomy and adjuvant systemic chemotherapy for liver-confined recurrence of colorectal cancer can yield long-term survival comparable with that associated with primary hepatectomy... - Lymphatic mapping and sentinel node analysis in colon cancerSteve R Martinez
John Wayne Cancer Institute, Santa Monica, CA 90404, USA
Clin Colorectal Cancer 4:320-4. 2005..The prognostic significance of micrometastatic disease detected via ultrastaging techniques remains controversial... - One hundred consecutive cases of sentinel lymph node mapping in early colorectal carcinoma: detection of missed micrometastasesThomas F Wood
John Wayne Cancer Institute, Santa Monica, CA 90404, USA
J Gastrointest Surg 6:322-9; discussion 229-30. 2002..Further studies are necessary to elucidate the clinical relevance of these micrometastases... - Serum total gangliosides and TA90-IC levels: novel immunologic markers in colorectal cancerCarlos A Perez
Laboratory of Glyco-Immunotherapy, John Wayne Cancer Institute, Santa Monica, California 90404-23023, USA
Cancer J 8:55-61. 2002..The potential prognostic significance of TA90-IC status in advanced disease warrants further investigation... - Quality control issues in the management of colon cancer patientsS R Martinez
Department of Gastrointestinal Surgical Oncology, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA, USA
Eur J Surg Oncol 31:616-29. 2005..We seek to identify those issues most relevant to the quality of care we provide our colon cancer patients... - Hepatic cytoreduction followed by a novel long-acting somatostatin analog: a paradigm for intractable neuroendocrine tumors metastatic to the liverM H Chung
John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA 90404, USA
Surgery 130:954-62. 2001..CONCLUSIONS: Hepatic surgical cytoreduction can palliate progressive symptoms associated with liver metastases from intractable neuroendocrine tumors. Postoperative adjuvant therapy with octreotide LAR can prolong symptom-free survival... - A novel lymphatic mapping technique to improve localization and staging of early colon cancer during laparoscopic colectomyGeorge J Tsioulias
John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, California 90404, USA
Am Surg 68:561-5. 2002..Focused pathologic examination of this node can upstage CRC and thereby may improve selection of patients for adjuvant chemotherapy... - The utility of estrogen receptor, progesterone receptor, and Her-2/neu status to predict survival in patients undergoing hepatic resection for breast cancer metastasesSteve R Martinez
Department of Surgical Oncology, Division of Gastrointestinal Surgery, John Wayne Cancer Institute, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
Am J Surg 191:281-3. 2006..Hepatic metastases from breast cancer signal a dismal prognosis, with a median survival of 9.5 months... - Cryosurgical ablation of liver tumors in colon cancer patients increases the serum total ganglioside level and then selectively augments antiganglioside IgMMepur H Ravindranath
Laboratory of Glycoimmunotherapy, John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404 2302, USA
Cryobiology 45:10-21. 2002..The post-CSA decline in the STG level correlated with the increase in the antibodies, suggesting a homeostatic role of the antibodies... - Chemokine receptor CXCR4 expression in patients with melanoma and colorectal cancer liver metastases and the association with disease outcomeJoseph Kim
Department of Molecular Oncology, Gastrointestinal Cancer Section, John Wayne Cancer Institute, Saint John's Health Center, Santa Monica, CA 90404, USA
Ann Surg 244:113-20. 2006..Quantitative analysis of CXCR4 gene expression in patients with liver metastases has prognostic significance for disease outcome... - More extensive nodal dissection improves survival for stages I to III of colon cancer: a population-based studySteven L Chen
Department of Surgical Oncology, John Wayne Cancer Institute, Santa Monica, CA 90404, USA
Ann Surg 244:602-10. 2006..Currently, most procedures do not meet this guideline. Future trials of adjuvant therapy should include extent of lymphadenectomy as a stratification factor... 
