C F Bennett

Summary

Affiliation: Isis Pharmaceuticals
Country: USA

Publications

  1. pmc Antisense-based therapy for the treatment of spinal muscular atrophy
    Frank Rigo
    Isis Pharmaceuticals, Carlsbad, CA 92010, USA
    J Cell Biol 199:21-5. 2012
  2. doi request reprint RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform
    C Frank Bennett
    Isis Pharmaceuticals, Inc, Carlsbad, California 92008, USA
    Annu Rev Pharmacol Toxicol 50:259-93. 2010
  3. ncbi request reprint Application of antisense oligonucleotides for gene functionalization and target validation
    C F Bennett
    Isis Pharmaceuticals Inc, Carlsbad, CA 92008, USA
    Curr Opin Mol Ther 1:359-71. 1999
  4. ncbi request reprint Efficiency of antisense oligonucleotide drug discovery
    C Frank Bennett
    Isis Pharmaceuticals, Carlsbad, CA 92008, USA
    Antisense Nucleic Acid Drug Dev 12:215-24. 2002
  5. ncbi request reprint Chemically modified oligonucleotides exhibit decreased immune stimulation in mice
    S Henry
    Isis Pharmaceuticals, Inc, Carlsbad, California, USA
    J Pharmacol Exp Ther 292:468-79. 2000
  6. ncbi request reprint Intercellular adhesion molecule-1 suppression in skin by topical delivery of anti-sense oligonucleotides
    R C Mehta
    Isis Pharmaceuticals, Inc, Carlsbad, California 92008, USA
    J Invest Dermatol 115:805-12. 2000
  7. pmc Fully modified 2' MOE oligonucleotides redirect polyadenylation
    T A Vickers
    Isis Pharmaceuticals, Department of Molecular and Structural Biology, 2280 Faraday Avenue, Carlsbad, CA 92008, USA
    Nucleic Acids Res 29:1293-9. 2001
  8. ncbi request reprint ADAM17 but not ADAM10 mediates tumor necrosis factor-alpha and L-selectin shedding from leukocyte membranes
    T P Condon
    Isis Pharmaceuticals, Carlsbad, CA 92008, USA
    Antisense Nucleic Acid Drug Dev 11:107-16. 2001
  9. ncbi request reprint An ICAM-1 antisense oligonucleotide prevents and reverses dextran sulfate sodium-induced colitis in mice
    C F Bennett
    Isis Pharmaceuticals, Carlsbad, California 92008, USA
    J Pharmacol Exp Ther 280:988-1000. 1997
  10. ncbi request reprint Phosphorothioate oligodeoxynucleotides distribute similarly in class A scavenger receptor knockout and wild-type mice
    M Butler
    Isis Pharmaceuticals, Carlsbad, California, USA
    J Pharmacol Exp Ther 292:489-96. 2000

