Peter Buchwald

Summary

Affiliation: IVAX Research
Country: USA

Publications

  1. ncbi request reprint Direct, differential-equation-based in-vitro-in-vivo correlation (IVIVC) method
    Peter Buchwald
    IVAX Research, Inc, 4400 Biscayne Blvd, Miami, Florida 33137, USA
    J Pharm Pharmacol 55:495-504. 2003
  2. ncbi request reprint General linearized biexponential model for QSAR data showing bilinear-type distribution
    Peter Buchwald
    IVAX Research, Inc, 4400 Biscayne Blvd, Miami, Florida 33137, USA
    J Pharm Sci 94:2355-79. 2005
  3. ncbi request reprint Unified pharmacogenetics-based parent-metabolite pharmacokinetic model incorporating acetylation polymorphism for talampanel in humans
    Peter Buchwald
    IVAX Research, Inc, 4400 Biscayne Boulevard, Miami, FL 33137, USA
    J Pharmacokinet Pharmacodyn 32:377-400. 2005
  4. ncbi request reprint Designing safer (soft) drugs by avoiding the formation of toxic and oxidative metabolites
    Nicholas Bodor
    Department of Pharmaceutics, Center for Drug Discovery, University of Florida, College of Pharmacy, Gainesville, FL, USA
    Methods Mol Biol 186:301-12. 2002
  5. ncbi request reprint Physicochemical aspects of the enzymatic hydrolysis of carboxylic esters
    P Buchwald
    IVAX Research, Inc, Miami, Florida, USA
    Pharmazie 57:87-93. 2002
  6. ncbi request reprint Influence of the N-acetylation polymorphism on the metabolism of talampanel: an investigation in fasted and fed subjects genotyped for NAT2 variants
    P Buchwald
    IVAX Research, Inc, 4400 Biscayne Boulevard, Miami, FL 33137, USA
    Pharmazie 61:125-34. 2006
  7. pmc The time-profile of cell growth in fission yeast: model selection criteria favoring bilinear models over exponential ones
    Peter Buchwald
    IVAX Research, Inc, Miami, FL 33137, USA
    Theor Biol Med Model 3:16. 2006
  8. ncbi request reprint A general bilinear model to describe growth or decline time profiles
    Peter Buchwald
    IVAX Research Inc, 4400 Biscayne Blvd, Miami, FL 33137, USA
    Math Biosci 205:108-36. 2007
  9. ncbi request reprint Structure-metabolism relationships: steric effects and the enzymatic hydrolysis of carboxylic esters
    P Buchwald
    IVAX Corp, Miami, FL 33137, USA
    Mini Rev Med Chem 1:101-11. 2001
  10. ncbi request reprint Soft quaternary anticholinergics: comprehensive quantitative structure-activity relationship (QSAR) with a linearized biexponential (LinBiExp) model
    Peter Buchwald
    IVAX Research, Inc, 4400 Biscayne Boulevard, Miami, FL 33137, USA
    J Med Chem 49:883-91. 2006

