Jeffrey L Anderson

Summary

Affiliation: Intermountain Medical Center
Country: USA

Publications

  1. doi request reprint A randomized and clinical effectiveness trial comparing two pharmacogenetic algorithms and standard care for individualizing warfarin dosing (CoumaGen-II)
    Jeffrey L Anderson
    Intermountain Medical Center, Cardiovascular Department, Murray, UT 84107 5701, USA
    Circulation 125:1997-2005. 2012
  2. pmc Statistical design of personalized medicine interventions: the Clarification of Optimal Anticoagulation through Genetics (COAG) trial
    Benjamin French
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, Pennsylvania 19104, USA
    Trials 11:108. 2010
  3. pmc Cardiac magnetic resonance versus transthoracic echocardiography for the assessment of cardiac volumes and regional function after myocardial infarction: an intrasubject comparison using simultaneous intrasubject recordings
    Blake I Gardner
    Cardiovascular Department, Intermountain Medical Center, Intermountain Healthcare, Murray, UT 84157, USA
    Cardiovasc Ultrasound 7:38. 2009
  4. pmc Evaluation of genetic risk scores for lipid levels using genome-wide markers in the Framingham Heart Study
    Stephen R Piccolo
    Department of Biomedical Informatics, School of Medicine, University of Utah, 26 South 2000 East, Salt Lake City, Utah 84112, USA
    BMC Proc 3:S46. 2009
  5. ncbi request reprint Parathyroid hormone, vitamin D, renal dysfunction, and cardiovascular disease: dependent or independent risk factors?
    Jeffrey L Anderson
    Cardiovascular Department, Intermountain Medical Center, Murray, UT 84107 5701, USA
    Am Heart J 162:331-339.e2. 2011
  6. doi request reprint Lack of association of tegaserod with adverse cardiovascular outcomes in a matched case-control study
    Jeffrey L Anderson
    Cardiovascular Department, Intermountain Medical Center, Murray, Utah 84107, USA
    J Cardiovasc Pharmacol Ther 14:170-5. 2009
  7. doi request reprint Genetic variation at the 9p21 locus predicts angiographic coronary artery disease prevalence but not extent and has clinical utility
    Jeffrey L Anderson
    Cardiovascular Department, Intermountain Medical Center, Murray, UT 84107, USA
    Am Heart J 156:1155-1162.e2. 2008
  8. pmc Joint effects of common genetic variants from multiple genes and pathways on the risk of premature coronary artery disease
    Jeffrey L Anderson
    Cardiovascular Department, Intermountain Medical Center, Murray, UT 84107, USA
    Am Heart J 160:250-256.e3. 2010
  9. doi request reprint Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population
    Jeffrey L Anderson
    Cardiovascular Department, Intermountain Medical Center, Murray, Utah, USA
    Am J Cardiol 106:963-8. 2010
  10. ncbi request reprint Candidate gene susceptibility variants predict intermediate end points but not angiographic coronary artery disease
    Bryant M Whiting
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    Am Heart J 150:243-50. 2005

Detail Information

Publications81

  1. doi request reprint A randomized and clinical effectiveness trial comparing two pharmacogenetic algorithms and standard care for individualizing warfarin dosing (CoumaGen-II)
    Jeffrey L Anderson
    Intermountain Medical Center, Cardiovascular Department, Murray, UT 84107 5701, USA
    Circulation 125:1997-2005. 2012
    ..Warfarin is characterized by marked variations in individual dose requirements and a narrow therapeutic window. Pharmacogenetics (PG) could improve dosing efficiency and safety, but clinical trials evidence is meager...
  2. pmc Statistical design of personalized medicine interventions: the Clarification of Optimal Anticoagulation through Genetics (COAG) trial
    Benjamin French
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, Pennsylvania 19104, USA
    Trials 11:108. 2010
    ....
  3. pmc Cardiac magnetic resonance versus transthoracic echocardiography for the assessment of cardiac volumes and regional function after myocardial infarction: an intrasubject comparison using simultaneous intrasubject recordings
    Blake I Gardner
    Cardiovascular Department, Intermountain Medical Center, Intermountain Healthcare, Murray, UT 84157, USA
    Cardiovasc Ultrasound 7:38. 2009
    ....
  4. pmc Evaluation of genetic risk scores for lipid levels using genome-wide markers in the Framingham Heart Study
    Stephen R Piccolo
    Department of Biomedical Informatics, School of Medicine, University of Utah, 26 South 2000 East, Salt Lake City, Utah 84112, USA
    BMC Proc 3:S46. 2009
    ..In this paper, we evaluate a weighted and an unweighted approach for estimating the combined effect of multiple markers (using genotypes and haplotypes) on lipid levels for a given individual...
