Benjamin D Horne

Summary

Affiliation: Intermountain Medical Center
Country: USA

Publications

  1. pmc Usefulness of routine periodic fasting to lower risk of coronary artery disease in patients undergoing coronary angiography
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, Murray, Utah, USA
    Am J Cardiol 102:814-819. 2008
  2. doi request reprint The Intermountain Risk Score (including the red cell distribution width) predicts heart failure and other morbidity endpoints
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, 5121 S Cottonwood St, Salt Lake City, UT 84107, USA
    Eur J Heart Fail 12:1203-13. 2010
  3. doi request reprint Randomized cross-over trial of short-term water-only fasting: metabolic and cardiovascular consequences
    B D Horne
    Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT, USA Genetic Epidemiology Division, Department of Medicine, University of Utah, Salt Lake City, UT, USA Electronic address
    Nutr Metab Cardiovasc Dis 23:1050-7. 2013
  4. pmc Repeated measurement of the intermountain risk score enhances prognostication for mortality
    Benjamin D Horne
    Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, Utah, USA
    PLoS ONE 8:e69160. 2013
  5. pmc A new ratio for better predicting future death/myocardial infarction than standard lipid measurements in women >50 years undergoing coronary angiography: the apolipoprotein A1 remnant ratio (Apo A1/ [VLDL₃+IDL])
    Heidi T May
    Intermountain Medical Center, Cardiovascular Department, 5121 S Cottonwood Street, Murray, UT 84157, USA
    Lipids Health Dis 12:55. 2013
  6. ncbi request reprint Panoptic total cardiovascular risk prediction using all predictors versus optimized risk assessment using variable subsets
    Benjamin D Horne
    Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT 84107, USA
    Future Cardiol 8:765-78. 2012
  7. doi request reprint Relation of routine, periodic fasting to risk of diabetes mellitus, and coronary artery disease in patients undergoing coronary angiography
    Benjamin D Horne
    Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, Utah, USA
    Am J Cardiol 109:1558-62. 2012
  8. pmc Pharmacogenetic warfarin dose refinements remain significantly influenced by genetic factors after one week of therapy
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, Salt Lake City, Utah 84107, USA
    Thromb Haemost 107:232-40. 2012
  9. pmc Evaluation of genetic risk scores for lipid levels using genome-wide markers in the Framingham Heart Study
    Stephen R Piccolo
    Department of Biomedical Informatics, School of Medicine, University of Utah, 26 South 2000 East, Salt Lake City, Utah 84112, USA
    BMC Proc 3:S46. 2009
  10. doi request reprint Genome-wide significance and replication of the chromosome 12p11.22 locus near the PTHLH gene for peripartum cardiomyopathy
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, Genetic Epidemiology Division, University of Utah, USA
    Circ Cardiovasc Genet 4:359-66. 2011

Detail Information

Publications100

  1. pmc Usefulness of routine periodic fasting to lower risk of coronary artery disease in patients undergoing coronary angiography
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, Murray, Utah, USA
    Am J Cardiol 102:814-819. 2008
    ..In conclusion, not only proscription of tobacco, but also routine periodic fasting was associated with lower risk of CAD...
  2. doi request reprint The Intermountain Risk Score (including the red cell distribution width) predicts heart failure and other morbidity endpoints
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, 5121 S Cottonwood St, Salt Lake City, UT 84107, USA
    Eur J Heart Fail 12:1203-13. 2010
    ..Mortality is the most definitive clinical endpoint, but medical care is more easily applied to modify morbidity and thereby prevent death. This study tested whether IMRS is associated with clinical morbidity endpoints...
  3. doi request reprint Randomized cross-over trial of short-term water-only fasting: metabolic and cardiovascular consequences
    B D Horne
    Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT, USA Genetic Epidemiology Division, Department of Medicine, University of Utah, Salt Lake City, UT, USA Electronic address
    Nutr Metab Cardiovasc Dis 23:1050-7. 2013
    ..We evaluated whether fasting initiates acute changes in biomarker expression in humans that may impact short- and long-term health...
  4. pmc Repeated measurement of the intermountain risk score enhances prognostication for mortality
    Benjamin D Horne
    Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, Utah, USA
    PLoS ONE 8:e69160. 2013
    ..Whether longitudinal repeated measurement of IMRS is useful for prognostication is an important question for its clinical applicability...
  5. pmc A new ratio for better predicting future death/myocardial infarction than standard lipid measurements in women >50 years undergoing coronary angiography: the apolipoprotein A1 remnant ratio (Apo A1/ [VLDL₃+IDL])
    Heidi T May
    Intermountain Medical Center, Cardiovascular Department, 5121 S Cottonwood Street, Murray, UT 84157, USA
    Lipids Health Dis 12:55. 2013
    ..Our objective was to evaluate standard- and sub-lipid parameters and the apo A1 remnant ratio: (apo A1/[VLDL₃-C+IDL-C]) for their associations with death/myocardial infarction among peri- and post-menopausal women...
  6. ncbi request reprint Panoptic total cardiovascular risk prediction using all predictors versus optimized risk assessment using variable subsets
    Benjamin D Horne
    Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT 84107, USA
    Future Cardiol 8:765-78. 2012
    ..Future research should focus on how to utilize risk scores most effectively and efficiently in clinical practice...
  7. doi request reprint Relation of routine, periodic fasting to risk of diabetes mellitus, and coronary artery disease in patients undergoing coronary angiography
    Benjamin D Horne
    Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, Utah, USA
    Am J Cardiol 109:1558-62. 2012
    ..A reported fasting association with a lower CAD risk was also validated and fasting associations with lower glucose and BMI were found...