Collaborators

Detail Information

Publications33

  1. pmc Antisense-based therapy for the treatment of spinal muscular atrophy
    Frank Rigo
    Isis Pharmaceuticals, Carlsbad, CA 92010, USA
    J Cell Biol 199:21-5. 2012
    ..Here, we describe the journey that has led to a promising drug based on the biology underlying the disease...
  2. doi request reprint RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform
    C Frank Bennett
    Isis Pharmaceuticals, Inc, Carlsbad, California 92008, USA
    Annu Rev Pharmacol Toxicol 50:259-93. 2010
    ..This review focuses on the molecular mechanisms by which antisense oligonucleotides can be designed to modulate RNA function in mammalian cells and how synthetic oligonucleotides behave in the body...
  3. ncbi request reprint Application of antisense oligonucleotides for gene functionalization and target validation
    C F Bennett
    Isis Pharmaceuticals Inc, Carlsbad, CA 92008, USA
    Curr Opin Mol Ther 1:359-71. 1999
    ..In this review the use of antisense oligonucleotides as a research tool for gene functionalization and target validation is discussed...
  4. ncbi request reprint Efficiency of antisense oligonucleotide drug discovery
    C Frank Bennett
    Isis Pharmaceuticals, Carlsbad, CA 92008, USA
    Antisense Nucleic Acid Drug Dev 12:215-24. 2002
    ..This review will highlight some of the efficiencies of antisense oligonucleotide drug discovery compared to traditional drugs and will point out some of the current limitations of the technology...
  5. ncbi request reprint Chemically modified oligonucleotides exhibit decreased immune stimulation in mice
    S Henry
    Isis Pharmaceuticals, Inc, Carlsbad, California, USA
    J Pharmacol Exp Ther 292:468-79. 2000
    ..Thus, chemical modifications appeared to increase the tolerability profile for these compounds that are representative of the second generation of antisense oligonucleotides...
  6. ncbi request reprint Intercellular adhesion molecule-1 suppression in skin by topical delivery of anti-sense oligonucleotides
    R C Mehta
    Isis Pharmaceuticals, Inc, Carlsbad, California 92008, USA
    J Invest Dermatol 115:805-12. 2000
    ..The results strongly suggest that topically applied anti-sense oligonucleotides can be delivered to target sites in the skin and may be of considerable value in the treatment of psoriasis and other inflammatory skin disorders...
  7. pmc Fully modified 2' MOE oligonucleotides redirect polyadenylation
    T A Vickers
    Isis Pharmaceuticals, Department of Molecular and Structural Biology, 2280 Faraday Avenue, Carlsbad, CA 92008, USA
    Nucleic Acids Res 29:1293-9. 2001
    ..This study demonstrates that antisense oligonucleotides can be successfully employed to redirect polyadenylation. This is the first demonstration of the use of oligonucleotides to increase, rather than decrease, abundance of a message...
  8. ncbi request reprint ADAM17 but not ADAM10 mediates tumor necrosis factor-alpha and L-selectin shedding from leukocyte membranes
    T P Condon
    Isis Pharmaceuticals, Carlsbad, CA 92008, USA
    Antisense Nucleic Acid Drug Dev 11:107-16. 2001
    ..These results suggest that ADAM17 is one of the major metalloproteases involved in L-selectin shedding as well as TNF-alpha processing. The biologic substrates for ADAM10 in Jurkat and THP-1 cells remain to be elucidated...
  9. ncbi request reprint An ICAM-1 antisense oligonucleotide prevents and reverses dextran sulfate sodium-induced colitis in mice
    C F Bennett
    Isis Pharmaceuticals, Carlsbad, California 92008, USA
    J Pharmacol Exp Ther 280:988-1000. 1997
    ....
  10. ncbi request reprint Phosphorothioate oligodeoxynucleotides distribute similarly in class A scavenger receptor knockout and wild-type mice
    M Butler
    Isis Pharmaceuticals, Carlsbad, California, USA
    J Pharmacol Exp Ther 292:489-96. 2000
    ....
  11. ncbi request reprint Regulating gene expression through RNA nuclear retention
    Kannanganattu V Prasanth
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Cell 123:249-63. 2005
    ..This mechanism of action highlights an important paradigm for the role of a nuclear-retained stable RNA transcript in regulating gene expression...
  12. ncbi request reprint Evaluation of basic amphipathic peptides for cellular delivery of antisense peptide nucleic acids
