roy W Beck

..The weight of evidence suggests that CGM is beneficial for individuals with type 1 diabetes who have already achieved excellent control with A1C <7.0%...

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..Continuous glucose monitoring inaccuracy can be accounted for in the study design by increasing sample size and/or study duration...

..To compare daily atropine to weekend atropine as prescribed treatments for moderate amblyopia in children younger than 7 years...

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..To compare 2 hours vs 6 hours of daily patching as treatments for moderate amblyopia in children younger than 7 years...

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..Herein, the results of these studies are summarized, and the current and future studies of the group are described...

..The beneficial effect is present for optic neuritis, brainstem-cerebellar syndromes, and spinal cord syndromes...

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..To compare 2 hours of daily patching (combined with 1 hour of concurrent near visual activities) with a control group of spectacle wear alone (if needed) for treatment of moderate to severe amblyopia in children 3 to 7 years old...

..To compare patching and atropine sulfate as treatments for moderate amblyopia in children 18 months after completion of a 6-month randomized trial...

..To compare patching with atropine eyedrops in the treatment of moderate amblyopia (visual acuity, 20/40-20/100) in children aged 7 to 12 years...

..We conducted a pilot study of the FreeStyle Navigator Continuous Glucose Monitoring System (Abbott Diabetes Care) to examine the feasibility of daily use of a continuous glucose monitor (CGM) in an extended ambulatory setting...

..To assess the stability of visual acuity improvement during the first year after cessation of amblyopia treatment other than spectacle wear in children aged 7 to 12 years...

..Although amblyopia can be successfully treated with patching or atropine, there have been few prospective studies of amblyopia recurrence once treatment is discontinued...

..To evaluate the accuracy and precision of the FreeStyle Navigator continuous glucose monitoring system in children with type 1 diabetes...

..To report data on the response of previously untreated strabismic amblyopia to spectacle correction...

..The objective of this study was to assess how the accuracy of the FreeStyle Flash (Abbott Diabetes Care, Alameda, CA) meter compares with that of the One Touch Ultra (Lifescan, Milpitas, CA) home glucose meter (HGM)...

..To examine the acute glucose-lowering effects of aerobic exercise in children and adolescents with type 1 diabetes...

..To evaluate diurnal variation in retinal thickness measured with optical coherence tomography (OCT) in patients with center-involved diabetic macular edema...

..To determine the amount and time course of binocular visual acuity improvement during treatment of bilateral refractive amblyopia in children three to less than 10 years of age...

..To evaluate the effectiveness of refractive correction alone for the treatment of untreated anisometropic amblyopia in children 3 to <7 years old...

..CONCLUSION: Most patients who develop clinically definite multiple sclerosis following an initial episode of optic neuritis will have a relatively benign course for at least 10 years...

..To compare the effect of intravitreal triamcinolone acetonide with focal/grid photocoagulation on the progression of diabetic retinopathy...

..To evaluate optical coherence tomography (OCT) reproducibility in patients with diabetic macular edema (DME)...

..To examine the effect of exercise on overnight hypoglycemia in children with type 1 diabetes mellitus (T1DM)...

..To evaluate the success of masking study participants to treatment allocation using sham intravitreal injections...

..To evaluate the effectiveness of treatment of amblyopia in children aged 7 to 17 years...

..To provide data on the short-term effect of intravitreal bevacizumab for diabetic macular edema (DME)...

..To determine whether endothelial cell loss 5 years after successful corneal transplantation is related to the age of the donor...

..Shorter periods of sampling can be useful, but the correlation with 3-month measures of glycemic control is lower...

..A secondary aim was to obtain a preliminary estimate of the effect of near versus non-near activities on amblyopic eye visual acuity, when combined with 2 hours of daily patching...

..CONCLUSIONS: Most patients retained good to excellent vision more than 10 years after an attack of optic neuritis. Recurrences were more frequent in patients with MS...

..To determine whether visual acuity improvement with Bangerter filters is similar to improvement with patching as initial therapy for children with moderate amblyopia...

..To analyze the value of reading center error correction in automated optical coherence tomography (OCT; Stratus; Carl Zeiss Meditec, Inc., Dublin, CA) retinal thickness measurements in eyes with diabetic macular edema (DME)...

..CONCLUSIONS: Neither the CGMS nor the GW2B is accurate enough to establish population standards of the glycemic profile of healthy children and cannot be recommended in the workup of hypoglycemia in nondiabetic youth...

..Various statistical methods are commonly used to assess the accuracy of near-continuous glucose sensors. The performance and reliability of these methods have not been well described...

..The authors investigated the stability of ocular alignment over 18 weeks in children with infantile esotropia (IET), acquired nonaccommodative esotropia (ANAET), or acquired partially accommodative esotropia (APAET)...

..19%; P < 0.001]. Baseline data from a subsequent outpatient study provide an opportunity to further assess the accuracy of the modified sensor in a much larger sample of children with type 1 diabetes...

..To determine the central corneal thickness (CCT) in healthy white, African American, and Hispanic children from birth to 17 years of age and to determine whether CCT varies by age, race, or ethnicity...

..The purpose of this article is to contrast these 2 approaches...