  8. pmc Pharmacogenetic warfarin dose refinements remain significantly influenced by genetic factors after one week of therapy
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, Salt Lake City, Utah 84107, USA
    Thromb Haemost 107:232-40. 2012
    ..7 mg/week. In conclusion, a pharmacogenetic warfarin dose-refinement algorithm based on clinical, INR, and genetic factors can explain at least 69.1% of therapeutic warfarin dose variability after about one week of therapy...
  9. pmc Evaluation of genetic risk scores for lipid levels using genome-wide markers in the Framingham Heart Study
    Stephen R Piccolo
    Department of Biomedical Informatics, School of Medicine, University of Utah, 26 South 2000 East, Salt Lake City, Utah 84112, USA
    BMC Proc 3:S46. 2009
    ..In this paper, we evaluate a weighted and an unweighted approach for estimating the combined effect of multiple markers (using genotypes and haplotypes) on lipid levels for a given individual...
  10. doi request reprint Genome-wide significance and replication of the chromosome 12p11.22 locus near the PTHLH gene for peripartum cardiomyopathy
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, Genetic Epidemiology Division, University of Utah, USA
    Circ Cardiovasc Genet 4:359-66. 2011
    ..Initial evidence suggests that genetic factors may influence PPCM. This study evaluated and replicated genome-wide association of single nucleotide polymorphisms with PPCM...
  11. pmc Association of variation in the chromosome 9p21 locus with myocardial infarction versus chronic coronary artery disease
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, Murray, UT 84157, USA
    Circ Cardiovasc Genet 1:85-92. 2008
    ..Using angiographic coronary artery disease (CAD) phenotyping, this study evaluated whether 9p21 single-nucleotide polymorphisms predict ischemic events (eg, myocardial infarction [MI]) among CAD patients...
  12. doi request reprint The intermountain risk score predicts incremental age-specific long-term survival and life expectancy
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, Salt Lake City, Utah, USA
    Transl Res 158:307-14. 2011
    ..IMRS may be used to stratify age-specific risk of mortality in research, clinical/preventive, and quality improvement applications. A web calculator is located at http://intermountainhealthcare.org/IMRS...
  13. doi request reprint Exceptional mortality prediction by risk scores from common laboratory tests
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, Murray, Utah 84157, USA
    Am J Med 122:550-8. 2009
    ..Many of their components are not commonly used, but they might contain independent risk information. This study tested the ability of a risk score combining all components to predict all-cause mortality...
  14. ncbi request reprint Candidate gene susceptibility variants predict intermediate end points but not angiographic coronary artery disease
    Bryant M Whiting
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    Am Heart J 150:243-50. 2005
    ..Moderate-sized studies have suggested that variants of candidate genes can influence laboratory markers of coronary artery disease (CAD), but whether they predict parallel changes in clinical CAD risk is unknown...
  15. ncbi request reprint C-reactive protein predicts death in patients with non-ischemic cardiomyopathy
    Brianna S Ronnow
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    Cardiology 104:196-201. 2005
    ..0) significantly and independently predicted mortality. Even in the absence of coronary artery disease, patients with left ventricular dysfunction are at increased risk of mortality based on their baseline CRP concentrations...
  16. doi request reprint Genetic variation at the 9p21 locus predicts angiographic coronary artery disease prevalence but not extent and has clinical utility
    Jeffrey L Anderson
    Cardiovascular Department, Intermountain Medical Center, Murray, UT 84107, USA
    Am Heart J 156:1155-1162.e2. 2008
    ..Variants at the 9p21 locus have been associated with coronary heart disease, but their precise disease phenotype and utility for clinical risk assessment are uncertain...
  17. pmc Joint effects of common genetic variants from multiple genes and pathways on the risk of premature coronary artery disease
    Jeffrey L Anderson
    Cardiovascular Department, Intermountain Medical Center, Murray, UT 84107, USA
    Am Heart J 160:250-256.e3. 2010
    ....
  18. ncbi request reprint Rapid melting curve analysis for genetic variants that underlie inter-individual variability in stable warfarin dosing
    John F Carlquist
    Department of Internal Medicine, Division of Cardiology, University of Utah School of Medicine, Salt Lake City, UT, USA
    J Thromb Thrombolysis 26:1-7. 2008
    ..99. Combined with a method for rapid buccal swab DNA extraction, genotyping results were obtained in a median of 59 min. These methods should facilitate genotype-driven warfarin dosing in "real-time" clinical practice...
  19. ncbi request reprint Multiple less common genetic variants explain the association of the cholesteryl ester transfer protein gene with coronary artery disease
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Intermountain Medical Center, University of Utah, Salt Lake City, Utah 84143, USA
    J Am Coll Cardiol 49:2053-60. 2007
    ....
  20. ncbi request reprint Effect of fasting glucose levels on mortality rate in patients with and without diabetes mellitus and coronary artery disease undergoing percutaneous coronary intervention
    Joseph B Muhlestein
    LDS Hospital, Salt Lake City, Utah 84143, USA
    Am Heart J 146:351-8. 2003
    ..Diabetes mellitus (DM) is predictive of increased mortality for patients with coronary artery disease (CAD). To what extent this risk extends below the diabetic threshold (fasting glucose level [FG] <126 mg/dL) is uncertain...
