D Wodarz

Summary

Affiliation: Institute for Advanced Study
Country: USA

Publications

  1. ncbi request reprint Helper-dependent vs. helper-independent CTL responses in HIV infection: implications for drug therapy and resistance
    D Wodarz
    Institute for Advanced Study, Einstein Drive, Princeton, NJ 08540, USA
    J Theor Biol 213:447-59. 2001
  2. ncbi request reprint Evolutionary dynamics of HIV-induced subversion of the immune response
    D Wodarz
    Institute for Advanced Study, Princeton, NJ 08540, USA
    Immunol Rev 168:75-89. 1999
  3. ncbi request reprint The importance of lytic and nonlytic immune responses in viral infections
    Dominik Wodarz
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP 665, WA 98109 1024, Seattle, USA
    Trends Immunol 23:194-200. 2002
  4. ncbi request reprint Genetic instability and the evolution of angiogenic tumor cell lines (review)
    D Wodarz
    Institute for Advanced Study, Einstein Drive, Princeton, NJ 08540, USA
    Oncol Rep 8:1195-201. 2001
  5. ncbi request reprint The role of T cell help for anti-viral CTL responses
    D Wodarz
    Institute for Advanced Study, Olden Lane, Princeton, NJ 08540, USA
    J Theor Biol 211:419-32. 2001
  6. ncbi request reprint Viruses as antitumor weapons: defining conditions for tumor remission
    D Wodarz
    Institute for Advanced Study, Einstein Drive, Princeton, New Jersey 08540
    Cancer Res 61:3501-7. 2001
  7. pmc Cytotoxic T-lymphocyte memory, virus clearance and antigenic heterogeneity
    D Wodarz
    Institute for Advanced Study, Princeton, NJ 08540, USA
    Proc Biol Sci 268:429-36. 2001
  8. pmc Correlates of cytotoxic T-lymphocyte-mediated virus control: implications for immunosuppressive infections and their treatment
    D Wodarz
    Institute for Advanced Study, Princeton, NJ 08540, USA
    Philos Trans R Soc Lond B Biol Sci 355:1059-70. 2000
  9. pmc Specific therapy regimes could lead to long-term immunological control of HIV
    D Wodarz
    Institute for Advanced Study, Olden Lane, Princeton, NJ 08540, USA
    Proc Natl Acad Sci U S A 96:14464-9. 1999
  10. pmc A new theory of cytotoxic T-lymphocyte memory: implications for HIV treatment
    D Wodarz
    Institute for Advanced Study, Princeton, NJ 08540, USA
    Philos Trans R Soc Lond B Biol Sci 355:329-43. 2000

