E L Thacker

Summary

Affiliation: Iowa State University
Country: USA

Publications

  1. ncbi request reprint Immunology of the porcine respiratory disease complex
    E L Thacker
    Veterinary Medical Research Institute, Iowa State University, Ames, Iowa, USA
    Vet Clin North Am Food Anim Pract 17:551-65. 2001
  2. ncbi request reprint Diagnosis of Mycoplasma hyopneumoniae
    Eileen L Thacker
    College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
    Anim Health Res Rev 5:317-20. 2004
  3. ncbi request reprint Plasmid-mediated growth hormone-releasing hormone efficacy in reducing disease associated with Mycoplasma hyopneumoniae and porcine reproductive and respiratory syndrome virus infection
    E L Thacker
    Department of VMPM, College of Veterinary Medicine, Iowa State University, Ames, 50011, USA
    J Anim Sci 84:733-42. 2006
  4. ncbi request reprint Lung inflammatory responses
    Eileen L Thacker
    Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, 50011, USA
    Vet Res 37:469-86. 2006
  5. doi request reprint Swine influenza virus: zoonotic potential and vaccination strategies for the control of avian and swine influenzas
    Eileen Thacker
    Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
    J Infect Dis 197:S19-24. 2008
  6. ncbi request reprint Summary of workshop findings for porcine myelomonocytic markers
    E Thacker
    Veterinary Medical Research Institute, Iowa State University, Ames, IA 50010, USA
    Vet Immunol Immunopathol 80:93-109. 2001
  7. pmc Interaction between Mycoplasma hyopneumoniae and swine influenza virus
    E L Thacker
    Iowa State University, Ames, Iowa 50011, USA
    J Clin Microbiol 39:2525-30. 2001
  8. ncbi request reprint Differential production of proinflammatory cytokines: in vitro PRRSV and Mycoplasma hyopneumoniae co-infection model
    R Thanawongnuwech
    Department of Veterinary Pathology, Faculty of Veterinary Science, Chulalongkorn University, 10330, Bangkok, Thailand
    Vet Immunol Immunopathol 79:115-27. 2001
  9. ncbi request reprint Effect of vaccination on the potentiation of porcine reproductive and respiratory syndrome virus (PRRSV)-induced pneumonia by Mycoplasma hyopneumoniae
    E L Thacker
    Veterinary Medical Research Institute, Iowa State University, Ames 50011, USA
    Vaccine 18:1244-52. 2000
  10. pmc Mycoplasma hyopneumoniae potentiation of porcine reproductive and respiratory syndrome virus-induced pneumonia
    E L Thacker
    Veterinary Medical Research Institute, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA
    J Clin Microbiol 37:620-7. 1999