  5. ncbi request reprint Parathyroid hormone, vitamin D, renal dysfunction, and cardiovascular disease: dependent or independent risk factors?
    Jeffrey L Anderson
    Cardiovascular Department, Intermountain Medical Center, Murray, UT 84107 5701, USA
    Am Heart J 162:331-339.e2. 2011
    ..We tested whether elevated PTH is associated with CV disease and whether risk associations depend on Vit D status and renal function...
  6. doi request reprint Lack of association of tegaserod with adverse cardiovascular outcomes in a matched case-control study
    Jeffrey L Anderson
    Cardiovascular Department, Intermountain Medical Center, Murray, Utah 84107, USA
    J Cardiovasc Pharmacol Ther 14:170-5. 2009
    ..This large epidemiologic study failed to confirm a reported large event differential for tegaserod that was noted incidentally in a clinical trials database, suggesting that the prior observation may have been due to chance...
  7. doi request reprint Genetic variation at the 9p21 locus predicts angiographic coronary artery disease prevalence but not extent and has clinical utility
    Jeffrey L Anderson
    Cardiovascular Department, Intermountain Medical Center, Murray, UT 84107, USA
    Am Heart J 156:1155-1162.e2. 2008
    ..Variants at the 9p21 locus have been associated with coronary heart disease, but their precise disease phenotype and utility for clinical risk assessment are uncertain...
  8. pmc Joint effects of common genetic variants from multiple genes and pathways on the risk of premature coronary artery disease
    Jeffrey L Anderson
    Cardiovascular Department, Intermountain Medical Center, Murray, UT 84107, USA
    Am Heart J 160:250-256.e3. 2010
    ....
  9. doi request reprint Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population
    Jeffrey L Anderson
    Cardiovascular Department, Intermountain Medical Center, Murray, Utah, USA
    Am J Cardiol 106:963-8. 2010
    ..Given the ease of vitamin D measurement and replacement, prospective studies of vitamin D supplementation to prevent and treat CV disease are urgently needed...
  10. ncbi request reprint Candidate gene susceptibility variants predict intermediate end points but not angiographic coronary artery disease
    Bryant M Whiting
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    Am Heart J 150:243-50. 2005
    ..Moderate-sized studies have suggested that variants of candidate genes can influence laboratory markers of coronary artery disease (CAD), but whether they predict parallel changes in clinical CAD risk is unknown...
  11. ncbi request reprint C-reactive protein predicts death in patients with non-ischemic cardiomyopathy
    Brianna S Ronnow
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    Cardiology 104:196-201. 2005
    ..0) significantly and independently predicted mortality. Even in the absence of coronary artery disease, patients with left ventricular dysfunction are at increased risk of mortality based on their baseline CRP concentrations...
  12. doi request reprint Exceptional mortality prediction by risk scores from common laboratory tests
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, Murray, Utah 84157, USA
    Am J Med 122:550-8. 2009
    ..Many of their components are not commonly used, but they might contain independent risk information. This study tested the ability of a risk score combining all components to predict all-cause mortality...
  13. ncbi request reprint Multiple less common genetic variants explain the association of the cholesteryl ester transfer protein gene with coronary artery disease
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Intermountain Medical Center, University of Utah, Salt Lake City, Utah 84143, USA
    J Am Coll Cardiol 49:2053-60. 2007
    ....
  14. doi request reprint The Intermountain Risk Score (including the red cell distribution width) predicts heart failure and other morbidity endpoints
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, 5121 S Cottonwood St, Salt Lake City, UT 84107, USA
    Eur J Heart Fail 12:1203-13. 2010
    ..Mortality is the most definitive clinical endpoint, but medical care is more easily applied to modify morbidity and thereby prevent death. This study tested whether IMRS is associated with clinical morbidity endpoints...
  15. ncbi request reprint Randomized trial of genotype-guided versus standard warfarin dosing in patients initiating oral anticoagulation
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, Intermountain Healthcare, Salt Lake City, UT, USA
    Circulation 116:2563-70. 2007
    ..Pharmacogenetic-guided dosing of warfarin is a promising application of "personalized medicine" but has not been adequately tested in randomized trials...
  16. doi request reprint Comparison of effects of simvastatin alone versus fenofibrate alone versus simvastatin plus fenofibrate on lipoprotein subparticle profiles in diabetic patients with mixed dyslipidemia (from the Diabetes and Combined Lipid Therapy Regimen study)
    Heidi T May
    Intermountain Medical Center and LDS Hospital, Salt Lake City, Utah, USA
    Am J Cardiol 101:486-9. 2008
    ..In conclusion, in this trial of mixed dyslipidemic patients with diabetes, combination therapy was more effective in changing a variety of other cardiovascular risk markers...
