D K Meyerholz

Summary

Affiliation: Iowa State University
Country: USA

Publications

  1. ncbi request reprint Developmental expression and distribution of sheep beta-defensin-2
    David K Meyerholz
    Department of Veterinary Pathology, 2740 Veterinary Medicine, Iowa State University, Ames, IA 50011 1250, USA
    Dev Comp Immunol 28:171-8. 2004
  2. pmc Adenovirus-mediated gene therapy enhances parainfluenza virus 3 infection in neonatal lambs
    David K Meyerholz
    Department of Veterinary Pathology, Iowa State University, Ames, Iowa 50011 1250, USA
    J Clin Microbiol 42:4780-7. 2004
  3. pmc Reduced clearance of respiratory syncytial virus infection in a preterm lamb model
    David K Meyerholz
    Department of Veterinary Pathology, Iowa State University, 2740 Veterinary Medicine, Ames, IA 50011 1250, USA
    Microbes Infect 6:1312-9. 2004
  4. pmc Expression of select immune genes (surfactant proteins A and D, sheep beta defensin 1, and toll-like receptor 4) by respiratory epithelia is developmentally regulated in the preterm neonatal lamb
    David K Meyerholz
    Department of Veterinary Pathology, 2740 College of Veterinary Medicine, Iowa State University, Ames, IA 50011 1250, USA
    Dev Comp Immunol 30:1060-9. 2006
  5. ncbi request reprint Unilateral perinephric pseudocyst secondary to hydronephrosis in a C57BL/6J mouse
    D K Meyerholz
    Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, 2740 Veterinary Medicine, Ames, IA 50011 1250, USA
    Vet Pathol 42:496-8. 2005
  6. pmc Antimicrobial peptides and surfactant proteins in ruminant respiratory tract disease
    David K Meyerholz
    Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, 2740 Veterinary Medicine, Ames, IA 50011 1250, USA
    Vet Immunol Immunopathol 108:91-6. 2005
  7. pmc Regulation of surfactant protein and defensin mRNA expression in cultured ovine type II pneumocytes by all-trans retinoic acid and VEGF
    B Grubor
    Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA 50011 1250, USA
    Int J Exp Pathol 87:393-403. 2006
  8. pmc Collectins and cationic antimicrobial peptides of the respiratory epithelia
    B Grubor
    Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA, USA
    Vet Pathol 43:595-612. 2006
  9. pmc Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs
    Christopher S Rogers
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Science 321:1837-41. 2008
  10. pmc Surfactant-associated protein A provides critical immunoprotection in neonatal mice
    Caroline L S George
    Department of Pediatrics, University of Iowa, Carver College of Medicine, Iowa City, Iowa 52242, USA
    Infect Immun 76:380-90. 2008