Predictors of occult nodal metastasis in colon cancer: results from a prospective multicenter trialNabil Wasif
John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA, USA
Surgery 147:352-7. 2010..We sought to investigate the correlation of clinicopathologic features of colon cancer with OMs and to identify predictors of OM...- Differential expression of thymidylate synthase in colorectal tumors and matched lymph nodes: impact on adjuvant treatmentSteven D Trocha
Division of Surgical Oncology, John Wayne Cancer Institute, Santa Monica, California 90404, USA
Am Surg 69:918-22. 2003..Nodal expression of TS may be important in predicting response to 5-fluorouracil when a primary CRC is TS-negative... - Lymphatic mapping and sentinel lymphadenectomy for early-stage melanoma: therapeutic utility and implications of nodal microanatomy and molecular staging for improving the accuracy of detection of nodal micrometastasesDonald L Morton
Roy E Coats Research Laboratories of the John Wayne Cancer Insstitute at Saint John s Health Center, Santa Monica, CA 90404, USA
Ann Surg 238:538-49; discussion 549-50. 2003.... - Unfavourable prognosis associated with K-ras gene mutation in pancreatic cancer surgical marginsJ Kim
Department of Molecular Oncology, John Wayne Cancer Institute, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
Gut 55:1598-605. 2006..The study demonstrates that molecular-genetic evaluation of surgical resection margins can improve pathological staging and prognostic evaluation of patients with pancreatic ductal adenocarcinoma... - Chemokine receptor CXCR4 expression in colorectal cancer patients increases the risk for recurrence and for poor survivalJoseph Kim
Department of Molecular Oncology, John Wayne Cancer Institute, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
J Clin Oncol 23:2744-53. 2005..The CXCR4-CXCL12 signaling mechanism may be clinically relevant for patients with CRC and represents a potential novel target for disease-directed therapy... - Lymphatic mapping and sentinel node analysis: current concepts and applicationsSteven L Chen
Surgical Oncology, John Wayne Cancer Institute, Santa Monica, CA, USA
CA Cancer J Clin 56:292-309; quiz 316-7. 2006..Variations on techniques specific to each organ are explained, and the current role of sentinel node biopsy in diagnosis and treatment is discussed... - Combination probe and dye-directed lymphatic mapping detects micrometastases in early colorectal cancerSteven D Trocha
Division of Surgical Oncology, John Wayne Cancer Institute, Santa Monica, CA, USA
J Gastrointest Surg 7:340-5; discussion 345-6. 2003.... - Peptide nucleic acid clamp PCR: a novel K-ras mutation detection assay for colorectal cancer micrometastases in lymph nodesBret Taback
Department of Molecular Oncology, John Wayne Cancer Institute, Saint John s Health Center, Santa Monica, CA 90404, USA
Int J Cancer 111:409-14. 2004..This study demonstrates the utility, specificity and sensitivity of PNA clamp PCR assay in identifying occult micrometastases in the SLN of CRC patients by single-base mutation analysis... - Long-term survival after radiofrequency ablation of complex unresectable liver tumorsFarin F Amersi
John Wayne Cancer Institute, Saint John's Health Center, Santa Monica, Calif 90404, USA
Arch Surg 141:581-7; discussion 587-8. 2006..In these patients, RFA is safe and may prolong survival... - Treatment disparities in Hispanic rectal cancer patients: a SEER database studySteve R Martinez
Division of Surgical Oncology, John Wayne Cancer Institute, Santa Monica, California 90404, USA
Am Surg 72:906-8. 2006..Further studies are required to assess the impact of these treatment disparities on patient outcome... - Historical review of lymphatic mapping in gastrointestinal malignanciesSukamal Saha
Departments of Surgery, Michigan State University and McLaren Regional Medical Center, Flint, Michigan, USA
Ann Surg Oncol 11:245S-9S. 2004..Over the past 2 years, research and publications related to gastrointestinal lymphatic mapping have dramatically increased worldwide... - The clinical significance of MAGEA3 expression in pancreatic cancerJoseph Kim
Gastrointestinal Research Section, Department of Molecular Oncology, John Wayne Cancer Institute, Saint John's Health Center, Santa Monica, CA 90404, USA
Int J Cancer 118:2269-75. 2006..Molecular assessment for MAGEA3 should be considered to improve prognostic evaluation and to identify eligible patients for potential immune-based therapy... - Neoadjuvant chemotherapy for metastatic colon cancer: a cautionary noteAnton J Bilchik
John Wayne Cancer Institute at St John's Health Center, Santa Monica, CA, USA
J Clin Oncol 23:9073-8. 2005 - Allelic imbalance of APAF-1 locus at 12q23 is related to progression of colorectal carcinomaNaoyuki Umetani
Department of Molecular Oncology, John Wayne Cancer Institute, Saint Johns Health Science Center, Santa Monica, CA 90404, USA
Oncogene 23:8292-300. 2004..MIN was observed in 11 of 49 (23%) primary CRCs and was a favorable prognostic factor. Our results suggest that APAF-1 gene haploinsufficiency caused by AI increases with tumor progression, and relates to hepatic metastasis... - Radiofrequency ablation in 447 complex unresectable liver tumors: lessons learnedRichard J Bleicher
