| Raji E JosephAffiliation: Iowa State University Country: USA Andreotti A, Joseph R, Conley J, Iwasa J, Berg L. Multidomain Control Over TEC Kinase Activation State Tunes the T Cell Response. Annu Rev Immunol. 2018;36:549-578 pubmed publisher ..This multidomain control over kinase activation state provides a structural mechanism to account for ITK's ability to tune the TCR signal. .. Andreotti A, Schwartzberg P, Joseph R, Berg L. T-cell signaling regulated by the Tec family kinase, Itk. Cold Spring Harb Perspect Biol. 2010;2:a002287 pubmed publisher ..Finally, we describe the complex role of Itk signaling in effector T-cell differentiation and the regulation of cytokine gene expression. Together, these data implicate Itk as an important modulator of T-cell signaling and function. .. Boyken S, Chopra N, Xie Q, Joseph R, Wales T, Fulton D, et al. A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase. J Mol Biol. 2014;426:3656-69 pubmed publisher  Andreotti A. Opening the pore hinges on proline. Nat Chem Biol. 2006;2:13-4 pubmed Devkota S, Joseph R, Min L, Bruce Fulton D, Andreotti A. Scaffold Protein SLP-76 Primes PLCγ1 for Activation by ITK-Mediated Phosphorylation. J Mol Biol. 2015;427:2734-47 pubmed publisher ..These data contribute to the evolving model for the molecular events occurring early in the T cell activation process. .. Joseph R, Wales T, Fulton D, Engen J, Andreotti A. Achieving a Graded Immune Response: BTK Adopts a Range of Active/Inactive Conformations Dictated by Multiple Interdomain Contacts. Structure. 2017;25:1481-1494.e4 pubmed publisher ..The findings illustrate how previously modeled information for recalcitrant full-length proteins can be expanded and validated with a convergent multidisciplinary experimental approach. ..
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