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Immunology of the porcine respiratory disease complex
    E L Thacker
    Veterinary Medical Research Institute, Iowa State University, Ames, Iowa, USA
    Vet Clin North Am Food Anim Pract 17:551-65. 2001
    ..As we learn more about the pathogens of the respiratory system, their interactions with each other, and the mechanisms by which they modulate the immune system, our ability to develop effective control measures will improve...
  2. ncbi request reprint Diagnosis of Mycoplasma hyopneumoniae
    Eileen L Thacker
    College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
    Anim Health Res Rev 5:317-20. 2004
    ....
  3. ncbi request reprint Plasmid-mediated growth hormone-releasing hormone efficacy in reducing disease associated with Mycoplasma hyopneumoniae and porcine reproductive and respiratory syndrome virus infection
    E L Thacker
    Department of VMPM, College of Veterinary Medicine, Iowa State University, Ames, 50011, USA
    J Anim Sci 84:733-42. 2006
    ..hyo-induced pneumonia and that a single dose of GHRH-expressing plasmid was sufficient to elicit an improved clinical outcome in this disease challenge model...
  4. ncbi request reprint Lung inflammatory responses
    Eileen L Thacker
    Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, 50011, USA
    Vet Res 37:469-86. 2006
    ....
  5. doi request reprint Swine influenza virus: zoonotic potential and vaccination strategies for the control of avian and swine influenzas
    Eileen Thacker
    Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
    J Infect Dis 197:S19-24. 2008
    ..Control of influenza virus infection in poultry and swine is critical to the reduction of potential cross-species adaptation and spread of influenza viruses, which will minimize the risk of animals being the source of the next pandemic...
  6. ncbi request reprint Summary of workshop findings for porcine myelomonocytic markers
    E Thacker
    Veterinary Medical Research Institute, Iowa State University, Ames, IA 50010, USA
    Vet Immunol Immunopathol 80:93-109. 2001
    ..Two antibodies were assigned to CD163. Further work is required to determine the antigens recognized by many of the other mAb...
  7. pmc Interaction between Mycoplasma hyopneumoniae and swine influenza virus
    E L Thacker
    Iowa State University, Ames, Iowa 50011, USA
    J Clin Microbiol 39:2525-30. 2001
    ..hyopneumoniae and PRRSV. These findings demonstrate that the relationship between mycoplasmas and viruses varies with the individual agent...
  8. ncbi request reprint Differential production of proinflammatory cytokines: in vitro PRRSV and Mycoplasma hyopneumoniae co-infection model
    R Thanawongnuwech
    Department of Veterinary Pathology, Faculty of Veterinary Science, Chulalongkorn University, 10330, Bangkok, Thailand
    Vet Immunol Immunopathol 79:115-27. 2001
    ..hyopneumoniae and PRRSV suggests that cytokine induced inflammation may play an important role in the severe, chronic pneumonia induced by the concurrent infection of the two pathogens...
  9. ncbi request reprint Effect of vaccination on the potentiation of porcine reproductive and respiratory syndrome virus (PRRSV)-induced pneumonia by Mycoplasma hyopneumoniae
    E L Thacker
    Veterinary Medical Research Institute, Iowa State University, Ames 50011, USA
    Vaccine 18:1244-52. 2000
    ..hyopneumoniae bacterin eliminated this benefit and the amount of pneumonia induced by PRRSV increased. PRRSV vaccine alone did not decrease the potentiation of PRRSV pneumonia by M. hyopneumoniae...
  10. pmc Mycoplasma hyopneumoniae potentiation of porcine reproductive and respiratory syndrome virus-induced pneumonia
    E L Thacker
    Veterinary Medical Research Institute, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA
    J Clin Microbiol 37:620-7. 1999
    ....
  11. ncbi request reprint Effects of the timing of the administration of Mycoplasma hyopneumoniae bacterin on the development of lesions associated with porcine circovirus type 2
    T Opriessnig
    Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
    Vet Rec 158:149-54. 2006
    ..05) more severe in groups 4 and 5 than in groups 2, 3, 7 and 8...
  12. ncbi request reprint Effect of porcine parvovirus vaccination on the development of PMWS in segregated early weaned pigs coinfected with type 2 porcine circovirus and porcine parvovirus
    T Opriessnig
    Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011 1250, USA
    Vet Microbiol 98:209-20. 2004
    ..Evidence of increased incidence of clinical PMWS due to vaccination was not observed in this model...
  13. ncbi request reprint Experimental reproduction of postweaning multisystemic wasting syndrome in pigs by dual infection with Mycoplasma hyopneumoniae and porcine circovirus type 2
    T Opriessnig
    Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011 1250, USA
    Vet Pathol 41:624-40. 2004
    ..This study indicates that M. hyopneumoniae potentiates the severity of PCV2-associated lung and lymphoid lesions, increases the amount and prolongs the presence of PCV2-antigen, and increases the incidence of PMWS in pigs...
  14. ncbi request reprint Influence of pig age on virus titer and bactericidal activity of porcine reproductive and respiratory syndrome virus (PRRSV)-infected pulmonary intravascular macrophages (PIMs)
    R Thanawongnuwech
    Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames 50011, USA
    Vet Microbiol 63:177-87. 1998
    ....
  15. ncbi request reprint An investigation of susceptibility to porcine reproductive and respiratory syndrome virus between two genetically diverse commercial lines of pigs
    A L Vincent
    Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, 50011, USA
    J Anim Sci 84:49-57. 2006
    ....
  16. ncbi request reprint The antibody responses to swine influenza virus (SIV) recombinant matrix 1 (rM1), matrix 2 (M2), and hemagglutinin (HA) proteins in pigs with different SIV exposure
    P Kitikoon
    Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50010, USA
    Vet Microbiol 126:51-62. 2008
    ..Pigs with MDA had different levels of HA antibodies and were positive to M2e antibodies, but results were not correlated to HA antibodies levels and inconsistently present...
  17. ncbi request reprint In vitro susceptibility of macrophages to porcine reproductive and respiratory syndrome virus varies between genetically diverse lines of pigs
    A L Vincent
    Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA 50010, USA
    Viral Immunol 18:506-12. 2005
    ..This report suggests a genetic component for susceptibility to PRRSV exists and that the in vitro assay may be useful in predicting the relative susceptibility to PRRSV in large groups of animals...
