Michael A Pfaller

Summary

Affiliation: JMI Laboratories
Country: USA

Publications

  1. pmc In vitro activity of a new oral glucan synthase inhibitor (MK-3118) tested against Aspergillus spp. by CLSI and EUCAST broth microdilution methods
    Michael A Pfaller
    JMI Laboratories, North Liberty, Iowa, USA
    Antimicrob Agents Chemother 57:1065-8. 2013
  2. doi Epidemiology and outcomes of candidemia in 3648 patients: data from the Prospective Antifungal Therapy (PATH Alliance®) registry, 2004-2008
    Michael Pfaller
    JMI Laboratories, North Liberty, IA 52317, USA
    Diagn Microbiol Infect Dis 74:323-31. 2012
  3. doi AWARE Ceftaroline Surveillance Program (2008-2010): trends in resistance patterns among Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in the United States
    Michael A Pfaller
    JMI Laboratories, North Liberty, Iowa 52317, USA
    Clin Infect Dis 55:S187-93. 2012
  4. doi Significance of molecular identification and antifungal susceptibility of clinically significant yeasts and moulds in a global antifungal surveillance programme
    Michael A Pfaller
    JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA
    Mycopathologia 174:259-71. 2012
  5. pmc Wild-type MIC distributions and epidemiological cutoff values for amphotericin B, flucytosine, and itraconazole and Candida spp. as determined by CLSI broth microdilution
    M A Pfaller
    JMI Laboratories, North Liberty, Iowa, USA
    J Clin Microbiol 50:2040-6. 2012
  6. doi Wild-type MIC distributions and epidemiologic cutoff values for fluconazole, posaconazole, and voriconazole when testing Cryptococcus neoformans as determined by the CLSI broth microdilution method
    Michael A Pfaller
    University of Iowa, Iowa City, Iowa 52242, USA
    Diagn Microbiol Infect Dis 71:252-9. 2011
  7. doi A global evaluation of voriconazole activity tested against recent clinical isolates of Candida spp
    Daniel J Diekema
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Diagn Microbiol Infect Dis 63:233-6. 2009
  8. pmc Low prevalence of fks1 hot spot 1 mutations in a worldwide collection of Candida strains
    Mariana Castanheira
    JMI Laboratories, North Liberty, IA 52317, USA
    Antimicrob Agents Chemother 54:2655-9. 2010
  9. pmc In vitro activity of a novel broad-spectrum antifungal, E1210, tested against Aspergillus spp. determined by CLSI and EUCAST broth microdilution methods
    Michael A Pfaller
    JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA
    Antimicrob Agents Chemother 55:5155-8. 2011
  10. pmc Candida bloodstream infections: comparison of species distributions and antifungal resistance patterns in community-onset and nosocomial isolates in the SENTRY Antimicrobial Surveillance Program, 2008-2009
    Michael A Pfaller
    JMI Laboratories, North Liberty, IA 52317, USA
    Antimicrob Agents Chemother 55:561-6. 2011

Detail Information

Publications74

  1. pmc In vitro activity of a new oral glucan synthase inhibitor (MK-3118) tested against Aspergillus spp. by CLSI and EUCAST broth microdilution methods
    Michael A Pfaller
    JMI Laboratories, North Liberty, Iowa, USA
    Antimicrob Agents Chemother 57:1065-8. 2013
    ..3%. MK-3118 was determined to be a potent agent regardless of the in vitro method applied, with excellent activity against contemporary wild-type and itraconazole-resistant strains of Aspergillus spp...
  2. doi Epidemiology and outcomes of candidemia in 3648 patients: data from the Prospective Antifungal Therapy (PATH Alliance®) registry, 2004-2008
    Michael Pfaller
    JMI Laboratories, North Liberty, IA 52317, USA
    Diagn Microbiol Infect Dis 74:323-31. 2012
    ..the highest 90-day survival rate was observed for C. parapsilosis (70.0%) and the lowest for C. krusei (53.6%). In conclusion, this study expands the current knowledge of the epidemiology and outcomes of candidemia...
  3. doi AWARE Ceftaroline Surveillance Program (2008-2010): trends in resistance patterns among Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis in the United States
    Michael A Pfaller
    JMI Laboratories, North Liberty, Iowa 52317, USA
    Clin Infect Dis 55:S187-93. 2012
    ....
  4. doi Significance of molecular identification and antifungal susceptibility of clinically significant yeasts and moulds in a global antifungal surveillance programme
    Michael A Pfaller
    JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA
    Mycopathologia 174:259-71. 2012
    ..Molecular confirmation of fungal identification is essential in epidemiological surveys such as SENTRY...