  21. ncbi request reprint Statin therapy interacts with cytomegalovirus seropositivity and high C-reactive protein in reducing mortality among patients with angiographically significant coronary disease
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    Circulation 107:258-63. 2003
    ..This study prospectively evaluated the effect of statins on CMV-and CRP-associated death among patients with significant, angiographically defined CAD...
  22. doi request reprint Relation of elevated plasma renin activity at baseline to cardiac events in patients with angiographically proven coronary artery disease
    Joseph B Muhlestein
    Intermountain Medical Center, Murray, Utah University of Utah, Salt Lake City, Utah, USA
    Am J Cardiol 106:764-9. 2010
    ..In conclusion, elevated baseline PRA is associated with cardiac morbidity and mortality in patients with coronary artery disease but normal left ventricular function and no previous MI or HF...
  23. doi request reprint Comparison of effects of simvastatin alone versus fenofibrate alone versus simvastatin plus fenofibrate on lipoprotein subparticle profiles in diabetic patients with mixed dyslipidemia (from the Diabetes and Combined Lipid Therapy Regimen study)
    Heidi T May
    Intermountain Medical Center and LDS Hospital, Salt Lake City, Utah, USA
    Am J Cardiol 101:486-9. 2008
    ..In conclusion, in this trial of mixed dyslipidemic patients with diabetes, combination therapy was more effective in changing a variety of other cardiovascular risk markers...
  24. doi request reprint Cardiovascular risk among patients on clopidogrel anti-platelet therapy after placement of drug-eluting stents is modified by genetic variants in both the CYP2C19 and ABCB1 genes
    John F Carlquist
    John Carlquist, PhD, Intermountain Heart Institute, Intermountain Medical Center, 5121 S Cottonwood Street, Murray, UT 84157, USA
    Thromb Haemost 109:744-54. 2013
    ..This trend was largely reversed by the simultaneous carriage of one or two *17 alleles. These findings suggest that assessment of a combined genotype may improve risk assessment...
  25. doi request reprint Trends in early and late mortality in patients undergoing coronary catheterization for myocardial infarction: implications on observation periods and risk factors to determine ICD candidacy
    T Jared Bunch
    Intermountain Heart Rhythm Specialists, Intermountain Medical Center, Murray, Utah 84107, USA
    Heart Rhythm 8:1460-6. 2011
    ..Survivors of acute myocardial infarction (MI) are at high risk for death from both sudden cardiac death and progressive heart failure...
  26. ncbi request reprint Genotypes of the cytochrome p450 isoform, CYP2C9, and the vitamin K epoxide reductase complex subunit 1 conjointly determine stable warfarin dose: a prospective study
    John F Carlquist
    Department of Medicine, Division of Cardiology, University of Utah School of Medicine, Cardiovascular Department, LDS Hospital, Salt Lake City, Utah, USA
    J Thromb Thrombolysis 22:191-7. 2006
    ..vitamin K epoxide reductase complex subunit 1-VKORC1). We hypothesized that variants in these two genes explain a substantial proportion of variability in stable warfarin dose and could be used as a basis for improved dosing algorithms...
  27. ncbi request reprint Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammation, angiographic coronary artery disease, and clinical diabetes
    Matthew J Kolek
    Cardiovascular Department, Division of Cardiology, LDS Hospital, Salt Lake City, Utah 84143, USA
    Am Heart J 148:1034-40. 2004
    ..We evaluated whether the Asp299Gly polymorphism in the TLR4 gene, which impairs inflammatory responses, is associated with reduced vascular inflammation (assessed by C-reactive protein [CRP]) and a decreased risk for CAD and diabetes...
  28. ncbi request reprint Homocysteine levels are associated with increased risk of congestive heart failure in patients with and without coronary artery disease
    Heidi T May
    LDS Hospital, Salt Lake City, Utah 84143, USA
    Cardiology 107:178-84. 2007
    ..Whether HCY affects development of congestive heart failure (CHF) independent of coronary artery disease (CAD) is uncertain. We evaluated whether increased HCY predicts low ejection fraction or clinical CHF...
  29. ncbi request reprint The role of a common adenosine monophosphate deaminase (AMPD)-1 polymorphism in outcomes of ischemic and nonischemic heart failure
    Matthew J Kolek
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    J Card Fail 11:677-83. 2005
    ..A common variant of the adenosine monophosphate deaminase (AMPD)-1 gene (C34T) results in enzymatic inactivity and may increase adenosine in cardiac muscle and confer cardioprotection through ischemic preconditioning...
  30. ncbi request reprint Less affluent area of residence and lesser-insured status predict an increased risk of death or myocardial infarction after angiographic diagnosis of coronary disease
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    Ann Epidemiol 14:143-50. 2004
    ..Low socioeconomic status (SES) predicts coronary artery disease (CAD) onset, but its value among patients with CAD is uncertain. Geographic measures (e.g., residential neighborhood) may predict risk, but this requires further evaluation...
  31. doi request reprint Validation and quantification of genetic determinants of lipoprotein-a levels and predictive value for angiographic coronary artery disease
    Jeffrey L Anderson
    Intermountain Healthcare Intermountain Medical Center, Murray, UT, USA
    Am J Cardiol 112:799-804. 2013
    ..The percentage of intersubject variability in Lp(a) cholesterol and the percentage of prevalent CAD explained were small...
  32. ncbi request reprint Lipoprotein-associated phospholipase A2 independently predicts the angiographic diagnosis of coronary artery disease and coronary death
    Heidi T May
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    Am Heart J 152:997-1003. 2006
    ..We evaluated the independent association of lipoprotein-associated phospholipase A2 (Lp-PLA2) to angiographic CAD and CV events adjusting for standard factors, lipids, and CRP...