Research Grants

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Developmental expression and distribution of sheep beta-defensin-2
    David K Meyerholz
    Department of Veterinary Pathology, 2740 Veterinary Medicine, Iowa State University, Ames, IA 50011 1250, USA
    Dev Comp Immunol 28:171-8. 2004
    ..Interestingly, ileal follicle-associated epithelium lacked detectable SBD-2 immunoreactivity. SBD-2 mRNA and peptide expression are greatest in the intestinal tract and tissue distribution progressively decreases with maturity...
  2. pmc Adenovirus-mediated gene therapy enhances parainfluenza virus 3 infection in neonatal lambs
    David K Meyerholz
    Department of Veterinary Pathology, Iowa State University, Ames, Iowa 50011 1250, USA
    J Clin Microbiol 42:4780-7. 2004
    ..Additionally, this study showed that adenovirus-mediated HBD6 expression increases neutrophil recruitment, a recently described attribute of beta-defensins, with mild accentuation of PIV3 activity and inflammation...
  3. pmc Reduced clearance of respiratory syncytial virus infection in a preterm lamb model
    David K Meyerholz
    Department of Veterinary Pathology, Iowa State University, 2740 Veterinary Medicine, Ames, IA 50011 1250, USA
    Microbes Infect 6:1312-9. 2004
    ..This work suggests that perinatal RSV clearance is age-dependent, which may explain the severity of RSV infection in preterm infants. The preterm lamb model is useful for assessing age-dependent mechanisms of severe RSV infection...
  4. pmc Expression of select immune genes (surfactant proteins A and D, sheep beta defensin 1, and toll-like receptor 4) by respiratory epithelia is developmentally regulated in the preterm neonatal lamb
    David K Meyerholz
    Department of Veterinary Pathology, 2740 College of Veterinary Medicine, Iowa State University, Ames, IA 50011 1250, USA
    Dev Comp Immunol 30:1060-9. 2006
    ..These studies show reduced SBD1, SP-AD, and TLR4 expression in the preterm lung and this may underlie enhanced RSV susceptibility...
  5. ncbi request reprint Unilateral perinephric pseudocyst secondary to hydronephrosis in a C57BL/6J mouse
    D K Meyerholz
    Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, 2740 Veterinary Medicine, Ames, IA 50011 1250, USA
    Vet Pathol 42:496-8. 2005
    ..To our knowledge, this is the first case report to characterize a perinephric pseudocyst secondary to severe hydronephrosis in a mouse...
  6. pmc Antimicrobial peptides and surfactant proteins in ruminant respiratory tract disease
    David K Meyerholz
    Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, 2740 Veterinary Medicine, Ames, IA 50011 1250, USA
    Vet Immunol Immunopathol 108:91-6. 2005
    ..Understanding the regulation of antimicrobial peptide/protein expression will further enhance the potential for novel prophylactic and therapeutic modalities to minimize the impact of respiratory disease...
  7. pmc Regulation of surfactant protein and defensin mRNA expression in cultured ovine type II pneumocytes by all-trans retinoic acid and VEGF
    B Grubor
    Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA 50011 1250, USA
    Int J Exp Pathol 87:393-403. 2006
    ..The lack of changes induced by VEGF treatment suggests that VEGF does not have a direct effect on epithelial cells, but may affect gene expression indirectly...
  8. pmc Collectins and cationic antimicrobial peptides of the respiratory epithelia
    B Grubor
    Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA, USA
    Vet Pathol 43:595-612. 2006
    ..The purpose of this review is to discuss antimicrobial innate immune elements within the respiratory tract of healthy and pneumonic lung with emphasis on hydrophilic surfactant proteins and beta-defensins...
  9. pmc Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs
    Christopher S Rogers
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Science 321:1837-41. 2008
    ..The pig model may provide opportunities to address persistent questions about CF pathogenesis and accelerate discovery of strategies for prevention and treatment...
  10. pmc Surfactant-associated protein A provides critical immunoprotection in neonatal mice
    Caroline L S George
    Department of Pediatrics, University of Iowa, Carver College of Medicine, Iowa City, Iowa 52242, USA
    Infect Immun 76:380-90. 2008
    ....
  11. pmc Maternal alcohol ingestion reduces surfactant protein A expression by preterm fetal lung epithelia
    Tatjana Lazic
    Department of Veterinary Pathology, 2740 College of Veterinary Medicine, Iowa State University, Ames, IA 50011 1250, USA
    Alcohol 41:347-55. 2007
    ..These alterations may underlie increased susceptibility of preterm infants, exposed to ethanol in utero, to RSV and other microbial agents...
  12. pmc Pretreatment with recombinant human vascular endothelial growth factor reduces virus replication and inflammation in a perinatal lamb model of respiratory syncytial virus infection
    David K Meyerholz
    Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011 1250, USA
    Viral Immunol 20:188-96. 2007
    ..This novel study demonstrates that rhVEGF pretreatment mitigates RSV disease and, in addition, rhVEGF regulation of innate immune genes is dependent on RSV infection status...
  13. pmc Neonatal ovine pulmonary dendritic cells support bovine respiratory syncytial virus replication with enhanced interleukin (IL)-4 And IL-10 gene transcripts
    Sasha J Fach