  5. pmc Wild-type MIC distributions and epidemiological cutoff values for amphotericin B, flucytosine, and itraconazole and Candida spp. as determined by CLSI broth microdilution
    M A Pfaller
    JMI Laboratories, North Liberty, Iowa, USA
    J Clin Microbiol 50:2040-6. 2012
    ..0) for C. guilliermondii. In the absence of species-specific CBP values, these wild-type (WT) MIC distributions and ECVs will be useful for monitoring the emergence of reduced susceptibility to these well-established antifungal agents...
  6. doi Wild-type MIC distributions and epidemiologic cutoff values for fluconazole, posaconazole, and voriconazole when testing Cryptococcus neoformans as determined by the CLSI broth microdilution method
    Michael A Pfaller
    University of Iowa, Iowa City, Iowa 52242, USA
    Diagn Microbiol Infect Dis 71:252-9. 2011
    ..Continued surveillance using these ECVs for the azoles and CNEO appears warranted...
  7. doi A global evaluation of voriconazole activity tested against recent clinical isolates of Candida spp
    Daniel J Diekema
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Diagn Microbiol Infect Dis 63:233-6. 2009
    ..008/0.25 microg/mL; 98% susceptible). In comparison to 5866 Candida spp. isolates collected during global surveillance from 1997 to 2001, there were no changes in voriconazole mean MIC or MIC distribution...
  8. pmc Low prevalence of fks1 hot spot 1 mutations in a worldwide collection of Candida strains
    Mariana Castanheira
    JMI Laboratories, North Liberty, IA 52317, USA
    Antimicrob Agents Chemother 54:2655-9. 2010
    ..Furthermore, results from this large, geographically diverse Candida spp. collection demonstrated that fks1 HS1 mutations remain uncommon among isolates with various echinocandin MIC levels...
  9. pmc In vitro activity of a novel broad-spectrum antifungal, E1210, tested against Aspergillus spp. determined by CLSI and EUCAST broth microdilution methods
    Michael A Pfaller
    JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA
    Antimicrob Agents Chemother 55:5155-8. 2011
    ..terreus SC (MEC, 0.015 μg/ml). In conclusion, E1210 was a very potent and broad-spectrum antifungal agent regardless of in vitro method applied, with excellent activity against AMB-R and itraconazole-R strains of Aspergillus spp...
  10. pmc Candida bloodstream infections: comparison of species distributions and antifungal resistance patterns in community-onset and nosocomial isolates in the SENTRY Antimicrobial Surveillance Program, 2008-2009
    Michael A Pfaller
    JMI Laboratories, North Liberty, IA 52317, USA
    Antimicrob Agents Chemother 55:561-6. 2011
    ..Although resistance to the azoles and echinocandins remains uncommon among CO isolates, we demonstrate the emergence of nosocomial occurrences of C. glabrata expressing resistance to both monitored classes of antifungal agents...
  11. pmc Evaluation of Etest and disk diffusion methods compared with broth microdilution antifungal susceptibility testing of clinical isolates of Candida spp. against posaconazole
    Daniel J Diekema
    Department of Pathology, Roy J and Lucille A Carver College of Medicine and College of Public Health, University of Iowa, Iowa City, IA 52242, USA
    J Clin Microbiol 45:1974-7. 2007
    ..These agar-based methods hold promise as simple and reliable methods for determination of the posaconzole susceptibilities of Candida spp...
  12. doi Comparison of results of fluconazole and voriconazole disk diffusion testing for Candida spp. with results from a central reference laboratory in the ARTEMIS DISK Global Antifungal Surveillance Program
    Michael A Pfaller
    Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Diagn Microbiol Infect Dis 65:27-34. 2009
    ....
  13. pmc In vitro activities of isavuconazole and comparator antifungal agents tested against a global collection of opportunistic yeasts and molds
    Michael A Pfaller
    JMI Laboratories, North Liberty, Iowa, USA
    J Clin Microbiol 51:2608-16. 2013
    ..Isavuconazole demonstrates broad-spectrum activity against this global collection of opportunistic fungi, and the CLSI and EUCAST methods can be used to test this agent against Candida, with highly comparable results. ..
  14. pmc Activities of E1210 and comparator agents tested by CLSI and EUCAST broth microdilution methods against Fusarium and Scedosporium species identified using molecular methods
    Mariana Castanheira
    JMI Laboratories, North Liberty, Iowa, USA
    Antimicrob Agents Chemother 56:352-7. 2012
    ..and Scedosporium spp. Furthermore, in vitro susceptibility testing of E1210 against isolates of Fusarium and Scedosporium may be accomplished using either of the CLSI or EUCAST BMD methods, each producing very similar results...
