Kai Wang

Summary

Affiliation: Institute for Systems Biology
Country: USA

Publications

  1. ncbi request reprint Comment on "Evidence for positive epistasis in HIV-1"
    Kai Wang
    Department of Microbiology, University of Washington, Seattle, WA 98195, USA
    Science 312:848; author reply 848. 2006
  2. pmc Systems biology and the discovery of diagnostic biomarkers
    Kai Wang
    Institute for Systems Biology, WA, USA
    Dis Markers 28:199-207. 2010
  3. doi request reprint The spectrum of circulating RNA: a window into systems toxicology
    Kai Wang
    Institute for Systems Biology, Seattle, Washington 98109, USA
    Toxicol Sci 132:478-92. 2013
  4. pmc The complex exogenous RNA spectra in human plasma: an interface with human gut biota?
    Kai Wang
    Institute for Systems Biology, Seattle, Washington, United States of America
    PLoS ONE 7:e51009. 2012
  5. pmc Comparing the MicroRNA spectrum between serum and plasma
    Kai Wang
    Institute for Systems Biology, Seattle, Washington, United States of America
    PLoS ONE 7:e41561. 2012
  6. pmc Circulating microRNAs, potential biomarkers for drug-induced liver injury
    Kai Wang
    Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 106:4402-7. 2009
  7. pmc Characterizing dynamic changes in the human blood transcriptional network
    Jun Zhu
    Department of Genetics, Rosetta Inpharmatics, LLC, a wholly owned subsidiary of Merck and Co, Inc, Seattle, Washington, USA
    PLoS Comput Biol 6:e1000671. 2010
  8. pmc Extracellular microRNA: a new source of biomarkers
    Alton Etheridge
    Institute for Systems Biology, Seattle, WA 98103, USA
    Mutat Res 717:85-90. 2011
  9. pmc Predictive genes in adjacent normal tissue are preferentially altered by sCNV during tumorigenesis in liver cancer and may rate limiting
    John R Lamb
    Rosetta Inpharmatics, LLC, Seattle, Washington, United States of America
    PLoS ONE 6:e20090. 2011
  10. pmc Systems biology of interstitial lung diseases: integration of mRNA and microRNA expression changes
    Ji Hoon Cho
    Institute for Systems Biology, Seattle, WA, USA
    BMC Med Genomics 4:8. 2011

