Leslie Recio

Summary

Affiliation: Integrated Laboratory Systems
Country: USA

Publications

  1. doi request reprint Dose-response assessment of naphthalene-induced genotoxicity and glutathione detoxication in human TK6 lymphoblasts
    Leslie Recio
    Integrated Laboratory Systems, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 126:405-12. 2012
  2. doi request reprint Comparison of Comet assay dose-response for ethyl methanesulfonate using freshly prepared versus cryopreserved tissues
    Leslie Recio
    Genetic and Molecular Toxicology Division, ILS, Research Triangle Park, NC, USA
    Environ Mol Mutagen 53:101-13. 2012
  3. ncbi request reprint Exposure of hematopoietic stem cells to benzene or 1,4-benzoquinone induces gender-specific gene expression
    Brenda Faiola
    CIIT Centers for Health Research, Research Triangle Park, NC, USA
    Stem Cells 22:750-8. 2004
  4. ncbi request reprint Variations in Prkdc and susceptibility to benzene-induced toxicity in mice
    Brenda Faiola
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 75:321-32. 2003
  5. pmc Dose-response assessment of four genotoxic chemicals in a combined mouse and rat micronucleus (MN) and Comet assay protocol
    Leslie Recio
    Genetic Toxicology Division, ILS, Inc, RTP, NC 27709, USA
    J Toxicol Sci 35:149-62. 2010
  6. ncbi request reprint Use of genetically modified mouse models to assess pathways of benzene-induced bone marrow cytotoxicity and genotoxicity
    Leslie Recio
    Integrated Laboratory Systems Inc, Genetic Toxicology Program, P O Box 13501, Research Triangle Park, NC 27709, USA
    Chem Biol Interact 153:159-64. 2005
  7. ncbi request reprint Gene expression profile in bone marrow and hematopoietic stem cells in mice exposed to inhaled benzene
    Brenda Faiola
    CIIT Centers for Health Research, Research Triangle Park, NC 27709, USA
    Mutat Res 549:195-212. 2004
  8. pmc No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days
    Kristine L Witt
    Biomolecular Screening Branch, NIEHS NTP, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Environ Mol Mutagen 51:80-8. 2010
  9. pmc Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals
    Kristine L Witt
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Mutat Res 649:101-13. 2008
  10. doi request reprint Evaluation of the genotoxicity of the food additive, gum ghatti
    Cheryl A Hobbs
    Genetic and Molecular Toxicology Division, ILS, Inc, P O Box 13501, Research Triangle Park, NC 27709, USA
    Food Chem Toxicol 50:854-60. 2012

