Research TopicsSpecies | W WangSummaryAffiliation: Iowa State University Country: USA Publications
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Publications
Induction of NADPH:quinone reductase by dietary phytoestrogens in colonic Colo205 cellsW Wang
Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA
Biochem Pharmacol 56:189-95. 1998....- A five-year follow-up study of goiter and thyroid nodules in three regions with different iodine intakes in ChinaX Yu
Institute of Endocrinology, First Hospital Affiliated to China Medical University, Shenyang, Liaoning Province, PR China
J Endocrinol Invest 31:243-50. 2008..The aim of the study was to determine the incidence of goiter and thyroid nodules in 3 regions with different iodine intake levels: mildly deficient, more than adequate, and excessive... - Transgene delivery with a cationic lipid in the presence of amyloid beta (betaAP) peptideP S Ajmani
Department of Pharmaceutics, University of Florida, Gainesville 32610, USA
Neurochem Res 26:195-202. 2001..These results demonstrate that betaAP (25-35) peptide may interfere with gene delivery with cationic systems... - Pharmacogenomic dissection of resistance to thymidylate synthase inhibitorsW Wang
Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
Cancer Res 61:5505-10. 2001..These data provide encouragement that comprehensive transcript analysis will aid the quest for more enlightened therapeutics... - Enhancement of antigen-presenting ability of B lymphoma cells by immunostimulatory CpG-oligonucleotides and anti-CD40 antibodyW Chen
Institute of Immunology, Zhejiang University, Hangzhou 310031, Zhejiang, People's Republic of China
Immunol Lett 77:17-23. 2001..Our data expanded the potential application of CpG-ODN as an immunotherapeutic agent in cancer treatment... - The involvement of TNF-alpha-related apoptosis-inducing ligand in the enhanced cytotoxicity of IFN-beta-stimulated human dendritic cells to tumor cellsS Liu
Department of Immunology, Second Military Medical University, Shanghei, People's Republic of China
J Immunol 166:5407-15. 2001..Subsequently, DCs act as APCs involved in the uptake, processing, and presentation of apoptotic tumor Ags to cross-prime CD8(+) CTL cells... - Interleukin-18 enhances the production of interleukin-8 by eosinophilsW Wang
Department of Internal Medicine III, Osaka University Medical School, Osaka, Japan
Eur J Immunol 31:1010-6. 2001..Our findings using peripheral blood eosinophils and eosinophilic cell line suggest the functional importance of IL-18 in the induction of IL-8 and a potential proinflammatory role in allergy... - Dietary energy restriction inhibits ERK but not JNK or p38 activity in the epidermis of SENCAR miceY Liu
Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, USA
Carcinogenesis 22:607-12. 2001.... - Characterization of the 5' flanking region of the rat D(3) dopamine receptor geneW Wang
Genetic Pharmacology Unit, Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurochem 76:1736-44. 2001..The D(3) promoter is inactive in C6 and COS7 cells. We conclude that the D(3) gene, similar to the closely related D(2) gene, is transcribed from a tissue specific promoter which is under intense negative control... - Variations of dose and electrode spacing for rat breast cancer electrochemical treatmentR L Ren
Department of Radiation Research, City of Hope National Medical Center, Duarte, California, USA
Bioelectromagnetics 22:205-11. 2001..For a diameter of 2.0-2.5 cm rat breast cancer, EChT should be applied with 5-10 mm spacing and a minimum dosage of 80 C... - Irofulven (6-hydroxymethylacylfulvene, MGI 114) induces caspase 8 and 9-mediated apoptosis in human pancreatic adenocarcinoma cellsW Wang
Department of Surgery, University of Texas Health Science Center at San Antonio, 78229, USA
Anticancer Res 21:1789-94. 2001..CONCLUSION: Our data demonstrate that the cytotoxicity of irofulven in human pancreatic carcinoma cell lines is mediated by caspase-induced apoptosis... - [Overexpression of p27(KIP1) induced by Bak gene leads to the arrest in G(1) phase of HCC-9204 cell line]J Li
Department of Pathology, Fourth Military Medical University, Xin 710033, China
Zhonghua Gan Zang Bing Za Zhi 9:27-9. 2001..CONCLUSIONS: Bak may induce cell cycle arrest in G(1) phase through up-regulating expression of p27(KIP1). The inducible p27(KIP1)-expressing cells provide a model to assess p27(KIP1) function... 