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Direct, differential-equation-based in-vitro-in-vivo correlation (IVIVC) method
    Peter Buchwald
    IVAX Research, Inc, 4400 Biscayne Blvd, Miami, Florida 33137, USA
    J Pharm Pharmacol 55:495-504. 2003
    ..By avoiding the integral transforms used in the existing deconvolution- or convolution-based IVIVC models, the present method can provide increased transparency, improved performance, and greater modelling flexibility...
  2. ncbi request reprint General linearized biexponential model for QSAR data showing bilinear-type distribution
    Peter Buchwald
    IVAX Research, Inc, 4400 Biscayne Blvd, Miami, Florida 33137, USA
    J Pharm Sci 94:2355-79. 2005
    ....
  3. ncbi request reprint Unified pharmacogenetics-based parent-metabolite pharmacokinetic model incorporating acetylation polymorphism for talampanel in humans
    Peter Buchwald
    IVAX Research, Inc, 4400 Biscayne Boulevard, Miami, FL 33137, USA
    J Pharmacokinet Pharmacodyn 32:377-400. 2005
    ..Such PK models can provide quantitative estimates of relative in vivo metabolism rates for routes catalyzed by functionally polymorphic enzymes...
  4. ncbi request reprint Designing safer (soft) drugs by avoiding the formation of toxic and oxidative metabolites
    Nicholas Bodor
    Department of Pharmaceutics, Center for Drug Discovery, University of Florida, College of Pharmacy, Gainesville, FL, USA
    Methods Mol Biol 186:301-12. 2002
  5. ncbi request reprint Physicochemical aspects of the enzymatic hydrolysis of carboxylic esters
    P Buchwald
    IVAX Research, Inc, Miami, Florida, USA
    Pharmazie 57:87-93. 2002
    ..Available in vitro human blood data suggest that shortest half-lives are achieved with sterically non-hindered chains that are neither too short nor too long and are of around four carbon-atom long...
  6. ncbi request reprint Influence of the N-acetylation polymorphism on the metabolism of talampanel: an investigation in fasted and fed subjects genotyped for NAT2 variants
    P Buchwald
    IVAX Research, Inc, 4400 Biscayne Boulevard, Miami, FL 33137, USA
    Pharmazie 61:125-34. 2006
    ....
  7. pmc The time-profile of cell growth in fission yeast: model selection criteria favoring bilinear models over exponential ones
    Peter Buchwald
    IVAX Research, Inc, Miami, FL 33137, USA
    Theor Biol Med Model 3:16. 2006
    ....
  8. ncbi request reprint A general bilinear model to describe growth or decline time profiles
    Peter Buchwald
    IVAX Research Inc, 4400 Biscayne Blvd, Miami, FL 33137, USA
    Math Biosci 205:108-36. 2007
    ..LinBiExp provides a versatile and useful five-parameter bilinear functional form that is convenient to implement, is suitable for full optimization, and uses intuitive and easily interpretable parameters...
  9. ncbi request reprint Structure-metabolism relationships: steric effects and the enzymatic hydrolysis of carboxylic esters
    P Buchwald
    IVAX Corp, Miami, FL 33137, USA
    Mini Rev Med Chem 1:101-11. 2001
    ..They were obtained for in vitro human blood enzymatic hydrolysis of noncongener esters by introduction of the inaccessible solid angle as a novel measure of steric hindrance...
  10. ncbi request reprint Soft quaternary anticholinergics: comprehensive quantitative structure-activity relationship (QSAR) with a linearized biexponential (LinBiExp) model
    Peter Buchwald
    IVAX Research, Inc, 4400 Biscayne Boulevard, Miami, FL 33137, USA
    J Med Chem 49:883-91. 2006
    ....
  11. doi request reprint Effective and specific inhibition of the CD40-CD154 costimulatory interaction by a naphthalenesulphonic acid derivative
    Emilio Margolles-Clark
    Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL, USA
    Chem Biol Drug Des 76:305-13. 2010
    ..There is now sufficient structure-activity relationship information to serve as the basis of a drug discovery initiative targeting this important costimulatory interaction...
  12. pmc The promiscuous protein binding ability of erythrosine B studied by metachromasy (metachromasia)
    Lakshmi Ganesan
    Department of Molecular and Cellular Pharmacology and Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL, USA
    J Mol Recognit 26:181-9. 2013
    ....
  13. ncbi request reprint Pharmacokinetic and pharmacodynamic evaluations of the zwitterionic metabolite of a new series of N-substituted soft anticholinergics
    Whei Mei Wu
    Center for Drug Discovery, College of Pharmacy, University of Florida, Gainesville, Florida, USA
    Pharm Res 22:2035-44. 2005
    ..This study was conducted to evaluate the zwitterionic common metabolite of a novel series of N-substituted soft analogs of glycopyrrolate both as racemates and as 2R isomers...
  14. ncbi request reprint In vitro and in vivo evaluations of dihydroquinoline- and dihydroisoquinoline-based targetor moieties for brain-specific chemical delivery systems
    Nicholas Bodor
    Center for Drug Discovery, University of Florida, Health Science Center, Gainesville 32610 0497, USA
    J Drug Target 10:63-71. 2002
    ....
  15. doi request reprint Choice of immunosuppression influences cytomegalovirus DNAemia in cynomolgus monkey (Macaca fascicularis) islet allograft recipients
    Dongmei Han
    Diabetes Research Institute, University of Miami School of Medicine, 1450 NW 10th Avenue, Miami, FL 33136, USA
    Cell Transplant 19:1547-61. 2010
    ..Oral valganciclovir prophylaxis did not completely prevent the appearance of CMV DNAemia...
  16. doi request reprint The food colorant erythrosine is a promiscuous protein-protein interaction inhibitor
    Lakshmi Ganesan
    Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Biochem Pharmacol 81:810-8. 2011
    ....
  17. pmc A local glucose-and oxygen concentration-based insulin secretion model for pancreatic islets
    Peter Buchwald
    Diabetes Research Institute and the Department of Molecular and Cellular Pharmacology, University of Miami, Miller School of Medicine, Miami, FL, USA
    Theor Biol Med Model 8:20. 2011
    ....
