David M Underhill

Summary

Affiliation: Institute for Systems Biology
Country: USA

Publications

  1. pmc Macrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation state
    D A Hume
    Institute for Molecular Bioscience, University of Queensland, Brisbane, Q4072, Australia
    BMC Immunol 2:11. 2001
  2. pmc Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production
    David M Underhill
    Institute for Systems Biology, Seattle, WA 98103, USA
    Blood 106:2543-50. 2005
  3. ncbi Integration of Toll-like receptor and phagocytic signaling for tailored immunity
    David M Underhill
    Institute for Systems Biology, 1441 N 34th Street, Seattle, WA 98103, USA
    Microbes Infect 6:1368-73. 2004
  4. ncbi Toll-like receptors and microbes take aim at each other
    David M Underhill
    Institute for Systems Biology, 1441 N 34th St, Seattle, Washington 98103, USA
    Curr Opin Immunol 16:483-7. 2004
  5. ncbi Macrophage recognition of zymosan particles
    David M Underhill
    Institute for Systems Biology, 1441 N 34th Street, Seattle, WA 98103, USA
    J Endotoxin Res 9:176-80. 2003
  6. ncbi Toll-like receptors: networking for success
    David M Underhill
    Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98105, USA
    Eur J Immunol 33:1767-75. 2003
  7. ncbi Phagocytosis of microbes: complexity in action
    David M Underhill
    Institute for Systems Biology, 1441 North 34 Street, Seattle, Washington 98103, USA
    Annu Rev Immunol 20:825-52. 2002
  8. ncbi Toll-like receptors: key mediators of microbe detection
    David M Underhill
    Institute for Systems Biology, 4225 Roosevelt Way NE, Seattle, WA 98105, USA
    Curr Opin Immunol 14:103-10. 2002
  9. pmc Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2
    Benjamin N Gantner
    Department of Immunology, University of Washington, Seattle, 98103, USA
    J Exp Med 197:1107-17. 2003
  10. pmc Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments
    Benjamin N Gantner
    The Department of Immunology, University of Washington, Seattle, WA, USA
    EMBO J 24:1277-86. 2005