  15. doi Evaluation of the activity of fusidic acid tested against contemporary Gram-positive clinical isolates from the USA and Canada
    Michael A Pfaller
    University of Iowa College of Medicine, Iowa City, IA, USA
    Int J Antimicrob Agents 35:282-7. 2010
    ..Fusidic acid was equally active against community-acquired MRSA and linezolid-resistant staphylococci. Fusidic acid exhibited equal or greater potency against staphylococci compared with vancomycin, daptomycin and linezolid...
  16. doi Candida bloodstream infections: comparison of species distribution and resistance to echinocandin and azole antifungal agents in Intensive Care Unit (ICU) and non-ICU settings in the SENTRY Antimicrobial Surveillance Program (2008-2009)
    Michael A Pfaller
    JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA
    Int J Antimicrob Agents 38:65-9. 2011
    ..Concern regarding C. glabrata must now include resistance to echinocandins as well as azole antifungal agents...
  17. ncbi Geographic variations in garenoxacin (BMS284756) activity tested against pathogens associated with skin and soft tissue infections: report from the SENTRY Antimicrobial Surveillance Program (2000)
    Jeffrey T Kirby
    The JONES Group JMI Laboratories, North Liberty, Iowa, USA
    Diagn Microbiol Infect Dis 43:303-9. 2002
    ..pneumoniae) was documented in all three monitored regions (Latin America > Europe > North America). Continued development of garenoxacin as a treatment of pathogens that commonly cause SSTIs appears to be warranted...
  18. pmc Echinocandin and triazole antifungal susceptibility profiles for clinical opportunistic yeast and mold isolates collected from 2010 to 2011: application of new CLSI clinical breakpoints and epidemiological cutoff values for characterization of geographic
    Michael A Pfaller
    JMI Laboratories, North Liberty, Iowa, USA
    J Clin Microbiol 51:2571-81. 2013
    ..Overall, echinocandin and triazole resistance rates were low; however, the fluconazole and echinocandin coresistance among C. glabrata strains warrants continued close surveillance. ..
  19. doi Activity of MK-3118, a new oral glucan synthase inhibitor, tested against Candida spp. by two international methods (CLSI and EUCAST)
    Michael A Pfaller
    JMI Laboratories, North Liberty, IA, USA
    J Antimicrob Chemother 68:858-63. 2013
    ..using CLSI and EUCAST broth microdilution (BMD) methods...
  20. doi In vitro activity of a novel broad-spectrum antifungal, E1210, tested against Candida spp. as determined by CLSI broth microdilution method
    Michael A Pfaller
    JMI Laboratories, North Liberty, IA 52317, USA
    Diagn Microbiol Infect Dis 71:167-70. 2011
    ..008-0.06 μg/mL), and was the most potent agent tested against caspofungin-resistant strains of C. albicans (MIC range, 0.008-0.12 μg/mL), C. glabrata (MIC range, 0.03-0.06 μg/mL), and C. tropicalis (MIC range, 0.015-0.06 μg/mL)...
  21. ncbi Preoperative risk factors for nasal carriage of Staphylococcus aureus
    Loreen A Herwaldt
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa 52242 1081, USA
    Infect Control Hosp Epidemiol 25:481-4. 2004
    ..aureus, and eradication of carriage reduces postoperative nosocomial infections caused by it. No study has compared large groups of preoperative carriers and non-carriers to identify factors that are linked to S. aureus nasal carriage...
  22. doi Echinocandin and triazole antifungal susceptibility profiles for Candida spp., Cryptococcus neoformans, and Aspergillus fumigatus: application of new CLSI clinical breakpoints and epidemiologic cutoff values to characterize resistance in the SENTRY Antimi
    Michael A Pfaller
    JMI Laboratories, North Liberty, IA 52317, USA
    Diagn Microbiol Infect Dis 69:45-50. 2011
    ..fumigatus. Overall, echinocandin and triazole resistance rates were minimal; however, the distinct increase in echinocandin resistance observed among C. glabrata strains warrants further surveillance associated with molecular support...
  23. doi Initial treatment and outcome of Candida glabrata versus Candida albicans bloodstream infection
    Michael J Klevay
    Department of Medicine, University of Iowa, Iowa City, 52242, USA
    Diagn Microbiol Infect Dis 64:152-7. 2009
    ..The lack of difference in mortality between species may reflect the overriding importance of host variables and/or a difference in virulence by species: further study is needed to investigate these hypotheses...