  17. doi request reprint Relation of elevated plasma renin activity at baseline to cardiac events in patients with angiographically proven coronary artery disease
    Joseph B Muhlestein
    Intermountain Medical Center, Murray, Utah University of Utah, Salt Lake City, Utah, USA
    Am J Cardiol 106:764-9. 2010
    ..In conclusion, elevated baseline PRA is associated with cardiac morbidity and mortality in patients with coronary artery disease but normal left ventricular function and no previous MI or HF...
  18. doi request reprint Trends in early and late mortality in patients undergoing coronary catheterization for myocardial infarction: implications on observation periods and risk factors to determine ICD candidacy
    T Jared Bunch
    Intermountain Heart Rhythm Specialists, Intermountain Medical Center, Murray, Utah 84107, USA
    Heart Rhythm 8:1460-6. 2011
    ..Survivors of acute myocardial infarction (MI) are at high risk for death from both sudden cardiac death and progressive heart failure...
  19. doi request reprint Validation and quantification of genetic determinants of lipoprotein-a levels and predictive value for angiographic coronary artery disease
    Jeffrey L Anderson
    Intermountain Healthcare Intermountain Medical Center, Murray, UT, USA
    Am J Cardiol 112:799-804. 2013
    ..The percentage of intersubject variability in Lp(a) cholesterol and the percentage of prevalent CAD explained were small...
  20. ncbi request reprint Lipoprotein-associated phospholipase A2 independently predicts the angiographic diagnosis of coronary artery disease and coronary death
    Heidi T May
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    Am Heart J 152:997-1003. 2006
    ..We evaluated the independent association of lipoprotein-associated phospholipase A2 (Lp-PLA2) to angiographic CAD and CV events adjusting for standard factors, lipids, and CRP...
  21. doi request reprint Relation of routine, periodic fasting to risk of diabetes mellitus, and coronary artery disease in patients undergoing coronary angiography
    Benjamin D Horne
    Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, Utah, USA
    Am J Cardiol 109:1558-62. 2012
    ..A reported fasting association with a lower CAD risk was also validated and fasting associations with lower glucose and BMI were found...
  22. ncbi request reprint Genotypes of the cytochrome p450 isoform, CYP2C9, and the vitamin K epoxide reductase complex subunit 1 conjointly determine stable warfarin dose: a prospective study
    John F Carlquist
    Department of Medicine, Division of Cardiology, University of Utah School of Medicine, Cardiovascular Department, LDS Hospital, Salt Lake City, Utah, USA
    J Thromb Thrombolysis 22:191-7. 2006
    ..vitamin K epoxide reductase complex subunit 1-VKORC1). We hypothesized that variants in these two genes explain a substantial proportion of variability in stable warfarin dose and could be used as a basis for improved dosing algorithms...
  23. doi request reprint The intermountain risk score predicts incremental age-specific long-term survival and life expectancy
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, Salt Lake City, Utah, USA
    Transl Res 158:307-14. 2011
    ..IMRS may be used to stratify age-specific risk of mortality in research, clinical/preventive, and quality improvement applications. A web calculator is located at http://intermountainhealthcare.org/IMRS...
  24. doi request reprint Long-term clinical efficacy and risk of catheter ablation for atrial fibrillation in octogenarians
    T Jared Bunch
    Intermountain Heart Rhythm Specialists, Intermountain Medical Center, Eccles Outpatient Care Center, 5169 Cottonwood St, Murray, UT 84107, USA
    Pacing Clin Electrophysiol 33:146-52. 2010
    ..With improved safety, the therapy has been offered to increasingly older populations. Arrhythmia mechanisms, medical comorbidities, and safety may vary in the very elderly population...
  25. doi request reprint Warfarin is not needed in low-risk patients following atrial fibrillation ablation procedures
    T Jared Bunch
    Intermountain Heart Rhythm Specialists, Intermountain Medical Center, Murray, Utah 84107, USA
    J Cardiovasc Electrophysiol 20:988-93. 2009
    ..The objective of the study was to assess outcomes based upon anticoagulation practice after atrial fibrillation (AF) ablation to determine relative risk of a strategy of aspirin only in low-risk patients...
  26. doi request reprint Superior predictive ability for death of a basic metabolic profile risk score
    Heidi T May
    Intermountain Medical Center, Murray, UT 84157, USA
    Am Heart J 157:946-54. 2009
    ..Although individual variables are checked for cardiovascular health and risk, combining them into a total BMP-derived score, as to maximize BMP predictive ability, has not been previously attempted...
