Genomes and Genes
Jeffrey J Essner
Affiliation: Iowa State University
- Transient axonal glycoprotein-1 (TAG-1) and laminin-alpha1 regulate dynamic growth cone behaviors and initial axon direction in vivoMarc A Wolman
Department of Zoology, and Neuroscience Training Program, University of Wisconsin, Madison, Wisconsin 53706, USA
Neural Dev 3:6. 2008..We have taken advantage of the unique features of the zebrafish embryo to visualize dynamic growth cone behaviors and analyze guidance mechanisms of axons emerging from a central brain nucleus in vivo...
- Zebrafish RNase T2 genes and the evolution of secretory ribonucleases in animalsMelissa S Hillwig
Interdepartmental Genetics Graduate Program, Iowa State University, Ames, IA 50011, USA
BMC Evol Biol 9:170. 2009..Interestingly, in vertebrates most of the biological roles of plant RNase T2 proteins are carried out by members of a different family, RNase A. Still, RNase T2 proteins are conserved in these animals..
- Syndecan-2Jeffrey J Essner
Discovery Genomics Inc, 614 McKinley Place N E, Minneapolis, MN 55413, USA
Int J Biochem Cell Biol 38:152-6. 2006..This unique combination of activities suggests that syndecan-2 can function as a potential drug target for the development of multi-functional, anti-cancer therapeutics...
- Expression of the zebrafish CD133/prominin1 genes in cellular proliferation zones in the embryonic central nervous system and sensory organsMaura McGrail
Department of Genetics, Development and Cell Biology, Iowa State University, Ames, Iowa 50011, USA
Dev Dyn 239:1849-57. 2010..Based on these analyses, the zebrafish prominin1 genes will be useful markers for examining proliferating cell populations in adult organs, tissues, and tumors...
- Somatic mutagenesis with a Sleeping Beauty transposon system leads to solid tumor formation in zebrafishMaura McGrail
Department of Genetics, Development and Cell Biology, Iowa State University, Ames, Iowa, United States of America
PLoS ONE 6:e18826. 2011..The zebrafish T2/OncZ cancer model will be useful for identifying novel and conserved genetic drivers of human cancers...
- SCORE imaging: specimen in a corrected optical rotational enclosureAndrew M Petzold
Comparative and Molecular Biology, University of Minnesota, Minneapolis, Minnesota, USA
Zebrafish 7:149-54. 2010..The method described here could be applied to chemical genetic screening and other related high-throughput methods within the fish community and among other scientific fields...
- Expression of VE-cadherin in zebrafish embryos: a new tool to evaluate vascular developmentJon D Larson
Discovery Genomics, Incorporated, Minneapolis, Minnesota, USA
Dev Dyn 231:204-13. 2004..This loss can be restored in embryos supplemented with either zebrafish or human VEGF-A, the latter indicating that genes crucial to angiogenesis have highly conserved functional activities in vertebrates...
- A gap junction connexin is required in the vertebrate left-right organizerJulia M Hatler
Department of Genetics, Cell Biology and Development, University of Minnesota, 420 Washington Ave SE, MCB 6 150, Minneapolis, MN 55455, USA
Dev Biol 336:183-91. 2009..4 during L-R patterning. This is the first report linking connexin function in the ciliated, node-like cells of KV with normal L-R axis development...
- ANGIOGENESIS TARGETS FOR THERAPEUTIC DEVELOPMENTJEFFREY ESSNER; Fiscal Year: 2004..Based on these tests, the highest priority gene(s) will be used for future testing in mammalian tissue culture and mouse tumor models for development as therapeutics for cancer treatment. ..