20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol, a novel natural product for prostate cancer therapy: activity in vitro and in vivo and mechanisms of actionW Wang
Department of Pharmacology and Toxicology, Division of Clinical Pharmacology, and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham AL 35294, USA
Br J Cancer 98:792-802. 2008..In conclusion, our preclinical data indicate that 25-OCH3-PPD is a potential therapeutic agent against both androgen-dependent and androgen-independent prostate cancer...- Changes in cholinergic function in the frontal cortex and hippocampus of rat exposed to ethanol and acetaldehydeM Jamal
Department of Forensic Medicine, Faculty of Medicine, Kagawa University, 1750 1, Ikenobe, Miki, Kita, Kagawa 761 0793, Japan
Neuroscience 144:232-8. 2007.... - Genetic polymorphisms of CYP3A5 genes and concentration of the cyclosporine and tacrolimusY Zhao
The First Hospital of Tsinghua University, Beijing, China
Transplant Proc 37:178-81. 2005..Our objective was to determine the relationship between genetic polymorphisms of CYP3A5 with respect to interindividual variability in CsA and tacrolimus pharmacokinetics... - Molecular and functional characterization of a vasotocin-sensitive aquaporin water channel in quail kidneyY Yang
Dept. of Physiology, Univ. of Tennessee Health Science Center, 894 Union Ave, Memphis, TN 38163, USA
Am J Physiol Regul Integr Comp Physiol 287:R915-24. 2004..This is the first clear identification of AQP2 homolog in nonmammalian vertebrates... - Constitutive nuclear factor-kappa B mRNA, protein overexpression and enhanced DNA-binding activity in thymidylate synthase inhibitor-resistant tumour cellsW Wang
Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, UK
Br J Cancer 88:624-9. 2003..NF-kappa B can antagonise anticancer drug-induced apoptosis. High NF-kappa B expression and nuclear activity in TS inhibitor-resistant cancer cells may play an important role in the chemoresistance... - Aquaporin expression in developing human teeth and selected orofacial tissuesW Wang
Center for Craniofacial and Dental Genetics, Division of Oral Biology, School of Dental Medicine, University of Pittsburgh, 614 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA
Calcif Tissue Int 72:222-7. 2003..These results demonstrate that multiple aquaporins are expressed in developing teeth and in selected orofacial tissues... - An association between genetic polymorphisms in the ileal sodium-dependent bile acid transporter gene and the risk of colorectal adenomasW Wang
Department of Preventive Medicine, University of Southern California Norris Cancer Center, Los Angeles, California 94587, USA
Cancer Epidemiol Biomarkers Prev 10:931-6. 2001.... - Inhibition of phorbol ester-induced AP-1-DNA binding, c-Jun protein and c-jun mRNA by dietary energy restriction is reversed by adrenalectomy in SENCAR mouse epidermisJ Przybyszewski
Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011-1061, USA
Carcinogenesis 22:1421-7. 2001..05). Thus, dietary energy restriction may inhibit cancer mechanistically by reducing overall AP-1 transcription through a process that is mediated in part by glucocorticoid hormones... - Analyses of the genomic methylation status of the human cyclin A1 promoter by a novel real-time PCR-based methodologyC Muller-Tidow
Department of Medicine, Hematology and Oncology, University of Munster, Domagkstr 3, 48129 Munster, Germany
FEBS Lett 490:75-8. 2001..Taken together, our data provide evidence that CpG methylation patterns of the human cyclin A1 promoter in human organs do not generally correlate with cyclin A1 gene expression in vivo... - Characterization of SWI/SNF protein expression in human breast cancer cell lines and other malignanciesM F DeCristofaro
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill 27599, USA
J Cell Physiol 186:136-45. 2001..In this study, we identified the first cell line negative for the BAF57 protein as well as a pancreatic carcinoma cell line negative for both the BRG-1 and hBRM proteins... - Ski represses bone morphogenic protein signaling in Xenopus and mammalian cellsW Wang