John Wayne Cancer Institute, Saint John's Health Center, Santa Monica, California 90404, USA
Ann Surg Oncol 10:52-8. 2003..Large, complex lesions can be safely serially ablated, but because of morbidity and recurrence, RFA should not replace resection as the primary treatment of resectable liver tumors... - Increased integrity of free circulating DNA in sera of patients with colorectal or periampullary cancer: direct quantitative PCR for ALU repeatsNaoyuki Umetani
Department of Molecular Oncology and Division of Surgical Oncology, John Wayne Cancer Institute, Santa Monica, CA 90404, USA
Clin Chem 52:1062-9. 2006..78 and 0.80, respectively. CONCLUSIONS: Direct ALU-qPCR is a robust, highly sensitive, and high-throughput method to measure serum DNA integrity. DNA integrity is a potential serum biomarker for detection and evaluation of CRC and PACs... - New approaches to assessing and treating early-stage colon and rectal cancer: summary statement from 2007 Santa Monica ConferenceLee S Rosen
Premiere Oncology, Santa Monica, CA 90404, USA
Clin Cancer Res 13:6853s-6s. 2007.... - Management of T2 gallbladder cancer: are practice patterns consistent with national recommendations?Byron E Wright
Department of Surgical Oncology, Division of Gastrointestinal Surgical Oncology, John Wayne Cancer Institute at St John s Health Center, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
Am J Surg 194:820-5; discussion 825-6. 2007..Although reported survival for localized T2 disease has been poor, groups have documented improvement with radical resection. We hypothesized that a discrepancy exists between national recommendations and current practice patterns... - Modulators of ceramide metabolism sensitize colorectal cancer cells to chemotherapy: a novel treatment strategyDavid A Litvak
Division of Surgical Oncology, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, California 90404, USA
J Gastrointest Surg 7:140-8; discussion 148. 2003..Blocking further metabolism of ceramide can enhance this cytotoxicity. Targeting ceramide pathways is a novel strategy for the treatment of patients with CRC... - Hepatic cytoreductive surgery for neuroendocrine cancerByron E Wright
Department of Surgical Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA 90404, USA
Surg Oncol Clin N Am 16:627-37, ix-x. 2007.... - Colorectal cancer screening and surveillance: current standards and future trendsSteve R Martinez
Division of Surgical Oncology, John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, California 90404, USA
Ann Surg Oncol 13:768-75. 2006.... - Epigenetic inactivation of ID4 in colorectal carcinomas correlates with poor differentiation and unfavorable prognosisNaoyuki Umetani
Department of Molecular Oncology, and Division of Gastrointestinal Oncology, John Wayne Cancer Institute, Santa Monica, California 90404, USA
Clin Cancer Res 10:7475-83. 2004..The epigenetic inactivation of ID4 gene on colorectal cancer (CRC) development and its clinical significance was assessed... - Resecting lymph nodes in colon cancer: more than a staging operation?Steven L Chen
Ann Surg Oncol 14:2175-6. 2007 - Urgent need for a new staging system in advanced colorectal cancerGraeme J Poston
Department of Surgery, University Hospital Aintree, Liverpool, L9 7AL, United Kingdom
J Clin Oncol 26:4828-33. 2008.... - Perioperative risks of bevacizumab and other biologic agents for hepatectomy: theoretical or evidence based?Anton J Bilchik
J Clin Oncol 26:1786-8. 2008 - Significance of the lymph node ratio in stage III colon cancerSimon H Telian
Ann Surg Oncol 15:1557-8. 2008 - Sentinel lymph node mapping with GI cancerTakashi Aikou
Department of Surgical Oncology and Digestive Surgery, Kagoshima University, Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Cancer Metastasis Rev 25:269-77. 2006..Although more evidence from large-scale multicenter clinical trials is required, SLN mapping may be very useful for individualizing multi-modal treatment for esophageal cancer and might be widely acceptable even for GI cancer... - Improving resectability of hepatic colorectal metastases: expert consensus statementEddie K Abdalla
The University of Texas M. D Anderson Cancer Center, Houston, 77030, USA
Ann Surg Oncol 13:1271-80. 2006 - Close collaboration between surgeon and pathologist is essential for accurate staging of early colon cancerAnton J Bilchik
Ann Surg 245:864-6. 2007 - Is routine use of sentinel node biopsy justified in colon cancer?Michael Nicholl
Ann Surg Oncol 15:1-3. 2008 - Novel effective drugs and evolving ablation technology: a more comprehensive approach to hepatic malignanciesAnton J Bilchik
Ann Surg Oncol 11:458-9. 2004 - Radiofrequency ablation of hepatic malignancies: inexpensive and minimally invasive but should it replace resection?Anton J Bilchik
Ann Surg Oncol 10:1002-4. 2003 - Lymphatic mapping of nodal micrometastasis in colon cancer: putting the cart before the horse?Anton J Bilchik
Ann Surg Oncol 9:529-31. 2002