Detail Information

Publications40

  1. ncbi request reprint Helper-dependent vs. helper-independent CTL responses in HIV infection: implications for drug therapy and resistance
    D Wodarz
    Institute for Advanced Study, Einstein Drive, Princeton, NJ 08540, USA
    J Theor Biol 213:447-59. 2001
    ..Issues concerning the timing and duration of treatment are discussed. The CTL kinetics during drug therapy also provide new insights into the principles underlying the emergence of drug-resistant strains during the course of treatment...
  2. ncbi request reprint Evolutionary dynamics of HIV-induced subversion of the immune response
    D Wodarz
    Institute for Advanced Study, Princeton, NJ 08540, USA
    Immunol Rev 168:75-89. 1999
    ..These insights are important for understanding the disease process itself and for designing effective treatment regimes...
  3. ncbi request reprint The importance of lytic and nonlytic immune responses in viral infections
    Dominik Wodarz
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP 665, WA 98109 1024, Seattle, USA
    Trends Immunol 23:194-200. 2002
    ..We discuss our findings in the context of specific viral infections and use our model to interpret empirical data...
  4. ncbi request reprint Genetic instability and the evolution of angiogenic tumor cell lines (review)
    D Wodarz
    Institute for Advanced Study, Einstein Drive, Princeton, NJ 08540, USA
    Oncol Rep 8:1195-201. 2001
    ..We observe that genetic instability is of value early in tumorigenesis but becomes a liability later. This is because instability decreases the fitness of the angiogenic tumor once it has become established...
  5. ncbi request reprint The role of T cell help for anti-viral CTL responses
    D Wodarz
    Institute for Advanced Study, Olden Lane, Princeton, NJ 08540, USA
    J Theor Biol 211:419-32. 2001
    ..In particular, the models offer further suggestions for the development of treatment regimes aimed at achieving immunological control of HIV infection which has been shown to crucially depend on the availability of helper cell responses...
  6. ncbi request reprint Viruses as antitumor weapons: defining conditions for tumor remission
    D Wodarz
    Institute for Advanced Study, Einstein Drive, Princeton, New Jersey 08540
    Cancer Res 61:3501-7. 2001
    ..The models precisely define conditions required for successful therapy. They identify the parameters that need to be measured and modulated to evaluate and refine the existing therapy regimes...
  7. pmc Cytotoxic T-lymphocyte memory, virus clearance and antigenic heterogeneity
    D Wodarz
    Institute for Advanced Study, Princeton, NJ 08540, USA
    Proc Biol Sci 268:429-36. 2001
    ..These results have important implications for vaccination and treatment strategies directed against viral infections...
  8. pmc Correlates of cytotoxic T-lymphocyte-mediated virus control: implications for immunosuppressive infections and their treatment
    D Wodarz
    Institute for Advanced Study, Princeton, NJ 08540, USA
    Philos Trans R Soc Lond B Biol Sci 355:1059-70. 2000
    ..We show how mathematical models can help us devise therapy regimens that can restore CTL memory in HIV patients and result in long-term immunological control of the virus in the absence of life-long treatment...
  9. pmc Specific therapy regimes could lead to long-term immunological control of HIV
    D Wodarz
    Institute for Advanced Study, Olden Lane, Princeton, NJ 08540, USA
    Proc Natl Acad Sci U S A 96:14464-9. 1999
    ..Whether such treatment regimes would lead to long-term immunologic control deserves investigation under carefully controlled conditions...
  10. pmc A new theory of cytotoxic T-lymphocyte memory: implications for HIV treatment
    D Wodarz
    Institute for Advanced Study, Princeton, NJ 08540, USA
    Philos Trans R Soc Lond B Biol Sci 355:329-43. 2000
    ..Based on our models we suggest conceptual treatment regimes which ensure establishment of CTL memory. This would allow the immune response to control HIV in the long term in the absence of continued therapy...
  11. ncbi request reprint Defining CTL-induced pathology: implications for HIV
    D Wodarz
    Institute for Advanced Study, Olden Lane, Princeton, New Jersey 08540, USA
    Virology 274:94-104. 2000
    ..However, according to the model, fast viral replication can result in the evolution of virus strains that are susceptible to chemokine-mediated inhibition of viral replication...
  12. pmc HIV-1 dynamics revisited: biphasic decay by cytotoxic T lymphocyte killing?
    R A Arnaout
    Theoretical Biology Program, Institute for Advanced Study, Princeton, NJ 08540, USA
    Proc Biol Sci 267:1347-54. 2000
    ..We propose a method to test this idea, and develop a framework that is readily applicable to treatment of other infections...
  13. pmc Cytotoxic T-cell abundance and virus load in human immunodeficiency virus type 1 and human T-cell leukaemia virus type 1
    D Wodarz