Life Sciences Division, Lawrence Berkeley National Laboratory, and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 97:14394-9. 2000..Thus, Ski is able to repress the activity of all receptor-associated Smads and may regulate vertebrate development by modulating the signaling activity of transforming growth factor-beta family members... - Purification, crystallization and preliminary X-ray diffraction data from selenomethionine glycinamide ribonucleotide synthetaseT M Weaver
Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14853, USA
Acta Crystallogr D Biol Crystallogr 55:518-21. 1999..2, b = 62.4 and c = 129.8 A and a single monomer in the asymmetric unit. The crystals diffract to 1.6 A resolution and have led to the determination of multiple-wavelength anomalous diffraction phases to 2.2 A resolution... - Adenovirus early region 1A protein binds to mammalian SUG1-a regulatory component of the proteasomeR J Grand
CRC Institute for Cancer Studies, University of Birmingham, Edgbaston, UK
Oncogene 18:449-58. 1999..We have also demonstrated that SUGI can be co-immunoprecipitated with SV40 T and therefore we suggest that this may represent a common interaction of transforming proteins of DNA tumour viruses... - NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activitiesY Xue
Laboratory of Genetics, National Institute on Aging, National Institute of Health, Gerontology Research Center, Baltimore, Maryland 21224, USA
Mol Cell 2:851-61. 1998..These results suggest that ATP-dependent chromatin remodeling can participate in transcriptional repression by assisting repressors in gaining access to chromatin... - Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox geneW Wang
Brookdale Center for Development and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
Development 125:621-34. 1998..Interestingly, expression of both Hmx1 and Hmx2 is downregulated in the Hmx3 null uterus, suggesting a hierarchical relationship among the three Hmx genes during pregnancy... - Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5G V Kalpana
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, College of Physicians and Surgeons, New York, NY 10032
Science 266:2002-6. 1994..The gene, termed INI1 (for integrase interactor 1), may encode a nuclear factor that promotes integration and targets incoming viral DNA to active genes... - The Down regulated in Adenoma (dra) gene encodes an intestine-specific membrane sulfate transport proteinD G Silberg
Department of Medicine and Genetics, University of Pennsylvania, Philadelphia 19104, USA
J Biol Chem 270:11897-902. 1995..This functional characterization provides the foundation for investigation of the role of Dra in intestinal sulfate transport and in the malignant phenotype... - [A preliminary study on metastasis-associated gene screened by monoclonal antibodies HIL]T Qi
Department of Pathology, Harbin Medical University
Zhonghua Zhong Liu Za Zhi 17:163-6. 1995..The metastatic potential of Anip[973] cells was markedly decreased after being pretreated with MoAb H4. The above findings indicate that H4-D has a certain relationship with the metastatic phenotype of Anip[973] cells... - Isolation and characterization of the human sucrase-isomaltase gene and demonstration of intestine-specific transcriptional elementsG D Wu
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor
J Biol Chem 267:7863-70. 1992.... - Bidirectional transmembrane modulation of integrin alphaIIbbeta3 conformationsT M Leisner
Department of Pharmacology, University of Illinois, Chicago, Illinois 60612, USA
J Biol Chem 274:12945-9. 1999..Such bidirectional modulation of alphaIIbbeta3 conformation across the cell membrane may play a key role in inside-out and outside-in signaling via this integrin... - Transcriptional activation of E2F1 gene expression by 17beta-estradiol in MCF-7 cells is regulated by NF-Y-Sp1/estrogen receptor interactionsW Wang
Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
Mol Endocrinol 13:1373-87. 1999..This represents a unique trans-acting protein complex in which ligand-dependent transactivation by the ER is independent of direct ER interactions with promoter elements... - The murine Otp homeobox gene plays an essential role in the specification of neuronal cell lineages in the developing hypothalamusW Wang
Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029 6574, USA
Dev Biol 227:432-49. 2000..The involvement of Otp and Sim1 in specifying specific hypothalamic neurosecretory cell lineages is shown to operate via distinct signaling pathways that partially overlap with Brn2... - Possible association of BLM in decreasing DNA double strand breaks during DNA replicationW Wang
Molecular Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai
EMBO J 19:3428-35. 2000..The BLM(-/-)/RAD54(-/-) cells showed a slow growth phenotype and an increased incidence of chromosome-type breaks/gaps while each single mutant showed relatively small numbers of chromosome-type breaks/gaps... - Characterization of retinoic acid receptor-deficient keratinocytesP Goyette
Department of Molecular Biology, Universite de Montreal, Division of Experimental Medicine, McGill University, and the Institut de Recherches Cliniques de Montréal, 110 Avenue des Pins, ouest, Montreal, Quebec H2W 1R7, Canada
J Biol Chem 275:16497-505. 2000..Finally, both RARalpha and RARgamma differently affected the expression of some genes, suggesting both specific and overlapping roles for the RARs in keratinocytes... - HuR regulates p21 mRNA stabilization by UV lightW Wang
Laboratory of Biological Chemistry, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
Mol Cell Biol 20:760-9. 2000..Our findings indicate that HuR plays a major role in regulating stress-induced p21 expression by enhancing p21 mRNA stability and that these effects are coupled to HuR's elevated presence in the cytoplasm... - The alpha1-6-fucosyltransferase gene and its biological significanceE Miyoshi
Department of Biochemistry, Osaka University Medical School, Room B 1, 2 2 Yamadaoka, Suita, Osaka, Japan
Biochim Biophys Acta 1473:9-20. 1999..In this review, we focus on alpha1-6FucT and summarize its properties, gene expression and biological significance... - Negative feedback regulation of TGF-beta signaling by the SnoN oncoproteinS L Stroschein
Life Sciences Division, Lawrence Berkeley National Laboratory, and Department of Molecular and Cell Biology, University of California, Berkeley, 229 Stanley Hall, Mail Code 3206, Berkeley, CA 94720, USA
Science 286:771-4. 1999..Thus, SnoN maintains the repressed state of TGF-beta-responsive genes in the absence of ligand and participates in negative feedback regulation of TGF-beta signaling... - Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand binding functions. The talin n-terminal head domain interacts with the membrane-proximal region of the beta(3) cytoplasmic tailS Patil
Department of Pharmacology, The University of Illinois, Chicago, Illinois 60612, USA
J Biol Chem 274:28575-83. 1999..Moreover, talin was shown to bind through its N-terminal head domain to the membrane-proximal sequence of the beta(3) cytoplasmic tail... - Regulation of constitutive gene expression through interactions of Sp1 protein with the nuclear aryl hydrocarbon receptor complexF Wang
Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
Biochemistry 38:11490-500. 1999..These studies show that regulation of basal expression of some genes by Sp1 may also require interactions with AhR-Arnt... - Expression and regulation of cytochrome P-450I genes (CYP1A1 and CYP1A2) in the rat alimentary tractP G Traber
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor
Biochim Biophys Acta 1171:167-75. 1992..In addition, these data suggest that the aromatic hydrocarbon receptor, which mediates transcriptional induction of multiple genes by xenobiotics, is expressed through the alimentary tract...