David R Piper

Summary

Affiliation: Invitrogen Corporation
Country: USA

Publications

  1. doi request reprint Development of the predictor HERG fluorescence polarization assay using a membrane protein enrichment approach
    David R Piper
    Invitrogen Discovery Sciences, Madison, WI 53719, USA
    Assay Drug Dev Technol 6:213-23. 2008
  2. ncbi request reprint Voltage sensing and activation gating of HCN pacemaker channels
    Jun Chen
    Department of Medicine, Division of Cardiology and Eccles Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, UT 84112 5330, USA
    Trends Cardiovasc Med 12:42-5. 2002
  3. ncbi request reprint Regional specificity of human ether-a'-go-go-related gene channel activation and inactivation gating
    David R Piper
    Department of Physiology, Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 280:7206-17. 2005
  4. ncbi request reprint Voltage sensor movement in the hERG K+ channel
    David R Piper
    Department of Physiology, University of Utah, Salt Lake City, UT 84113, USA
    Novartis Found Symp 266:46-52; discussion 52-6, 95-9. 2005
  5. ncbi request reprint The S4-S5 linker directly couples voltage sensor movement to the activation gate in the human ether-a'-go-go-related gene (hERG) K+ channel
    Tania Ferrer
    Department of Pediatrics, University of Utah, Salt Lake City, Utah 94113, USA
    J Biol Chem 281:12858-64. 2006

Collaborators

  • Jun Chen
  • Tania Ferrer
  • Jason Rupp
  • Martin Tristani-Firouzi

Detail Information

Publications5

  1. doi request reprint Development of the predictor HERG fluorescence polarization assay using a membrane protein enrichment approach
    David R Piper
    Invitrogen Discovery Sciences, Madison, WI 53719, USA
    Assay Drug Dev Technol 6:213-23. 2008
    ..This strategy enabled the Predictor (Invitrogen, Carlsbad, CA) hERG fluorescence polarization assay and should be useful in the development of other fluorescence polarization-based assays that use membrane proteins...
  2. ncbi request reprint Voltage sensing and activation gating of HCN pacemaker channels
    Jun Chen
    Department of Medicine, Division of Cardiology and Eccles Program in Human Molecular Biology and Genetics, University of Utah, Salt Lake City, UT 84112 5330, USA
    Trends Cardiovasc Med 12:42-5. 2002
    ..However, unlike most other channels channel, opening occurs in response to membrane hyperpolarization rather than depolarization...
  3. ncbi request reprint Regional specificity of human ether-a'-go-go-related gene channel activation and inactivation gating
    David R Piper
    Department of Physiology, Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 280:7206-17. 2005
    ..These results define regions on the S4 voltage sensor that contribute differentially to hERG activation and inactivation gating...
  4. ncbi request reprint Voltage sensor movement in the hERG K+ channel
    David R Piper
    Department of Physiology, University of Utah, Salt Lake City, UT 84113, USA
    Novartis Found Symp 266:46-52; discussion 52-6, 95-9. 2005
    ..We conclude that S4 acts as the voltage sensor for hERG activation and inactivation and that S4 movement is translated to the activation gate via the S4-S5 linker...
  5. ncbi request reprint The S4-S5 linker directly couples voltage sensor movement to the activation gate in the human ether-a'-go-go-related gene (hERG) K+ channel
    Tania Ferrer
    Department of Pediatrics, University of Utah, Salt Lake City, Utah 94113, USA
    J Biol Chem 281:12858-64. 2006
    ..Moreover, rather than functioning simply as a mechanical lever, these findings imply that specific interactions between the S4-S5 linker and the activation gate stabilize the closed channel conformation...