Research Topics
| Kai WangSummaryAffiliation: Institute for Systems Biology Country: USA Publications
| Collaborators
|
Detail Information
Publications
Comment on "Evidence for positive epistasis in HIV-1"Kai Wang
Department of Microbiology, University of Washington, Seattle, WA 98195, USA
Science 312:848; author reply 848. 2006..We demonstrate that biases in the original and simulated data sets may lead to erroneous evidence for epistasis. More rigorous statistical tests must be used to account for such biases before one can infer epistasis...
Systems biology and the discovery of diagnostic biomarkersKai Wang
Institute for Systems Biology, WA, USA
Dis Markers 28:199-207. 2010..This general approach, including diagnostics and therapeutics, is becoming known as systems medicine...
The spectrum of circulating RNA: a window into systems toxicologyKai Wang
Institute for Systems Biology, Seattle, Washington 98109, USA
Toxicol Sci 132:478-92. 2013..This could also lead to a new approach for a more comprehensive assessment of the efficacy and safety of therapeutics...- The complex exogenous RNA spectra in human plasma: an interface with human gut biota?Kai Wang
Institute for Systems Biology, Seattle, Washington, United States of America
PLoS ONE 7:e51009. 2012..These findings raise the possibility that plasma RNAs of exogenous origin may serve as signaling molecules mediating for example the human-microbiome interaction and may affect and/or indicate the state of human health... - Comparing the MicroRNA spectrum between serum and plasmaKai Wang
Institute for Systems Biology, Seattle, Washington, United States of America
PLoS ONE 7:e41561. 2012..Our results suggest that there are a number of factors that might affect the measurement of circulating miRNA concentration. Caution must be taken when comparing miRNA data generated from different sample types or measurement platforms... - Circulating microRNAs, potential biomarkers for drug-induced liver injuryKai Wang
Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103, USA
Proc Natl Acad Sci U S A 106:4402-7. 2009..These findings suggest the potential of using specific circulating microRNAs as sensitive and informative biomarkers for drug-induced liver injury... - Characterizing dynamic changes in the human blood transcriptional networkJun Zhu
Department of Genetics, Rosetta Inpharmatics, LLC, a wholly owned subsidiary of Merck and Co, Inc, Seattle, Washington, USA
PLoS Comput Biol 6:e1000671. 2010..The results could have broader implications for the design of studies of disease association and drug response in clinical trials... - Extracellular microRNA: a new source of biomarkersAlton Etheridge
Institute for Systems Biology, Seattle, WA 98103, USA
Mutat Res 717:85-90. 2011..Finally, we address several issues associated with the accurate measurement of miRNAs from biological samples... - Systems biology of interstitial lung diseases: integration of mRNA and microRNA expression changesJi Hoon Cho
Institute for Systems Biology, Seattle, WA, USA
BMC Med Genomics 4:8. 2011.... - Predictive genes in adjacent normal tissue are preferentially altered by sCNV during tumorigenesis in liver cancer and may rate limitingJohn R Lamb
Rosetta Inpharmatics, LLC, Seattle, Washington, United States of America
PLoS ONE 6:e20090. 2011..The relationships between these two sets of predictive genes and the general process of tumorigenesis and disease progression remains unclear... - Complexity of the microRNA repertoire revealed by next-generation sequencingLik Wee Lee
Institute for Systems Biology, 1441 N 34th Street, Seattle, WA 98103, USA
RNA 16:2170-80. 2010..This information will be useful both to better understand the functions of isomirs and to improve probe or primer design for miRNA detection and measurement... - Export of microRNAs and microRNA-protective protein by mammalian cellsKai Wang
Institute for Systems Biology, 1441 N 34th Street, Seattle, WA 98103, USA
Nucleic Acids Res 38:7248-59. 2010..Our results point to a hitherto unrecognized and uncharacterized miRNA trafficking system in mammalian cells that is consistent with the cell-cell communication hypothesis... - RNASEQR--a streamlined and accurate RNA-seq sequence analysis programLeslie Y Chen
Institute for Systems Biology, Seattle, WA 98109, USA
Nucleic Acids Res 40:e42. 2012..RNASEQR analyzes raw data from RNA-seq experiments effectively and outputs results in a manner that is compatible with a wide variety of specialized downstream analyses on desktop computers... - An integrative approach to inferring biologically meaningful gene modulesJi Hoon Cho
Institute for Systems Biology, Seattle, WA 98109, USA
BMC Syst Biol 5:117. 2011..We have devised a method which directly incorporates gene ontology (GO) annotation in construction of gene modules in order to gain better functional association... - The microRNA spectrum in 12 body fluidsJessica A Weber
Institute for Systems Biology, 1441 North 34th St, Seattle, WA 98103, USA
Clin Chem 56:1733-41. 2010..Extracellular miRNAs in serum, plasma, saliva, and urine have recently been shown to be associated with various pathological conditions including cancer... - Interchromosomal segmental duplications explain the unusual structure of PRSS3, the gene for an inhibitor-resistant trypsinogenLee Rowen
Institute for Systems Biology, Seattle, Washington, USA
Mol Biol Evol 22:1712-20. 2005..These residues could be involved in interactions with inhibitors... - A genetic approach to the prediction of drug side effects: bleomycin induces concordant phenotypes in mice of the collaborative crossRichard Gelinas
Battelle Memorial Institute, Columbus, OH Institute for Systems Biology, Seattle, WA, USA
Pharmgenomics Pers Med 4:35-45. 2011..This finding suggests that the genetically diverse Collaborative Cross animals may reveal drug effects that might be missed if a study were based on a conventional mouse strain... - The effect of food intake on gene expression in human peripheral bloodAmy S Leonardson
Rosetta Inpharmatics, LLC, Merck and Co, Inc, Seattle, WA 98109, USA
Hum Mol Genet 19:159-69. 2010..Our results suggest that the pair of fasted/fed blood expression profiles provide more comprehensive information about an individual's metabolic states... - Meta-analysis of inter-species liver co-expression networks elucidates traits associated with common human diseasesKai Wang
Department of Genetics, Rosetta Inpharmatics, Seattle, Washington, USA
PLoS Comput Biol 5:e1000616. 2009..Taken together, our approach represents a novel step forward in integrating gene co-expression networks from multiple large scale datasets to leverage not only common information but also differences that are dataset-specific... - Disease risk of missense mutations using structural inference from predicted functionJeremy A Horst
Department of Microbiology School of Medicine, University of Washington, 1959 NE Pacific St 357132, Seattle, WA 98195, USA
Curr Protein Pept Sci 11:573-88. 2010..This approach to pathogenetics enables new insight into the mechanistic relationship of missense mutations to disease phenotypes in our patients...