W Wang

Summary

Affiliation: Iowa State University
Country: USA

Publications

  1. ncbi request reprint Induction of NADPH:quinone reductase by dietary phytoestrogens in colonic Colo205 cells
    W Wang
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA
    Biochem Pharmacol 56:189-95. 1998
  2. ncbi request reprint A five-year follow-up study of goiter and thyroid nodules in three regions with different iodine intakes in China
    X Yu
    Institute of Endocrinology, First Hospital Affiliated to China Medical University, Shenyang, Liaoning Province, PR China
    J Endocrinol Invest 31:243-50. 2008
  3. ncbi request reprint Transgene delivery with a cationic lipid in the presence of amyloid beta (betaAP) peptide
    P S Ajmani
    Department of Pharmaceutics, University of Florida, Gainesville 32610, USA
    Neurochem Res 26:195-202. 2001
  4. ncbi request reprint Pharmacogenomic dissection of resistance to thymidylate synthase inhibitors
    W Wang
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    Cancer Res 61:5505-10. 2001
  5. ncbi request reprint Enhancement of antigen-presenting ability of B lymphoma cells by immunostimulatory CpG-oligonucleotides and anti-CD40 antibody
    W Chen
    Institute of Immunology, Zhejiang University, Hangzhou 310031, Zhejiang, People's Republic of China
    Immunol Lett 77:17-23. 2001
  6. ncbi request reprint The involvement of TNF-alpha-related apoptosis-inducing ligand in the enhanced cytotoxicity of IFN-beta-stimulated human dendritic cells to tumor cells
    S Liu
    Department of Immunology, Second Military Medical University, Shanghei, People's Republic of China
    J Immunol 166:5407-15. 2001
  7. ncbi request reprint Interleukin-18 enhances the production of interleukin-8 by eosinophils
    W Wang
    Department of Internal Medicine III, Osaka University Medical School, Osaka, Japan
    Eur J Immunol 31:1010-6. 2001
  8. ncbi request reprint Dietary energy restriction inhibits ERK but not JNK or p38 activity in the epidermis of SENCAR mice
    Y Liu
    Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, USA
    Carcinogenesis 22:607-12. 2001
  9. ncbi request reprint Characterization of the 5' flanking region of the rat D(3) dopamine receptor gene
    W Wang
    Genetic Pharmacology Unit, Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurochem 76:1736-44. 2001
  10. ncbi request reprint Variations of dose and electrode spacing for rat breast cancer electrochemical treatment
    R L Ren
    Department of Radiation Research, City of Hope National Medical Center, Duarte, California, USA
    Bioelectromagnetics 22:205-11. 2001

Collaborators

  • Yuh Min Chen
  • S Safe
  • Honglei Chen
  • K Yamada
  • T Tanaka
  • X Yang
  • X Yu
  • J Li
  • Y Yu
  • M Jamal
  • Y Zhao
  • F Yang
  • Y Yang
  • L Zhang
  • C Muller-Tidow
  • J Przybyszewski
  • A Au
  • R L Ren
  • A L Yaktine
  • P S Ajmani
  • D F Birt
  • M F DeCristofaro
  • S Liu
  • Y Liu
  • X Cao
  • E Duysen
  • W Chen
  • M Zhang
  • P Goyette
  • Y Li
  • R Yang
  • C Li
  • F Wang
  • C Fan
  • X Shi
  • W Chong
  • Y Tong
  • W Teng
  • X Teng
  • S L Stroschein
  • X Gu
  • T Gao
  • Y Jin
  • Z Shan
  • S C Lam
  • H Guan
  • D Teng
  • E Miyoshi
  • H Dai
  • R J Grand
  • J Mao
  • T M Leisner
  • S Patil
  • D Zhao
  • F Hu
  • J D Wencel-Drake
  • T M Weaver
  • J Morishita
  • S Ameno
  • K Ameno
  • U Ikuo
  • I Ijiri
  • T Miki
  • M Kumihashi
  • Y Xue
  • Q Li
  • J Meng
  • S Bi
  • D Guan
  • M Song
  • L Bufford
  • H Nishimura
  • Z Fan
  • Y Cui
  • S Sasaki
  • B L Betz
  • B E Weissman
  • E M Meyer
  • C J Rorie
  • L Weiss
  • S Klumpen
  • F Tang
  • W E Berdel
  • C Staud
  • J Longmate
  • C Shao
  • P G Traber
  • P Zuo
  • D N Reisman
  • A Westermann

