D Alekel

Summary

Affiliation: Iowa State University
Country: USA

Publications

  1. ncbi request reprint Lifestyle and biologic contributors to proximal femur bone mineral density and hip axis length in two distinct ethnic groups of premenopausal women
    D L Alekel
    Department of Food Science and Human Nutrition, Iowa State University, Ames, Iowa, USA
    Osteoporos Int 9:327-38. 1999
  2. pmc The soy isoflavones for reducing bone loss (SIRBL) study: a 3-y randomized controlled trial in postmenopausal women
    D Lee Alekel
    Nutrition and Wellness Research Center, Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50010 8281, USA
    Am J Clin Nutr 91:218-30. 2010
  3. ncbi request reprint Frame size, ethnicity, lifestyle, and biologic contributors to areal and volumetric lumbar spine bone mineral density in Indian/Pakistani and American Caucasian premenopausal women
    D Lee Alekel
    Department of Food Science and Human Nutrition, Iowa State University, Ames, Iowa 50011, USA
    J Clin Densitom 5:175-86. 2002
  4. ncbi request reprint Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women
    D L Alekel
    Department of Food Science and Human Nutrition, Human Metabolic Unit, Center for Designing Foods to Improve Nutrition, the Department of Statistics, Iowa State University, Ames 50011 1120, USA
    Am J Clin Nutr 72:844-52. 2000
  5. pmc Serum 25-hydroxyvitamin D is related to indicators of overall physical fitness in healthy postmenopausal women
    Jeanne W Stewart
    Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50010 8281, USA
    Menopause 16:1093-101. 2009
  6. ncbi request reprint Isoflavone-rich soy protein prevents loss of hip lean mass but does not prevent the shift in regional fat distribution in perimenopausal women
    Laura E Moeller
    Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Menopause 10:322-31. 2003
  7. ncbi request reprint Effects of soy isoflavones and phytate on homocysteine, C-reactive protein, and iron status in postmenopausal women
    Laura N Hanson
    Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, USA
    Am J Clin Nutr 84:774-80. 2006
  8. ncbi request reprint Rapid gut transit time and slow fecal isoflavone disappearance phenotype are associated with greater genistein bioavailability in women
    Yan Zheng
    Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, USA
    J Nutr 133:3110-6. 2003
  9. pmc Centrally located body fat is related to appetitive hormones in healthy postmenopausal women
    Laura M Ritland
    Human Metabolic Unit, Department of Food Science and Human Nutrition, Iowa State University, 1115 Human Nutritional Sciences Building, Ames, Iowa 50011, USA
    Eur J Endocrinol 158:889-97. 2008
  10. pmc Relationship of circulating total homocysteine and C-reactive protein to trabecular bone in postmenopausal women
    Shilpa N Bhupathiraju
    Department of Food Science and Human Nutrition, Human Metabolic Unit, Center for Designing Foods to Improve Nutrition, Iowa State University, Ames, IA 50011, USA
    J Clin Densitom 10:395-403. 2007