  24. doi Variation in Candida spp. distribution and antifungal resistance rates among bloodstream infection isolates by patient age: report from the SENTRY Antimicrobial Surveillance Program (2008-2009)
    Michael A Pfaller
    JMI Laboratories, North Liberty, IA 52317, USA
    Diagn Microbiol Infect Dis 68:278-83. 2010
    ..Cg BSI isolates may show lower susceptibility rates to both azoles and echinocandins with the highest rates of resistance detected in 20- to 59-year-old patients...
  25. pmc Geographic variations in species distribution and echinocandin and azole antifungal resistance rates among Candida bloodstream infection isolates: report from the SENTRY Antimicrobial Surveillance Program (2008 to 2009)
    Michael A Pfaller
    JMI Laboratories, 345 Beaver Kreek Centre, North Liberty, Iowa 52317, USA
    J Clin Microbiol 49:396-9. 2011
    ..5%), and C. albicans isolates were more common in APAC (56.9%), with C. parapsilosis (25.6%) and C. tropicalis (17.0%) being more prominent in LAM. Emerging resistance patterns among C. glabrata cases in NAM require focused surveillance...
  26. doi Geographic variation in the frequency of isolation and fluconazole and voriconazole susceptibilities of Candida glabrata: an assessment from the ARTEMIS DISK Global Antifungal Surveillance Program
    Michael A Pfaller
    Medical Microbiology Division, Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Diagn Microbiol Infect Dis 67:162-71. 2010
    ..glabrata. Prompt species identification and fluconazole susceptibility testing are necessary to optimize therapy for invasive candidiasis...
  27. doi Wild-type minimum effective concentration distributions and epidemiologic cutoff values for caspofungin and Aspergillus spp. as determined by Clinical and Laboratory Standards Institute broth microdilution methods
    Michael A Pfaller
    Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Diagn Microbiol Infect Dis 67:56-60. 2010
    ..The establishment of the WT MEC distributions and ECVs for caspofungin and the major species of Aspergillus will be useful in resistance surveillance and is an important step toward the development of clinical breakpoints...
  28. ncbi Epidemiology of methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus in a rural state
    Philip M Polgreen
    Division of Infectious Diseases, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, 52246, USA
    Infect Control Hosp Epidemiol 27:252-6. 2006
    ..Infection control personnel need to understand the epidemiology of MRSA and VRE across the continuum of care, including small rural hospitals, to develop effective control strategies...
  29. pmc Identification of Candida nivariensis and Candida bracarensis in a large global collection of Candida glabrata isolates: comparison to the literature
    Shawn R Lockhart
    University of Iowa, Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Microbiol 47:1216-7. 2009
    ..Both species were very rare in this collection (0.2% prevalence), despite the number of isolates analyzed and the global distribution of the isolates. We saw no associated antifungal resistance in C. nivariensis...
  30. ncbi Antimicrobial activity of cefepime tested against ceftazidime-resistant Gram-negative clinical strains from North American Hospitals: report from the SENTRY Antimicrobial Surveillance Program (1998-2004)
    Michael A Pfaller
    Department of Pathology and Epidemiology, University of Iowa College of Medicine and College of Public Health, Iowa City, IA 52242, USA
    Diagn Microbiol Infect Dis 56:63-8. 2006
    ..isolated in North American medical centers. Continued resistances surveillance monitoring will be necessary to assess the effectiveness of widely used broad-spectrum antimicrobials as novel resistance mechanisms emerge...
  31. pmc Evaluation of disk diffusion and Etest compared to broth microdilution for antifungal susceptibility testing of posaconazole against clinical isolates of filamentous fungi
    Shawn A Messer
    University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    J Clin Microbiol 45:1322-4. 2007
    ..These agar-based methods hold promise as simple and reliable methods for determining the posaconazole susceptibilities of filamentous fungi...
  32. pmc Performance of fusidic acid (CEM-102) susceptibility testing reagents: broth microdilution, disk diffusion, and Etest methods as applied to Staphylococcus aureus
    Ronald N Jones
    JMI Laboratories, North Liberty, Iowa 52317, USA
    J Clin Microbiol 48:972-6. 2010
    ..7% +/- one log2 dilution. The diagnostic susceptibility testing reagents (including Etest) for fusidic acid (CEM-102) performed at an excellent level of intermethod agreement for the proposed breakpoint criteria...
  33. ncbi Gatifloxacin phase IV surveillance trial (TeqCES study) utilizing 5000 primary care physician practices: report of pathogens isolated and susceptibility patterns in community-acquired respiratory tract infections
    Michael A Pfaller
    CAST Laboratories, University of Iowa College of Medicine, Iowa City, Iowa, USA
    Diagn Microbiol Infect Dis 44:77-84. 2002
    ..catarrhalis in CARTI, and high fluoroquinolone potency/spectrum (>97% susceptible). beta-lactams and macrolides continue to be compromised by increasing resistances in pathogens isolated in these monitored primary care settings...
