Yan J Jiang

Summary

Country: USA

Publications

  1. pmc The expression and regulation of enzymes mediating the biosynthesis of triglycerides and phospholipids in keratinocytes/epidermis
    Yan J Jiang
    Metabolism Section and Dermatology Department of Veterans Affairs Medical Center University of California, San Francisco San Francisco, CA USA
    Dermatoendocrinol 3:70-6. 2011
  2. doi request reprint Ceramides stimulate caspase-14 expression in human keratinocytes
    Yan J Jiang
    Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA 94121, USA
    Exp Dermatol 22:113-8. 2013
  3. pmc Ceramide stimulates ABCA12 expression via peroxisome proliferator-activated receptor {delta} in human keratinocytes
    Yan J Jiang
    Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California, San Francisco, California 94121, USA
    J Biol Chem 284:18942-52. 2009
  4. pmc Regulation of ABCG1 expression in human keratinocytes and murine epidermis
    Yan J Jiang
    Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA 94121, USA
    J Lipid Res 51:3185-95. 2010
  5. doi request reprint IL-6 stimulates but is not essential for stratum corneum formation and permeability barrier development during gestation
    Yan J Jiang
    Metabolism Section, NCIRE, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Exp Dermatol 19:e31-6. 2010
  6. doi request reprint PPARδ activation promotes stratum corneum formation and epidermal permeability barrier development during late gestation
    Yan J Jiang
    Department of Veterans Affairs Medical Center, Metabolism Section, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 130:511-9. 2010
  7. doi request reprint IL-1alpha accelerates stratum corneum formation and improves permeability barrier homeostasis during murine fetal development
    Yan J Jiang
    Metabolism Section, Veterans Affairs Medical Center, and Departments of Dermatology and Medicine, University of California at San Francisco, United States
    J Dermatol Sci 54:88-98. 2009
  8. ncbi request reprint PPAR and LXR activators regulate ABCA12 expression in human keratinocytes
    Yan J Jiang
    Metabolism Section, Department of Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, California 94121, USA
    J Invest Dermatol 128:104-9. 2008
  9. ncbi request reprint Regulation of ABCA1 expression in human keratinocytes and murine epidermis
    Yan J Jiang
    Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA 94121, USA
    J Lipid Res 47:2248-58. 2006
  10. pmc PPARgamma activators stimulate aquaporin 3 expression in keratinocytes/epidermis
    Yan J Jiang
    Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA, USA
    Exp Dermatol 20:595-9. 2011