Research Grants

  1. Bone Response to Soy Isoflavones in Women
    D Lee Alekel; Fiscal Year: 2007

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Lifestyle and biologic contributors to proximal femur bone mineral density and hip axis length in two distinct ethnic groups of premenopausal women
    D L Alekel
    Department of Food Science and Human Nutrition, Iowa State University, Ames, Iowa, USA
    Osteoporos Int 9:327-38. 1999
    ..These results suggest that a clinical trial to increase BMD and reduce osteoporotic risk is warranted in this ethnic group of premenopausal women...
  2. pmc The soy isoflavones for reducing bone loss (SIRBL) study: a 3-y randomized controlled trial in postmenopausal women
    D Lee Alekel
    Nutrition and Wellness Research Center, Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50010 8281, USA
    Am J Clin Nutr 91:218-30. 2010
    ..Our previous study indicated that soy protein with isoflavones lessened lumbar spine bone loss in midlife women...
  3. ncbi request reprint Frame size, ethnicity, lifestyle, and biologic contributors to areal and volumetric lumbar spine bone mineral density in Indian/Pakistani and American Caucasian premenopausal women
    D Lee Alekel
    Department of Food Science and Human Nutrition, Iowa State University, Ames, Iowa 50011, USA
    J Clin Densitom 5:175-86. 2002
    ..Upon accounting for frame size using regression, much variability in BMD, aBMD, and vBMD was explained by lifestyle and biologic factors, not by ethnicity...
  4. ncbi request reprint Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women
    D L Alekel
    Department of Food Science and Human Nutrition, Human Metabolic Unit, Center for Designing Foods to Improve Nutrition, the Department of Statistics, Iowa State University, Ames 50011 1120, USA
    Am J Clin Nutr 72:844-52. 2000
    ..No published studies have directly examined the effect of soy protein with isoflavones on bone or bone turnover in perimenopausal women...
  5. pmc Serum 25-hydroxyvitamin D is related to indicators of overall physical fitness in healthy postmenopausal women
    Jeanne W Stewart
    Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50010 8281, USA
    Menopause 16:1093-101. 2009
    ..We hypothesized that serum 25-hydroxyvitamin D [25(OH)D] is related to physical fitness indices (androidal fat, whole body lean mass, balance, strength) in healthy postmenopausal women...
  6. ncbi request reprint Isoflavone-rich soy protein prevents loss of hip lean mass but does not prevent the shift in regional fat distribution in perimenopausal women
    Laura E Moeller
    Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Menopause 10:322-31. 2003
    ..We tested the hypothesis that estrogen-like isoflavones in soy protein isolate (SPI+) would lessen both regional fat gain and lean loss compared with isoflavone-poor soy (SPI-)...
  7. ncbi request reprint Effects of soy isoflavones and phytate on homocysteine, C-reactive protein, and iron status in postmenopausal women
    Laura N Hanson
    Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, USA
    Am J Clin Nutr 84:774-80. 2006
    ..Soy protein or its components may protect against the atherosclerotic cardiovascular disease (CVD) risk factors total homocysteine (tHcy), C-reactive protein (CRP), and excess body iron, which generally increase with menopause...
  8. ncbi request reprint Rapid gut transit time and slow fecal isoflavone disappearance phenotype are associated with greater genistein bioavailability in women
    Yan Zheng
    Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, USA
    J Nutr 133:3110-6. 2003
    ..Relatively rapid GTT coupled with a low fecal isoflavone disappearance phenotype as occurred in Asian but not Caucasian subjects produced greater genistein bioavailability, as reflected in urinary genistein excretion...
  9. pmc Centrally located body fat is related to appetitive hormones in healthy postmenopausal women
    Laura M Ritland
    Human Metabolic Unit, Department of Food Science and Human Nutrition, Iowa State University, 1115 Human Nutritional Sciences Building, Ames, Iowa 50011, USA
    Eur J Endocrinol 158:889-97. 2008
    ..This study examined whether centrally located fat and/or overall adiposity were related to these appetitive hormones in healthy postmenopausal women...
  10. pmc Relationship of circulating total homocysteine and C-reactive protein to trabecular bone in postmenopausal women
    Shilpa N Bhupathiraju
    Department of Food Science and Human Nutrition, Human Metabolic Unit, Center for Designing Foods to Improve Nutrition, Iowa State University, Ames, IA 50011, USA
    J Clin Densitom 10:395-403. 2007
    ..Further investigation is needed to examine the relationship of Hcy as an endogenous bioactive molecule to trabecular bone loss in early postmenopausal women and the response of trabecular bone to dietary intervention...
  11. pmc Association of oxidative stress, iron, and centralized fat mass in healthy postmenopausal women
    Betsy L Crist
    Department of Food Science and Human Nutrition, Iowa State University, Ames, Iowa 50011, USA
    J Womens Health (Larchmt) 18:795-801. 2009
    ..The objective of this study was to determine the relationship among excess iron, oxidative stress, and centralized fat mass in healthy postmenopausal women...
  12. ncbi request reprint Iron indexes and total antioxidant status in response to soy protein intake in perimenopausal women
    James H Swain
    Department of Food Science and Human Nutrition, Iowa State University, Ames, 50011, USA
    Am J Clin Nutr 76:165-71. 2002
    ..Elevated iron stores, oxidative stress, and estrogen deficiency may place postmenopausal women at greater risk of heart disease and cancer than premenopausal women...
  13. ncbi request reprint Body composition, dietary intake, and iron status of female collegiate swimmers and divers
    Heidi L Petersen
    Iowa State University, Ames 50011, USA
    Int J Sport Nutr Exerc Metab 16:281-95. 2006
    ..046) and hematocrit (P = 0.014) and decreases in serum transferrin receptor (P < or = 0.0001). Studies are needed to further evaluate body composition and iron status in relation to dietary intake in female swimmers...
  14. ncbi request reprint Blood lipid and oxidative stress responses to soy protein with isoflavones and phytic acid in postmenopausal women
    Heather M Engelman
    Department of Food Science and Human Nutrition, Center for Designing Foods to Improve Nutrition, Iowa State University, Ames, IA 50011, USA
    Am J Clin Nutr 81:590-6. 2005
    ..Postmenopausal women are at risk of cardiovascular disease (CVD) as a result of unfavorable blood lipid profiles and increased oxidative stress. Soy protein consumption may help protect against these risk factors...
  15. pmc Centrally located body fat is related to inflammatory markers in healthy postmenopausal women
    Courtney D Perry
    Department of Food Science and Human Nutrition, Human Metabolic Unit, Center for Designing Foods to Improve Nutrition, Iowa State University, Ames, IA 50011, USA
    Menopause 15:619-27. 2008
    ..The purpose of this multicenter study was to identify whether centrally located fat and/or overall adiposity were related to these inflammatory markers in healthy postmenopausal women...
  16. ncbi request reprint A single daily dose of soybean phytosterols in ground beef decreases serum total cholesterol and LDL cholesterol in young, mildly hypercholesterolemic men
    Oksana A Matvienko
    Department of Food Science and Human Nutrition, Human Metabolic Unit, Iowa State University, Ames, USA
    Am J Clin Nutr 76:57-64. 2002
    ..The effects of incorporating phytosterols into lower-fat foods on the plasma lipids of young men at increased risk of developing cardiovascular disease have not been studied...
  17. pmc Quantifying leisure physical activity and its relation to bone density and strength
    Kristine M Shedd
    Nutrition Department, University of California, Davis, CA 95616, USA
    Med Sci Sports Exerc 39:2189-98. 2007
    ....
  18. ncbi request reprint Isoflavones and postmenopausal women
    D Lee Alekel
    JAMA 292:2336; author reply 2337. 2004
  19. ncbi request reprint Skeletal benefits of soy isoflavones: a review of the clinical trial and epidemiologic data
    Mark Messina
    Department of Nutrition, School of Public Health, Loma Linda University, Loma Linda, California, USA
    Curr Opin Clin Nutr Metab Care 7:649-58. 2004
    ..The purpose of this review is to evaluate the clinical and epidemiologic studies relevant to the hypothesis that isoflavones promote bone health...

Research Grants6

  1. Bone Response to Soy Isoflavones in Women
    D Lee Alekel; Fiscal Year: 2007
    ....