    Immunobiology Graduate Program, Iowa State University, Ames, Iowa, USA
    Viral Immunol 20:119-30. 2007
    ..Overall, these findings are the first to demonstrate that neonatal lung DCs support in vivo BRSV replication and produce type II cytokines after viral infection...
  14. pmc Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus
    Paul B McCray
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    J Virol 81:813-21. 2007
    ..This model of lethal infection with SARS-CoV should be useful for studies of pathogenesis and for the development of antiviral therapies...
  15. pmc Enhanced surfactant protein and defensin mRNA levels and reduced viral replication during parainfluenza virus type 3 pneumonia in neonatal lambs
    Branka Grubor
    Department of Veterinary Pathology, 2740 Veterinary Medicine, Iowa State University, Ames, IA 50011 1250, USA
    Clin Diagn Lab Immunol 11:599-607. 2004
    ....
  16. ncbi request reprint Differential expression of sheep beta-defensin-1 and -2 and interleukin 8 during acute Mannheimia haemolytica pneumonia
    Mark R Ackermann
    Department of Veterinary Pathology, College of Veterinary Medicine, 2738 Veterinary Medicine, Iowa State University, Ames, IA 50011 1250, USA
    Microb Pathog 37:21-7. 2004
    ..This study suggests that SDB-1 expression occurs in epithelia and decreases during severe bacterial pneumonia, which is in contrast to the increase that occurs with PI-3 infection...
  17. pmc Depletion of alveolar glycogen corresponds with immunohistochemical development of CD208 antigen expression in perinatal lamb lung
    David K Meyerholz
    DVM, DACVP Professor and J G Salsbury Endowed Chair, Department of Veterinary Pathology, 2738 Veterinary Medicine, Iowa State University, Ames, IA 50011 1250, USA
    J Histochem Cytochem 54:1247-53. 2006
    ..0001) and consistent with the premise that CD208 is localized to developing lamellar bodies. The findings suggest that CD208 antigen expression may serve as a marker for pneumocyte maturation in the developing fetal lung...
  18. pmc Differential expression of ovine innate immune genes by preterm and neonatal lung epithelia infected with respiratory syncytial virus
    Kenji Kawashima
    Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University Ames, Iowa 50011 1250, USA
    Viral Immunol 19:316-23. 2006
    ..These in vivo gene expression results provide a framework for future studies on age-dependent susceptibility to RSV and RSV pathogenesis...
  19. pmc Differential role of gamma interferon in inhibiting pulmonary eosinophilia and exacerbating systemic disease in fusion protein-immunized mice undergoing challenge infection with respiratory syncytial virus
    Elaine M Castilow
    Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    J Virol 82:2196-207. 2008
    ..These data demonstrate that IFN-gamma can have both beneficial and detrimental effects during a secondary RSV infection...
  20. pmc Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2
    Jason Netland
    Interdisciplinary Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    J Virol 82:7264-75. 2008
    ..Our results show that neurons are a highly susceptible target for SARS-CoV and that only the absence of the host cell receptor prevents severe murine brain disease...
  21. pmc The porcine lung as a potential model for cystic fibrosis
    Christopher S Rogers
    Department of Internal Medicine, Roy J Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Physiol Lung Cell Mol Physiol 295:L240-63. 2008
    ..Thus pigs with a targeted CFTR gene might provide a good model for CF. Here, we review aspects of porcine airways and lung that are relevant to CF...
  22. ncbi request reprint IL-13 is required for eosinophil entry into the lung during respiratory syncytial virus vaccine-enhanced disease
    Elaine M Castilow
    Interdisciplinary Graduate Program in Immunology, University of Iowa, 51 Newton Road, Iowa City, IA 52242, USA
    J Immunol 180:2376-84. 2008
    ....
  23. pmc Morphologic characterization of early ligation-induced acute pancreatitis in rats
    David K Meyerholz
    Department of Pathology, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
    Am J Surg 194:652-8. 2007
    ..Bile-pancreatic duct ligation in rats causes acute pancreatic inflammation. We performed serial morphologic evaluation of the exocrine pancreas after duct ligation to facilitate further investigations using the model...
  24. ncbi request reprint Ddb2 is a haploinsufficient tumor suppressor and controls spontaneous germ cell apoptosis
    Toshiki Itoh
    Department of Pathology, The University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA
    Hum Mol Genet 16:1578-86. 2007
    ..These results demonstrate that in whole animals as in cultured cells Ddb2 can regulate apoptosis and tumor incidence...
  25. ncbi request reprint Actinobacillus capsulatus septicemia in a domestic rabbit (Oryctolagus cuniculus)
    David K Meyerholz
    Department of Veterinary Pathology, Iowa State University, Ames, IA 50011 1250, USA
    J Vet Diagn Invest 17:83-5. 2005
    ..Acute septicemia is a novel presentation for this pathogen. This is the first documented case of A. capsulatus disease in the contiguous United States and may represent an underdiagnosed to emerging disease of lagomorphs...

Research Grants1

  1. VEGF regulation of surfactant proteins in preventing RSV
    DAVID MEYERHOLZ; Fiscal Year: 2005
    ....