Research Topics
| Marian KohutSummaryAffiliation: Iowa State University Country: USA Publications
Research Grants
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Detail Information
Publications
Echinacea-induced cytosolic Ca2+ elevation in HEK293Lankun Wu
Department of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, 50011, USA
BMC Complement Altern Med 10:72. 2010..Here, we show that unidentified compounds from Echinacea purpurea induce cytosolic Ca2+ elevation in non-immune-related cells, which lack CB2 receptors and that the Ca2+ elevation is not influenced by alkamides...- Chronic exercise reduces illness severity, decreases viral load, and results in greater anti-inflammatory effects than acute exercise during influenza infectionYoung Je Sim
Department of Immunobiology, College of Human Sciences, Iowa State University, Ames, Iowa 50011 1160, USA
J Infect Dis 200:1434-42. 2009..It is assumed that moderate exercise may improve resistance to infection and reduce inflammation, but there are limited data to support this assumption in an infection model... 
Prolonged exercise suppresses antigen-specific cytokine response to upper respiratory infectionM L Kohut
The Center for Psychoneuroimmunology Research, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Appl Physiol 90:678-84. 2001..These findings suggest that fatiguing exercise may alter the kinetics of antigen-specific cytokine production...- Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of beta-blockers, BMI, and psychosocial factors in older adultsM L Kohut
Department of Health and Human Performance, Immunobiology, Gerontology, Animal Science, Iowa State University, Ames, IA, USA
Brain Behav Immun 20:201-9. 2006..In summary, we have observed that an aerobic exercise intervention can significantly reduce serum inflammatory mediators, but beta-adrenergic receptors and psychosocial factors do not appear to be involved... - The exercise-induced enhancement of influenza immunity is mediated in part by improvements in psychosocial factors in older adultsM L Kohut
Department of Health and Human Performance, Immunobiology, Gerontology, Animal Science, Veterinary Diagnostic and Production Animal Medicine, Iowa State University, USA
Brain Behav Immun 19:357-66. 2005..Taken together, our findings may suggest that the mechanism(s) of exercise-induced improvement in immunocompetence involve both physiological and psychological pathways... - Glucocorticoids produced during exercise may be necessary for optimal virus-induced IL-2 and cell proliferation whereas both catecholamines and glucocorticoids may be required for adequate immune defense to viral infectionM L Kohut
Immunobiology Program, Department of Health and Human Performance, Iowa State University, Ames, 50011 1160, USA
Brain Behav Immun 19:423-35. 2005..These findings suggest that suppression of immune defenses during viral infection persists for at least 3 days post-exercise, and stress hormones may be essential for optimal immune defense to viral challenge, rather than detrimental... - Reversing age-associated immunosenescence via exerciseMarian L Kohut
HHP Immunobiology, Iowa State University, Ames, 50011, USA
Exerc Immunol Rev 10:6-41. 2004..This review summarizes the major findings of these studies and proposes directions for future exploration... - Age effects on macrophage function vary by tissue site, nature of stimulant, and exercise behaviorMarian L Kohut
Department of Health and Human Performance, Iowa State University, 235 Forker, Ames, IA 50011 1160, USA
Exp Gerontol 39:1347-60. 2004..Chronic moderate exercise tended to reverse age-associated changes in macrophage function in old mice... - Exercise and psychosocial factors modulate immunity to influenza vaccine in elderly individualsMarian L Kohut
Department of Health and Human Performance, Iowa State University, Ames 50011, USA
J Gerontol A Biol Sci Med Sci 57:M557-62. 2002..The objective of this study was to determine whether exercise, diet, and psychosocial factors were associated with altered immune response to influenza vaccine... - Ingestion of a dietary supplement containing dehydroepiandrosterone (DHEA) and androstenedione has minimal effect on immune function in middle-aged menMarian L Kohut
Department of Health and Human Performance, Iowa State University, Ames, Iowa 50011, USA