Collaborators

Detail Information

Publications16

  1. doi request reprint Dose-response assessment of naphthalene-induced genotoxicity and glutathione detoxication in human TK6 lymphoblasts
    Leslie Recio
    Integrated Laboratory Systems, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 126:405-12. 2012
    ..These data demonstrate a nonlinear dose-response for naphthalene-induced genotoxicity that is eliminated by GSH, and both observations should be considered when assessing human risk from naphthalene exposures...
  2. doi request reprint Comparison of Comet assay dose-response for ethyl methanesulfonate using freshly prepared versus cryopreserved tissues
    Leslie Recio
    Genetic and Molecular Toxicology Division, ILS, Research Triangle Park, NC, USA
    Environ Mol Mutagen 53:101-13. 2012
    ..We also demonstrated that for three tissues (blood, liver, stomach), air transport did not alter the sensitivity of the Comet assay for detecting DNA damage...
  3. ncbi request reprint Exposure of hematopoietic stem cells to benzene or 1,4-benzoquinone induces gender-specific gene expression
    Brenda Faiola
    CIIT Centers for Health Research, Research Triangle Park, NC, USA
    Stem Cells 22:750-8. 2004
    ..HSC culture systems such as the one used here will be useful for testing the hematotoxicity of various substances, including other benzene metabolites...
  4. ncbi request reprint Variations in Prkdc and susceptibility to benzene-induced toxicity in mice
    Brenda Faiola
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 75:321-32. 2003
    ..Prkdc does not appear to be a significant genetic susceptibility factor for acute benzene toxicity. Moreover, the role of NHEJ, mediated by DNA-PK, in restoring genomic integrity following benzene-induced DSB remains equivocal...
  5. pmc Dose-response assessment of four genotoxic chemicals in a combined mouse and rat micronucleus (MN) and Comet assay protocol
    Leslie Recio
    Genetic Toxicology Division, ILS, Inc, RTP, NC 27709, USA
    J Toxicol Sci 35:149-62. 2010
    ....
  6. ncbi request reprint Use of genetically modified mouse models to assess pathways of benzene-induced bone marrow cytotoxicity and genotoxicity
    Leslie Recio
    Integrated Laboratory Systems Inc, Genetic Toxicology Program, P O Box 13501, Research Triangle Park, NC 27709, USA
    Chem Biol Interact 153:159-64. 2005
    ..These studies show that benzene toxicity is regulated by a number of genetic pathways that affect the production of reactive metabolites and DNA damage response pathways in a target tissue...
  7. ncbi request reprint Gene expression profile in bone marrow and hematopoietic stem cells in mice exposed to inhaled benzene
    Brenda Faiola
    CIIT Centers for Health Research, Research Triangle Park, NC 27709, USA
    Mutat Res 549:195-212. 2004
    ....
  8. pmc No increases in biomarkers of genetic damage or pathological changes in heart and brain tissues in male rats administered methylphenidate hydrochloride (Ritalin) for 28 days
    Kristine L Witt
    Biomolecular Screening Branch, NIEHS NTP, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Environ Mol Mutagen 51:80-8. 2010
    ..Additionally, no histopathological changes in brain or heart, or elevated serum biomarkers of cardiac injury were observed in these MPH-exposed rats...
  9. pmc Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals
    Kristine L Witt
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Mutat Res 649:101-13. 2008
    ..No significant differences were observed between results obtained by the two methods in either species. These results support the use of FCM for determining MN-RET frequency in rodents after chemical exposure...
  10. doi request reprint Evaluation of the genotoxicity of the food additive, gum ghatti
    Cheryl A Hobbs
    Genetic and Molecular Toxicology Division, ILS, Inc, P O Box 13501, Research Triangle Park, NC 27709, USA
    Food Chem Toxicol 50:854-60. 2012
    ..Our results show no evidence of genotoxic potential of gum ghatti administered up to the maximum concentrations recommended by OECD guidelines...
  11. pmc Genotoxicity of styrene-acrylonitrile trimer in brain, liver, and blood cells of weanling F344 rats
    Cheryl A Hobbs
    Department of Genetic and Molecular Toxicology, Research Triangle Park, North Carolina 27709, USA
    Environ Mol Mutagen 53:227-38. 2012
    ..The results of this subacute MN/Comet assay indicate induction of significant genetic damage in multiple tissues of weanling F344 male and female rats after oral exposure to SAN Trimer...
  12. ncbi request reprint Human CD34+ hematopoietic progenitor cells are sensitive targets for toxicity induced by 1,4-benzoquinone
    Diane J Abernethy
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 79:82-9. 2004
    ..Human CD34(+) HPC will be useful for testing the toxicity of other benzene metabolites and various hematotoxic chemicals...
  13. ncbi request reprint Differential expression of long noncoding RNAs in the livers of female B6C3F1 mice exposed to the carcinogen furan
    Leslie Recio
    ILS, Research Triangle Park, North Carolina 27709
    Toxicol Sci 135:369-79. 2013
    ..In addition, certain lncRNA transcripts are associated with the expression of nearby coding protein genes. We hypothesize that lncRNAs have potential as epigenetic biomarkers of carcinogenic exposures. ..
  14. ncbi request reprint Genotoxicity of 10 cigarette smoke condensates in four test systems: comparisons between assays and condensates
    David M DeMarini
    Environmental Carcinogenesis Division, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Mutat Res 650:15-29. 2008
    ....
  15. ncbi request reprint In vivo mutagenicity and mutation spectrum in the bone marrow and testes of B6C3F1 lacI transgenic mice following inhalation exposure to ethylene oxide
    Leslie Recio
    CIIT Centers for Health Research, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Mutagenesis 19:215-22. 2004
    ..p.m. EO was not due to an increase in mutant siblings (clonality). These data demonstrate that inhalation exposure to EO for up to 48 weeks produces distinct mutagenic responses in bone marrow and testes...
  16. ncbi request reprint Male mice deficient in microsomal epoxide hydrolase are not susceptible to benzene-induced toxicity
    Alison K Bauer
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 72:201-9. 2003
    ..Thus mEH appears to be critical in benzene-induced toxicity in male, but not female, mice...