A J Janckila

Summary

Country: USA

Publications

  1. doi request reprint Serum tartrate-resistant acid phosphatase isoform 5a (TRACP5a) as a potential risk marker in cardiovascular disease
    Anthony J Janckila
    Department of Veterans Affairs Medical Center, University of Louisville School of Medicine, Louisville, KY 40206, USA
    Clin Chim Acta 412:963-9. 2011
  2. doi request reprint Biology and clinical significance of tartrate-resistant acid phosphatases: new perspectives on an old enzyme
    Anthony J Janckila
    Special Hematology Laboratory, U S Department of Veterans Affairs Medical Center, 800 Zorn Ave, Louisville, KY 40206, USA
    Calcif Tissue Int 85:465-83. 2009
  3. ncbi request reprint Tartrate-resistant acid phosphatase isoform 5a as an inflammation marker in end-stage renal disease
    A J Janckila
    Special Hematology Laboratory, Veterans Affairs Medical Center, Louisville, KY 40206, USA
    Clin Nephrol 71:387-96. 2009
  4. doi request reprint Significance of serum TRACP in rheumatoid arthritis
    Anthony J Janckila
    U S Department of Veterans Affairs Medical Center, Louisville, Kentucky 40206, USA
    J Bone Miner Res 23:1287-95. 2008
  5. ncbi request reprint Tartrate-resistant acid phosphatase isoform 5b as serum marker for osteoclastic activity
    A J Janckila
    Special Hematology Laboratory, Veterans Affairs Medical Center, Louisville, KY 40206, USA
    Clin Chem 47:74-80. 2001
  6. ncbi request reprint Naphthol-ASBI phosphate as a preferred substrate for tartrate-resistant acid phosphatase isoform 5b
    A J Janckila
    Department of Veterans Affairs Medical Center, Louisville, Kentucky 40206, USA
    J Bone Miner Res 16:788-93. 2001
  7. doi request reprint Rat brain myo-inositol 3-phosphate synthase is a phosphoprotein
    R N Parthasarathy
    Molecular Neuroscience and Bioinformatics Laboratories, Mental Health, Behavioral Science and Research Services, Robley Rex Veterans Affairs Medical Center, Louisville, KY 40206, USA
    Mol Cell Biochem 378:83-9. 2013
  8. ncbi request reprint Tartrate-resistant acid phosphatase (TRACP): a personal perspective
    Lung T Yam
    Special Hematology Laboratory, Veterans Affairs Medical Center, Louisville, Kentucky 40206, USA
    J Bone Miner Res 18:1894-6. 2003
  9. ncbi request reprint Serum tartrate-resistant acid phosphatase isoforms in rheumatoid arthritis
    Anthony J Janckila
    Special Hematology Laboratory, US Department of Veterans Affairs Medical Center, 800 Zorn Ave, Louisville, KY 40206, USA
    Clin Chim Acta 320:49-58. 2002
  10. ncbi request reprint Stable expression of human tartrate-resistant acid phosphatase isoforms by CHO cells
    Anthony J Janckila
    Special Hematology Laboratory, Veterans Administration Medical Center, 800 Zorn Avenue 151, Louisville, KY 40206, USA
    Clin Chim Acta 326:113-22. 2002