  34. pmc Triazole and echinocandin MIC distributions with epidemiological cutoff values for differentiation of wild-type strains from non-wild-type strains of six uncommon species of Candida
    Michael A Pfaller
    JMI Laboratories, North Liberty, IA 52317, USA
    J Clin Microbiol 49:3800-4. 2011
    ..2]), and VRC (0.25 [98.2]). In the absence of species-specific CBP values, these WT MIC distributions and ECVs will be useful for monitoring the emergence of reduced susceptibility to the triazole and echinocandin antifungals...
  35. pmc Clade-specific flucytosine resistance is due to a single nucleotide change in the FUR1 gene of Candida albicans
    Andrew R Dodgson
    Department of Biological Sciences, 302 BBE, The University of Iowa, Iowa City, IA 52242, USA
    Antimicrob Agents Chemother 48:2223-7. 2004
    ..albicans population and thus by inference is likely to be the major underlying 5FC resistance mechanism in C. albicans. This represents the first description of the genetic mutation responsible for 5FC resistance...
  36. pmc Caspofungin activity against clinical isolates of fluconazole-resistant Candida
    Michael A Pfaller
    Departments of Pathology, University of Iowa College of Medicine and College of Public Health, Iowa City, Iowa 52242, USA
    J Clin Microbiol 41:5729-31. 2003
    ..All fluconazole-resistant isolates were inhibited by caspofungin at concentrations that can be exceeded by standard doses (MIC at which 90% of the isolates were inhibited, 1 micro g/ml; 99% of the MICs were </=2 micro g/ml)...
  37. ncbi Evaluation of the in vitro activity of daptomycin against 19615 clinical isolates of Gram-positive cocci collected in North American hospitals (2002-2005)
    Michael A Pfaller
    University of Iowa, Iowa City, IA 52242, USA
    Diagn Microbiol Infect Dis 57:459-65. 2007
    ..5, and 1 microg/mL for staphylococci, enterococci, beta-hemolytic streptococci, and viridans group streptococci, respectively, and no significant loss in potency was observed over the period studied...
  38. ncbi Are United States hospitals following national guidelines for the analysis and presentation of cumulative antimicrobial susceptibility data?
    Erika J Ernst
    University of Iowa College of Pharmacy, Iowa City, IA, USA
    Diagn Microbiol Infect Dis 49:141-5. 2004
    ..0031). Adherence to guidelines for preparation and dissemination of antibiograms could be improved. Institutional commitment to high quality, on-site microbiology laboratory services will improve adherence to these guidelines...
  39. pmc Candida guilliermondii and other species of candida misidentified as Candida famata: assessment by vitek 2, DNA sequencing analysis, and matrix-assisted laser desorption ionization-time of flight mass spectrometry in two global antifungal surveillance pro
    Mariana Castanheira
    JMI Laboratories, North Liberty, Iowa, USA
    J Clin Microbiol 51:117-24. 2013
    ..famata in fungal infections is much lower than previously appreciated and that commercial systems do not produce accurate identifications except for the newly introduced MALDI-TOF instruments...
  40. pmc Decreasing prevalence of beta-lactamase production among respiratory tract isolates of Haemophilus influenzae in the United States
    Kris P Heilmann
    Division of Medical Microbiology, Department of Pathology, Roy J and Lucille A Carver University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Antimicrob Agents Chemother 49:2561-4. 2005
    ..In comparison to the results of four previous national surveys conducted since 1994, the prevalence of beta-lactamase production with this pathogen appears to be decreasing...
  41. pmc Molecular epidemiology of macrolide resistance in neonatal bloodstream isolates of group B streptococci
    Daniel J Diekema
    Department of Internal Medicine, University of Iowa Colleges of Medicine and Public Health, Iowa City, Iowa 52242, USA
    J Clin Microbiol 41:2659-61. 2003
    ..Erm methylase (ermA and ermB) was the most common resistance mechanism detected, present in 12 of 20 macrolide-resistant GBS...
  42. ncbi A prospective study of outcomes, healthcare resource utilization, and costs associated with postoperative nosocomial infections
    Loreen A Herwaldt
    Department of Internal Medicine, University of Iowa College of Public Health, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Infect Control Hosp Epidemiol 27:1291-8. 2006
    ..We evaluated 4 important outcomes associated with postoperative nosocomial infection: costs, mortality, excess length of stay, and utilization of healthcare resources...