..The DCA 2000 + Analyzer (Bayer Inc., Tarrytown, NY, USA), which uses an immunoassay, is a very popular device for measuring HbA1c levels in pediatric diabetes practices...

..Although developed to be a management tool for individuals with diabetes, continuous glucose monitoring (CGM) also has potential value for the assessment of outcomes in clinical studies. We evaluated using CGM as such an outcome measure...

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..Baseline patient data, including indications for transplant, intraoperative complication rates, and early postoperative complication rates are described herein...

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..To compare the peripapillary retinal nerve fiber layer (RNFL) thickness of amblyopic and fellow eyes. We hypothesized that the RNFL of the amblyopic eye may be thinner...

..To identify recipient factors that may be related to risk of corneal graft failure...

..To determine the effectiveness of weekend atropine for severe amblyopia from strabismus, anisometropia, or both combined among children 3 to 12 years of age...

..The effect of intensive treatment and patient age on sympathoadrenal responses has not been established in youth with type 1 diabetes because of difficulties in testing procedures...

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..The use of continuous glucose monitoring (CGM) in the pediatric population is not well characterized. We have evaluated the use of CGM over a 12-month interval in youth with type 1 diabetes (TID) and have provided a description of CGM use...

..To identify baseline (donor, recipient, and operative) factors that affect endothelial cell loss following penetrating keratoplasty for a moderate-risk condition (principally Fuchs dystrophy or pseudophakic or aphakic corneal edema)...

..To characterize glucose levels during daily living using continuous glucose monitors (CGMs) in nondiabetic individuals...

..To evaluate the effect of pupillary dilation on electronic-ETDRS visual acuity (EVA) in diabetic subjects and to assess postdilation EVA as a surrogate for predilation VA...

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..To determine whether graft survival over a 5-year follow-up period using corneal tissue from donors older than 65 is similar to graft survival using corneas from younger donors...

..To evaluate the monocular oral reading rate, accuracy, fluency, and comprehension in 10-year-old children previously treated for amblyopia...

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..This study assesses whether use of the GlucoWatch G2 Biographer (GW2B) in addition to standard glucose monitoring lowers HbA(1c) and reduces hypoglycemia compared with standard glucose monitoring alone...

..These data sets are, or will be, available at no charge on the study group's public Web site. Several psychosocial questionnaires developed by DirecNet are also available...

..To identify factors associated with a high and low risk of developing multiple sclerosis after an initial episode of optic neuritis...

..To compare the outcomes of balloon catheter dilation and nasolacrimal intubation as treatment for congenital nasolacrimal duct obstruction after failed probing in children younger than 4 years...

..To compare optical coherence tomography (OCT)-measured retinal thickness and visual acuity in eyes with diabetic macular edema (DME) both before and after macular laser photocoagulation...

..The T1D Exchange includes a clinic-based registry, a patient-centric web site called Glu, and a biobank...

..This computerized testing method should be considered when visual acuity is used as an outcome measure in eye research involving children 7 to <13 years old...

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..The results provide a compelling rationale for conducting a randomized trial of daily use of a continuous glucose monitor in children with T1D...

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..APPLICATION TO CLINICAL PRACTICE: Modified ETDRS focal photocoagulation should continue to be a standard approach for treating diabetic macular edema. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00071773...

..The Guardian RT has an accuracy similar to that of other available continuous glucose monitors and can give important and useful clinical information...

..Further work is needed to identify barriers to effectiveness of continuous monitoring in children and adolescents. (ClinicalTrials.gov number, NCT00406133.)..

..Fewer epithelial abnormalities were observed with shorter death to preservation time...

..The outcome is similar regardless of initial treatment with atropine or patching...

..CONCLUSIONS: Discontinuing basal insulin during exercise is an effective strategy for reducing hypoglycemia in children with type 1 diabetes, but the risk of hyperglycemia is increased...

..We sought to describe the change in ocular alignment at 2 years after treatment of amblyopia in children younger than 7 years of age at enrollment...

..The importance of two independent readings is evident in that image quality ratings differed between the two readers by one grade in 36% of all images and ECD counts differed by >or=5% for 31% of analyzable images...

..RESULTS: Recruitment for the study was completed on December 15, 2007. CONCLUSION: Results of this clinical trial should help establish whether or not current RT-CGM devices are beneficial to patients with T1D...

..This natural history information is important when considering prophylactic treatment for MS at the time of a first acute onset of optic neuritis...

..CONCLUSIONS: These results show the feasibility of implementing the DATA when real-time continuous glucose monitoring is initiated and support its use in future clinical trials of real-time continuous glucose monitoring...

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..We believe that our track record as the DCC in phase 1 overwhelmingly justifies our continuing as the DCC in phase 2. ..

..This proposal will detail the capabilities of the Jaeb Center to serve as the CC for the network and our plans to carry out the objectives of the project. ..

..The structure is not intended to support studies requiring complex procedures requiring extensive site training and/or expensive equipment with limited availability. ..

..This research is focused on reducing hypoglycemia as well as hyperglycemia after meals in people with type 1 diabetes. Hopefully this will lead to improved glycemic control for participants. ..