Detail Information

Publications20

  1. pmc The expression and regulation of enzymes mediating the biosynthesis of triglycerides and phospholipids in keratinocytes/epidermis
    Yan J Jiang
    Metabolism Section and Dermatology Department of Veterans Affairs Medical Center University of California, San Francisco San Francisco, CA USA
    Dermatoendocrinol 3:70-6. 2011
    ..Additionally, the factors regulating their gene expression, including calcium induced differentiation, PPAR and LXR activators, and the effect of acute permeability barrier disruption will be discussed...
  2. doi request reprint Ceramides stimulate caspase-14 expression in human keratinocytes
    Yan J Jiang
    Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA 94121, USA
    Exp Dermatol 22:113-8. 2013
    ..These studies show that ceramides, an important structural lipid, stimulate caspase-14 expression providing a mechanism for coordinately regulating the formation of lipid lamellar membranes with the formation of corneocytes...
  3. pmc Ceramide stimulates ABCA12 expression via peroxisome proliferator-activated receptor {delta} in human keratinocytes
    Yan J Jiang
    Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California, San Francisco, California 94121, USA
    J Biol Chem 284:18942-52. 2009
    ....
  4. pmc Regulation of ABCG1 expression in human keratinocytes and murine epidermis
    Yan J Jiang
    Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA 94121, USA
    J Lipid Res 51:3185-95. 2010
    ....
  5. doi request reprint IL-6 stimulates but is not essential for stratum corneum formation and permeability barrier development during gestation
    Yan J Jiang
    Metabolism Section, NCIRE, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Exp Dermatol 19:e31-6. 2010
    ..These low IL-6 levels may account, at least in part, for the absence of epidermal abnormalities in IL-6 KO mice. In conclusion, exogenous IL-6 accelerates epidermal ontogenesis, but it is not essential for normal epidermal maturation...
  6. doi request reprint PPARδ activation promotes stratum corneum formation and epidermal permeability barrier development during late gestation
    Yan J Jiang
    Department of Veterans Affairs Medical Center, Metabolism Section, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 130:511-9. 2010
    ..These studies show that PPARdelta has a role in SC formation and permeability barrier development...
  7. doi request reprint IL-1alpha accelerates stratum corneum formation and improves permeability barrier homeostasis during murine fetal development
    Yan J Jiang
    Metabolism Section, Veterans Affairs Medical Center, and Departments of Dermatology and Medicine, University of California at San Francisco, United States
    J Dermatol Sci 54:88-98. 2009
    ..The ontogenesis of the epidermal permeability barrier is complex and incompletely understood. Previously we showed that IL-1 and TNFalpha regulate permeability barrier homeostasis in adult mice...
  8. ncbi request reprint PPAR and LXR activators regulate ABCA12 expression in human keratinocytes
    Yan J Jiang
    Metabolism Section, Department of Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, California 94121, USA
    J Invest Dermatol 128:104-9. 2008
    ..Together, our data demonstrate that PPAR and LXR activators increase ABCA12 expression, providing an additional mechanism by which PPAR and LXR activators promote epidermal permeability barrier homeostasis...
  9. ncbi request reprint Regulation of ABCA1 expression in human keratinocytes and murine epidermis
    Yan J Jiang
    Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA 94121, USA
    J Lipid Res 47:2248-58. 2006
    ....
  10. pmc PPARgamma activators stimulate aquaporin 3 expression in keratinocytes/epidermis
    Yan J Jiang
    Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA, USA
    Exp Dermatol 20:595-9. 2011
    ..Our data demonstrate that PPAR and LXR activators stimulate AQP3 expression, providing an additional mechanism by which PPAR and LXR activators regulate epidermal function...
  11. doi request reprint Thematic review series: skin lipids. Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology
    Matthias Schmuth
    Department of Dermatology, University of California, San Francisco, CA, USA
    J Lipid Res 49:499-509. 2008
    ..Because of their broad profile of beneficial effects on skin homeostasis, PPAR and LXR have great potential to serve as drug targets for common skin diseases such as psoriasis, atopic dermatitis, and skin cancer...
  12. ncbi request reprint LXR and PPAR activators stimulate cholesterol sulfotransferase type 2 isoform 1b in human keratinocytes
    Yan J Jiang
    Department of Medicine, University of California San Francisco, San Francisco, CA 94121, USA
    J Lipid Res 46:2657-66. 2005
    ..Thus, LXR and PPAR activators regulate the expression of SULT2B1b, the key enzyme in the synthesis of CS, which is a potent regulator of epidermal differentiation and corneocyte desquamation...
  13. ncbi request reprint Expression and regulation of 1-acyl-sn-glycerol- 3-phosphate acyltransferases in the epidermis
    Biao Lu
    Dermatology and Medicine Services, Veterans Administration Medical Center and University of California School of Medicine, San Francisco, CA 94121, USA
    J Lipid Res 46:2448-57. 2005
    ..Because upregulation of mAGPAT mRNAs after tape-stripping could be partially reversed by artificial barrier restoration by occlusion, these studies suggest that an increase in the expression of AGPATs is linked to barrier requirements...
  14. ncbi request reprint Stratum corneum acidification is impaired in moderately aged human and murine skin
    Eung Ho Choi
    Department of Dermatology, University of California San Francisco and Dermatology Service, Veteran s Administration Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 127:2847-56. 2007
    ..These abnormalities were normalized by exogenously acidifying the SC, suggesting a basis for the well-known acidification therapies that are widely used to treat the pathologic xerosis/eczema seen in moderately aged humans...
  15. ncbi request reprint Cloning and characterization of a cDNA encoding human cardiolipin synthase (hCLS1)
    Biao Lu
    Department of Dermatology, University of California, San Francisco, CA 94121, USA
    J Lipid Res 47:1140-5. 2006
    ..Furthermore, the hCLS1 gene was highly expressed in tissues such as heart, skeletal muscle, and liver, which have been shown to have high CLS activities. These results demonstrate that hCLS1 encodes an enzyme that synthesizes CL...
  16. pmc Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism
    Peter M Elias
    Dermatology Services, Veterans Affairs Medical Center, University of California, San Francisco, CA, USA
    J Lipid Res 49:697-714. 2008
    ..The barrier abnormality provokes the clinical phenotype in these disorders not only by stimulating epidermal proliferation, but also by inducing inflammation...
  17. doi request reprint 1α,25(OH)2-dihydroxyvitamin D3/VDR protects the skin from UVB-induced tumor formation by interacting with the β-catenin pathway
    Yan J Jiang
    Endocrine Unit, Department of Medicine and Dermatology, VA Medical Center and University of California at San Francisco, CA 94121, USA
    J Steroid Biochem Mol Biol 136:229-32. 2013
    ..Further study using VDR or β-catenin single null mice is necessary to compare with the data from double null mice. This article is part of a Special Issue entitled 'Vitamin D Workshop'...
  18. pmc Tight junction properties change during epidermis development
    Anna Celli
    Dermatology Service, Veterans Affairs Medical Center, University of San Francisco, San Francisco, CA, USA
    Exp Dermatol 21:798-801. 2012
    ..These findings demonstrate that the role of TJ changes during epidermal development, and further suggest that the TJ-based and lipid-based epidermal permeability barriers are interdependent...
  19. doi request reprint LncRNA: a new player in 1α, 25(OH)(2) vitamin D(3) /VDR protection against skin cancer formation
    Yan J Jiang
    Endocrine Research Unit 111N, Department of Medicine, VAMC UCSF, NCIRE, San Francisco, CA, USA
    Exp Dermatol 23:147-50. 2014
    ..Modulation of lncRNA profile by VDS may also provide insight into regulating pathways such as Wnt/ß-catenin and hedgehog...
  20. ncbi request reprint Stimulation of cardiac cardiolipin biosynthesis by PPARalpha activation
    Yan J Jiang
    Center for Research and Treatment of Atherosclerosis and Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Lipid Res 45:244-52. 2004
    ..This study is the first to demonstrate that CL de novo biosynthesis is regulated by PPARalpha activation...