    Institute for Advanced Study, Einstein Drive, Princeton, NJ 08540, USA
    Proc Biol Sci 268:1215-21. 2001
    ..Virus-mediated impairment of specific CTL production in HIV-1 infection can account for the negative correlation observed...
  14. ncbi request reprint The persistence of CTL memory
    D Wodarz
    Institute for Advanced Study, Princeton, New Jersey 08540, USA
    Neth J Med 60:4-13; discussion 14-6. 2002
    ..We show how mathematical models can help us devise therapy regimes that can restore CTL memory in HIV-infected patients and result in long-term immunological control of the virus in the absence of lifelong treatment...
  15. ncbi request reprint A dynamical perspective of CTL cross-priming and regulation: implications for cancer immunology
    Dominik Wodarz
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP 665 Seattle, WA 98109, USA
    Immunol Lett 86:213-27. 2003
    ..We apply the model to study the role of CTL in cancer initiation, cancer evolution/progression, and therapeutic vaccination against cancers...
  16. ncbi request reprint Mathematical models of HIV and the immune system
    Dominik Wodarz
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP 665, Seattle, WA 98109 1024, USA
    Novartis Found Symp 254:193-207; discussion 207-22, 250-2. 2003
    ....
  17. ncbi request reprint Evolution of immunological memory and the regulation of competition between pathogens
    Dominik Wodarz
    Fred Hutchison Cancer Research Center, 1100 Fairview Avenue North, MP 665, Seattle, WA 98109, USA
    Curr Biol 13:1648-52. 2003
    ..Thus, while in the absence of pathogen diversity memory is always expected to evolve to a long duration, under specific circumstances, memory can evolve toward shorter durations in the presence of pathogen diversity...
  18. ncbi request reprint Hepatitis C virus dynamics and pathology: the role of CTL and antibody responses
    Dominik Wodarz
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP 665, Seattle, WA 98109, USA
    J Gen Virol 84:1743-50. 2003
    ..Virus evolution can shift this balance towards pathology over time. Theoretical results are discussed in the context of published data...
  19. ncbi request reprint Gene therapy for killing p53-negative cancer cells: use of replicating versus nonreplicating agents
    Dominik Wodarz
    Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Hum Gene Ther 14:153-9. 2003
    ..If a high multiplicity of infection is used, the virus that appears most efficient in this evaluation can be least efficient at eradicating the cancer in vivo. Theoretical results are discussed in the context of experimental data...
  20. pmc Boosting immunity by antiviral drug therapy: a simple relationship among timing, efficacy, and success
    Natalia L Komarova
    Institute for Advanced Study, Einstein Drive, Princeton, NJ 08540, USA
    Proc Natl Acad Sci U S A 100:1855-60. 2003
    ..Although the therapy regimes explored here also have implications for HIV, virus-mediated destruction of specific immune cells renders success unlikely during the chronic phase of the infection...
  21. ncbi request reprint Mathematical models of HIV pathogenesis and treatment
    Dominik Wodarz
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP 665, Seattle, WA 98109 1024, USA
    Bioessays 24:1178-87. 2002
    ..Finally, we show how mathematical models can be used to understand correlates of long-term immunological control of HIV, and to design therapy regimes that convert a progressing patient into a state of long-term non-progression...
  22. ncbi request reprint Effect of the CTL proliferation program on virus dynamics
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, 321 Steinhaus Hall, University of California, Irvine, CA 92697, USA
    Int Immunol 17:1269-76. 2005
    ..We discuss these results in the context of data from murine virus infections and explore implications for virus dynamics in CD4 helper-deficient hosts...
  23. pmc Dynamics of killer T cell inflation in viral infections
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    J R Soc Interface 4:533-43. 2007
    ..This model provides valuable information and may help to explain the inflation of CMV specific CD8+T cells seen in humans as they age...
  24. ncbi request reprint Targeted cancer treatment: resisting arrest
    Dominik Wodarz
    Nat Med 12:1125-6. 2006
  25. pmc Model-driven approaches for in vitro combination therapy using ONYX-015 replicating oncolytic adenovirus
    Ryan Zurakowski
    Department of Electrical and Computer Engineering, 140 Evans Hall, University of Delaware, Newark, DE 19716, USA
    J Theor Biol 245:1-8. 2007
    ..We introduce a mathematical model of these dynamics and show simple optimal control based strategies which motivate this approach...
  26. pmc Effect of cellular quiescence on the success of targeted CML therapy
    Natalia L Komarova
    Department of Mathematics, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 2:e990. 2007