J Am Coll Nutr 22:363-71. 2003..This study investigated the effects of four weeks of intake of a supplement containing dehydroepiandrosterone (DHEA), androstenedione and herbal extracts on immune function in middle-aged men... - Exercise training-induced adaptations of immune response are mediated by beta-adrenergic receptors in aged but not young miceMarian L Kohut
Department of Health and Human Performance, Iowa State University, Ames, IA 50011, USA
J Appl Physiol 96:1312-22. 2004..The findings suggest that some of the immunomodulatory effects of chronic exercise are mediated via beta-adrenergic receptors and that the role of beta-adrenergic receptors is age dependent... - Moderate exercise improves antibody response to influenza immunization in older adultsMarian L Kohut
Department of Health and Human Performance Immunobiology, Iowa State University, 235 Forker Building, Ames, IA 50011, USA
Vaccine 22:2298-306. 2004..These findings suggest that exercise may enhance the mean fold increase in antibody titer in response to influenza immunization if the influenza antigen was contained in the previous year's vaccine... - Moderate exercise is associated with enhanced antigen-specific cytokine, but not IgM antibody production in aged miceM L Kohut
Department of Health and Human Performance, 235 Forker Building, Iowa State University, 235 Forker Building Ames, IA 50011, USA
Mech Ageing Dev 122:1135-50. 2001..In conclusion, moderate exercise was associated with increased antigen-specific IL-2 and IFN-gamma production in response to viral challenge in older mice... - Year-and-a-half old, dried Echinacea roots retain cytokine-modulating capabilities in an in vitro human older adult model of influenza vaccinationDavid S Senchina
Immunobiology Program, Iowa State University, Ames, IA 50011, USA
Planta Med 72:1207-15. 2006.... - Exercise, fitness, and neurocognitive function in older adults: the "selective improvement" and "cardiovascular fitness" hypothesesAnn L Smiley-Oyen
Department of Kinesiology, Iowa State University, Ames, IA 50011, USA
Ann Behav Med 36:280-91. 2008..Although basic research has uncovered biological mechanisms by which exercise could maintain and enhance adult brain health, experimental human studies with older adults have produced equivocal results... 
Is job-related stress the link between cardiovascular disease and the law enforcement profession?Warren D Franke
Department of Kinesiology, Institute for Social and Behavioral Research, Iowa State University, Ames, Iowa, USA
J Occup Environ Med 52:561-5. 2010..To determine whether job-related stress is associated with alterations in pro- and anti-atherogenic inflammatory mediators among law enforcement officers...- Cytokine- and interferon-modulating properties of Echinacea spp. root tinctures stored at -20 degrees C for 2 yearsDustin A McCann
Department of Health and Human Performance, Iowa State University, Ames, IA 50011 1061
J Interferon Cytokine Res 27:425-36. 2007..For in vitro models using Echinacea, immune response may vary based on stimulus (Echinacea alone vs. Echinacea + recall stimulation with virus)... - Enhancement of innate and adaptive immune functions by multiple Echinacea speciesZili Zhai
Department of Animal Science, Iowa State University, Ames, IA 50011, USA
J Med Food 10:423-34. 2007..In particular, E. angustifolia or E. pallida may have more anti-inflammatory potential... - Deoxynivalenol suppresses circulating and splenic leukocyte subpopulations in BALB/c mice: dose response, time course and sex differencesXianai Wu
Department of Food Science and Human Nutrition, Iowa State University, Ames, 50011, USA
Food Addit Contam Part A Chem Anal Control Expo Risk Assess 26:1070-80. 2009..This suggests that female sex hormones potentiate one potential marker of DON immunotoxicity in BALB/c mice... - Echinacea increases arginase activity and has anti-inflammatory properties in RAW 264.7 macrophage cells, indicative of alternative macrophage activationZili Zhai
Department of Animal Science, Iowa State University, Ames, IA 50011, USA
J Ethnopharmacol 122:76-85. 2009..The genus Echinacea is a popular herbal immunomodulator. Recent reports indicate that Echinacea products inhibit nitric oxide (NO) production in activated macrophages... - A direct synthesis of 5,6-dihydroindolo[2,1-a]isoquinolines that exhibit immunosuppressive activityGeorge A Kraus