Collaborators

Detail Information

Publications27

  1. doi request reprint Serum tartrate-resistant acid phosphatase isoform 5a (TRACP5a) as a potential risk marker in cardiovascular disease
    Anthony J Janckila
    Department of Veterans Affairs Medical Center, University of Louisville School of Medicine, Louisville, KY 40206, USA
    Clin Chim Acta 412:963-9. 2011
    ..This study was undertaken to determine the association between serum tartrate-resistant acid phosphatase 5a (TRACP5a) and cardiovascular disease (CVD) risk...
  2. doi request reprint Biology and clinical significance of tartrate-resistant acid phosphatases: new perspectives on an old enzyme
    Anthony J Janckila
    Special Hematology Laboratory, U S Department of Veterans Affairs Medical Center, 800 Zorn Ave, Louisville, KY 40206, USA
    Calcif Tissue Int 85:465-83. 2009
    ..Many unanswered questions remain, providing a wealth of opportunity for continued research of this multifaceted enzyme...
  3. ncbi request reprint Tartrate-resistant acid phosphatase isoform 5a as an inflammation marker in end-stage renal disease
    A J Janckila
    Special Hematology Laboratory, Veterans Affairs Medical Center, Louisville, KY 40206, USA
    Clin Nephrol 71:387-96. 2009
    ..End-stage renal disease (ESRD) is often complicated by chronic inflammation and malnutrition. We tested whether serum tartrate-resistant acid phosphatase (TRACP) isoform 5a relates to other markers of inflammation in ESRD...
  4. doi request reprint Significance of serum TRACP in rheumatoid arthritis
    Anthony J Janckila
    U S Department of Veterans Affairs Medical Center, Louisville, Kentucky 40206, USA
    J Bone Miner Res 23:1287-95. 2008
    ..TRACP 5b activity is a marker for osteoclast number and perhaps local or systemic bone destruction...
  5. ncbi request reprint Tartrate-resistant acid phosphatase isoform 5b as serum marker for osteoclastic activity
    A J Janckila
    Special Hematology Laboratory, Veterans Affairs Medical Center, Louisville, KY 40206, USA
    Clin Chem 47:74-80. 2001
    ..The purpose of this study was to isolate the serum isoforms, quantify their disease-related expressions, and test an improved immunoassay for TRAcP 5b...
  6. ncbi request reprint Naphthol-ASBI phosphate as a preferred substrate for tartrate-resistant acid phosphatase isoform 5b
    A J Janckila
    Department of Veterans Affairs Medical Center, Louisville, Kentucky 40206, USA
    J Bone Miner Res 16:788-93. 2001
    ..This method can be adapted to simple microplate biochemical or immunochemical assays. This simplified method for assessment of osteoclastic TRAP 5b activity warrants a detailed investigation in diseases of bone metabolism...
  7. doi request reprint Rat brain myo-inositol 3-phosphate synthase is a phosphoprotein
    R N Parthasarathy
    Molecular Neuroscience and Bioinformatics Laboratories, Mental Health, Behavioral Science and Research Services, Robley Rex Veterans Affairs Medical Center, Louisville, KY 40206, USA
    Mol Cell Biochem 378:83-9. 2013
    ..These observations suggest a novel function for IPS in brain and other tissues. Future studies should resolve the functional role of phospho-IPS in brain inositol signaling...
  8. ncbi request reprint Tartrate-resistant acid phosphatase (TRACP): a personal perspective
    Lung T Yam
    Special Hematology Laboratory, Veterans Affairs Medical Center, Louisville, Kentucky 40206, USA
    J Bone Miner Res 18:1894-6. 2003
  9. ncbi request reprint Serum tartrate-resistant acid phosphatase isoforms in rheumatoid arthritis
    Anthony J Janckila
    Special Hematology Laboratory, US Department of Veterans Affairs Medical Center, 800 Zorn Ave, Louisville, KY 40206, USA
    Clin Chim Acta 320:49-58. 2002
    ..Our objective was to evaluate the significance and source of serum tartrate-resistant acid phosphatase (TRACP) in patients with rheumatoid arthritis (RA)...
  10. ncbi request reprint Stable expression of human tartrate-resistant acid phosphatase isoforms by CHO cells
    Anthony J Janckila
    Special Hematology Laboratory, Veterans Administration Medical Center, 800 Zorn Avenue 151, Louisville, KY 40206, USA