  27. pmc Usefulness of routine periodic fasting to lower risk of coronary artery disease in patients undergoing coronary angiography
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, Murray, Utah, USA
    Am J Cardiol 102:814-819. 2008
    ..In conclusion, not only proscription of tobacco, but also routine periodic fasting was associated with lower risk of CAD...
  28. pmc Association of variation in the chromosome 9p21 locus with myocardial infarction versus chronic coronary artery disease
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, Murray, UT 84157, USA
    Circ Cardiovasc Genet 1:85-92. 2008
    ..Using angiographic coronary artery disease (CAD) phenotyping, this study evaluated whether 9p21 single-nucleotide polymorphisms predict ischemic events (eg, myocardial infarction [MI]) among CAD patients...
  29. ncbi request reprint Asymmetric dimethylarginine, cortisol/cortisone ratio, and C-peptide: markers for diabetes and cardiovascular risk?
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    Am Heart J 153:67-73. 2007
    ....
  30. doi request reprint Association of vitamin D levels with incident depression among a general cardiovascular population
    Heidi T May
    Intermountain Medical Center, Murray, UT 84157, USA
    Am Heart J 159:1037-43. 2010
    ..Therefore, we evaluated whether there is an association between vitD and incident depression among a CV population...
  31. ncbi request reprint The role of a common adenosine monophosphate deaminase (AMPD)-1 polymorphism in outcomes of ischemic and nonischemic heart failure
    Matthew J Kolek
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    J Card Fail 11:677-83. 2005
    ..A common variant of the adenosine monophosphate deaminase (AMPD)-1 gene (C34T) results in enzymatic inactivity and may increase adenosine in cardiac muscle and confer cardioprotection through ischemic preconditioning...
  32. ncbi request reprint Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammation, angiographic coronary artery disease, and clinical diabetes
    Matthew J Kolek
    Cardiovascular Department, Division of Cardiology, LDS Hospital, Salt Lake City, Utah 84143, USA
    Am Heart J 148:1034-40. 2004
    ..We evaluated whether the Asp299Gly polymorphism in the TLR4 gene, which impairs inflammatory responses, is associated with reduced vascular inflammation (assessed by C-reactive protein [CRP]) and a decreased risk for CAD and diabetes...
  33. doi request reprint Atrial fibrillation ablation patients have long-term stroke rates similar to patients without atrial fibrillation regardless of CHADS2 score
    T Jared Bunch
    Intermountain Heart Institute, Intermountain Medical Center, Murray, Utah 84107, USA
    Heart Rhythm 10:1272-7. 2013
    ..Stroke risk after AF ablation appears to be favorably affected; however, it is largely unknown whether the benefit extends to all stroke CHADS2 risk profiles of AF patients...
  34. doi request reprint Increasing time between first diagnosis of atrial fibrillation and catheter ablation adversely affects long-term outcomes
    T Jared Bunch
    Intermountain Heart Institute, Intermountain Medical Center, Murray, Utah 84107, USA
    Heart Rhythm 10:1257-62. 2013
    ..The optimal time to proceed with catheter ablation during the disease course is unknown. Further, whether delays in treatment will negatively influence outcomes is unknown...
  35. ncbi request reprint Patients treated with catheter ablation for atrial fibrillation have long-term rates of death, stroke, and dementia similar to patients without atrial fibrillation
    T Jared Bunch
    Intermountain Heart Rhythm Specialists Department of Cardiology, Intermountain Medical Center, Murray, Utah 84107, USA
    J Cardiovasc Electrophysiol 22:839-45. 2011
    ..AF ablation eliminates AF in most patients. We evaluated the long-term impact of AF ablation on mortality, heart failure (HF), stroke, and dementia in a large system-wide patient population...
  36. ncbi request reprint Associations with myocardial infarction of six polymorphisms selected from a three-stage genome-wide association study
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Intermountain Medical Center, Salt Lake City, UT 84143, USA
    Am Heart J 154:969-75. 2007
    ..In an independent but demographically similar population, this study tested 6 SNPs that were previously reported to be associated with MI...
  37. ncbi request reprint Less affluent area of residence and lesser-insured status predict an increased risk of death or myocardial infarction after angiographic diagnosis of coronary disease
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    Ann Epidemiol 14:143-50. 2004
    ..Low socioeconomic status (SES) predicts coronary artery disease (CAD) onset, but its value among patients with CAD is uncertain. Geographic measures (e.g., residential neighborhood) may predict risk, but this requires further evaluation...