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Comment on "Evidence for positive epistasis in HIV-1"
    Kai Wang
    Department of Microbiology, University of Washington, Seattle, WA 98195, USA
    Science 312:848; author reply 848. 2006
    ..We demonstrate that biases in the original and simulated data sets may lead to erroneous evidence for epistasis. More rigorous statistical tests must be used to account for such biases before one can infer epistasis...
  2. pmc Systems biology and the discovery of diagnostic biomarkers
    Kai Wang
    Institute for Systems Biology, WA, USA
    Dis Markers 28:199-207. 2010
    ..This general approach, including diagnostics and therapeutics, is becoming known as systems medicine...
  3. doi request reprint The spectrum of circulating RNA: a window into systems toxicology
    Kai Wang
    Institute for Systems Biology, Seattle, Washington 98109, USA
    Toxicol Sci 132:478-92. 2013
    ..This could also lead to a new approach for a more comprehensive assessment of the efficacy and safety of therapeutics...
  4. pmc The complex exogenous RNA spectra in human plasma: an interface with human gut biota?
    Kai Wang
    Institute for Systems Biology, Seattle, Washington, United States of America
    PLoS ONE 7:e51009. 2012
    ..These findings raise the possibility that plasma RNAs of exogenous origin may serve as signaling molecules mediating for example the human-microbiome interaction and may affect and/or indicate the state of human health...
  5. pmc Comparing the MicroRNA spectrum between serum and plasma
    Kai Wang
    Institute for Systems Biology, Seattle, Washington, United States of America
    PLoS ONE 7:e41561. 2012
    ..Our results suggest that there are a number of factors that might affect the measurement of circulating miRNA concentration. Caution must be taken when comparing miRNA data generated from different sample types or measurement platforms...
  6. pmc Circulating microRNAs, potential biomarkers for drug-induced liver injury
    Kai Wang
    Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 106:4402-7. 2009
    ..These findings suggest the potential of using specific circulating microRNAs as sensitive and informative biomarkers for drug-induced liver injury...
  7. pmc Characterizing dynamic changes in the human blood transcriptional network
    Jun Zhu
    Department of Genetics, Rosetta Inpharmatics, LLC, a wholly owned subsidiary of Merck and Co, Inc, Seattle, Washington, USA
    PLoS Comput Biol 6:e1000671. 2010
    ..The results could have broader implications for the design of studies of disease association and drug response in clinical trials...
  8. pmc Extracellular microRNA: a new source of biomarkers
    Alton Etheridge
    Institute for Systems Biology, Seattle, WA 98103, USA
    Mutat Res 717:85-90. 2011
    ..Finally, we address several issues associated with the accurate measurement of miRNAs from biological samples...
  9. pmc Predictive genes in adjacent normal tissue are preferentially altered by sCNV during tumorigenesis in liver cancer and may rate limiting
    John R Lamb
    Rosetta Inpharmatics, LLC, Seattle, Washington, United States of America
    PLoS ONE 6:e20090. 2011
    ..The relationships between these two sets of predictive genes and the general process of tumorigenesis and disease progression remains unclear...
  10. pmc Systems biology of interstitial lung diseases: integration of mRNA and microRNA expression changes
    Ji Hoon Cho
    Institute for Systems Biology, Seattle, WA, USA
    BMC Med Genomics 4:8. 2011
    ....
  11. doi request reprint Systems approach to neurodegenerative disease biomarker discovery
    Christopher Lausted
    Institute for Systems Biology, Seattle, Washington 98109 email
    Annu Rev Pharmacol Toxicol 54:457-81. 2014
    ..In this review, we summarize current proteomic and nucleic acid technologies involved in the discovery of biomarkers of neurodegenerative diseases, particularly Alzheimer's, Parkinson's, Huntington's, and prion diseases. ..
  12. pmc Complexity of the microRNA repertoire revealed by next-generation sequencing
    Lik Wee Lee
    Institute for Systems Biology, 1441 N 34th Street, Seattle, WA 98103, USA
    RNA 16:2170-80. 2010
    ..This information will be useful both to better understand the functions of isomirs and to improve probe or primer design for miRNA detection and measurement...
  13. pmc Export of microRNAs and microRNA-protective protein by mammalian cells
    Kai Wang
    Institute for Systems Biology, 1441 N 34th Street, Seattle, WA 98103, USA
    Nucleic Acids Res 38:7248-59. 2010
    ..Our results point to a hitherto unrecognized and uncharacterized miRNA trafficking system in mammalian cells that is consistent with the cell-cell communication hypothesis...
  14. pmc RNASEQR--a streamlined and accurate RNA-seq sequence analysis program
    Leslie Y Chen
    Institute for Systems Biology, Seattle, WA 98109, USA
    Nucleic Acids Res 40:e42. 2012
    ..RNASEQR analyzes raw data from RNA-seq experiments effectively and outputs results in a manner that is compatible with a wide variety of specialized downstream analyses on desktop computers...
  15. pmc An integrative approach to inferring biologically meaningful gene modules
    Ji Hoon Cho
    Institute for Systems Biology, Seattle, WA 98109, USA
    BMC Syst Biol 5:117. 2011
    ..We have devised a method which directly incorporates gene ontology (GO) annotation in construction of gene modules in order to gain better functional association...
  16. doi request reprint The microRNA spectrum in 12 body fluids
    Jessica A Weber
    Institute for Systems Biology, 1441 North 34th St, Seattle, WA 98103, USA
    Clin Chem 56:1733-41. 2010
    ..Extracellular miRNAs in serum, plasma, saliva, and urine have recently been shown to be associated with various pathological conditions including cancer...
  17. ncbi request reprint Interchromosomal segmental duplications explain the unusual structure of PRSS3, the gene for an inhibitor-resistant trypsinogen
    Lee Rowen
    Institute for Systems Biology, Seattle, Washington, USA
    Mol Biol Evol 22:1712-20. 2005
    ..These residues could be involved in interactions with inhibitors...
  18. pmc Francisella tularensis subsp. tularensis induces a unique pulmonary inflammatory response: role of bacterial gene expression in temporal regulation of host defense responses
    Kathie Anne Walters
    Institute for Systems Biology, Seattle, Washington, USA
    PLoS ONE 8:e62412. 2013
    ....
  19. pmc A genetic approach to the prediction of drug side effects: bleomycin induces concordant phenotypes in mice of the collaborative cross
    Richard Gelinas
    Battelle Memorial Institute, Columbus, OH Institute for Systems Biology, Seattle, WA, USA
    Pharmgenomics Pers Med 4:35-45. 2011
    ..This finding suggests that the genetically diverse Collaborative Cross animals may reveal drug effects that might be missed if a study were based on a conventional mouse strain...
  20. pmc The effect of food intake on gene expression in human peripheral blood
    Amy S Leonardson
    Rosetta Inpharmatics, LLC, Merck and Co, Inc, Seattle, WA 98109, USA
    Hum Mol Genet 19:159-69. 2010
    ..Our results suggest that the pair of fasted/fed blood expression profiles provide more comprehensive information about an individual's metabolic states...
  21. pmc Meta-analysis of inter-species liver co-expression networks elucidates traits associated with common human diseases
    Kai Wang
    Department of Genetics, Rosetta Inpharmatics, Seattle, Washington, USA
    PLoS Comput Biol 5:e1000616. 2009
    ..Taken together, our approach represents a novel step forward in integrating gene co-expression networks from multiple large scale datasets to leverage not only common information but also differences that are dataset-specific...
  22. pmc Disease risk of missense mutations using structural inference from predicted function
    Jeremy A Horst
    Department of Microbiology School of Medicine, University of Washington, 1959 NE Pacific St 357132, Seattle, WA 98195, USA
    Curr Protein Pept Sci 11:573-88. 2010
    ..This approach to pathogenetics enables new insight into the mechanistic relationship of missense mutations to disease phenotypes in our patients...