    Clin Chim Acta 326:113-22. 2002
    ..Isoform 5a protein is often increased in rheumatoid arthritis (RA) sera and may be a product of inflammatory macrophages. Our objective was to compare the biochemical characteristics of TRACP 5a and 5b...
  11. ncbi request reprint A novel immunoassay for the determination of tartrate-resistant acid phosphatase 5b from rat serum
    Sari L Alatalo
    Department of Anatomy, Institute of Biomedicine, University of Turku, Turku, Finland
    J Bone Miner Res 18:134-9. 2003
    ..We conclude that serum TRACP 5b is a useful marker for monitoring changes in the bone resorption rate in rat ORC model...
  12. ncbi request reprint Correlation between histomorphometric parameters of bone resorption and serum type 5b tartrate-resistant acid phosphatase in uremic patients on maintenance hemodialysis
    Pauling Chu
    Division of Nephrology, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Am J Kidney Dis 41:1052-9. 2003
    ..The relationship between histomorphometric parameters of bone resorption and serum TRACP was evaluated in 14 chronically dialyzed patients and 6 healthy control subjects...
  13. ncbi request reprint The semiquantitative bone scintigraphy index correlates with serum tartrate-resistant acid phosphatase activity in breast cancer patients with bone metastasis
    Shih Hung Tsai
    Division of Hematology Oncology, Department of Medicine, Tri Service General Hospital, National Defense Medical Center, No 325 Cheng Kung Road, Sec 2, Neihu 114, Taipei, Taiwan
    Mayo Clin Proc 82:917-26. 2007
    ....
  14. ncbi request reprint Sequence and TLR9 independent increase of TRACP expression by antisense DNA and siRNA molecules
    Pirkko Muhonen
    Institute of Biomedicine, Department of Anatomy, University of Turku, FIN 20520 Turku, Finland
    Biochem Biophys Res Commun 359:889-95. 2007
    ..Conclusion: DNA oligonucleotides and RNA molecules extensively increase TRACP expression in monocyte-macrophage lineage. These results suggest a potential role of TRACP in pathogen recognition and in innate immunity...
  15. ncbi request reprint Tartrate-resistant acid phosphatase as an immunohistochemical marker for inflammatory macrophages
    Anthony J Janckila
    Department of Veterans Affairs Medical Center, The Special Hematology Laboratory, University of Louisville, Louisville, KY 40206, USA
    Am J Clin Pathol 127:556-66. 2007
    ..Restricted expression of TRACP primarily in inflammatory MPhi supports our hypothesis that circulating TRACP-5a could be a biomarker of chronic inflammatory disease activity...
  16. ncbi request reprint Effects of calcitriol on type 5b tartrate-resistant acid phosphatase and interleukin-6 in secondary hyperparathyroidism
    Kuo Cheng Lu
    Division of Nephrology, Department of Medicine, Cardinal Tien Hospital, School of Medicine, Fu Jen Catholic University, Taipei, Taiwan
    Blood Purif 24:423-30. 2006
    ..This study investigates the effects of intravenous calcitriol on serum bone resorptive markers, namely, type 5b tartrate-resistant acid phosphatase (TRACP5b) and IL-6 in patients with SHP...
  17. ncbi request reprint Effects of proteolysis and reduction on phosphatase and ROS-generating activity of human tartrate-resistant acid phosphatase
    Katja M Fagerlund
    Institute of Biomedicine, Department of Anatomy, University of Turku, Turku, Finland
    Arch Biochem Biophys 449:1-7. 2006
    ....
  18. ncbi request reprint Tartrate-resistant acid phosphatase 5b is a useful serum marker for extensive bone metastasis in breast cancer patients
    Tsu Yi Chao
    Breast Cancer Research Group, Tri Service General Hospital, National Defense Medical Center, No 325 Cheng Kung Road, Section 2, Nei Hu 114, Taipei, Taiwan
    Clin Cancer Res 11:544-50. 2005
    ..This study aims to determine whether serum TRACP5b is useful for identifying limited or extensive BM in BC patients...
  19. ncbi request reprint Disease-specific expression of tartrate-resistant acid phosphatase isoforms
    Anthony J Janckila
    Department of Veterans Affairs Medical Center, Louisville, Kentucky 40206, USA