  43. ncbi Antimicrobial resistance trends and outbreak frequency in United States hospitals
    Daniel J Diekema
    Iowa City Veterans Affairs Medical Center, Dept of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Clin Infect Dis 38:78-85. 2004
    ..The most common resistant pathogen in US hospitals is ORSA, which accounts for many recognized outbreaks and is increasing in frequency in most facilities. Current practices to prevent and control antimicrobial resistance are inadequate...
  44. pmc Geographic distribution and antifungal susceptibility of the newly described species Candida orthopsilosis and Candida metapsilosis in comparison to the closely related species Candida parapsilosis
    Shawn R Lockhart
    Department of Pathology, University of Iowa Carver College of Medicine, University of Iowa Hospitals and Clinics, 6008 BT GH, 200 Hawkins Drive, Iowa City, IA 52242 1009, USA
    J Clin Microbiol 46:2659-64. 2008
    ..001 for all). No C. orthopsilosis or C. metapsilosis isolates were fluconazole resistant, and all were susceptible to caspofungin, anidulafungin, and micafungin...
  45. pmc Identification and Susceptibility Profile of Candida fermentati from a worldwide collection of Candida guilliermondii clinical isolates
    Shawn R Lockhart
    University of Iowa, Carver College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Microbiol 47:242-4. 2009
    ..With the exception that the MICs of micafungin were significantly lower, the calculated average MICs for C. fermentati were not significantly different from those for C. guilliermondii...
  46. ncbi Geographic variations in activity of broad-spectrum beta-lactams against Pseudomonas aeruginosa: summary of the worldwide SENTRY Antimicrobial Surveillance Program (1997-2000)
    Ronald N Jones
    The JONES Group JMI Laboratories, North Liberty, IA, USA
    Diagn Microbiol Infect Dis 43:239-43. 2002
    ..In all regions, aminoglycosides in combination with carbapenems, cefepime, or piperacillin/tazobactam would provide more potential antipseudomonal activity than fluoroquinolone combinations for wide-spectrum empiric regimens...
  47. doi Pre-clinical development of antifungal susceptibility test methods for the testing of the novel antifungal agent E1210 versus Candida: comparison of CLSI and European Committee on Antimicrobial Susceptibility Testing methods
    Michael A Pfaller
    JMI Laboratories, North Liberty, IA 52317, USA
    J Antimicrob Chemother 66:2581-4. 2011
    ..To compare European Committee on Antimicrobial Susceptibility Testing (EUCAST) and CLSI broth microdilution (BMD) methods for testing the novel antifungal E1210 against a recent collection of 102 clinical isolates of Candida spp...
  48. doi Telavancin activity against Gram-positive bacteria isolated from respiratory tract specimens of patients with nosocomial pneumonia
    Michael A Pfaller
    JMI Laboratories, North Liberty, IA, USA
    J Antimicrob Chemother 65:2396-404. 2010
    ....
  49. doi Clinical breakpoints for voriconazole and Candida spp. revisited: review of microbiologic, molecular, pharmacodynamic, and clinical data as they pertain to the development of species-specific interpretive criteria
    Michael A Pfaller
    University of Iowa Carver College of Medicine, Iowa City, IA 52246, USA
    Diagn Microbiol Infect Dis 70:330-43. 2011
    ..In the absence of CBPs for voriconazole and C. glabrata (and less common species), we recommend that their respective ECVs be used to detect the emergence of non-WT strains...
  50. ncbi Therapy and outcome of Candida glabrata versus Candida albicans bloodstream infection
    Michael J Klevay
    Department of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Diagn Microbiol Infect Dis 60:273-7. 2008
    ..002). Twelve percent of patients received no antifungal therapy and contributed disproportionately to overall crude mortality. Strategies to decrease the incidence of untreated candidemia may favorably impact outcome...
  51. pmc Antifungal susceptibilities of Candida species causing vulvovaginitis and epidemiology of recurrent cases
    Sandra S Richter
    Department of Pathology, University of Iowa Roy J and Lucille A Carver College of Medicine, 200 Hawkins Drive, C606 GH, Iowa City, IA 52242 1009, USA
    J Clin Microbiol 43:2155-62. 2005
    ..These results support the use of azoles for empirical therapy of uncomplicated candidal vulvovaginitis. Recurrent episodes are more often caused by non-albicans species, for which azole agents are less likely to be effective...
