Affiliation: Institute for Systems Biology
Wang K, Lee I, Carlson G, Hood L, Galas D. Systems biology and the discovery of diagnostic biomarkers. Dis Markers. 2010;28:199-207 pubmed publisher
..This general approach, including diagnostics and therapeutics, is becoming known as systems medicine. ..
He Y, Yang J, Kong D, Lin J, Xu C, Ren H, et al
. Association of miR-146a rs2910164 polymorphism with cardio-cerebrovascular diseases: A systematic review and meta-analysis. Gene. 2015;565:171-9 pubmed publisher
..Our findings suggested that miR-146a CC genotype might be a protective factor for cardiovascular diseases in Chinese population, but a risk factor in Korean and Indian populations. ..
Lee I, Baxter D, Lee M, Scherler K, Wang K. The Importance of Standardization on Analyzing Circulating RNA. Mol Diagn Ther. 2017;21:259-268 pubmed publisher
Wang K, Li H, Yuan Y, Etheridge A, Zhou Y, Huang D, et al
. The complex exogenous RNA spectra in human plasma: an interface with human gut biota?. PLoS ONE. 2012;7:e51009 pubmed publisher
..These findings raise the possibility that plasma RNAs of exogenous origin may serve as signaling molecules mediating for example the human-microbiome interaction and may affect and/or indicate the state of human health. ..
Wang K, Zhang S, Marzolf B, Troisch P, Brightman A, Hu Z, et al
. Circulating microRNAs, potential biomarkers for drug-induced liver injury. Proc Natl Acad Sci U S A. 2009;106:4402-7 pubmed publisher
..These findings suggest the potential of using specific circulating microRNAs as sensitive and informative biomarkers for drug-induced liver injury. ..
Wang K, Yuan Y, Cho J, McClarty S, Baxter D, Galas D. Comparing the MicroRNA spectrum between serum and plasma. PLoS ONE. 2012;7:e41561 pubmed publisher
..Our results suggest that there are a number of factors that might affect the measurement of circulating miRNA concentration. Caution must be taken when comparing miRNA data generated from different sample types or measurement platforms...
He Y, Zeng K, Zhang X, Chen Q, Wu J, Li H, et al
. A gain-of-function mutation in TRPV3 causes focal palmoplantar keratoderma in a Chinese family. J Invest Dermatol. 2015;135:907-909 pubmed publisher
He Y, Ding Y, Liang B, Lin J, Kim T, Yu H, et al
. A Systematic Study of Dysregulated MicroRNA in Type 2 Diabetes Mellitus. Int J Mol Sci. 2017;18: pubmed publisher
..Some of these miRNAs and their mRNA targets may have diagnostic and/or therapeutic utilities in T2DM. ..