  33. pmc Soluble CD40 ligand as a predictor of coronary artery disease and long-term clinical outcomes in stable patients undergoing coronary angiography
    Matthew T Rondina
    Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Cardiology 109:196-201. 2008
    ..We evaluated sCD40L levels and future cardiovascular events in patients not experiencing ACS...
  34. doi request reprint A randomized and clinical effectiveness trial comparing two pharmacogenetic algorithms and standard care for individualizing warfarin dosing (CoumaGen-II)
    Jeffrey L Anderson
    Intermountain Medical Center, Cardiovascular Department, Murray, UT 84107 5701, USA
    Circulation 125:1997-2005. 2012
    ..Warfarin is characterized by marked variations in individual dose requirements and a narrow therapeutic window. Pharmacogenetics (PG) could improve dosing efficiency and safety, but clinical trials evidence is meager...
  35. doi request reprint Atrial fibrillation hospitalization is not increased with short-term elevations in exposure to fine particulate air pollution
    T Jared Bunch
    Intermountain Heart Rhythm Specialists, Intermountain Medical Center, Murray, Utah 84107, USA
    Pacing Clin Electrophysiol 34:1475-9. 2011
    ..This study explored the potential associations between short-term elevations in PM exposure and atrial fibrillation (AF)...
  36. ncbi request reprint Asymmetric dimethylarginine, cortisol/cortisone ratio, and C-peptide: markers for diabetes and cardiovascular risk?
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    Am Heart J 153:67-73. 2007
    ....
  37. ncbi request reprint Associations with myocardial infarction of six polymorphisms selected from a three-stage genome-wide association study
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Intermountain Medical Center, Salt Lake City, UT 84143, USA
    Am Heart J 154:969-75. 2007
    ..In an independent but demographically similar population, this study tested 6 SNPs that were previously reported to be associated with MI...
  38. ncbi request reprint Usefulness of a complete blood count-derived risk score to predict incident mortality in patients with suspected cardiovascular disease
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, and University of Utah, Salt Lake City, Utah, USA
    Am J Cardiol 99:169-74. 2007
    ..A total CBC score is an important new addition to risk prediction, and it can be easily generated by computer for clinical use at negligible incremental cost...
  39. doi request reprint Superior predictive ability for death of a basic metabolic profile risk score
    Heidi T May
    Intermountain Medical Center, Murray, UT 84157, USA
    Am Heart J 157:946-54. 2009
    ..Although individual variables are checked for cardiovascular health and risk, combining them into a total BMP-derived score, as to maximize BMP predictive ability, has not been previously attempted...
  40. ncbi request reprint The cholesteryl ester transfer protein Taq1B gene polymorphism predicts clinical benefit of statin therapy in patients with significant coronary artery disease
    John F Carlquist
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    Am Heart J 146:1007-14. 2003
    ..We studied CETP Taq1B genotype, plasma HDL, and clinical events among all patients and patients stratified by statin treatment...
  41. doi request reprint Antilipidemic adherence post-coronary artery disease diagnosis among those with and without an ICD-9 diagnosis of depression
    Heidi T May
    Intermountain Medical Center, Murray, UT 84157, USA
    J Psychosom Res 69:169-74. 2010
    ..We sought to evaluate whether adherence to antilipid medication, a therapy shown to be beneficial in secondary prevention of coronary events, differs among CAD patients with and without an ICD-9 depression diagnosis...
  42. doi request reprint Association of vitamin D levels with incident depression among a general cardiovascular population
    Heidi T May
    Intermountain Medical Center, Murray, UT 84157, USA
    Am Heart J 159:1037-43. 2010
    ..Therefore, we evaluated whether there is an association between vitD and incident depression among a CV population...
  43. doi request reprint Red cell distribution width, C-reactive protein, the complete blood count, and mortality in patients with coronary disease and a normal comparison population
    Jason M Lappe
    Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC, USA
    Clin Chim Acta 412:2094-9. 2011
    ..Red cell distribution width (RDW) is associated with morbidity and mortality in coronary artery disease (CAD), but the connection of RDW with chronic inflammation is equivocal...
  44. ncbi request reprint Early postoperative use of unfractionated heparin or enoxaparin is associated with increased surgical re-exploration for bleeding
    Heath U Jones
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah, USA
    Ann Thorac Surg 80:518-22. 2005
    ..exist for the use of unfractionated heparin (UFH) and enoxaparin (ENOX) in the early postoperative period following open-heart surgery. However, the overall postoperative risk for hemorrhage from the use of UFH and ENOX are not known...
  45. ncbi request reprint Randomized trial of genotype-guided versus standard warfarin dosing in patients initiating oral anticoagulation
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, Intermountain Healthcare, Salt Lake City, UT, USA
    Circulation 116:2563-70. 2007
    ..Pharmacogenetic-guided dosing of warfarin is a promising application of "personalized medicine" but has not been adequately tested in randomized trials...
  46. doi request reprint Patients treated with catheter ablation for atrial fibrillation have long-term rates of death, stroke, and dementia similar to patients without atrial fibrillation
    T Jared Bunch
    Intermountain Heart Rhythm Specialists Department of Cardiology, Intermountain Medical Center, Murray, Utah 84107, USA
    J Cardiovasc Electrophysiol 22:839-45. 2011
    ..AF ablation eliminates AF in most patients. We evaluated the long-term impact of AF ablation on mortality, heart failure (HF), stroke, and dementia in a large system-wide patient population...
