Marian Kohut

Summary

Affiliation: Iowa State University
Country: USA

Publications

  1. pmc Immunological outcomes of exercise in older adults
    David S Senchina
    Biology Department, Drake University, Des Moines, IA, USA
    Clin Interv Aging 2:3-16. 2007
  2. pmc Echinacea-induced cytosolic Ca2+ elevation in HEK293
    Lankun Wu
    Department of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, 50011, USA
    BMC Complement Altern Med 10:72. 2010
  3. ncbi request reprint Prolonged exercise suppresses antigen-specific cytokine response to upper respiratory infection
    M L Kohut
    The Center for Psychoneuroimmunology Research, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Appl Physiol (1985) 90:678-84. 2001
  4. ncbi request reprint Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of beta-blockers, BMI, and psychosocial factors in older adults
    M L Kohut
    Department of Health and Human Performance, Immunobiology, Gerontology, Animal Science, Iowa State University, Ames, IA, USA
    Brain Behav Immun 20:201-9. 2006
  5. ncbi request reprint The exercise-induced enhancement of influenza immunity is mediated in part by improvements in psychosocial factors in older adults
    M L Kohut
    Department of Health and Human Performance, Immunobiology, Gerontology, Animal Science, Veterinary Diagnostic and Production Animal Medicine, Iowa State University, USA
    Brain Behav Immun 19:357-66. 2005
  6. ncbi request reprint Glucocorticoids produced during exercise may be necessary for optimal virus-induced IL-2 and cell proliferation whereas both catecholamines and glucocorticoids may be required for adequate immune defense to viral infection
    M L Kohut
    Immunobiology Program, Department of Health and Human Performance, Iowa State University, Ames, 50011 1160, USA
    Brain Behav Immun 19:423-35. 2005
  7. pmc Chronic exercise reduces illness severity, decreases viral load, and results in greater anti-inflammatory effects than acute exercise during influenza infection
    Young Je Sim
    Department of Immunobiology, College of Human Sciences, Iowa State University, Ames, Iowa 50011 1160, USA
    J Infect Dis 200:1434-42. 2009
  8. ncbi request reprint Reversing age-associated immunosenescence via exercise
    Marian L Kohut
    HHP Immunobiology, Iowa State University, Ames, 50011, USA
    Exerc Immunol Rev 10:6-41. 2004
  9. ncbi request reprint Age effects on macrophage function vary by tissue site, nature of stimulant, and exercise behavior
    Marian L Kohut
    Department of Health and Human Performance, Iowa State University, 235 Forker, Ames, IA 50011 1160, USA
    Exp Gerontol 39:1347-60. 2004
  10. ncbi request reprint Moderate exercise improves antibody response to influenza immunization in older adults
    Marian L Kohut
    Department of Health and Human Performance Immunobiology, Iowa State University, 235 Forker Building, Ames, IA 50011, USA
    Vaccine 22:2298-306. 2004