  38. ncbi request reprint Early effects of statins in patients with coronary artery disease and high C-reactive protein
    Joseph B Muhlestein
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    Am J Cardiol 94:1107-12. 2004
    ..This provides further evidence of an anti-inflammatory effect of statins...
  39. pmc Multiple-polymorphism associations of 7 matrix metalloproteinase and tissue inhibitor metalloproteinase genes with myocardial infarction and angiographic coronary artery disease
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Intermountain Medical Center, Salt Lake City, UT 84143, USA
    Am Heart J 154:751-8. 2007
    ..Furthermore, differentiation of predictive ability by end point (MI vs CAD) has not been addressed. This study evaluated the association with MI of SNPs in genes encoding MMPs 1, 2, 3, and 9 and TIMPs 1, 2, and 3...
  40. ncbi request reprint Surgical revascularization is associated with improved long-term outcomes compared with percutaneous stenting in most subgroups of patients with multivessel coronary artery disease: results from the Intermountain Heart Registry
    Tami L Bair
    Cardiovascular Department, University of Utah, Salt Lake City, USA
    Circulation 116:I226-31. 2007
    ..In this study, we examined the outcomes of major adverse cardiovascular events and death for subgroups of typical "real-world" patients undergoing coronary revascularization in the modern era...
  41. ncbi request reprint Usefulness of a complete blood count-derived risk score to predict incident mortality in patients with suspected cardiovascular disease
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, and University of Utah, Salt Lake City, Utah, USA
    Am J Cardiol 99:169-74. 2007
    ..A total CBC score is an important new addition to risk prediction, and it can be easily generated by computer for clinical use at negligible incremental cost...
  42. pmc Repeated measurement of the intermountain risk score enhances prognostication for mortality
    Benjamin D Horne
    Intermountain Heart Institute, Intermountain Medical Center, Salt Lake City, Utah, USA
    PLoS ONE 8:e69160. 2013
    ..Whether longitudinal repeated measurement of IMRS is useful for prognostication is an important question for its clinical applicability...
  43. doi request reprint Cardiovascular risk among patients on clopidogrel anti-platelet therapy after placement of drug-eluting stents is modified by genetic variants in both the CYP2C19 and ABCB1 genes
    John F Carlquist
    John Carlquist, PhD, Intermountain Heart Institute, Intermountain Medical Center, 5121 S Cottonwood Street, Murray, UT 84157, USA
    Thromb Haemost 109:744-54. 2013
    ..This trend was largely reversed by the simultaneous carriage of one or two *17 alleles. These findings suggest that assessment of a combined genotype may improve risk assessment...
  44. ncbi request reprint Comparison of differing C-reactive protein assay methods and their impact on cardiovascular risk assessment
    Jessica L Clarke
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    Am J Cardiol 95:155-8. 2005
    ..This suggests that the conclusions of previous studies performed using the medium-sensitivity assay are still valid but that cross-study comparisons should use percentile rank...
  45. doi request reprint A strategy of rapid cardioversion minimizes the significance of early recurrent atrial tachyarrhythmias after ablation for atrial fibrillation
    Gangadhar Malasana
    University of Utah, Salt Lake City, Utah, USA
    J Cardiovasc Electrophysiol 22:761-6. 2011
    ..Aggressive attempts to restore sinus rhythm in the temporal period of healing after ablation might improve outcomes...
  46. doi request reprint Atrial fibrillation hospitalization is not increased with short-term elevations in exposure to fine particulate air pollution
    T Jared Bunch
    Intermountain Heart Rhythm Specialists, Intermountain Medical Center, Murray, Utah 84107, USA
    Pacing Clin Electrophysiol 34:1475-9. 2011
    ..This study explored the potential associations between short-term elevations in PM exposure and atrial fibrillation (AF)...
  47. ncbi request reprint A common variant of the AMPD1 gene predicts improved survival in patients with ischemic left ventricular dysfunction
    Yoshikazu Yazaki
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    J Card Fail 10:316-20. 2004
    ..This variant might lead to ischemic preconditioning by increasing tissue adenosine. We tested whether the survival benefit of C34T occurs preferentially in the setting of ischemic left ventricular dysfunction...
  48. ncbi request reprint Do statins increase the risk of idiopathic polyneuropathy?
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, Cardiology Division, Intermountain Health Care, Salt Lake City, Utah 84143, USA
    Am J Cardiol 95:1097-9. 2005
    ..It was found that statin use before diagnosis was not significantly greater in patients than controls (odds ratio 1.30, 95% confidence interval 0.3 to 2.1, p = 0.27), nor were doses different between patients and controls...