  47. doi request reprint Risk of nephropathy is not increased by the administration of larger volume of contrast during coronary angiography
    Troy E Madsen
    Division of Emergency Medicine, University of Utah, Salt Lake City, UT, USA
    Crit Pathw Cardiol 8:167-71. 2009
    ..The apparent inverse relation of risk with volume in the overall population is likely explained by clinical practice bias. If confirmed, these results may have important clinical implications...
  48. doi request reprint Parathyroid hormone, vitamin D, renal dysfunction, and cardiovascular disease: dependent or independent risk factors?
    Jeffrey L Anderson
    Cardiovascular Department, Intermountain Medical Center, Murray, UT 84107 5701, USA
    Am Heart J 162:331-339.e2. 2011
    ..We tested whether elevated PTH is associated with CV disease and whether risk associations depend on Vit D status and renal function...
  49. pmc Multiple-polymorphism associations of 7 matrix metalloproteinase and tissue inhibitor metalloproteinase genes with myocardial infarction and angiographic coronary artery disease
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Intermountain Medical Center, Salt Lake City, UT 84143, USA
    Am Heart J 154:751-8. 2007
    ..Furthermore, differentiation of predictive ability by end point (MI vs CAD) has not been addressed. This study evaluated the association with MI of SNPs in genes encoding MMPs 1, 2, 3, and 9 and TIMPs 1, 2, and 3...
  50. ncbi request reprint Surgical revascularization is associated with improved long-term outcomes compared with percutaneous stenting in most subgroups of patients with multivessel coronary artery disease: results from the Intermountain Heart Registry
    Tami L Bair
    Cardiovascular Department, University of Utah, Salt Lake City, USA
    Circulation 116:I226-31. 2007
    ..In this study, we examined the outcomes of major adverse cardiovascular events and death for subgroups of typical "real-world" patients undergoing coronary revascularization in the modern era...
  51. ncbi request reprint A common variant of the AMPD1 gene predicts improved survival in patients with ischemic left ventricular dysfunction
    Yoshikazu Yazaki
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    J Card Fail 10:316-20. 2004
    ..This variant might lead to ischemic preconditioning by increasing tissue adenosine. We tested whether the survival benefit of C34T occurs preferentially in the setting of ischemic left ventricular dysfunction...
  52. ncbi request reprint Relation of serum total cholesterol, C-reactive protein levels, and statin therapy to survival in heart failure
    Heidi T May
    LDS Hospital, Salt Lake City, Utah, USA
    Am J Cardiol 98:653-8. 2006
    ..In conclusion, elevated TC appears to be associated with improved survival. The effect was stronger in patients receiving statin therapy, but the cause of this differential effect is uncertain...
  53. ncbi request reprint High-resolution characterization of linkage disequilibrium structure and selection of tagging single nucleotide polymorphisms: application to the cholesteryl ester transfer protein gene
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    Ann Hum Genet 70:524-34. 2006
    ..This study provides an optimal set of tSNPs for association analyses of CETP. The observed complexity of LD structure highlights the importance of using methods, such as PCA, that allow for multiple dynamics in intragenic LD structure...
  54. ncbi request reprint Early effects of statins in patients with coronary artery disease and high C-reactive protein
    Joseph B Muhlestein
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    Am J Cardiol 94:1107-12. 2004
    ..This provides further evidence of an anti-inflammatory effect of statins...
  55. ncbi request reprint Comparison of effects of high (80 mg) versus low (20 mg) dose of simvastatin on C-reactive protein and lipoproteins in patients with angiographic evidence of coronary arterial narrowing
    Kent G Meredith
    Cardiovascular Department, LDS Hospital, Division of Cardiology, University of Utah, Salt Lake City, Utah, USA
    Am J Cardiol 99:149-53. 2007
    ..In conclusion, this randomized trial in patients with chronic stable coronary artery disease showed a strong dose response for simvastatin for total and low-density lipoprotein cholesterol lowering but not for hs-CRP...
  56. ncbi request reprint Beta-blockers reduce the incidence of clinical restenosis: prospective study of 4840 patients undergoing percutaneous coronary revascularization
    Jeffrey D Jackson
    Division of Cardiology, Department of Medicine, LDS Hospital, Salt Lake City, Utah 84143, USA
    Am Heart J 145:875-81. 2003
    ..Although beta-adrenergic receptor blockers (BBs) effectively reduce many cardiac events, no large prospective studies have examined the association of BBs with restenosis...
  57. ncbi request reprint Sex- and age-related differences in the prognostic value of C-reactive protein in patients with angiographic coronary artery disease
    Lillian L C Khor
    Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA
    Am J Med 117:657-64. 2004
    ..To determine whether sex and age affect serum C-reactive protein level and its prognostic value in patients with coronary artery disease...
  58. ncbi request reprint Do statins increase the risk of idiopathic polyneuropathy?
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, Cardiology Division, Intermountain Health Care, Salt Lake City, Utah 84143, USA
    Am J Cardiol 95:1097-9. 2005
    ..It was found that statin use before diagnosis was not significantly greater in patients than controls (odds ratio 1.30, 95% confidence interval 0.3 to 2.1, p = 0.27), nor were doses different between patients and controls...
  59. ncbi request reprint Frequency of elevation of C-reactive protein in atrial fibrillation
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, University of Utah, Salt Lake City 84143, USA
    Am J Cardiol 94:1255-9. 2004
    ..Increased CRP is a new risk marker for AF propensity, and testing therapies that target inflammation should be considered...