  52. ncbi Invasive zygomycosis in hematopoietic stem cell transplant recipients receiving voriconazole prophylaxis
    Greg T Siwek
    Division of Infectious Diseases, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Clin Infect Dis 39:584-7. 2004
    ..Profoundly immunosuppressed patients receiving voriconazole prophylaxis remain at risk for less-common pathogens that are intrinsically resistant to this agent...
  53. doi Antifungal drug resistance: mechanisms, epidemiology, and consequences for treatment
    Michael A Pfaller
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Med 125:S3-13. 2012
    ..This situation requires continuing attention. Rates of azole-resistant Aspergillus fumigatus are currently low, but there are reports of emerging resistance, including multi-azole resistant isolates in parts of Europe...
  54. ncbi Antifungal activities of fluconazole, caspofungin (MK0991), and anidulafungin (LY 303366) alone and in combination against Candida spp. and Crytococcus neoformans via time-kill methods
    Ellen E Roling
    College of Pharmacy, The University of Iowa, Iowa City, Iowa 52242, USA
    Diagn Microbiol Infect Dis 43:13-7. 2002
    ..Combinations of fluconazole and caspofungin or anidulafungin resulted in indifference. Azole-echinocandin combinations do not produce antagonistic effects; therefore, combinations of these agents may warrant future clinical evaluation...
  55. ncbi Performance accuracy of antibacterial and antifungal susceptibility test methods: report from the College of American Pathologists Microbiology Surveys Program (2001-2003)
    Michael A Pfaller
    Department of Pathology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Arch Pathol Lab Med 130:767-78. 2006
    ..The College of American Pathologists Microbiology Surveys Program provides external proficiency samples that monitor the performance of nearly 3000 laboratories that perform and report antimicrobial susceptibility tests...
  56. ncbi Incidence of invasive aspergillosis among allogeneic hematopoietic stem cell transplant patients receiving voriconazole prophylaxis
    Gregory T Siwek
    Program of Hospital Epidemiology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Diagn Microbiol Infect Dis 55:209-12. 2006
    ..We report no cases of IA among 92 HSCT recipients who received voriconazole prophylaxis compared with a 10% (23/223) incidence among those receiving other systemic antifungals for prophylaxis (P < .0005)...
  57. doi Frequency of fks mutations among Candida glabrata isolates from a 10-year global collection of bloodstream infection isolates
    Mariana Castanheira
    JMI Laboratories, North Liberty, Iowa, USA
    Antimicrob Agents Chemother 58:577-80. 2014
    ..Mutations that have been reported to decrease the echinocandin binding to the 1,3-β-d-glucan synthase were categorized as resistant by applying the new CLSI breakpoint criteria for all three echinocandins. ..
  58. pmc Flucytosine resistance is restricted to a single genetic clade of Candida albicans
    Claude Pujol
    Department of Biological Sciences, The University of Iowa, Iowa City, Iowa 52242, USA
    Antimicrob Agents Chemother 48:262-6. 2004
    ..These results demonstrate for the first time the clade specificity of a clinically relevant trait (5FC resistance) and suggest that while intraclade recombination may be common, interclade recombination is rare...
  59. ncbi Antimicrobial susceptibility of inducible AmpC beta-lactamase-producing Enterobacteriaceae from the Meropenem Yearly Susceptibility Test Information Collection (MYSTIC) Programme, Europe 1997-2000
    Michael A Pfaller
    Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, 200 Hawikins Drive, Iowa City, IA 52242, USA
    Int J Antimicrob Agents 19:383-8. 2002
    ..We suggest increased attention in Europe to: (1) the recognition of these resistant phenotypes, (2) infection control practices, and (3) limiting the overuse of certain selecting extended-spectrum beta-lactam agents (e.g. ceftazidime)...
  60. ncbi BMS284756 (formerly T-3811, a des-fluoroquinolone) potency and spectrum tested against over 10,000 bacterial bloodstream infection isolates from the SENTRY antimicrobial surveillance programme (2000)
    Kelley A Gordon
    University of Iowa College of Medicine, Iowa City, USA
    J Antimicrob Chemother 49:851-5. 2002
    ..03-1 mg/L). With a proposed breakpoint of < or =4 mg/L, BMS284756 may be a therapeutic alternative pending the results of clinical trials...
  61. pmc Rapid detection of antimicrobial-resistant organism carriage: an unmet clinical need
    Daniel J Diekema
    Department of Internal Medicine, Division of Medical Microbiology, C 606 GH, 200 Hawkins Dr, Iowa City, IA 52242, USA
    J Clin Microbiol 42:2879-83. 2004
  62. doi Epidemiology of invasive mycoses in North America
    Michael A Pfaller
    Department of Pathology, University of Iowa, Iowa City, USA
    Crit Rev Microbiol 36:1-53. 2010
    ..This review discusses the epidemiologic profiles of these invasive mycoses in North America, as well as risk factors for infection, and the pathogens' antifungal susceptibility...
