Affiliation: J. Craig Venter Institute
Shah N, Hou Y, Yu H, Sainger R, Caskey C, Venter J, et al
. Identification of Misclassified ClinVar Variants via Disease Population Prevalence. Am J Hum Genet. 2018;102:609-619 pubmed publisher
..The study shows that databases include a significant proportion of wrongly ascertained variants; however, it underscores the critical role of ClinVar to contrast claims and foster validation across submitters. ..
Moustafa A, Li W, Singh H, Moncera K, Torralba M, Yu Y, et al
. Microbial metagenome of urinary tract infection. Sci Rep. 2018;8:4333 pubmed publisher
Cohen I, Cirulli E, Mitchell M, Jönsson T, Yu J, Shah N, et al
. Acetaminophen (Paracetamol) Use Modifies the Sulfation of Sex Hormones. EBioMedicine. 2018;28:316-323 pubmed publisher
..In addition, it modifies views on the mechanism of action of acetaminophen in pain management as sulfated sex hormones can function as neurosteroids and modify nociceptive thresholds. ..
Pino M, Erkizia I, Benet S, Erikson E, FernÃ¡ndez Figueras M, Guerrero D, et al
. HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells. Retrovirology. 2015;12:37 pubmed publisher
..Siglec-1 on myeloid cells could fuel novel CD4(+) T-cell infections and contribute to HIV-1 dissemination in vivo. ..
McLaren P, Gawanbacht A, Pyndiah N, Krapp C, Hotter D, Kluge S, et al
. Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses. Retrovirology. 2015;12:41 pubmed publisher
..A limited number of human genes share multiple characteristics of genes encoding for known restriction factors. Most of them display anti-retroviral activity in transient transfection assays and are expressed in primary CD4+ T cells. ..
Ciuffi A, Rato S, Telenti A. Single-Cell Genomics for Virology. Viruses. 2016;8: pubmed publisher
..It was only in the past year that single-cell sequencing analyses has been applied in the field of virology, providing new ways to explore viral diversity and cell response to viral infection, which are summarized in the present review. ..
Rato S, Golumbeanu M, Telenti A, Ciuffi A. Exploring viral infection using single-cell sequencing. Virus Res. 2017;239:55-68 pubmed publisher
..In this review, we will focus on recent studies that use single-cell sequencing to explore viral diversity and cell variability in response to viral replication. ..