  49. ncbi request reprint Comparison of effects of high (80 mg) versus low (20 mg) dose of simvastatin on C-reactive protein and lipoproteins in patients with angiographic evidence of coronary arterial narrowing
    Kent G Meredith
    Cardiovascular Department, LDS Hospital, Division of Cardiology, University of Utah, Salt Lake City, Utah, USA
    Am J Cardiol 99:149-53. 2007
    ..In conclusion, this randomized trial in patients with chronic stable coronary artery disease showed a strong dose response for simvastatin for total and low-density lipoprotein cholesterol lowering but not for hs-CRP...
  50. ncbi request reprint Statin therapy interacts with cytomegalovirus seropositivity and high C-reactive protein in reducing mortality among patients with angiographically significant coronary disease
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    Circulation 107:258-63. 2003
    ..This study prospectively evaluated the effect of statins on CMV-and CRP-associated death among patients with significant, angiographically defined CAD...
  51. ncbi request reprint High-resolution characterization of linkage disequilibrium structure and selection of tagging single nucleotide polymorphisms: application to the cholesteryl ester transfer protein gene
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Salt Lake City, UT 84143, USA
    Ann Hum Genet 70:524-34. 2006
    ..This study provides an optimal set of tSNPs for association analyses of CETP. The observed complexity of LD structure highlights the importance of using methods, such as PCA, that allow for multiple dynamics in intragenic LD structure...
  52. ncbi request reprint The cholesteryl ester transfer protein Taq1B gene polymorphism predicts clinical benefit of statin therapy in patients with significant coronary artery disease
    John F Carlquist
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    Am Heart J 146:1007-14. 2003
    ..We studied CETP Taq1B genotype, plasma HDL, and clinical events among all patients and patients stratified by statin treatment...
  53. doi request reprint Intracardiac ultrasound for esophageal anatomic assessment and localization during left atrial ablation for atrial fibrillation
    T Jared Bunch
    Intermountain Heart Rhythm Specialists, Intermountain Medical Center, Murray, Utah 84107, USA
    J Cardiovasc Electrophysiol 24:33-9. 2013
    ..Intracardiac ultrasound (ICE) can provide a real-time assessment of the esophagus during ablation. We hypothesized that ICE can accurately define esophageal anatomy and location to enhance avoidance strategies during ablation...
  54. doi request reprint Ranolazine reduces ventricular tachycardia burden and ICD shocks in patients with drug-refractory ICD shocks
    T Jared Bunch
    Intermountain Heart Rhythm Specialists, Intermountain Medical Center, Murray, Utah 84107, USA
    Pacing Clin Electrophysiol 34:1600-6. 2011
    ..Ranolazine may be an option for recurrent AAD-refractory ICD shocks secondary to VT, but its efficacy, outcomes, and tolerance are unknown...
  55. ncbi request reprint Sex- and age-related differences in the prognostic value of C-reactive protein in patients with angiographic coronary artery disease
    Lillian L C Khor
    Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA
    Am J Med 117:657-64. 2004
    ..To determine whether sex and age affect serum C-reactive protein level and its prognostic value in patients with coronary artery disease...
  56. ncbi request reprint Warfarin knowledge in patients with atrial fibrillation: implications for safety, efficacy, and education strategies
    Megan B Smith
    Department of Nutrition, Dietetics and Food Sciences, Utah State University, Logan, Utah, USA
    Cardiology 116:61-9. 2010
    ..Multiple factors influence warfarin metabolism and can significantly affect the risk of adverse events. The extent to which patients understand the modifiable factors that impact on warfarin safety and efficacy is unclear...
  57. doi request reprint Atrial fibrillation is independently associated with senile, vascular, and Alzheimer's dementia
    T Jared Bunch
    Intermountain Heart Rhythm Specialists, Intermountain Medical Center, Murray, Utah 84107, USA
    Heart Rhythm 7:433-7. 2010
    ..Recent focus has been placed on understanding the long-term consequences of chronic cardiovascular disease, such as a potential increased risk of dementia...
  58. pmc A new ratio for better predicting future death/myocardial infarction than standard lipid measurements in women >50 years undergoing coronary angiography: the apolipoprotein A1 remnant ratio (Apo A1/ [VLDL₃+IDL])
    Heidi T May
    Intermountain Medical Center, Cardiovascular Department, 5121 S Cottonwood Street, Murray, UT 84157, USA
    Lipids Health Dis 12:55. 2013
    ..Our objective was to evaluate standard- and sub-lipid parameters and the apo A1 remnant ratio: (apo A1/[VLDL₃-C+IDL-C]) for their associations with death/myocardial infarction among peri- and post-menopausal women...
