Andrew S Peek

Summary

Affiliation: Integrated DNA Technologies
Country: USA

Publications

  1. pmc Improving model predictions for RNA interference activities that use support vector machine regression by combining and filtering features
    Andrew S Peek
    Department of Bioinformatics, Integrated DNA Technologies, Inc, Coralville, IA 52241, USA
    BMC Bioinformatics 8:182. 2007
  2. pmc Comparing artificial neural networks, general linear models and support vector machines in building predictive models for small interfering RNAs
    Kyle A McQuisten
    Department of Bioinformatics, Integrated DNA Technologies, Inc, Coralville, Iowa, United States of America
    PLoS ONE 4:e7522. 2009
  3. pmc Identification of sequence motifs significantly associated with antisense activity
    Kyle A McQuisten
    Department of Bioinformatics, Integrated DNA Technologies, Coralville, IA 52241, USA
    BMC Bioinformatics 8:184. 2007
  4. pmc IDT SciTools: a suite for analysis and design of nucleic acid oligomers
    Richard Owczarzy
    Department of Molecular Genetics and Biophysics, Integrated DNA Technologies, Inc, 1710 Commercial Park, Coralville, IA 52241, USA
    Nucleic Acids Res 36:W163-9. 2008
  5. pmc Marsupial-specific microRNAs evolved from marsupial-specific transposable elements
    Eric J Devor
    Molecular Genetics and Bioinformatics, Integrated DNA Technologies, Coralville, IA 52241, USA
    Gene 448:187-91. 2009
  6. ncbi request reprint Design of active small interfering RNAs
    Andrew S Peek
    Integrated DNA Technologies Inc, 1710 Commercial Park, Coralville, IA 52241, USA
    Curr Opin Mol Ther 9:110-8. 2007
  7. pmc Population genetics of duplicated disease-defense genes, hm1 and hm2, in maize (Zea mays ssp. mays L.) and its wild ancestor (Zea mays ssp. parviglumis)
    Liqing Zhang
    Department of Ecology and Evolutionary Biology, University of California, Irvine 92697, USA
    Genetics 162:851-60. 2002
  8. ncbi request reprint Nox2-containing NADPH oxidase and Akt activation play a key role in angiotensin II-induced cardiomyocyte hypertrophy
    Shawn D Hingtgen
    Department of Anatomy and Cell Biology, The Free Radical and Radiation Biology Program, Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    Physiol Genomics 26:180-91. 2006

Collaborators

Detail Information

Publications8

  1. pmc Improving model predictions for RNA interference activities that use support vector machine regression by combining and filtering features
    Andrew S Peek
    Department of Bioinformatics, Integrated DNA Technologies, Inc, Coralville, IA 52241, USA
    BMC Bioinformatics 8:182. 2007
    ..To dissect the factors that result in effective siRNA sequences a regression kernel Support Vector Machine (SVM) approach was used to quantitatively model RNA interference activities...
  2. pmc Comparing artificial neural networks, general linear models and support vector machines in building predictive models for small interfering RNAs
    Kyle A McQuisten
    Department of Bioinformatics, Integrated DNA Technologies, Inc, Coralville, Iowa, United States of America
    PLoS ONE 4:e7522. 2009
    ..Also, there are few comparative studies that address what the effect of choosing learning technique, feature set or cross validation approach has on finding and discriminating among predictive models...
  3. pmc Identification of sequence motifs significantly associated with antisense activity
    Kyle A McQuisten
    Department of Bioinformatics, Integrated DNA Technologies, Coralville, IA 52241, USA
    BMC Bioinformatics 8:184. 2007
    ....
  4. pmc IDT SciTools: a suite for analysis and design of nucleic acid oligomers
    Richard Owczarzy
    Department of Molecular Genetics and Biophysics, Integrated DNA Technologies, Inc, 1710 Commercial Park, Coralville, IA 52241, USA
    Nucleic Acids Res 36:W163-9. 2008
    ..The latest, most accurate thermodynamic algorithms and models are implemented. This free software is available at http://www.idtdna.com/SciTools/SciTools.aspx...
  5. pmc Marsupial-specific microRNAs evolved from marsupial-specific transposable elements
    Eric J Devor
    Molecular Genetics and Bioinformatics, Integrated DNA Technologies, Coralville, IA 52241, USA
    Gene 448:187-91. 2009
    ..These findings reinforce the view that transposable elements are a previously unappreciated source of new, lineage-specific microRNAs...
  6. ncbi request reprint Design of active small interfering RNAs
    Andrew S Peek
    Integrated DNA Technologies Inc, 1710 Commercial Park, Coralville, IA 52241, USA
    Curr Opin Mol Ther 9:110-8. 2007
    ..In addition to rational design criteria, chemical modification of the RNA can improve function by improving stability, reducing the potential for off-target effects and avoiding stimulation of the innate immune system...
  7. pmc Population genetics of duplicated disease-defense genes, hm1 and hm2, in maize (Zea mays ssp. mays L.) and its wild ancestor (Zea mays ssp. parviglumis)
    Liqing Zhang
    Department of Ecology and Evolutionary Biology, University of California, Irvine 92697, USA
    Genetics 162:851-60. 2002
    ..Both defense genes retain >80% of the level of genetic variation in maize relative to the wild ancestor, and this level is similar to other maize genes that were not subject to artificial selection during domestication...
  8. ncbi request reprint Nox2-containing NADPH oxidase and Akt activation play a key role in angiotensin II-induced cardiomyocyte hypertrophy
    Shawn D Hingtgen
    Department of Anatomy and Cell Biology, The Free Radical and Radiation Biology Program, Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    Physiol Genomics 26:180-91. 2006
    ....