Michael E Spurlock

Summary

Affiliation: Iowa State University
Country: USA

Publications

  1. ncbi request reprint The development of porcine models of obesity and the metabolic syndrome
    Michael E Spurlock
    Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, USA
    J Nutr 138:397-402. 2008
  2. doi request reprint Effect of a mitochondria-targeted vitamin E derivative on mitochondrial alteration and systemic oxidative stress in mice
    Gaowei Mao
    Interdepartmental Graduate Program in Nutritional Sciences, Iowa State University, Ames, IA 50011 3150, USA
    Br J Nutr 106:87-95. 2011
  3. doi request reprint Low-dose dietary resveratrol has differential effects on colorectal tumorigenesis in adiponectin knockout and wild-type mice
    Rebecca L Boddicker
    Department of Food Science and Human Nutrition and Interdepartmental Graduate Program in Nutritional Sciences, Iowa State University, Ames, Iowa, USA
    Nutr Cancer 63:1328-38. 2011
  4. doi request reprint A mitochondria-targeted vitamin E derivative decreases hepatic oxidative stress and inhibits fat deposition in mice
    Gaowei Mao
    Interdepartmental Graduate Program in Nutritional Sciences, Iowa State University, Ames, IA 50011, USA
    J Nutr 140:1425-31. 2010
  5. doi request reprint Feeding long-chain n-3 polyunsaturated fatty acids during gestation increases intestinal glucose absorption potentially via the acute activation of AMPK
    Nicholas K Gabler
    Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, USA
    J Nutr Biochem 20:17-25. 2009
  6. doi request reprint Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat
    Jeremy E Davis
    Department of Food Science and Human Nutrition, Iowa State University, Ames, Iowa, USA
    Obesity (Silver Spring) 16:1248-55. 2008
  7. ncbi request reprint In utero and postnatal exposure to long chain (n-3) PUFA enhances intestinal glucose absorption and energy stores in weanling pigs
    Nicholas K Gabler
    Department of Food Science, Iowa State University, Ames, IA 50011, USA
    J Nutr 137:2351-8. 2007
  8. ncbi request reprint n-3 PUFA attenuate lipopolysaccharide-induced down-regulation of toll-like receptor 4 expression in porcine adipose tissue but does not alter the expression of other immune modulators
    Nicholas K Gabler
    Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, USA
    J Nutr Biochem 19:8-15. 2008
  9. pmc Inflammation in Response to n3 Fatty Acids in a Porcine Obesity Model
    Richard J Faris
    Interdepartmental Graduate Program in Nutritional Sciences, Department of Animal Science, Iowa State University, Ames, Iowa, USA
    Comp Med 62:495-503. 2012
  10. doi request reprint Early lesion formation in colorectal carcinogenesis is associated with adiponectin status whereas neoplastic lesions are associated with diet and sex in C57BL/6J mice
    Rebecca L Boddicker
    Department of Food Science and Human Nutrition, Iowa State University, Ames, Iowa 50011, USA
    Nutr Cancer 63:1297-306. 2011

Collaborators

  • Olayiwola Adeola
  • Karen L Houseknecht
  • Kolapo M Ajuwon
  • Nicholas K Gabler
  • Rebecca L Boddicker
  • Jeremy E Davis
  • Gaowei Mao
  • Jennifer Walker-Daniels
  • Joel D Spencer
  • Doug M Webel
  • Richard J Faris
  • Diane F Birt
  • Ikyon Kim
  • Donald C Beitz
  • George A Kraus
  • Theodore B Bailey
  • Joanne L Kuske
  • Priya Raman
  • Meghan C Wulster-Radcliffe
  • Deana L Hancock
  • David B Anderson
  • Jenny Li
  • Douglas E Jones
  • Elizabeth M Whitley
  • Douglas R Braucher
  • Elizabeth Whitley
  • Qijing Zhang
  • J Scott Radcliffe
  • Shawn S Donkin
  • Sheila K Jacobi
  • John A Christian
  • Jiazhen Wang
  • Darryl Ragland