  59. ncbi request reprint Frequency of elevation of C-reactive protein in atrial fibrillation
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, University of Utah, Salt Lake City 84143, USA
    Am J Cardiol 94:1255-9. 2004
    ..Increased CRP is a new risk marker for AF propensity, and testing therapies that target inflammation should be considered...
  60. ncbi request reprint Relation of bisphosphonate therapies and risk of developing atrial fibrillation
    T Jared Bunch
    Intermountain Heart Rhythm Specialists, Intermountain Medical Center, Murray, UT, USA
    Am J Cardiol 103:824-8. 2009
    ..However, patients who received bisphosphonates were older and had more cardiovascular disease that we suspect accounts for the increased arrhythmia risk reported in other trials...
  61. doi request reprint An evaluation of nine genetic variants related to metabolism and mechanism of action of warfarin as applied to stable dose prediction
    John F Carlquist
    Cardiovascular Department, Intermountain Medical Center, 5121 South Cottonwood Street, Murray, UT 84157, USA
    J Thromb Thrombolysis 30:358-64. 2010
    ..Addition of VKORC1 SNP -1639 to a model eliminated the association of VKORC1 3730 with warfarin dose (P-trend = 0.74), but -1639 remained highly significant. No impact on dose was observed for the other tested genetic variants...
  62. ncbi request reprint Early postoperative use of unfractionated heparin or enoxaparin is associated with increased surgical re-exploration for bleeding
    Heath U Jones
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah, USA
    Ann Thorac Surg 80:518-22. 2005
    ..exist for the use of unfractionated heparin (UFH) and enoxaparin (ENOX) in the early postoperative period following open-heart surgery. However, the overall postoperative risk for hemorrhage from the use of UFH and ENOX are not known...
  63. ncbi request reprint Which features of the metabolic syndrome predict the prevalence and clinical outcomes of angiographic coronary artery disease?
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital and University of Utah, Salt Lake City, Utah, USA
    Cardiology 101:185-93. 2004
    ..The prevalence of the metabolic syndrome (MS) is growing. The Adult Treatment Panel (ATP) III provided a uniform definition of MS but no information on its predictive ability...
  64. ncbi request reprint Effect of folic acid fortification of food on homocysteine-related mortality
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, and University of Utah, Salt Lake City, Utah 84143, USA
    Am J Med 116:158-64. 2004
    ..In 1998, the Food and Drug Administration mandated the fortification of food products with folic acid. The effect of this rule on mortality associated with homocysteine levels in patients with coronary artery disease is unknown...
  65. ncbi request reprint Validation of the Seattle Heart Failure Model in a community-based heart failure population and enhancement by adding B-type natriuretic peptide
    Heidi T May
    LDS Hospital, Intermountain Medical Center, Salt Lake City, Utah, USA
    Am J Cardiol 100:697-700. 2007
    ..02). In conclusion, the SHFM predicts survival in patients with HF in a hospital-based population, with areas under the curve similar to those from data on which models were initially fit...
  66. ncbi request reprint The reduction of inflammatory biomarkers by statin, fibrate, and combination therapy among diabetic patients with mixed dyslipidemia: the DIACOR (Diabetes and Combined Lipid Therapy Regimen) study
    Joseph B Muhlestein
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    J Am Coll Cardiol 48:396-401. 2006
    ..The primary objective was to determine the effect of statin-fibrate combination therapy on inflammatory biomarkers in patients with diabetes...
  67. ncbi request reprint Do associations with C-reactive protein and extent of coronary artery disease account for the increased cardiovascular risk of renal insufficiency?
    James S Zebrack
    Divisions of Cardiology and Nephrology, University of Utah School of Medicine, Salt Lake City, Utah, USA
    J Am Coll Cardiol 42:57-63. 2003
    ..We sought to determine whether the association of higher C-reactive protein levels (CRP) and more extensive coronary artery disease (CAD) explains the high cardiovascular risk of renal insufficiency (RI)...
  68. ncbi request reprint Which white blood cell subtypes predict increased cardiovascular risk?
    Benjamin D Horne
    Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    J Am Coll Cardiol 45:1638-43. 2005
    ..We sought to determine the predictive ability of total white blood cell (WBC) count and its subtypes for risk of death or myocardial infarction (MI)...
  69. pmc Pharmacogenetic warfarin dose refinements remain significantly influenced by genetic factors after one week of therapy
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, Salt Lake City, Utah 84107, USA
    Thromb Haemost 107:232-40. 2012
    ..7 mg/week. In conclusion, a pharmacogenetic warfarin dose-refinement algorithm based on clinical, INR, and genetic factors can explain at least 69.1% of therapeutic warfarin dose variability after about one week of therapy...