Collaborators

Detail Information

Publications17

  1. pmc Macrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation state
    D A Hume
    Institute for Molecular Bioscience, University of Queensland, Brisbane, Q4072, Australia
    BMC Immunol 2:11. 2001
    ..In this paper we examine whether the signal from Toll-like receptors [TLRs] is sustained for as long as the ligand is present, and whether responses to different TLR agonists are additive...
  2. pmc Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production
    David M Underhill
    Institute for Systems Biology, Seattle, WA 98103, USA
    Blood 106:2543-50. 2005
    ..The proportion of macrophages using this signaling pathway can be modulated by cytokine treatment. Thus, Dectin-1 signaling reveals dynamic macrophage heterogeneity in inflammatory activation potential...
  3. ncbi Integration of Toll-like receptor and phagocytic signaling for tailored immunity
    David M Underhill
    Institute for Systems Biology, 1441 N 34th Street, Seattle, WA 98103, USA
    Microbes Infect 6:1368-73. 2004
    ..In this review, we discuss the relationship between phagocytosis and TLRs from two additional perspectives: first, TLR signaling modulates phagocytosis; second, phagocytosis modulates the consequences of TLR activation...
  4. ncbi Toll-like receptors and microbes take aim at each other
    David M Underhill
    Institute for Systems Biology, 1441 N 34th St, Seattle, Washington 98103, USA
    Curr Opin Immunol 16:483-7. 2004
    ..Recent studies have improved our understanding of the various mechanisms by which pathogenic organisms manipulate the TLR recognition system...
  5. ncbi Macrophage recognition of zymosan particles
    David M Underhill
    Institute for Systems Biology, 1441 N 34th Street, Seattle, WA 98103, USA
    J Endotoxin Res 9:176-80. 2003
    ..Further, ablation of the Toll-like receptor-stimulating activity of zymosan does not affect the ability of phagocytic receptors to internalise the particle...
  6. ncbi Toll-like receptors: networking for success
    David M Underhill
    Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98105, USA
    Eur J Immunol 33:1767-75. 2003
    ..Useful models for these interacting signaling pathways are now emerging and should pave the way for understanding the molecular mechanisms that drive the rich diversity of inflammatory responses...
  7. ncbi Phagocytosis of microbes: complexity in action
    David M Underhill
    Institute for Systems Biology, 1441 North 34 Street, Seattle, Washington 98103, USA
    Annu Rev Immunol 20:825-52. 2002
    ..Indeed, pathogenic microorganisms target many of these molecules in their attempts to evade destruction...
  8. ncbi Toll-like receptors: key mediators of microbe detection
    David M Underhill
    Institute for Systems Biology, 4225 Roosevelt Way NE, Seattle, WA 98105, USA
    Curr Opin Immunol 14:103-10. 2002
    ..There has also been greater recognition of the importance of specific Toll-like receptors in host defense...
  9. pmc Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2
    Benjamin N Gantner
    Department of Immunology, University of Washington, Seattle, 98103, USA
    J Exp Med 197:1107-17. 2003
    ..The data demonstrate that collaborative recognition of distinct microbial components by different classes of innate immune receptors is crucial in orchestrating inflammatory responses...
  10. pmc Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments
    Benjamin N Gantner
    The Department of Immunology, University of Washington, Seattle, WA, USA
    EMBO J 24:1277-86. 2005
    ..The data demonstrate a mechanism by which C. albicans shape alone directly contributes to the method by which phagocytes recognize the fungus...
  11. ncbi Dectin-1 and TLRs permit macrophages to distinguish between different Aspergillus fumigatus cellular states
    Geoffrey M Gersuk
    Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    J Immunol 176:3717-24. 2006
    ..These data demonstrate one mechanism by which the pulmonary inflammatory response is tailored toward metabolically active cells, thereby avoiding unnecessary tissue damage with frequent inhalation of ubiquitous spores...
  12. ncbi Leishmania major activates IL-1 alpha expression in macrophages through a MyD88-dependent pathway
    Thomas R Hawn
    Division of Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Microbes Infect 4:763-71. 2002
    ..Examination of promoter activation is a powerful tool for understanding the early events in macrophage activation for anti-inflammatory pathogens such as Leishmania that have mechanisms to downregulate transcription and translation...
  13. ncbi Paired Ig-like receptors bind to bacteria and shape TLR-mediated cytokine production
    Masafumi Nakayama
    Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103, USA
    J Immunol 178:4250-9. 2007
    ..aureus and enhanced TLR-mediated inflammatory responses to the bacteria. These data suggest a novel mechanism for innate immune regulation by paired Ig-like receptor family members...
  14. ncbi Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cells
    Helen S Goodridge
    Immunobiology Research Institute, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    J Immunol 178:3107-15. 2007
    ..These data establish NFAT activation in myeloid cells as a novel mechanism of regulation of the innate antimicrobial response...
  15. ncbi Generation of diversity in the innate immune system: macrophage heterogeneity arises from gene-autonomous transcriptional probability of individual inducible genes
    Timothy Ravasi
    Institute for Molecular Bioscience, and Cooperative Research Center for Chronic Inflammatory Diseases, University of Queensland, Brisbane, Queensland 4072, Australia
    J Immunol 168:44-50. 2002
    ..The results indicate that each LPS-inducible gene has its own inherent probability of activation in response to LPS...
  16. ncbi Collaboration between the innate immune receptors dectin-1, TLRs, and Nods
    David M Underhill
    Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Immunol Rev 219:75-87. 2007
    ..Studies on the molecular mechanisms of cross-talk and synergy between these receptors provide a framework in which to understand the importance of having multiple receptors recognize individual microbes...
  17. ncbi Phagosome maturation: steady as she goes
    David M Underhill
    Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Immunity 23:343-4. 2005
    ..However, in this issue of Immunity, Yates and Russell use carefully defined particles and quantitative methodology to measure phagosome maturation and find no effect of TLR signaling on the process...