  63. ncbi Anidulafungin: an echinocandin antifungal
    Michael A Pfaller
    Section of Medical Microbiology, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Expert Opin Investig Drugs 13:1183-97. 2004
    ..Clinically, anidulafungin has been shown to be safe and effective in the treatment of oesophageal candidiasis and candidemia. Further clinical application of this new antifungal agent is warranted...
  64. pmc Modification of dienes mutual inhibition test for epidemiological characterization of Pseudomonas aeruginosa isolates
    Erik L Munson
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Microbiol 40:4285-8. 2002
    ..These observations suggest that further studies are warranted to assess the utility of the modified Dienes test as a simple, inexpensive, and reliable means for epidemiological typing of P. aeruginosa...
  65. ncbi Overview of the epidemiological profile and laboratory detection of extended-spectrum beta-lactamases
    Michael A Pfaller
    Department of Pathology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA, USA
    Clin Infect Dis 42:S153-63. 2006
    ....
  66. ncbi The yeast connection: is Candida linked to breastfeeding associated pain?
    Janet I Andrews
    Department of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, Iowa City, IA, USA
    Am J Obstet Gynecol 197:424.e1-4. 2007
    ..The objective of the study was to determine whether the isolation of Candida from breastfeeding women is associated with self-reported pain...
  67. pmc Lodderomyces elongisporus masquerading as Candida parapsilosis as a cause of bloodstream infections
    Shawn R Lockhart
    Carver College of Medicine, University of Iowa Hospitals and Clinics, Department of Pathology, 6008 BT GH, 200 Hawkins Drive, Iowa City, IA 52242 1009, USA
    J Clin Microbiol 46:374-6. 2008
    ..Subsequent sequence analysis showed that these isolates were the species Lodderomyces elongisporus. To our knowledge, this is the first published report of L. elongisporus as a cause of human disease...
  68. pmc Tiamulin activity against fastidious and nonfastidious veterinary and human bacterial isolates: initial development of in vitro susceptibility test methods
    Ronald N Jones
    The JONES Group JMI Laboratories, North Liberty, IA 52317, USA
    J Clin Microbiol 40:461-5. 2002
    ....
  69. ncbi Ciprofloxacin as broad-spectrum empiric therapy--are fluoroquinolones still viable monotherapeutic agents compared with beta-lactams: data from the MYSTIC Program (US)?
    Ronald N Jones
    The JONES Group and JMI Laboratories, North Liberty, IA, USA
    Diagn Microbiol Infect Dis 42:213-5. 2002
    ..Local susceptibility testing data must be assessed before fluoroquinolone empiric therapy can be used with confidence...
  70. pmc First description of Klebsiella pneumoniae harboring CTX-M beta-lactamases (CTX-M-14 and CTX-M-3) in Taiwan
    Wen Liang Yu
    University of Iowa College of Medicine, Iowa City, USA
    Antimicrob Agents Chemother 46:1098-100. 2002
    ..9 and 8.4 as CTX-M-14 and CTX-M-3, respectively. Molecular typing suggested inter- and intrahospital clonal dissemination of these Taiwanese CTX-M-producing Klebsiella strains...
  71. pmc Presumptive identification of Candida kefyr on levine formulation of eosin methylene blue agar
    Erik L Munson
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Clin Microbiol 40:4281-4. 2002
    ..8%, the high positive predictive value (100%) for yeast isolates with this phenotype belonging to C. kefyr suggests that these isolates can be presumptively identified as C. kefyr...
  72. ncbi Review of in vitro activity of sertaconazole nitrate in the treatment of superficial fungal infections
    Michael A Pfaller
    Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Diagn Microbiol Infect Dis 56:147-52. 2006
    ....
  73. ncbi Flavophospholipol use in animals: positive implications for antimicrobial resistance based on its microbiologic properties
    Michael A Pfaller
    Department of Pathology, Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
    Diagn Microbiol Infect Dis 56:115-21. 2006
    ..This brief review summarizes the antimicrobial properties of bambermycin, in particular, its potentially favorable role in decreasing antimicrobial resistance...
  74. ncbi Intranasal mupirocin to prevent postoperative Staphylococcus aureus infections
    Trish M Perl
    University of Iowa Colleges of Medicine and Public Health, Iowa City, USA
    N Engl J Med 346:1871-7. 2002
    ..Treatment with mupirocin ointment can reduce the rate of nasal carriage and may prevent postoperative S. aureus infections...