  70. doi request reprint Genotype-based dosing algorithms for warfarin therapy: data review and recommendations
    Eric G Johnson
    Cardiovascular Department, Intermountain Medical Center, Salt Lake City, UT, USA
    Mol Diagn Ther 15:255-64. 2011
    ....
  71. ncbi request reprint Cytomegalovirus stimulated mRNA accumulation and cell surface expression of the oxidized LDL scavenger receptor, CD36
    John F Carlquist
    Cardiovascular Department, LDS Hospital, 8th Avenue and C Street, Salt Lake City, UT 84143, USA
    Atherosclerosis 177:53-9. 2004
    ..Because CMV can activate host-cell gene transcription, we hypothesized that CMV may upregulate CD36 expression...
  72. ncbi request reprint Lipoprotein-associated phospholipase A2: an independent predictor of coronary artery disease events in primary and secondary prevention
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, University of Utah, 325 8th Avenue, Salt Lake City, UT 84143, USA
    Am J Cardiol 101:23F-33F. 2008
    ..02586 mmol/L) is now recommended as a reasonable therapeutic goal...
  73. pmc Validation study of genetic associations with coronary artery disease on chromosome 3q13-21 and potential effect modification by smoking
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, Salt Lake City, UT, USA
    Ann Hum Genet 73:551-8. 2009
    ..Genetic risk conferred by some of these genes may be modified by smoking. Future CAD association studies of these and other genes should evaluate effect modification by smoking...
  74. ncbi request reprint Effect of implementation of folic acid fortification of food on homocysteine concentrations in subjects with coronary artery disease
    Jeffrey L Anderson
    Cardiovascular Department, LDS Hospital, and University of Utah School of Medicine, Salt Lake City, Utah 84143, USA
    Am J Cardiol 90:536-9. 2002
  75. doi request reprint Incremental survival benefit with adherence to standardized heart failure core measures: a performance evaluation study of 2958 patients
    Abdallah G Kfoury
    Heart Failure Prevention and Treatment Program, Intermountain Medical Center and Intermountain Healthcare, 5121 S Cottonwood Street, Murray, UT 84107, USA
    J Card Fail 14:95-102. 2008
    ..Although adherence to these HF care processes may be improving, their collective impact on survival is not yet settled...
  76. ncbi request reprint Atrial dimensions in health and left ventricular disease using cardiovascular magnetic resonance
    Jeffrey L Anderson
    LDS Hospital, University of Utah School of Medicine, Salt Lake City, Utah, USA
    J Cardiovasc Magn Reson 7:671-5. 2005
    ..We assessed atrial size by CMR in healthy and diseased subjects to determine normal adult ranges...
  77. ncbi request reprint Impact of renal failure on the risk of myocardial infarction and death
    Srinivasan Beddhu
    Renal Section, Salt Lake VA Healthcare System, Salt Lake City, Utah, USA
    Kidney Int 62:1776-83. 2002
    ..We examined whether renal failure independently increases the risk of myocardial infarction and death...
  78. ncbi request reprint Genome-wide significance and replication of the chromosome 12p11.22 locus near the PTHLH gene for peripartum cardiomyopathy
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, Genetic Epidemiology Division, University of Utah, USA
    Circ Cardiovasc Genet 4:359-66. 2011
    ..Initial evidence suggests that genetic factors may influence PPCM. This study evaluated and replicated genome-wide association of single nucleotide polymorphisms with PPCM...
  79. ncbi request reprint Effects of statins on six-month survival and clinical restenosis frequency after coronary stent deployment
    T Jared Bunch
    Cardiovascular Department, LDS Hospital and University of Utah, Salt Lake City 84143, USA
    Am J Cardiol 90:299-302. 2002
  80. ncbi request reprint Left atrial sarcoma: resection and repair by cardiac autotransplant and in situ pericardial patch
    Donald B Doty
    Division of Cardiovascular and Thoracic Surgery, LDS Hospital, Salt Lake City, Utah, USA
    Ann Thorac Surg 82:1514-7. 2006
    ..The unique features are use of adjacent pericardium as an in situ patch to reconstruct the left atrium when there is no margin of left atrium remaining on the pulmonary veins and cardiac autotransplantation...
  81. pmc Antibiotic trials for coronary heart disease
    Jeffrey L Anderson
    University of Utah School of Medicine, Cardiovascular Department, LDS Hospital, Salt Lake City, Utah 84143, USA
    Tex Heart Inst J 31:33-8. 2004
    ..New and innovative experimental approaches, in addition to traditionally designed antibiotic trials, should be welcome in our attempts to gain adequate insight into the role of infection in atherosclerosis and its therapy...