    ..Using mathematical models, we investigate the effect of cellular quiescence on the outcome of therapy with targeted small molecule inhibitors...
  27. pmc Infection dynamics in HIV-specific CD4 T cells: does a CD4 T cell boost benefit the host or the virus?
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, 321 Steinhaus Hall, University of California, Irvine, CA 92697, USA
    Math Biosci 209:14-29. 2007
    ....
  28. pmc On the relative fitness of early and late stage Simian immunodeficiency virus isolates
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, 321 Steinhaus Hall, University of California, Irvine, CA 92697, USA
    Theor Popul Biol 72:426-35. 2007
    ..One possibility is that the ability of multiple virus particles to infect the same cell (coinfection) might be a pre-requisite for the emergence of the cytopathic strain SIVMne170 as the disease progresses...
  29. pmc Human immunodeficiency virus evolution towards reduced replicative fitness in vivo and the development of AIDS
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, University of California, 321 Steinhaus Hall, Irvine, CA 92697, USA
    Proc Biol Sci 274:2481-90. 2007
    ....
  30. ncbi request reprint Does programmed CTL proliferation optimize virus control?
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    Trends Immunol 26:305-10. 2005
    ..The 7-10 programmed cell divisions observed in vivo might be an optimization of this trade-off. We also discuss the conditions under which the program does or does not require CD4 T-cell help for clearance...
  31. ncbi request reprint Contrasting B cell- and T cell-based protective vaccines
    Vincent A A Jansen
    School of Biological Sciences, Royal Holloway University of London, Egham, Surrey TW20 0EX, UK
    J Theor Biol 234:39-48. 2005
    ..Thus, although a T cell vaccine might work against a high dose exposure, it might fail when exposed against to a low-dose exposure. This limits, we argue, the efficacy of T cell-based vaccines...
  32. pmc Compromised influenza virus-specific CD8(+)-T-cell memory in CD4(+)-T-cell-deficient mice
    Gabrielle T Belz
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Virol 76:12388-93. 2002
    ..These findings are consistent with mathematical models that predict virus-host dynamics in this, and other, models of infection...
  33. pmc Quantitative analysis of long-term virus-specific CD8+-T-cell memory in mice challenged with unrelated pathogens
    Haiyan Liu
    Department of Immunology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    J Virol 77:7756-63. 2003
    ....
  34. ncbi request reprint Mutants escape from killer T cells, invade population
    Dominik Wodarz
    Nat Med 9:1254-5. 2003
  35. ncbi request reprint Correspondence re: L. M. Wein et al., validation and analysis of a mathematical model of a replication-competent oncolytic virus for cancer treatment: implications for virus design and delivery. Cancer Res., 63: 1317-1324, 2003
    Dominik Wodarz
    Cancer Res 63:8554;author reply 8556-7. 2003
  36. ncbi request reprint Apparent competition and recovery from infection
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, Steinhaus Hall, University of California, Irvine, CA 92697, USA
    J Theor Biol 227:403-12. 2004
    ..The models presented are related to the concept of apparent competition, and our results are discussed in relation to both theoretical and empirical studies...
  37. pmc The optimal rate of chromosome loss for the inactivation of tumor suppressor genes in cancer
    Natalia L Komarova
    Department of Mathematics, Rutgers, The State University of New Jersey, 110 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 101:7017-21. 2004
    ..Instead, it arises for other reasons, such as environmental factors, and is subsequently fine-tuned by selection to minimize the time to further cancer progression by means of the inactivation of TSP genes...
  38. pmc Immune responses and the emergence of drug-resistant virus strains in vivo
    Dominik Wodarz
    Department of Ecology and Evolutionary Biology, 321 Steinhaus Hall, University of California, Irvine, CA 92697, USA
    Proc Biol Sci 271:1101-9. 2004
    ..Drug resistance is much more likely to be a problem in HIV than in acute and self-limiting infections...
  39. ncbi request reprint Checkpoint genes, ageing, and the development of cancer
    Dominik Wodarz
    Department of Ecology and Evolution, Steinhaus Hall, University of California, Irvine, CA 92697, USA
    Oncogene 23:7799-809. 2004
    ..The models help to identify differences in the experimental protocols which could explain the seemingly contradictory observations...
  40. pmc Immunity and protection by live attenuated HIV/SIV vaccines
    Dominik Wodarz
    Department of Ecology and Evolution, 321 Steinhaus Hall, University of California, Irvine CA 92697, USA
    Virology 378:299-305. 2008
    ..According to these arguments, an inverse correlation between the level of attenuation and the level of protection is expected, and this has indeed been observed in experimental data...