    Martin A Maier
    Department of Medicinal Chemistry, Isis Pharmaceuticals Inc, 1891 Rutherford Road, Carlsbad, CA 92008, USA
    J Med Chem 49:2534-42. 2006
    ..Two representative compounds were radiolabeled and evaluated for their biodistribution in healthy mice...
  13. ncbi request reprint miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
    Christine Esau
    Isis Pharmaceuticals, 1896 Rutherford Road, Carlsbad, California 92008, USA
    Cell Metab 3:87-98. 2006
    ..These results implicate miR-122 as a key regulator of cholesterol and fatty-acid metabolism in the adult liver and suggest that miR-122 may be an attractive therapeutic target for metabolic disease...
  14. ncbi request reprint Structure-activity relationship study on a simple cationic peptide motif for cellular delivery of antisense peptide nucleic acid
    Klaus Albertshofer
    Department of Medicinal Chemistry, Isis Pharmaceuticals, Inc, 1891 Rutherford Road, Carlsbad, CA 92008, USA
    J Med Chem 48:6741-9. 2005
    ..In a preliminary PK/tissue distribution study in healthy mice, the parent conjugate exhibited relatively broad tissue distribution and only modest elimination via excretion within the time frame of the study...
  15. ncbi request reprint Induction of toll-like receptors and NALP/PAN/PYPAF family members by modified oligonucleotides in lung epithelial carcinoma cells
    Denis Drygin
    Isis Pharmaceuticals, Carlsbad, CA 92008, USA
    Oligonucleotides 15:105-18. 2005
    ..DNA microarray analysis identified additional genes modulated by ISIS 199044, particularly genes involved in DNA damage/repair...
  16. ncbi request reprint Transfection protocol for antisense oligonucleotides affects uniformity of transfection in cell culture and efficiency of mRNA target reduction
    Chantal A Reed
    Isis Pharmaceuticals, Carlsbad, CA 92008, USA
    Oligonucleotides 15:12-22. 2005
    ..By maintaining a constant lipid concentration, more consistent transfection was achieved...
  17. pmc Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals
    Eric E Swayze
    Isis Pharmaceuticals, Inc, 1896 Rutherford Road, Carlsbad, CA 92008, USA
    Nucleic Acids Res 35:687-700. 2007
    ..These studies suggest that while LNA ASOs have the potential to improve potency, they impose a significant risk of hepatotoxicity...
  18. ncbi request reprint Reduction of coactivator expression by antisense oligodeoxynucleotides inhibits ERalpha transcriptional activity and MCF-7 proliferation
    Ilaria T R Cavarretta
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    Mol Endocrinol 16:253-70. 2002
    ....
  19. ncbi request reprint MicroRNA-143 regulates adipocyte differentiation
    Christine Esau
    Isis Pharmaceuticals, Carlsbad, California 92008, USA
    J Biol Chem 279:52361-5. 2004
    ..In addition, protein levels of the proposed miR-143 target ERK5 (4) were higher in ASO-treated adipocytes. These results demonstrate that miR-143 is involved in adipocyte differentiation and may act through target gene ERK5...
  20. ncbi request reprint Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication
    Anne B Eldrup
    Department of Medicinal Chemistry, Isis Pharmaceuticals, 2280 Faraday Avenue, Carlsbad, CA 92008, USA
    J Med Chem 47:5284-97. 2004
    ....
  21. pmc Identification and functional validation of PNAs that inhibit murine CD40 expression by redirection of splicing
    Andrew M Siwkowski
    Department of Medicinal Chemistry, Isis Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, CA 92008, USA
    Nucleic Acids Res 32:2695-706. 2004
    ..These results demonstrate that PNA oligomers can be effective inhibitors of CD40 expression and hence may be useful as novel immuno-modulatory agents...
  22. ncbi request reprint Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase
    Anne B Eldrup
    Department of Medicinal Chemistry, Isis Pharmaceuticals, 2280 Faraday Avenue, Carlsbad, California 92008, USA
    J Med Chem 47:2283-95. 2004
    ....
  23. ncbi request reprint Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis
    Timothy A Vickers
    GeneTrove Division and Antisense Core Research Department, Isis Pharmaceuticals, Inc, Carlsbad, California 92008, USA
    J Biol Chem 278:7108-18. 2003