Detail Information

Publications42

  1. ncbi request reprint Induction of NADPH:quinone reductase by dietary phytoestrogens in colonic Colo205 cells
    W Wang
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA
    Biochem Pharmacol 56:189-95. 1998
    ....
  2. ncbi request reprint A five-year follow-up study of goiter and thyroid nodules in three regions with different iodine intakes in China
    X Yu
    Institute of Endocrinology, First Hospital Affiliated to China Medical University, Shenyang, Liaoning Province, PR China
    J Endocrinol Invest 31:243-50. 2008
    ..The aim of the study was to determine the incidence of goiter and thyroid nodules in 3 regions with different iodine intake levels: mildly deficient, more than adequate, and excessive...
  3. ncbi request reprint Transgene delivery with a cationic lipid in the presence of amyloid beta (betaAP) peptide
    P S Ajmani
    Department of Pharmaceutics, University of Florida, Gainesville 32610, USA
    Neurochem Res 26:195-202. 2001
    ..These results demonstrate that betaAP (25-35) peptide may interfere with gene delivery with cationic systems...
  4. ncbi request reprint Pharmacogenomic dissection of resistance to thymidylate synthase inhibitors
    W Wang
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    Cancer Res 61:5505-10. 2001
    ..These data provide encouragement that comprehensive transcript analysis will aid the quest for more enlightened therapeutics...
  5. ncbi request reprint Enhancement of antigen-presenting ability of B lymphoma cells by immunostimulatory CpG-oligonucleotides and anti-CD40 antibody
    W Chen
    Institute of Immunology, Zhejiang University, Hangzhou 310031, Zhejiang, People's Republic of China
    Immunol Lett 77:17-23. 2001
    ..Our data expanded the potential application of CpG-ODN as an immunotherapeutic agent in cancer treatment...
  6. ncbi request reprint The involvement of TNF-alpha-related apoptosis-inducing ligand in the enhanced cytotoxicity of IFN-beta-stimulated human dendritic cells to tumor cells
    S Liu
    Department of Immunology, Second Military Medical University, Shanghei, People's Republic of China
    J Immunol 166:5407-15. 2001
    ..Subsequently, DCs act as APCs involved in the uptake, processing, and presentation of apoptotic tumor Ags to cross-prime CD8(+) CTL cells...
  7. ncbi request reprint Interleukin-18 enhances the production of interleukin-8 by eosinophils
    W Wang
    Department of Internal Medicine III, Osaka University Medical School, Osaka, Japan
    Eur J Immunol 31:1010-6. 2001
    ..Our findings using peripheral blood eosinophils and eosinophilic cell line suggest the functional importance of IL-18 in the induction of IL-8 and a potential proinflammatory role in allergy...
  8. ncbi request reprint Dietary energy restriction inhibits ERK but not JNK or p38 activity in the epidermis of SENCAR mice
    Y Liu
    Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, USA
    Carcinogenesis 22:607-12. 2001
    ....
  9. ncbi request reprint Characterization of the 5' flanking region of the rat D(3) dopamine receptor gene
    W Wang
    Genetic Pharmacology Unit, Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurochem 76:1736-44. 2001
    ..The D(3) promoter is inactive in C6 and COS7 cells. We conclude that the D(3) gene, similar to the closely related D(2) gene, is transcribed from a tissue specific promoter which is under intense negative control...
  10. ncbi request reprint Variations of dose and electrode spacing for rat breast cancer electrochemical treatment
    R L Ren
    Department of Radiation Research, City of Hope National Medical Center, Duarte, California, USA
    Bioelectromagnetics 22:205-11. 2001
    ..For a diameter of 2.0-2.5 cm rat breast cancer, EChT should be applied with 5-10 mm spacing and a minimum dosage of 80 C...
  11. ncbi request reprint Irofulven (6-hydroxymethylacylfulvene, MGI 114) induces caspase 8 and 9-mediated apoptosis in human pancreatic adenocarcinoma cells
    W Wang
    Department of Surgery, University of Texas Health Science Center at San Antonio, 78229, USA
    Anticancer Res 21:1789-94. 2001
    ..CONCLUSION: Our data demonstrate that the cytotoxicity of irofulven in human pancreatic carcinoma cell lines is mediated by caspase-induced apoptosis...
  12. ncbi request reprint [Overexpression of p27(KIP1) induced by Bak gene leads to the arrest in G(1) phase of HCC-9204 cell line]
    J Li