  18. ncbi request reprint Corticosteroid design for the treatment of asthma: structural insights and the therapeutic potential of soft corticosteroids
    Nicholas Bodor
    IVAX Research, Inc, Miami, Florida, USA
    Curr Pharm Des 12:3241-60. 2006
    ....
  19. ncbi request reprint Designing safer (soft) drugs by avoiding the formation of toxic and oxidative metabolites
    Nicholas Bodor
    IVAX Research Inc, 4400 Biscayne Boulecard, Miami, FL 33137, USA
    Mol Biotechnol 26:123-32. 2004
    ..Design principles for various soft drug classes are briefly summarized together with computerized tools intended to make the application of these principles more quantitative and more accessible...
  20. pmc Oscillatory dynamics of Cdc42 GTPase in the control of polarized growth
    Maitreyi Das
    Department of Molecular and Cellular Pharmacology R 189, University of Miami Miller School of Medicine, Post Office Box 016189, Miami, FL 33101, USA
    Science 337:239-43. 2012
    ..Feedbacks regulating Cdc42 oscillations and spatial self-organization appear to provide a flexible mechanism for fission yeast cells to explore polarization states and to control their morphology...
  21. doi request reprint Small-molecule protein-protein interaction inhibitors: therapeutic potential in light of molecular size, chemical space, and ligand binding efficiency considerations
    Peter Buchwald
    Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    IUBMB Life 62:724-31. 2010
    ....
  22. pmc FEM-based oxygen consumption and cell viability models for avascular pancreatic islets
    Peter Buchwald
    Diabetes Research Institute and the Department of Molecular and Cellular Pharmacology, University of Miami, Miller School of Medicine, Miami, FL, USA
    Theor Biol Med Model 6:5. 2009
    ..Here, finite element method (FEM) based multiphysics models are explored to describe oxygen transport and cell viability in avascular islets both in static and in moving culture media...
  23. pmc Molecular organization of the complex between the muscarinic M3 receptor and the regulator of G protein signaling, Gbeta(5)-RGS7
    Simone L Sandiford
    Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Biochemistry 49:4998-5006. 2010
    ....
  24. pmc An open-label, single-dose, crossover study of the pharmacokinetics and metabolism of two oral formulations of 1-octanol in patients with essential tremor
    Fatta B Nahab
    Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Neurotherapeutics 8:753-62. 2011
    ..OA pharmacokinetics mirrored the timing of clinical improvement. These findings provide preliminary evidence for a new class of compound that may be effective in the treatment of ET...
  25. doi request reprint Quantitative assessment of islet cell products: estimating the accuracy of the existing protocol and accounting for islet size distribution
    Peter Buchwald
    Diabetes Research Institute, University of Miami Leonard M Miller School of Medicine, Miami, FL 33136, USA
    Cell Transplant 18:1223-35. 2009
    ..Compared to the current calculation method, these factors introduce a 4-8% downward correction of the total IEQ estimate, but they reflect a statistically more accurate contribution of differently sized islets...
  26. doi request reprint Small-molecule costimulatory blockade: organic dye inhibitors of the CD40-CD154 interaction
    Emilio Margolles-Clark
    Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    J Mol Med (Berl) 87:1133-43. 2009
    ....
  27. pmc High-throughput screening for human galactokinase inhibitors
    Klaas J Wierenga
    Department of Pediatrics, Leonard M Miller School of Medicine, University of Miami, Miami, Florida 33101, USA
    J Biomol Screen 13:415-23. 2008
    ..Of these 150 compounds, 34 were chosen for further characterization. Preliminary results indicated that these 34 compounds have potential to serve as leads to the development of more effective therapy of classic galactosemia...
  28. ncbi request reprint Barriers to remember: brain-targeting chemical delivery systems and Alzheimer's disease
    Nicholas Bodor
    IVAX Research, 4400 Biscayne Boulevard, Miami, FL 33137, USA
    Drug Discov Today 7:766-74. 2002
    ..Many potential therapeutic applications can be envisioned for such CDSs; here, the potential of brain-targeted estradiol for the prevention and treatment of Alzheimer's disease is reviewed in detail...
  29. doi request reprint Pharmacokinetics of the sequential metabolites of loteprednol etabonate in rats
    Whei Mei Wu
    Center for Drug Discovery, College of Pharmacy, University of Florida, Gainesville, FL 32610 0497, USA
    J Pharm Pharmacol 60:291-7. 2008
    ..In a manner similar to that seen for LE, dose-dependent elimination was observed both in AE and A. These results suggested that both AE and A were ideal leads for the design of soft steroids based on the inactive metabolite approach...
  30. doi request reprint Structural studies on the chiral selector capacity of cyclodextrin derivatives
    Béla Tokés
    University of Medicine and Pharmacy at Targu Mures Marosvásárhely, Romania
    J Biochem Biophys Methods 70:1276-82. 2008
    ..Interactions between various cyclodextrins and pyrethroic acids are modeled, interpreted, and compared to experimental capillary electrophoresis data...
  31. pmc Ophthalmic drug design based on the metabolic activity of the eye: soft drugs and chemical delivery systems
    Nicholas Bodor
    Center for Drug Discovery, University of Florida, Health Science Center, PO Box 100497, Gainesville, FL 32610 0497, USA
    AAPS J 7:E820-33. 2005
    ....
  32. ncbi request reprint Glucocorticoid receptor binding: a biphasic dependence on molecular size as revealed by the bilinear LinBiExp model
    Peter Buchwald
    Molecular and Cellular Pharmacology and Diabetes Research Institute, Miller School of Medicine, University of Miami, 1450 NW 10 Avenue R 134, Miami, FL 33136, United States
    Steroids 73:193-208. 2008
    ..5 kJ/mol, corresponding to an almost doubling of the binding affinity...