Research Grants

Collaborators

Detail Information

Publications31

  1. pmc Immunological outcomes of exercise in older adults
    David S Senchina
    Biology Department, Drake University, Des Moines, IA, USA
    Clin Interv Aging 2:3-16. 2007
    ..Given this evidence, an increase in the use of physical activity programs by the healthcare community may result in improved health of geriatric populations...
  2. pmc Echinacea-induced cytosolic Ca2+ elevation in HEK293
    Lankun Wu
    Department of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA, 50011, USA
    BMC Complement Altern Med 10:72. 2010
    ..Here, we show that unidentified compounds from Echinacea purpurea induce cytosolic Ca2+ elevation in non-immune-related cells, which lack CB2 receptors and that the Ca2+ elevation is not influenced by alkamides...
  3. ncbi request reprint Prolonged exercise suppresses antigen-specific cytokine response to upper respiratory infection
    M L Kohut
    The Center for Psychoneuroimmunology Research, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Appl Physiol (1985) 90:678-84. 2001
    ..These findings suggest that fatiguing exercise may alter the kinetics of antigen-specific cytokine production...
  4. ncbi request reprint Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of beta-blockers, BMI, and psychosocial factors in older adults
    M L Kohut
    Department of Health and Human Performance, Immunobiology, Gerontology, Animal Science, Iowa State University, Ames, IA, USA
    Brain Behav Immun 20:201-9. 2006
    ..In summary, we have observed that an aerobic exercise intervention can significantly reduce serum inflammatory mediators, but beta-adrenergic receptors and psychosocial factors do not appear to be involved...
  5. ncbi request reprint The exercise-induced enhancement of influenza immunity is mediated in part by improvements in psychosocial factors in older adults
    M L Kohut
    Department of Health and Human Performance, Immunobiology, Gerontology, Animal Science, Veterinary Diagnostic and Production Animal Medicine, Iowa State University, USA
    Brain Behav Immun 19:357-66. 2005
    ..Taken together, our findings may suggest that the mechanism(s) of exercise-induced improvement in immunocompetence involve both physiological and psychological pathways...
  6. ncbi request reprint Glucocorticoids produced during exercise may be necessary for optimal virus-induced IL-2 and cell proliferation whereas both catecholamines and glucocorticoids may be required for adequate immune defense to viral infection
    M L Kohut
    Immunobiology Program, Department of Health and Human Performance, Iowa State University, Ames, 50011 1160, USA
    Brain Behav Immun 19:423-35. 2005
    ..These findings suggest that suppression of immune defenses during viral infection persists for at least 3 days post-exercise, and stress hormones may be essential for optimal immune defense to viral challenge, rather than detrimental...
  7. pmc Chronic exercise reduces illness severity, decreases viral load, and results in greater anti-inflammatory effects than acute exercise during influenza infection
    Young Je Sim
    Department of Immunobiology, College of Human Sciences, Iowa State University, Ames, Iowa 50011 1160, USA
    J Infect Dis 200:1434-42. 2009
    ..It is assumed that moderate exercise may improve resistance to infection and reduce inflammation, but there are limited data to support this assumption in an infection model...
  8. ncbi request reprint Reversing age-associated immunosenescence via exercise
    Marian L Kohut
    HHP Immunobiology, Iowa State University, Ames, 50011, USA
    Exerc Immunol Rev 10:6-41. 2004
    ..This review summarizes the major findings of these studies and proposes directions for future exploration...
  9. ncbi request reprint Age effects on macrophage function vary by tissue site, nature of stimulant, and exercise behavior
    Marian L Kohut
    Department of Health and Human Performance, Iowa State University, 235 Forker, Ames, IA 50011 1160, USA
    Exp Gerontol 39:1347-60. 2004
    ..Chronic moderate exercise tended to reverse age-associated changes in macrophage function in old mice...
  10. ncbi request reprint Moderate exercise improves antibody response to influenza immunization in older adults
    Marian L Kohut
    Department of Health and Human Performance Immunobiology, Iowa State University, 235 Forker Building, Ames, IA 50011, USA
    Vaccine 22:2298-306. 2004
    ..These findings suggest that exercise may enhance the mean fold increase in antibody titer in response to influenza immunization if the influenza antigen was contained in the previous year's vaccine...
  11. ncbi request reprint Exercise training-induced adaptations of immune response are mediated by beta-adrenergic receptors in aged but not young mice
    Marian L Kohut
    Department of Health and Human Performance, Iowa State University, Ames, IA 50011, USA