    Department of Pathology, Fourth Military Medical University, Xin 710033, China
    Zhonghua Gan Zang Bing Za Zhi 9:27-9. 2001
    ..CONCLUSIONS: Bak may induce cell cycle arrest in G(1) phase through up-regulating expression of p27(KIP1). The inducible p27(KIP1)-expressing cells provide a model to assess p27(KIP1) function...
  13. pmc 20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol, a novel natural product for prostate cancer therapy: activity in vitro and in vivo and mechanisms of action
    W Wang
    Department of Pharmacology and Toxicology, Division of Clinical Pharmacology, and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham AL 35294, USA
    Br J Cancer 98:792-802. 2008
    ..In conclusion, our preclinical data indicate that 25-OCH3-PPD is a potential therapeutic agent against both androgen-dependent and androgen-independent prostate cancer...
  14. ncbi request reprint Changes in cholinergic function in the frontal cortex and hippocampus of rat exposed to ethanol and acetaldehyde
    M Jamal
    Department of Forensic Medicine, Faculty of Medicine, Kagawa University, 1750 1, Ikenobe, Miki, Kita, Kagawa 761 0793, Japan
    Neuroscience 144:232-8. 2007
    ....
  15. ncbi request reprint Genetic polymorphisms of CYP3A5 genes and concentration of the cyclosporine and tacrolimus
    Y Zhao
    The First Hospital of Tsinghua University, Beijing, China
    Transplant Proc 37:178-81. 2005
    ..Our objective was to determine the relationship between genetic polymorphisms of CYP3A5 with respect to interindividual variability in CsA and tacrolimus pharmacokinetics...
  16. ncbi request reprint Molecular and functional characterization of a vasotocin-sensitive aquaporin water channel in quail kidney
    Y Yang
    Dept of Physiology, Univ of Tennessee Health Science Center, 894 Union Ave, Memphis, TN 38163, USA
    Am J Physiol Regul Integr Comp Physiol 287:R915-24. 2004
    ..This is the first clear identification of AQP2 homolog in nonmammalian vertebrates...
  17. pmc Constitutive nuclear factor-kappa B mRNA, protein overexpression and enhanced DNA-binding activity in thymidylate synthase inhibitor-resistant tumour cells
    W Wang
    Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, UK
    Br J Cancer 88:624-9. 2003
    ..NF-kappa B can antagonise anticancer drug-induced apoptosis. High NF-kappa B expression and nuclear activity in TS inhibitor-resistant cancer cells may play an important role in the chemoresistance...
  18. ncbi request reprint Aquaporin expression in developing human teeth and selected orofacial tissues
    W Wang
    Center for Craniofacial and Dental Genetics, Division of Oral Biology, School of Dental Medicine, University of Pittsburgh, 614 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA
    Calcif Tissue Int 72:222-7. 2003
    ..These results demonstrate that multiple aquaporins are expressed in developing teeth and in selected orofacial tissues...
  19. ncbi request reprint An association between genetic polymorphisms in the ileal sodium-dependent bile acid transporter gene and the risk of colorectal adenomas
    W Wang
    Department of Preventive Medicine, University of Southern California Norris Cancer Center, Los Angeles, California 94587, USA
    Cancer Epidemiol Biomarkers Prev 10:931-6. 2001
    ....
  20. ncbi request reprint Inhibition of phorbol ester-induced AP-1-DNA binding, c-Jun protein and c-jun mRNA by dietary energy restriction is reversed by adrenalectomy in SENCAR mouse epidermis
    J Przybyszewski
    Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011-1061, USA
    Carcinogenesis 22:1421-7. 2001
    ..05). Thus, dietary energy restriction may inhibit cancer mechanistically by reducing overall AP-1 transcription through a process that is mediated in part by glucocorticoid hormones...
  21. ncbi request reprint Analyses of the genomic methylation status of the human cyclin A1 promoter by a novel real-time PCR-based methodology
    C Muller-Tidow
    Department of Medicine, Hematology and Oncology, University of Munster, Domagkstr 3, 48129 Munster, Germany
    FEBS Lett 490:75-8. 2001
    ..Taken together, our data provide evidence that CpG methylation patterns of the human cyclin A1 promoter in human organs do not generally correlate with cyclin A1 gene expression in vivo...
  22. ncbi request reprint Characterization of SWI/SNF protein expression in human breast cancer cell lines and other malignancies
    M F DeCristofaro
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill 27599, USA