  18. ncbi request reprint Effect of vaccination with selective bacterins on conventional pigs infected with type 2 porcine circovirus
    T Opriessnig
    Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
    Vet Pathol 40:521-9. 2003
    ..hyopneumoniae vaccines and inoculated with PCV2 compared with PCV2-inoculated unvaccinated pigs. Swine producers and veterinarians may need to consider changes in vaccination protocols in herds with recurrent PCV2-associated PMWS...
  19. pmc Increased production of proinflammatory cytokines following infection with porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae
    Roongroje Thanawongnuwech
    Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA 50011, USA
    Clin Diagn Lab Immunol 11:901-8. 2004
    ..The increased levels of IL-10 may be a possible mechanism that PRRSV and M. hyopneumoniae use to exacerbate the severity and duration of pneumonia induced by PRRSV and modulate the respiratory immune response...
  20. pmc Real-time PCR assays to address genetic diversity among strains of Mycoplasma hyopneumoniae
    Erin L Strait
    Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA 50011, USA
    J Clin Microbiol 46:2491-8. 2008
    ..hyopneumoniae. To increase the efficiency of PCR testing, two new real-time PCR assays that are specific and capable of detecting all of the M. hyopneumoniae isolates used in this study were developed...
  21. pmc Transcriptome changes in Mycoplasma hyopneumoniae during infection
    Melissa L Madsen
    Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA 50011, USA
    Infect Immun 76:658-63. 2008
    ..003), adenylate kinase (adk [mhp208]) (P = 0.001), prolyl aminoacyl tRNA synthetase (proS [mhp397]) (P = 0.009), and cysteinyl-tRNA synthetase (cysS [mhp661]) (P < 0.001) were down-regulated in vivo...
  22. ncbi request reprint Evaluation of the ability of tilmicosin to prevent adherence of Mycoplasma hyopneumoniae to cilia using a differentiated swine respiratory epithelial culture system
    E L Thacker
    Iowa State University, Veterinary Medical Research Institute, 1802 Elwood Drive, Ames, IA 50011, USA
    Vet Ther 2:293-300. 2001
    ..The study demonstrated that tilmicosin inhibited the adherence of M. hyopneumoniae at the highest level tested in the system (2 microg/ml) suggesting that tilmicosin may be efficacious against mycoplasmal pneumonia...
  23. ncbi request reprint The immune response and maternal antibody interference to a heterologous H1N1 swine influenza virus infection following vaccination
    Pravina Kitikoon
    Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
    Vet Immunol Immunopathol 112:117-28. 2006
    ..The results of this study question the effectiveness of the current practice of generating increased MDA levels through sow vaccination in protecting piglets against disease...
  24. pmc Array-based genomic comparative hybridization analysis of field strains of Mycoplasma hyopneumoniae
    Melissa L Madsen
    Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA 50011, USA
    J Bacteriol 189:7977-82. 2007
    ..A permutation test identified a location in the M. hyopneumoniae genome where there is spatial clustering of variability between the field strains and strain 232...
  25. ncbi request reprint Use of a Mycoplasma hyopneumoniae nested polymerase chain reaction test to determine the optimal sampling sites in swine
    Kathy T Kurth
    Department of Veterinary Microbiology and Preventive Medicine, Veterinary Medical Research Institute, Iowa State University, Ames 50011, USA
    J Vet Diagn Invest 14:463-9. 2002
    ..In conclusion, the nested PCR developed for this study was found to be a highly sensitive and specific diagnostic tool for M. hyopneumoniae, but the enhanced sensitivity may be unnecessary if the proper sites are sampled...
  26. pmc Mycoplasma hyopneumoniae increases intracellular calcium release in porcine ciliated tracheal cells
    Seung Chun Park
    Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011, USA
    Infect Immun 70:2502-6. 2002
    ..Thus, an increase in Ca2+ may serve as a signal for the pathogenesis of M. hyopneumoniae...
  27. doi request reprint Swine influenza matrix 2 (M2) protein contributes to protection against infection with different H1 swine influenza virus (SIV) isolates
    Pravina Kitikoon
    College of Veterinary Medicine, Iowa State University, Ames, IA, USA
    Vaccine 28:523-31. 2009
    ..This study found that the M2 protein has potential as a vaccine for SIV-associated disease prevention. However, development of an immune response towards the major envelope HA protein was required to reduce SIV shedding...
  28. ncbi request reprint Transcriptional profiling of Mycoplasma hyopneumoniae during iron depletion using microarrays
    Melissa L Madsen
    Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA, USA
    Microbiology 152:937-44. 2006
    ..Ten of the 27 identified genes had no assigned function. These studies indicate that M. hyopneumoniae can respond to changes in environmental conditions, but the mechanism employed remains unknown...
  29. ncbi request reprint Interleukin-10, interleukin-12, and interferon-gamma levels in the respiratory tract following mycoplasma hyopneumoniae and PRRSV infection in pigs
    Roongroje Thanawongnuwech
    Department of Veterinary Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand
    Viral Immunol 16:357-67. 2003
    ..The increased levels of cytokines associated with both Th1 and Th2 responses in the respiratory tract of pigs infected with PRRSV and M. hyopneumoniae provides valuable information on the pathogenesis of these diseases...
  30. ncbi request reprint Impact of immunizations with porcine reproductive and respiratory syndrome virus on lymphoproliferative recall responses of CD8+ T cells
    Josep Bassaganya-Riera
    Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, Iowa, USA
    Viral Immunol 17:25-37. 2004
    ....
  31. pmc Transcriptional profiling of Mycoplasma hyopneumoniae during heat shock using microarrays
    Melissa L Madsen
    Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA 50011, USA
    Infect Immun 74:160-6. 2006
    ..5-fold or greater. Many of the heat shock proteins previously characterized in other bacteria were identified as significant in this study as well. A proportion of the identified genes (54 of 91) currently have no assigned function...
  32. pmc Are swine workers in the United States at increased risk of infection with zoonotic influenza virus?
    Kendall P Myers
    Center for Emerging Infectious Diseases, Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA 52242, USA
    Clin Infect Dis 42:14-20. 2006
    ..Pigs have an important role in interspecies transmission of the virus. We examined multiple swine-exposed human populations in the nation's number 1 swine-producing state for evidence of previous swine influenza virus infection...