    J Appl Physiol (1985) 96:1312-22. 2004
    ..The findings suggest that some of the immunomodulatory effects of chronic exercise are mediated via beta-adrenergic receptors and that the role of beta-adrenergic receptors is age dependent...
  12. ncbi request reprint Ingestion of a dietary supplement containing dehydroepiandrosterone (DHEA) and androstenedione has minimal effect on immune function in middle-aged men
    Marian L Kohut
    Department of Health and Human Performance, Iowa State University, Ames, Iowa 50011, USA
    J Am Coll Nutr 22:363-71. 2003
    ..This study investigated the effects of four weeks of intake of a supplement containing dehydroepiandrosterone (DHEA), androstenedione and herbal extracts on immune function in middle-aged men...
  13. ncbi request reprint Exercise and psychosocial factors modulate immunity to influenza vaccine in elderly individuals
    Marian L Kohut
    Department of Health and Human Performance, Iowa State University, Ames 50011, USA
    J Gerontol A Biol Sci Med Sci 57:M557-62. 2002
    ..The objective of this study was to determine whether exercise, diet, and psychosocial factors were associated with altered immune response to influenza vaccine...
  14. ncbi request reprint Moderate exercise is associated with enhanced antigen-specific cytokine, but not IgM antibody production in aged mice
    M L Kohut
    Department of Health and Human Performance, 235 Forker Building, Iowa State University, 235 Forker Building Ames, IA 50011, USA
    Mech Ageing Dev 122:1135-50. 2001
    ..In conclusion, moderate exercise was associated with increased antigen-specific IL-2 and IFN-gamma production in response to viral challenge in older mice...
  15. pmc Antibody and CD8+ T cell memory response to influenza A/PR/8/34 infection is reduced in treadmill-exercised mice, yet still protective
    Kristi Warren
    Program of Immunobiology, Iowa State University, Ames, Iowa, USA
    J Appl Physiol (1985) 114:1413-20. 2013
    ..Exercise-induced enhancement of respiratory host defense to primary influenza infection results in decreased serum antibody and lung CD8+ T cell memory response, but does not compromise resistance to secondary infectious challenge...
  16. pmc Year-and-a-half old, dried Echinacea roots retain cytokine-modulating capabilities in an in vitro human older adult model of influenza vaccination
    David S Senchina
    Immunobiology Program, Iowa State University, Ames, IA 50011, USA
    Planta Med 72:1207-15. 2006
    ....
  17. doi request reprint Is job-related stress the link between cardiovascular disease and the law enforcement profession?
    Warren D Franke
    Department of Kinesiology, Institute for Social and Behavioral Research, Iowa State University, Ames, Iowa, USA
    J Occup Environ Med 52:561-5. 2010
    ..To determine whether job-related stress is associated with alterations in pro- and anti-atherogenic inflammatory mediators among law enforcement officers...
  18. pmc Exercise, fitness, and neurocognitive function in older adults: the "selective improvement" and "cardiovascular fitness" hypotheses
    Ann L Smiley-Oyen
    Department of Kinesiology, Iowa State University, Ames, IA 50011, USA
    Ann Behav Med 36:280-91. 2008
    ..Although basic research has uncovered biological mechanisms by which exercise could maintain and enhance adult brain health, experimental human studies with older adults have produced equivocal results...
  19. pmc Cytokine- and interferon-modulating properties of Echinacea spp. root tinctures stored at -20 degrees C for 2 years
    Dustin A McCann
    Department of Health and Human Performance, Iowa State University, Ames, IA 50011 1061
    J Interferon Cytokine Res 27:425-36. 2007
    ..For in vitro models using Echinacea, immune response may vary based on stimulus (Echinacea alone vs. Echinacea + recall stimulation with virus)...
  20. pmc Enhancement of innate and adaptive immune functions by multiple Echinacea species
    Zili Zhai
    Department of Animal Science, Iowa State University, Ames, IA 50011, USA
    J Med Food 10:423-34. 2007
    ..In particular, E. angustifolia or E. pallida may have more anti-inflammatory potential...
  21. doi request reprint Deoxynivalenol suppresses circulating and splenic leukocyte subpopulations in BALB/c mice: dose response, time course and sex differences
    Xianai Wu
    Department of Food Science and Human Nutrition, Iowa State University, Ames, 50011, USA
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 26:1070-80. 2009
    ..This suggests that female sex hormones potentiate one potential marker of DON immunotoxicity in BALB/c mice...
  22. pmc Echinacea increases arginase activity and has anti-inflammatory properties in RAW 264.7 macrophage cells, indicative of alternative macrophage activation
    Zili Zhai
    Department of Animal Science, Iowa State University, Ames, IA 50011, USA