    J Cell Physiol 186:136-45. 2001
    ..In this study, we identified the first cell line negative for the BAF57 protein as well as a pancreatic carcinoma cell line negative for both the BRG-1 and hBRM proteins...
  23. pmc Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells
    W Wang
    Life Sciences Division, Lawrence Berkeley National Laboratory, and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 97:14394-9. 2000
    ..Thus, Ski is able to repress the activity of all receptor-associated Smads and may regulate vertebrate development by modulating the signaling activity of transforming growth factor-beta family members...
  24. ncbi request reprint Purification, crystallization and preliminary X-ray diffraction data from selenomethionine glycinamide ribonucleotide synthetase
    T M Weaver
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14853, USA
    Acta Crystallogr D Biol Crystallogr 55:518-21. 1999
    ..2, b = 62.4 and c = 129.8 A and a single monomer in the asymmetric unit. The crystals diffract to 1.6 A resolution and have led to the determination of multiple-wavelength anomalous diffraction phases to 2.2 A resolution...
  25. ncbi request reprint Adenovirus early region 1A protein binds to mammalian SUG1-a regulatory component of the proteasome
    R J Grand
    CRC Institute for Cancer Studies, University of Birmingham, Edgbaston, UK
    Oncogene 18:449-58. 1999
    ..We have also demonstrated that SUGI can be co-immunoprecipitated with SV40 T and therefore we suggest that this may represent a common interaction of transforming proteins of DNA tumour viruses...
  26. ncbi request reprint NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities
    Y Xue
    Laboratory of Genetics, National Institute on Aging, National Institute of Health, Gerontology Research Center, Baltimore, Maryland 21224, USA
    Mol Cell 2:851-61. 1998
    ..These results suggest that ATP-dependent chromatin remodeling can participate in transcriptional repression by assisting repressors in gaining access to chromatin...
  27. ncbi request reprint Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene
    W Wang
    Brookdale Center for Development and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Development 125:621-34. 1998
    ..Interestingly, expression of both Hmx1 and Hmx2 is downregulated in the Hmx3 null uterus, suggesting a hierarchical relationship among the three Hmx genes during pregnancy...
  28. ncbi request reprint Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5
    G V Kalpana
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, College of Physicians and Surgeons, New York, NY 10032
    Science 266:2002-6. 1994
    ..The gene, termed INI1 (for integrase interactor 1), may encode a nuclear factor that promotes integration and targets incoming viral DNA to active genes...
  29. ncbi request reprint The Down regulated in Adenoma (dra) gene encodes an intestine-specific membrane sulfate transport protein
    D G Silberg
    Department of Medicine and Genetics, University of Pennsylvania, Philadelphia 19104, USA
    J Biol Chem 270:11897-902. 1995
    ..This functional characterization provides the foundation for investigation of the role of Dra in intestinal sulfate transport and in the malignant phenotype...
  30. ncbi request reprint [A preliminary study on metastasis-associated gene screened by monoclonal antibodies HIL]
    T Qi
    Department of Pathology, Harbin Medical University
    Zhonghua Zhong Liu Za Zhi 17:163-6. 1995
    ..The metastatic potential of Anip[973] cells was markedly decreased after being pretreated with MoAb H4. The above findings indicate that H4-D has a certain relationship with the metastatic phenotype of Anip[973] cells...
  31. ncbi request reprint Isolation and characterization of the human sucrase-isomaltase gene and demonstration of intestine-specific transcriptional elements
    G D Wu
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor
    J Biol Chem 267:7863-70. 1992
    ....
  32. ncbi request reprint Bidirectional transmembrane modulation of integrin alphaIIbbeta3 conformations
    T M Leisner
    Department of Pharmacology, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 274:12945-9. 1999
    ..Such bidirectional modulation of alphaIIbbeta3 conformation across the cell membrane may play a key role in inside-out and outside-in signaling via this integrin...