Detail Information

Publications18

  1. ncbi request reprint The development of porcine models of obesity and the metabolic syndrome
    Michael E Spurlock
    Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, USA
    J Nutr 138:397-402. 2008
    ....
  2. doi request reprint Effect of a mitochondria-targeted vitamin E derivative on mitochondrial alteration and systemic oxidative stress in mice
    Gaowei Mao
    Interdepartmental Graduate Program in Nutritional Sciences, Iowa State University, Ames, IA 50011 3150, USA
    Br J Nutr 106:87-95. 2011
    ..Overall, these data suggest that MitoVit E affects subsarcolemmal mitochondrial density and systemic oxidative stress parameters such as plasma SOD activity and urinary isoprostane concentration...
  3. doi request reprint Low-dose dietary resveratrol has differential effects on colorectal tumorigenesis in adiponectin knockout and wild-type mice
    Rebecca L Boddicker
    Department of Food Science and Human Nutrition and Interdepartmental Graduate Program in Nutritional Sciences, Iowa State University, Ames, Iowa, USA
    Nutr Cancer 63:1328-38. 2011
    ..Taken together, resveratrol improved overall health of obese Wt but not KO mice as hypothesized with a differential sex response...
  4. doi request reprint A mitochondria-targeted vitamin E derivative decreases hepatic oxidative stress and inhibits fat deposition in mice
    Gaowei Mao
    Interdepartmental Graduate Program in Nutritional Sciences, Iowa State University, Ames, IA 50011, USA
    J Nutr 140:1425-31. 2010
    ..In conclusion, MitoVit E attenuates hepatic oxidative stress and inhibits fat deposition in mice but not through alleviation of the aconitase inhibition cascade...
  5. doi request reprint Feeding long-chain n-3 polyunsaturated fatty acids during gestation increases intestinal glucose absorption potentially via the acute activation of AMPK
    Nicholas K Gabler
    Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, USA
    J Nutr Biochem 20:17-25. 2009
    ..Thus, n-3 PUFA delivered in utero and postnatally via the maternal diet may help the offspring adapt quickly to rapidly changing diets early in life and allow optimal nutrient uptake...
  6. doi request reprint Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat
    Jeremy E Davis
    Department of Food Science and Human Nutrition, Iowa State University, Ames, Iowa, USA
    Obesity (Silver Spring) 16:1248-55. 2008
    ..These data indicate that Tlr-4 deficiency selectively protects against the obesigenic effects of SFA and alters obesity-related inflammatory responses in adipose tissue...
  7. ncbi request reprint In utero and postnatal exposure to long chain (n-3) PUFA enhances intestinal glucose absorption and energy stores in weanling pigs
    Nicholas K Gabler
    Department of Food Science, Iowa State University, Ames, IA 50011, USA
    J Nutr 137:2351-8. 2007
    ..These results indicate that (n-3) PUFA, particularly DHA, improves intestinal glucose absorption and muscle glycogen concentrations in newly weaned pigs. These findings may also have important implications for human mothers and infants...
  8. ncbi request reprint n-3 PUFA attenuate lipopolysaccharide-induced down-regulation of toll-like receptor 4 expression in porcine adipose tissue but does not alter the expression of other immune modulators
    Nicholas K Gabler
    Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, USA
    J Nutr Biochem 19:8-15. 2008
    ..These findings indicate that adipose tissue responds to LPS administration in vivo by reducing TLR4 mRNA and protein abundance and that the anti-inflammatory effects of n-3 PUFA do not include down-regulation of TLR4 in adipose tissue...
  9. pmc Inflammation in Response to n3 Fatty Acids in a Porcine Obesity Model
    Richard J Faris
    Interdepartmental Graduate Program in Nutritional Sciences, Department of Animal Science, Iowa State University, Ames, Iowa, USA
    Comp Med 62:495-503. 2012
    ..Therefore, in obese Ossabaw swine, n3 fatty acids partially attenuate insulin resistance but only marginally change inflammatory status and macrophage phenotype in adipose tissue...
