Research Topics
Genomes and Genes
| Yan J JiangSummaryCountry: USA Publications
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Detail Information
Publications
Ceramides stimulate caspase-14 expression in human keratinocytesYan J Jiang
Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA 94121, USA
Exp Dermatol 22:113-8. 2013..These studies show that ceramides, an important structural lipid, stimulate caspase-14 expression providing a mechanism for coordinately regulating the formation of lipid lamellar membranes with the formation of corneocytes...
Ceramide stimulates ABCA12 expression via peroxisome proliferator-activated receptor {delta} in human keratinocytesYan J Jiang
Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California, San Francisco, California 94121, USA
J Biol Chem 284:18942-52. 2009....
IL-1alpha accelerates stratum corneum formation and improves permeability barrier homeostasis during murine fetal developmentYan J Jiang
Metabolism Section, Veterans Affairs Medical Center, and Departments of Dermatology and Medicine, University of California at San Francisco, United States
J Dermatol Sci 54:88-98. 2009..The ontogenesis of the epidermal permeability barrier is complex and incompletely understood. Previously we showed that IL-1 and TNFalpha regulate permeability barrier homeostasis in adult mice...
IL-6 stimulates but is not essential for stratum corneum formation and permeability barrier development during gestationYan J Jiang
Metabolism Section, NCIRE, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Exp Dermatol 19:e31-6. 2010..These low IL-6 levels may account, at least in part, for the absence of epidermal abnormalities in IL-6 KO mice. In conclusion, exogenous IL-6 accelerates epidermal ontogenesis, but it is not essential for normal epidermal maturation...
PPAR and LXR activators regulate ABCA12 expression in human keratinocytesYan J Jiang
Metabolism Section, Department of Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, California 94121, USA
J Invest Dermatol 128:104-9. 2008..Together, our data demonstrate that PPAR and LXR activators increase ABCA12 expression, providing an additional mechanism by which PPAR and LXR activators promote epidermal permeability barrier homeostasis...
Regulation of ABCG1 expression in human keratinocytes and murine epidermisYan J Jiang
Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA 94121, USA
J Lipid Res 51:3185-95. 2010....
PPARĪ“ activation promotes stratum corneum formation and epidermal permeability barrier development during late gestationYan J Jiang
Department of Veterans Affairs Medical Center, Metabolism Section, Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Invest Dermatol 130:511-9. 2010..These studies show that PPARdelta has a role in SC formation and permeability barrier development...
Regulation of ABCA1 expression in human keratinocytes and murine epidermisYan J Jiang
Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA 94121, USA
J Lipid Res 47:2248-58. 2006....
PPARgamma activators stimulate aquaporin 3 expression in keratinocytes/epidermisYan J Jiang
Metabolism Section, Veterans Affairs Medical Center, Northern California Institute for Research and Education, University of California at San Francisco, San Francisco, CA, USA
Exp Dermatol 20:595-9. 2011..Our data demonstrate that PPAR and LXR activators stimulate AQP3 expression, providing an additional mechanism by which PPAR and LXR activators regulate epidermal function...
Thematic review series: skin lipids. Peroxisome proliferator-activated receptors and liver X receptors in epidermal biologyMatthias Schmuth
Department of Dermatology, University of California, San Francisco, CA, USA
J Lipid Res 49:499-509. 2008..Because of their broad profile of beneficial effects on skin homeostasis, PPAR and LXR have great potential to serve as drug targets for common skin diseases such as psoriasis, atopic dermatitis, and skin cancer...
LXR and PPAR activators stimulate cholesterol sulfotransferase type 2 isoform 1b in human keratinocytesYan J Jiang
Department of Medicine, University of California San Francisco, San Francisco, CA 94121, USA
J Lipid Res 46:2657-66. 2005..Thus, LXR and PPAR activators regulate the expression of SULT2B1b, the key enzyme in the synthesis of CS, which is a potent regulator of epidermal differentiation and corneocyte desquamation...
Expression and regulation of 1-acyl-sn-glycerol- 3-phosphate acyltransferases in the epidermisBiao Lu
Dermatology and Medicine Services, Veterans Administration Medical Center and University of California School of Medicine, San Francisco, CA 94121, USA
J Lipid Res 46:2448-57. 2005..Because upregulation of mAGPAT mRNAs after tape-stripping could be partially reversed by artificial barrier restoration by occlusion, these studies suggest that an increase in the expression of AGPATs is linked to barrier requirements...
Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolismPeter M Elias
Dermatology Services, Veterans Affairs Medical Center, University of California, San Francisco, CA, USA
J Lipid Res 49:697-714. 2008..The barrier abnormality provokes the clinical phenotype in these disorders not only by stimulating epidermal proliferation, but also by inducing inflammation...
Cloning and characterization of a cDNA encoding human cardiolipin synthase (hCLS1)Biao Lu
Department of Dermatology, University of California, San Francisco, CA 94121, USA
J Lipid Res 47:1140-5. 2006..Furthermore, the hCLS1 gene was highly expressed in tissues such as heart, skeletal muscle, and liver, which have been shown to have high CLS activities. These results demonstrate that hCLS1 encodes an enzyme that synthesizes CL...
Tight junction properties change during epidermis developmentAnna Celli
Dermatology Service, Veterans Affairs Medical Center, University of San Francisco, San Francisco, CA, USA
Exp Dermatol 21:798-801. 2012..These findings demonstrate that the role of TJ changes during epidermal development, and further suggest that the TJ-based and lipid-based epidermal permeability barriers are interdependent...
Stratum corneum acidification is impaired in moderately aged human and murine skinEung Ho Choi
Department of Dermatology, University of California San Francisco and Dermatology Service, Veteran s Administration Medical Center, San Francisco, California 94121, USA
J Invest Dermatol 127:2847-56. 2007..These abnormalities were normalized by exogenously acidifying the SC, suggesting a basis for the well-known acidification therapies that are widely used to treat the pathologic xerosis/eczema seen in moderately aged humans...
Stimulation of cardiac cardiolipin biosynthesis by PPARalpha activationYan J Jiang
Center for Research and Treatment of Atherosclerosis and Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
J Lipid Res 45:244-52. 2004..This study is the first to demonstrate that CL de novo biosynthesis is regulated by PPARalpha activation...