Department of Chemistry, Iowa State University, Ames, IA 50011, USA
Bioorg Med Chem Lett 19:5539-42. 2009..Dihydroindolo[2,1-a]isoquinolines were synthesized from tetrahydroisoquinolines and alpha-fluoroaldehydes by a novel two-step procedure. These compounds exhibited significant immunosuppressive activity against IL-2, IL-10 and IFN-gamma... - Enrichment of Echinacea angustifolia with Bauer alkylamide 11 and Bauer ketone 23 increased anti-inflammatory potential through interference with cox-2 enzyme activityCarlie A LaLone
The Center for Research on Botanical Dietary Supplements, Iowa State University, Ames, Iowa 50011, USA
J Agric Food Chem 58:8573-84. 2010..COX-2 activity was decreased with all treatments. The phytochemical inhibition of PGE(2) production by Echinacea may be due to the direct targeting of COX-2 enzyme... - Changes in immunomodulatory properties of Echinacea spp. root infusions and tinctures stored at 4 degrees C for four daysDavid S Senchina
Immunobiology Program, Iowa State University, Ames, IA 50011, USA
Clin Chim Acta 355:67-82. 2005.... - Immunological outcomes of exercise in older adultsDavid S Senchina
Biology Department, Drake University, Des Moines, IA, USA
Clin Interv Aging 2:3-16. 2007..Given this evidence, an increase in the use of physical activity programs by the healthcare community may result in improved health of geriatric populations... - Centrally located body fat is related to inflammatory markers in healthy postmenopausal womenCourtney D Perry
Department of Food Science and Human Nutrition, Human Metabolic Unit, Center for Designing Foods to Improve Nutrition, Iowa State University, Ames, IA 50011, USA
Menopause 15:619-27. 2008..The purpose of this multicenter study was to identify whether centrally located fat and/or overall adiposity were related to these inflammatory markers in healthy postmenopausal women... - Effects of soy isoflavones and phytate on homocysteine, C-reactive protein, and iron status in postmenopausal womenLaura N Hanson
Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, USA
Am J Clin Nutr 84:774-80. 2006..9%, P = 0.003) to the overall variance in tHcy. CONCLUSION: Consuming phytate-rich foods and maintaining a healthy weight may reduce atherosclerotic CVD risk factors in postmenopausal women... - Pseudohypericin is necessary for the light-activated inhibition of prostaglandin E2 pathways by a 4 component system mimicking an Hypericum perforatum fractionKimberly D P Hammer
The Center for Research on Botanical Dietary Supplements, 215 MacKay Hall, Ames, IA 50011, United States
Phytochemistry 69:2354-62. 2008..Thus, the Hp fraction and selected constituents from this fraction showed evidence of blocking pro-inflammatory mediators but not enhancing inflammation-suppressing mediators... - Effects of Echinacea extracts on macrophage antiviral activitiesDavid S Senchina
Biology Department, Drake University, Des Moines, IA, USA
Phytother Res 24:810-6. 2010..Together, these results suggest that any potential antiviral activities of Echinacea spp. extracts are likely not mediated through large inductions of Type I interferon, but may involve iNOS... - Comparability of the 6-min walk test using different test configurationsDel N Konopka
Dept of Kinesiology, Iowa State University, Ames, IA 50011, USA
J Aging Phys Act 16:355-61. 2008..7 yd + 0.807 x (oval walking distance), R2 = .85. Thus, within-participant responses are similar across both 6MWT, but the course configuration affects the distance walked... - Mood and cytokine response to influenza virus in older adultsErin S Costanzo
University of Iowa, Iowa City, IA 52242, USA
J Gerontol A Biol Sci Med Sci 59:1328-33. 2004..CONCLUSIONS: These findings suggest that among older adults, even mild to moderate mood disturbance is associated with an attenuated cellular immune response to live influenza virus and vaccine...
Research Grants
- Exercise & influenza immunity:Psychoneuroendocrine ModelMarian Kohut; Fiscal Year: 2004..The findings from this study may have relevance from both a clinical and basic research perspective, if moderate exercise is associated with enhanced anti-influenza immunity and improved protection from infection. ..
- Exercise-induced immunomodulation in the agedMarian Kohut; Fiscal Year: 2007....
- Exercise-induced immunomodulation in the aged: MechanismsMarian L Kohut; Fiscal Year: 2010....