  60. ncbi request reprint Which features of the metabolic syndrome predict the prevalence and clinical outcomes of angiographic coronary artery disease?
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital and University of Utah, Salt Lake City, Utah, USA
    Cardiology 101:185-93. 2004
    ..The prevalence of the metabolic syndrome (MS) is growing. The Adult Treatment Panel (ATP) III provided a uniform definition of MS but no information on its predictive ability...
  61. doi request reprint Atrial fibrillation is independently associated with senile, vascular, and Alzheimer's dementia
    T Jared Bunch
    Intermountain Heart Rhythm Specialists, Intermountain Medical Center, Murray, Utah 84107, USA
    Heart Rhythm 7:433-7. 2010
    ..Recent focus has been placed on understanding the long-term consequences of chronic cardiovascular disease, such as a potential increased risk of dementia...
  62. ncbi request reprint Prevalence and risks of allosensitization in HeartMate left ventricular assist device recipients: the impact of leukofiltered cellular blood product transfusions
    Stavros G Drakos
    Utah Transplantation Affiliated Hospitals UTAH Cardiac Transplant Program, Salt Lake City, Utah, USA
    J Thorac Cardiovasc Surg 133:1612-9. 2007
    ..We investigated the pattern of sensitization in left ventricular assist device recipients in relation to cellular blood product transfusions received...
  63. doi request reprint Lack of association of tegaserod with adverse cardiovascular outcomes in a matched case-control study
    Jeffrey L Anderson
    Cardiovascular Department, Intermountain Medical Center, Murray, Utah 84107, USA
    J Cardiovasc Pharmacol Ther 14:170-5. 2009
    ..This large epidemiologic study failed to confirm a reported large event differential for tegaserod that was noted incidentally in a clinical trials database, suggesting that the prior observation may have been due to chance...
  64. ncbi request reprint Do associations with C-reactive protein and extent of coronary artery disease account for the increased cardiovascular risk of renal insufficiency?
    James S Zebrack
    Divisions of Cardiology and Nephrology, University of Utah School of Medicine, Salt Lake City, Utah, USA
    J Am Coll Cardiol 42:57-63. 2003
    ..We sought to determine whether the association of higher C-reactive protein levels (CRP) and more extensive coronary artery disease (CAD) explains the high cardiovascular risk of renal insufficiency (RI)...
  65. ncbi request reprint Identification of excess clustering of coronary heart diseases among extended pedigrees in a genealogical population database
    Benjamin D Horne
    Genetic Epidemiology Division, Department of Medical Informatics, University of Utah, Salt Lake City, UT 84108 1266, USA
    Am Heart J 152:305-11. 2006
    ..This study evaluated deaths caused by CAD, MI, hypertensive heart disease (HtnHD), and congestive heart failure (CHF) among close and distant relatives...
  66. ncbi request reprint Validation of the Seattle Heart Failure Model in a community-based heart failure population and enhancement by adding B-type natriuretic peptide
    Heidi T May
    LDS Hospital, Intermountain Medical Center, Salt Lake City, Utah, USA
    Am J Cardiol 100:697-700. 2007
    ..02). In conclusion, the SHFM predicts survival in patients with HF in a hospital-based population, with areas under the curve similar to those from data on which models were initially fit...
  67. doi request reprint Warfarin knowledge in patients with atrial fibrillation: implications for safety, efficacy, and education strategies
    Megan B Smith
    Department of Nutrition, Dietetics and Food Sciences, Utah State University, Logan, Utah, USA
    Cardiology 116:61-9. 2010
    ..Multiple factors influence warfarin metabolism and can significantly affect the risk of adverse events. The extent to which patients understand the modifiable factors that impact on warfarin safety and efficacy is unclear...
  68. doi request reprint An evaluation of nine genetic variants related to metabolism and mechanism of action of warfarin as applied to stable dose prediction
    John F Carlquist
    Cardiovascular Department, Intermountain Medical Center, 5121 South Cottonwood Street, Murray, UT 84157, USA
    J Thromb Thrombolysis 30:358-64. 2010
    ..Addition of VKORC1 SNP -1639 to a model eliminated the association of VKORC1 3730 with warfarin dose (P-trend = 0.74), but -1639 remained highly significant. No impact on dose was observed for the other tested genetic variants...
  69. ncbi request reprint Effect of mechanical circulatory support on outcomes after heart transplantation
    Stavros G Drakos
    Utah Transplantation Affiliate Hospitals Cardiac Transplant Program, Salt Lake City, UT, USA
    J Heart Lung Transplant 25:22-8. 2006
    ....
  70. ncbi request reprint Which white blood cell subtypes predict increased cardiovascular risk?
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    J Am Coll Cardiol 45:1638-43. 2005
    ..We sought to determine the predictive ability of total white blood cell (WBC) count and its subtypes for risk of death or myocardial infarction (MI)...
  71. ncbi request reprint Improved long-term survival associated with stent deployment during percutaneous coronary interventions: results from a registry of 3399 patients
    Joseph B Muhlestein
    Division of Cardiology, Department of Cardiovascular Medicine, LDS Hospital, Salt Lake City, Utah 84143, USA
    Am Heart J 150:182-7. 2005
    ..However, few studies have had a sufficient sample size or adequate follow-up to determine whether this advantage results in a positive effect on mortality...