  33. ncbi request reprint Transcriptional activation of E2F1 gene expression by 17beta-estradiol in MCF-7 cells is regulated by NF-Y-Sp1/estrogen receptor interactions
    W Wang
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
    Mol Endocrinol 13:1373-87. 1999
    ..This represents a unique trans-acting protein complex in which ligand-dependent transactivation by the ER is independent of direct ER interactions with promoter elements...
  34. ncbi request reprint The murine Otp homeobox gene plays an essential role in the specification of neuronal cell lineages in the developing hypothalamus
    W Wang
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York 10029 6574, USA
    Dev Biol 227:432-49. 2000
    ..The involvement of Otp and Sim1 in specifying specific hypothalamic neurosecretory cell lineages is shown to operate via distinct signaling pathways that partially overlap with Brn2...
  35. pmc Possible association of BLM in decreasing DNA double strand breaks during DNA replication
    W Wang
    Molecular Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba ku, Sendai
    EMBO J 19:3428-35. 2000
    ..The BLM(-/-)/RAD54(-/-) cells showed a slow growth phenotype and an increased incidence of chromosome-type breaks/gaps while each single mutant showed relatively small numbers of chromosome-type breaks/gaps...
  36. ncbi request reprint Characterization of retinoic acid receptor-deficient keratinocytes
    P Goyette
    Department of Molecular Biology, Universite de Montreal, Division of Experimental Medicine, McGill University, and the Institut de Recherches Cliniques de Montréal, 110 Avenue des Pins, ouest, Montreal, Quebec H2W 1R7, Canada
    J Biol Chem 275:16497-505. 2000
    ..Finally, both RARalpha and RARgamma differently affected the expression of some genes, suggesting both specific and overlapping roles for the RARs in keratinocytes...
  37. pmc HuR regulates p21 mRNA stabilization by UV light
    W Wang
    Laboratory of Biological Chemistry, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Mol Cell Biol 20:760-9. 2000
    ..Our findings indicate that HuR plays a major role in regulating stress-induced p21 expression by enhancing p21 mRNA stability and that these effects are coupled to HuR's elevated presence in the cytoplasm...
  38. ncbi request reprint The alpha1-6-fucosyltransferase gene and its biological significance
    E Miyoshi
    Department of Biochemistry, Osaka University Medical School, Room B 1, 2 2 Yamadaoka, Suita, Osaka, Japan
    Biochim Biophys Acta 1473:9-20. 1999
    ..In this review, we focus on alpha1-6FucT and summarize its properties, gene expression and biological significance...
  39. ncbi request reprint Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein
    S L Stroschein
    Life Sciences Division, Lawrence Berkeley National Laboratory, and Department of Molecular and Cell Biology, University of California, Berkeley, 229 Stanley Hall, Mail Code 3206, Berkeley, CA 94720, USA
    Science 286:771-4. 1999
    ..Thus, SnoN maintains the repressed state of TGF-beta-responsive genes in the absence of ligand and participates in negative feedback regulation of TGF-beta signaling...
  40. ncbi request reprint Identification of a talin-binding site in the integrin beta(3) subunit distinct from the NPLY regulatory motif of post-ligand binding functions. The talin n-terminal head domain interacts with the membrane-proximal region of the beta(3) cytoplasmic tail
    S Patil
    Department of Pharmacology, The University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 274:28575-83. 1999
    ..Moreover, talin was shown to bind through its N-terminal head domain to the membrane-proximal sequence of the beta(3) cytoplasmic tail...
  41. ncbi request reprint Regulation of constitutive gene expression through interactions of Sp1 protein with the nuclear aryl hydrocarbon receptor complex
    F Wang
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
    Biochemistry 38:11490-500. 1999
    ..These studies show that regulation of basal expression of some genes by Sp1 may also require interactions with AhR-Arnt...
  42. ncbi request reprint Expression and regulation of cytochrome P-450I genes (CYP1A1 and CYP1A2) in the rat alimentary tract
    P G Traber
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor
    Biochim Biophys Acta 1171:167-75. 1992
    ..In addition, these data suggest that the aromatic hydrocarbon receptor, which mediates transcriptional induction of multiple genes by xenobiotics, is expressed through the alimentary tract...