    ..These results demonstrate that siRNA oligonucleotide- and RNase H-dependent antisense strategies are both valid strategies for evaluating function of genes in cell-based assays...
  24. doi request reprint Interferon-gamma induces X-linked inhibitor of apoptosis-associated factor-1 and Noxa expression and potentiates human vascular smooth muscle cell apoptosis by STAT3 activation
    Yalai Bai
    Interdepartmental Program in Vascular Biology and Transplantation and the Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 283:6832-42. 2008
    ..The data suggest STAT1-independent signaling by IFN-gamma via STAT3 that promotes the death of human VSMCs...
  25. pmc Enhancement of SMN2 exon 7 inclusion by antisense oligonucleotides targeting the exon
    Yimin Hua
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America
    PLoS Biol 5:e73. 2007
    ..Some of the ASOs we identified are sufficiently active to proceed with experiments in SMA mouse models...
  26. pmc Antisense masking of an hnRNP A1/A2 intronic splicing silencer corrects SMN2 splicing in transgenic mice
    Yimin Hua
    Cold Spring Harbor Laboratory, PO Box 100, Cold Spring Harbor, NY 11724, USA
    Am J Hum Genet 82:834-48. 2008
    ..Most importantly, our results highlight the therapeutic potential of some of these ASOs in the context of SMA...
  27. ncbi request reprint HBXIP, cellular target of hepatitis B virus oncoprotein, is a regulator of centrosome dynamics and cytokinesis
    Ryoji Fujii
    Burnham Institute for Medical Research, La Jolla, California and ISIS Pharmaceuticals, Inc, Carlsbad, California, USA
    Cancer Res 66:9099-107. 2006
    ..Thus, HBXIP is a critical regulator of hepatocyte cell growth in vivo, making it a strong candidate for explaining the tumorigenic actions of viral HBx...
  28. pmc Antisense oligonucleotide therapy for neurodegenerative disease
    Richard A Smith
    Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, California, USA
    J Clin Invest 116:2290-6. 2006
    ..This suggests that direct delivery of antisense oligonucleotides could be an effective, dosage-regulatable means of treating neurodegenerative diseases, including ALS, where appropriate target proteins are known...
  29. ncbi request reprint Defining the transcriptome of accelerated and replicatively senescent keratinocytes reveals links to differentiation, interferon signaling, and Notch related pathways
    Ranjan J Perera
    Keck Graduate Institute, Claremont, California, USA
    J Cell Biochem 98:394-408. 2006
    ..Integrating all of the transcriptional data revealed a key role for Notch receptor mediated signaling in the confluency induced differentiation phenotype using this model system...
  30. ncbi request reprint Role of ICAM-1 in chronic hepatic allograft rejection in the rat
    John Wong
    Liver Unit, Gastroenterology Research Group, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Am J Physiol Gastrointest Liver Physiol 283:G196-203. 2002
    ..These results showed that early leukocyte recruitment in the hepatic microvasculature of rejecting allografts is ICAM-1 dependent and suggest that impacting on early cell recruitment can significantly ameliorate chronic rejection...
  31. ncbi request reprint Methoxyethyl-modified intercellular adhesion molecule-1 antisense phosphorothiateoligonucleotides inhibit allograft rejection, ischemic-reperfusion injury, and cyclosporine-induced nephrotoxicity
    Wenhau Chen
    Division of Immunology and Organ Transplantation, The University of Texas Medical School Houston, 6431 Fannin, Houston, TX 77030, USA
    Transplantation 79:401-8. 2005
    ..To further improve oligo function 2'-methoxyethyl (ME) groups were attached to selected nucleotides at the 3'-end because ME groups block RNase activity...
  32. ncbi request reprint Antisense oligonucleotide-based therapeutics for cancer
    Nicholas M Dean
    Isis Pharmaceuticals, 2282 Faraday Ave, Carlsbad, CA 92008, USA
    Oncogene 22:9087-96. 2003
    ..Advances in the medicinal chemistry and formulation of antisense oligonucleotides will further enhance their therapeutic and commercial potential...
  33. pmc Sequence-dependent cytotoxicity of second-generation oligonucleotides
    Denis Drygin
    Isis Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, CA 92008, USA
    Nucleic Acids Res 32:6585-94. 2004
    ....