  72. ncbi request reprint Statin therapy is associated with reduced mortality across all age groups of individuals with significant coronary disease, including very elderly patients
    Chloe A Allen Maycock
    Cardiology Research, LDS Hospital, 8th Avenue and C Street, Salt Lake City, Utah 84143, USA
    J Am Coll Cardiol 40:1777-85. 2002
    ..This study evaluated the effect of statin therapy on mortality in individuals with significant coronary artery disease (CAD) stratified by age...
  73. ncbi request reprint Effect of reversible pulmonary hypertension on outcomes after heart transplantation
    Stavros G Drakos
    Utah Transplantation Affiliated Hospitals, Cardiac Transplant Program, LDS Hospital, Salt Lake City, Utah 84143, USA
    J Heart Lung Transplant 26:319-23. 2007
    ..Conflicting data exist regarding the impact of reversible pulmonary hypertension (PHTN) on post-transplant (Tx) outcomes. In this study we sought to determine the influence of reversible PHTN on outcomes after Tx...
  74. ncbi request reprint The reduction of inflammatory biomarkers by statin, fibrate, and combination therapy among diabetic patients with mixed dyslipidemia: the DIACOR (Diabetes and Combined Lipid Therapy Regimen) study
    Joseph B Muhlestein
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    J Am Coll Cardiol 48:396-401. 2006
    ..The primary objective was to determine the effect of statin-fibrate combination therapy on inflammatory biomarkers in patients with diabetes...
  75. ncbi request reprint Usefulness of high-sensitivity C-reactive protein in predicting long-term risk of death or acute myocardial infarction in patients with unstable or stable angina pectoris or acute myocardial infarction
    James S Zebrack
    University of Utah School of Medicine, Salt Lake City, Utah 84132 2401, USA
    Am J Cardiol 89:145-9. 2002
    ....
  76. doi request reprint Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population
    Jeffrey L Anderson
    Cardiovascular Department, Intermountain Medical Center, Murray, Utah, USA
    Am J Cardiol 106:963-8. 2010
    ..Given the ease of vitamin D measurement and replacement, prospective studies of vitamin D supplementation to prevent and treat CV disease are urgently needed...
  77. doi request reprint Depression after coronary artery disease is associated with heart failure
    Heidi T May
    Intermountain Medical Center, Cardiovascular Research, Murray, Utah 84157, USA
    J Am Coll Cardiol 53:1440-7. 2009
    ..The purpose of this study was to evaluate the influence of post-coronary artery disease (CAD) depression diagnosis on heart failure (HF) incidence...
  78. ncbi request reprint Preoperative use of enoxaparin compared with unfractionated heparin increases the incidence of re-exploration for postoperative bleeding after open-heart surgery in patients who present with an acute coronary syndrome: clinical investigation and reports
    Heath U Jones
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    Circulation 106:I19-22. 2002
    ....
  79. doi request reprint Relation of bisphosphonate therapies and risk of developing atrial fibrillation
    T Jared Bunch
    Intermountain Heart Rhythm Specialists, Intermountain Medical Center, Murray, UT, USA
    Am J Cardiol 103:824-8. 2009
    ..However, patients who received bisphosphonates were older and had more cardiovascular disease that we suspect accounts for the increased arrhythmia risk reported in other trials...
  80. ncbi request reprint Evidence for a heritable component in death resulting from aortic and mitral valve diseases
    Benjamin D Horne
    Genetic Epidemiology Division, Department of Medical Informatics, University of Utah, 391 Chipeta Way, Suite D, Salt Lake City, UT 84108 1266, USA
    Circulation 110:3143-8. 2004
    ..This study evaluated the familiality of death resulting from aortic, mitral, and all valvular diseases using a population-based genealogy linked to death records...
  81. ncbi request reprint Progress in unraveling the genetics of coronary artery disease and myocardial infarction
    Jeffrey L Anderson
    Department of Cardiology, LDS Hospital, Salt Lake City, UT 84143, USA
    Curr Atheroscler Rep 9:179-86. 2007
    ..Despite the complexity of coronary heart disease genetics, steady progress can be expected...
  82. ncbi request reprint Effect of implementation of folic acid fortification of food on homocysteine concentrations in subjects with coronary artery disease
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, and University of Utah School of Medicine, Salt Lake City, Utah 84143, USA
    Am J Cardiol 90:536-9. 2002
  83. ncbi request reprint Effects of statins on six-month survival and clinical restenosis frequency after coronary stent deployment
    T Jared Bunch
    Cardiovascular Department, LDS Hospital and University of Utah, Salt Lake City 84143, USA
    Am J Cardiol 90:299-302. 2002
  84. ncbi request reprint Principal component analysis for selection of optimal SNP-sets that capture intragenic genetic variation
    Benjamin D Horne
    Genetic Epidemiology Division, Department of Medical Informatics, University of Utah, Salt Lake City, Utah 84112, USA
    Genet Epidemiol 26:11-21. 2004
    ..Our findings suggest that PCA may be a powerful tool for establishing an optimal SNP set that maximizes the amount of genetic variation captured for a candidate gene using a minimal number of SNPs...
  85. ncbi request reprint C-reactive protein and angiographic coronary artery disease: independent and additive predictors of risk in subjects with angina
    James S Zebrack
    Division of Cardiology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    J Am Coll Cardiol 39:632-7. 2002
    ..The objective of this study was to determine the prognostic value of C-reactive protein (CRP) independent of coronary angiographic findings...