    J Bone Miner Res 18:1916-9. 2003
    ..quot; The differences in biochemical properties and disease-specific expression of TRACP isoforms 5a and 5b suggest that they are regulated differently and perform separate functions in a tissue-specific manner...
  20. ncbi request reprint Osteoblast and osteoclast activity in a malignant infantile osteopetrosis patient following bone marrow transplantation
    Chun Jung Chen
    Department of Pediatrics, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
    J Pediatr Hematol Oncol 26:5-8. 2004
    ..Treatment was successful, resulting in a decrease in the serum TRAcP 5b level. These bone-specific markers may be useful for the early assessment of malignant infantile osteopetrosis patients with stem cell transplantation...
  21. ncbi request reprint Alternative immunoassay for tartrate-resistant acid phosphatase isoform 5b using the fluorogenic substrate naphthol ASBI-phosphate and heparin
    Anthony J Janckila
    Special Hematology Laboratory, Department of Veterans Affairs Medical Center, Louisville, KY 40206, USA
    Clin Chim Acta 347:157-67. 2004
    ..Our purpose was to develop a specific immunoassay for tartrate-resistant acid phosphatase (TRACP) 5b using naphthol ASBI phosphate (N-ASBI-P) as a selective substrate for isoform 5b and heparin as a selective inhibitor of isoform 5a...
  22. ncbi request reprint Properties and expression of human tartrate-resistant acid phosphatase isoform 5a by monocyte-derived cells
    Anthony J Janckila
    Special Hematology Laboratory, of the U S Department of Veterans Affairs Medical Center, Louisville, KY 40206, USA
    J Leukoc Biol 77:209-18. 2005
    ..Antibody 220 is an important resource for studies of the biosynthetic relationship among TRACP isoforms and of the significance of serum TRACP 5a as a marker in diseases of bone metabolism and inflammation...
  23. ncbi request reprint Evaluation of the activity of tartrate-resistant acid phosphatase isoform 5b in normal Chinese children--a novel marker for bone growth
    Chun Jung Chen
    Department of Pediatrics, Tri Service General Hospital, Taipei, Taiwan
    J Pediatr Endocrinol Metab 18:55-62. 2005
    ..However, the TRAcP 5b levels of children at different ages are still unknown. It is necessary to accumulate and analyze the data for healthy children at different ages...
  24. ncbi request reprint Flow cytoenzymology of intracellular tartrate-resistant acid phosphatase
    Anthony J Janckila
    Special Hematology Laboratory, Veterans Affairs Medical Center, Louisville, Kentucky 40206, USA
    J Histochem Cytochem 51:1131-7. 2003
    ..The cytochemical method should be useful for basic investigations of differentiation, maturation, and function of macrophages, DCs, and osteoclasts, and for diagnosis and management of hairy cell leukemia...
  25. ncbi request reprint Development of immunoassays for serum tartrate-resistant acid phosphatase isoform 5a
    Tsu Yi Chao
    Division of Hematology and Oncology, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Clin Chim Acta 359:132-40. 2005
    ..TRACP 5b is from bone-resorbing osteoclasts. TRACP 5a may be a macrophage product of inflammation. We used a novel antibody to TRACP 5a to standardize immunoassays for serum TRACP 5a activity and protein...
  26. ncbi request reprint RNA interference tolerates 2'-fluoro modifications at the Argonaute2 cleavage site
    Pirkko Muhonen
    Bone Biology Research Consortium, Institute of Biomedicine, Department of Anatomy, University of Turku
    Chem Biodivers 4:858-73. 2007
    ..These experiments provide the first evidence that RISC activation not only allows 2'-F modifications at the sense-strand cleavage site, but also increase the biological efficacy of modified siRNAs in vitro...
  27. ncbi request reprint The importance of using equimolar DNA for transfection analysis of the 5' flanking promoter regions of genes
    Ratnam S Seelan
    Department of Psychiatry and Behavioral Sciences, Health Sciences Center, University of Louisville, Louisville, KY 40202, USA
    Anal Biochem 349:306-8. 2006