  10. doi request reprint Early lesion formation in colorectal carcinogenesis is associated with adiponectin status whereas neoplastic lesions are associated with diet and sex in C57BL/6J mice
    Rebecca L Boddicker
    Department of Food Science and Human Nutrition, Iowa State University, Ames, Iowa 50011, USA
    Nutr Cancer 63:1297-306. 2011
    ....
  11. doi request reprint Absence of Tlr2 protects against high-fat diet-induced inflammation and results in greater insulin-stimulated glucose transport in cultured adipocytes
    Jeremy E Davis
    Animal Science, Food and Nutrition, Southern Illinois University, Carbondale, IL 62901, USA
    J Nutr Biochem 22:136-41. 2011
    ..These data indicate that Tlr2 may be directly involved in HFD-induced inflammation and may also regulate basal and insulin-stimulated glucose uptake in adipocytes...
  12. ncbi request reprint Adiponectin inhibits LPS-induced NF-kappaB activation and IL-6 production and increases PPARgamma2 expression in adipocytes
    Kolapo M Ajuwon
    Department of Animal Sciences, Comparative Medicine Center, Purdue Univ, 3 230 Lilly Hall of Life Sciences, 915 W State St, West Lafayette, IN 47907 2054, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1220-5. 2005
    ..05). These findings indicate that adiponectin may be a local regulator of inflammation in the adipocyte and adipose tissue via its regulation of the NF-kappaB and PPARgamma2 transcription factors...
  13. ncbi request reprint Direct regulation of lipolysis by interleukin-15 in primary pig adipocytes
    Kolapo M Ajuwon
    Department of Animal Sciences, Comparative Medicine Program, Purdue University, Lilly Hall of Life Sciences, 915 W State St, West Lafayette, IN 47907 2054, USA
    Am J Physiol Regul Integr Comp Physiol 287:R608-11. 2004
    ..Thus, when induced by IFN-gamma or other inflammatory mediators, IL-15 may be a significant homeorhetic factor that mobilizes and directs energy away from the adipocyte to other cells during the acute phase of the inflammatory response...
  14. ncbi request reprint Adiponectin differentially regulates cytokines in porcine macrophages
    Meghan C Wulster-Radcliffe
    Department of Animal Sciences, Comparative Medicine Program, Purdue University, West Lafayette, IN, USA
    Biochem Biophys Res Commun 316:924-9. 2004
    ..In addition, we provide evidence that some of the anti-inflammatory actions of adiponectin are mediated in part by suppression of NFkappaB signaling and ERK1/2 activity...
  15. ncbi request reprint Interleukin-6 and interleukin-15 are selectively regulated by lipopolysaccharide and interferon-gamma in primary pig adipocytes
    Kolapo M Ajuwon
    Department of Animal Sciences, Comparative Medicine Program, Purdue University, West Lafayette, Indiana 47907 2054, USA
    Am J Physiol Regul Integr Comp Physiol 286:R547-53. 2004
    ....
  16. ncbi request reprint Chronic leptin administration increases serum NEFA in the pig and differentially regulates PPAR expression in adipose tissue
    Kolapo M Ajuwon
    Department of Animal Sciences, Purdue University, West Lafayette, IN, USA
    J Nutr Biochem 14:576-83. 2003
    ..The regulation of PPARgamma by leptin seems complex in that it varied in relation to dose in vivo, and may be impacted by in vitro vs. in vivo circumstances...
  17. ncbi request reprint Regulation of hepatic glucose metabolism by leptin in pig and rat primary hepatocyte cultures
    Priya Raman
    Department of Animal Sciences, Comparative Medicine Program, Purdue University, West Lafayette, IN 47907, USA
    Am J Physiol Regul Integr Comp Physiol 286:R206-16. 2004
    ..Furthermore, the unique action of leptin in porcine hepatocytes points to the utility of this model system for biomedical research and also underscores the value of comparative studies...
  18. ncbi request reprint The regulation of IGF-1 by leptin in the pig is tissue specific and independent of changes in growth hormone
    Kolapo M Ajuwon
    Department of Animal Sciences, Purdue University, West Lafayette, IN, USA
    J Nutr Biochem 14:522-30. 2003
    ..Collectively, these data indicate that leptin may regulate hepatic IGF-1 production in the pig, independent of GH, but that hepatocyte sensitivity to leptin may be depend on dose and in vitro vs. in vivo conditions...