    J Ethnopharmacol 122:76-85. 2009
    ..The genus Echinacea is a popular herbal immunomodulator. Recent reports indicate that Echinacea products inhibit nitric oxide (NO) production in activated macrophages...
  23. doi request reprint A direct synthesis of 5,6-dihydroindolo[2,1-a]isoquinolines that exhibit immunosuppressive activity
    George A Kraus
    Department of Chemistry, Iowa State University, Ames, IA 50011, USA
    Bioorg Med Chem Lett 19:5539-42. 2009
    ..Dihydroindolo[2,1-a]isoquinolines were synthesized from tetrahydroisoquinolines and alpha-fluoroaldehydes by a novel two-step procedure. These compounds exhibited significant immunosuppressive activity against IL-2, IL-10 and IFN-gamma...
  24. pmc Enrichment of Echinacea angustifolia with Bauer alkylamide 11 and Bauer ketone 23 increased anti-inflammatory potential through interference with cox-2 enzyme activity
    Carlie A LaLone
    The Center for Research on Botanical Dietary Supplements, Iowa State University, Ames, Iowa 50011, USA
    J Agric Food Chem 58:8573-84. 2010
    ..COX-2 activity was decreased with all treatments. The phytochemical inhibition of PGE(2) production by Echinacea may be due to the direct targeting of COX-2 enzyme...
  25. ncbi request reprint Changes in immunomodulatory properties of Echinacea spp. root infusions and tinctures stored at 4 degrees C for four days
    David S Senchina
    Immunobiology Program, Iowa State University, Ames, IA 50011, USA
    Clin Chim Acta 355:67-82. 2005
    ..We tested the hypothesis that Echinacea extracts made using homemade methods change in immunomodulatory efficacy with storage at 4 degrees C over a 4-day period...
  26. pmc Centrally located body fat is related to inflammatory markers in healthy postmenopausal women
    Courtney D Perry
    Department of Food Science and Human Nutrition, Human Metabolic Unit, Center for Designing Foods to Improve Nutrition, Iowa State University, Ames, IA 50011, USA
    Menopause 15:619-27. 2008
    ..The purpose of this multicenter study was to identify whether centrally located fat and/or overall adiposity were related to these inflammatory markers in healthy postmenopausal women...
  27. pmc Pseudohypericin is necessary for the light-activated inhibition of prostaglandin E2 pathways by a 4 component system mimicking an Hypericum perforatum fraction
    Kimberly D P Hammer
    The Center for Research on Botanical Dietary Supplements, 215 MacKay Hall, Ames, IA 50011, United States
    Phytochemistry 69:2354-62. 2008
    ..Thus, the Hp fraction and selected constituents from this fraction showed evidence of blocking pro-inflammatory mediators but not enhancing inflammation-suppressing mediators...
  28. doi request reprint Effects of Echinacea extracts on macrophage antiviral activities
    David S Senchina
    Biology Department, Drake University, Des Moines, IA, USA
    Phytother Res 24:810-6. 2010
    ..Together, these results suggest that any potential antiviral activities of Echinacea spp. extracts are likely not mediated through large inductions of Type I interferon, but may involve iNOS...
  29. ncbi request reprint Comparability of the 6-min walk test using different test configurations
    Del N Konopka
    Dept of Kinesiology, Iowa State University, Ames, IA 50011, USA
    J Aging Phys Act 16:355-61. 2008
    ..7 yd + 0.807 x (oval walking distance), R2 = .85. Thus, within-participant responses are similar across both 6MWT, but the course configuration affects the distance walked...
  30. ncbi request reprint Effects of soy isoflavones and phytate on homocysteine, C-reactive protein, and iron status in postmenopausal women
    Laura N Hanson
    Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, USA
    Am J Clin Nutr 84:774-80. 2006
    ..Soy protein or its components may protect against the atherosclerotic cardiovascular disease (CVD) risk factors total homocysteine (tHcy), C-reactive protein (CRP), and excess body iron, which generally increase with menopause...
  31. ncbi request reprint Mood and cytokine response to influenza virus in older adults
    Erin S Costanzo
    University of Iowa, Iowa City, IA 52242, USA
    J Gerontol A Biol Sci Med Sci 59:1328-33. 2004
    ..Associations among mood, optimism, stress, and the in vitro cytokine response to influenza virus and vaccine were evaluated in 18 healthy older adults with low to moderate life stress...

Research Grants7

  1. Exercise-induced immunomodulation in the aged
    Marian Kohut; Fiscal Year: 2007
    ....
  2. Exercise-induced immunomodulation in the aged: Mechanisms
    Marian L Kohut; Fiscal Year: 2010
    ....
  3. Exercise & influenza immunity:Psychoneuroendocrine Model
    Marian Kohut; Fiscal Year: 2004
    ..The findings from this study may have relevance from both a clinical and basic research perspective, if moderate exercise is associated with enhanced anti-influenza immunity and improved protection from infection. ..