  86. pmc Comparison of linkage analysis methods for genome-wide scanning of extended pedigrees, with application to the TG/HDL-C ratio in the Framingham Heart Study
    Benjamin D Horne
    Genetic Epidemiology, Department of Medical Informatics, University of Utah School of Medicine, Salt Lake City, Utah, USA
    BMC Genet 4:S93. 2003
    ..Results were compared to each other and to those from a previous evaluation using SOLAR for TG/HDL-C ratio on this sample. We also investigated linked pedigrees in each region using by-pedigree analysis...
  87. ncbi request reprint Characterization of linkage disequilibrium structure, mutation history, and tagging SNPs, and their use in association analyses: ELAC2 and familial early-onset prostate cancer
    Nicola J Camp
    Genetic Epidemiology Division, Department of Medical Informatics, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Genet Epidemiol 28:232-43. 2005
    ....
  88. ncbi request reprint Comparison of differing C-reactive protein assay methods and their impact on cardiovascular risk assessment
    Jessica L Clarke
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    Am J Cardiol 95:155-8. 2005
    ..This suggests that the conclusions of previous studies performed using the medium-sensitivity assay are still valid but that cross-study comparisons should use percentile rank...
  89. doi request reprint Relation of heart failure hospitalization to exposure to fine particulate air pollution
    C Arden Pope
    Brigham Young University, Provo, Utah, USA
    Am J Cardiol 102:1230-4. 2008
    ....
  90. pmc Validation study of genetic associations with coronary artery disease on chromosome 3q13-21 and potential effect modification by smoking
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, Salt Lake City, UT, USA
    Ann Hum Genet 73:551-8. 2009
    ..Genetic risk conferred by some of these genes may be modified by smoking. Future CAD association studies of these and other genes should evaluate effect modification by smoking...
  91. ncbi request reprint Atrial dimensions in health and left ventricular disease using cardiovascular magnetic resonance
    Jeffrey L Anderson
    LDS Hospital, University of Utah School of Medicine, Salt Lake City, Utah, USA
    J Cardiovasc Magn Reson 7:671-5. 2005
    ..We assessed atrial size by CMR in healthy and diseased subjects to determine normal adult ranges...
  92. ncbi request reprint Cardiovascular pharmacogenomics: current status, future prospects
    Jeffrey L Anderson
    Intermountain Heart Collaborative Research Group, LDS Hospital Cardiovascular Department, and University of Utah School of Medicine, Salt Lake City, Utah 84143, USA
    J Cardiovasc Pharmacol Ther 8:71-83. 2003
    ..Rapid research progress and initial clinical applications with pharmacogenomics are foreseen in the near future...
  93. ncbi request reprint Impact of renal failure on the risk of myocardial infarction and death
    Srinivasan Beddhu
    Renal Section, Salt Lake VA Healthcare System, Salt Lake City, Utah, USA
    Kidney Int 62:1776-83. 2002
    ..We examined whether renal failure independently increases the risk of myocardial infarction and death...
  94. ncbi request reprint Lack of association of Helicobacter pylori infection with coronary artery disease and frequency of acute myocardial infarction or death
    Jianhui Zhu
    Cardiovascular Research Institute of the MedStar Research Institute, Washington Hospital Center, Washington, DC 20010, USA
    Am J Cardiol 89:155-8. 2002
    ..pylori seropositivity was 1.12 (95% confidence interval 0.81 to 1.54). Our data suggest that prior infection with H. pylori is not a major factor determining either risk of CAD, AMI, or death in patients with CAD...
  95. ncbi request reprint Serum immunoglobulin G antibodies to chlamydial heat shock protein 60 but not to human and bacterial homologs are associated with coronary artery disease
    Olaimatu S Mahdi
    Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, USA
    Circulation 106:1659-63. 2002
    ..Our aim was to determine if chlamydial Hsp (cHsp) antibody responses are predictive of CAD...
  96. ncbi request reprint Greater pathogen burden but not elevated C-reactive protein increases the risk of clinical restenosis after percutaneous coronary intervention
    Benjamin D Horne
    LDS Hospital, Salt Lake City, Utah 84143, USA
    Am Heart J 144:491-500. 2002
    ....
  97. doi request reprint Frequency of helicobacter pylori seropositivity and C-reactive protein increase in atrial fibrillation in patients undergoing coronary angiography
    T Jared Bunch
    Division of Cardiovascular Disease, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Am J Cardiol 101:848-51. 2008
    ..Although older age was highly associated with AF risk in this population, H pylori was additive across 3 distinct age groups, with the highest risk conveyed in the younger cohort...
  98. ncbi request reprint Serum uric acid independently predicts mortality in patients with significant, angiographically defined coronary disease
    Troy E Madsen
    Ohio State University Medical Center, Columbus, OH 43210, USA
    Am J Nephrol 25:45-9. 2005
    ..This study prospectively evaluated the predictive value of serum uric acid (SUA) levels for mortality after angiographic diagnosis of CAD...
  99. ncbi request reprint Effect of folic acid fortification of food on homocysteine-related mortality
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, and University of Utah, Salt Lake City, Utah 84143, USA
    Am J Med 116:158-64. 2004
    ..In 1998, the Food and Drug Administration mandated the fortification of food products with folic acid. The effect of this rule on mortality associated with homocysteine levels in patients with coronary artery disease is unknown...
  100. ncbi request reprint Ischemic heart disease events triggered by short-term exposure to fine particulate air pollution
    C Arden Pope
    Brigham Young University, Provo, UT 84602 2363, USA
    Circulation 114:2443-8. 2006
    ..These findings are inconclusive and controversial and require further study. This study evaluates the role of short-term particulate exposure in triggering acute ischemic heart disease events...