Research Topics
Genomes and Genes | David M UnderhillSummaryAffiliation: Institute for Systems Biology Country: USA Publications
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Publications
Macrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation stateD A Hume
Institute for Molecular Bioscience, University of Queensland, Brisbane, Q4072, Australia
BMC Immunol 2:11. 2001..In this paper we examine whether the signal from Toll-like receptors [TLRs] is sustained for as long as the ligand is present, and whether responses to different TLR agonists are additive...
Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen productionDavid M Underhill
Institute for Systems Biology, Seattle, WA 98103, USA
Blood 106:2543-50. 2005..The proportion of macrophages using this signaling pathway can be modulated by cytokine treatment. Thus, Dectin-1 signaling reveals dynamic macrophage heterogeneity in inflammatory activation potential...
Integration of Toll-like receptor and phagocytic signaling for tailored immunityDavid M Underhill
Institute for Systems Biology, 1441 N 34th Street, Seattle, WA 98103, USA
Microbes Infect 6:1368-73. 2004..In this review, we discuss the relationship between phagocytosis and TLRs from two additional perspectives: first, TLR signaling modulates phagocytosis; second, phagocytosis modulates the consequences of TLR activation...- Toll-like receptors and microbes take aim at each otherDavid M Underhill
Institute for Systems Biology, 1441 N 34th St, Seattle, Washington 98103, USA
Curr Opin Immunol 16:483-7. 2004..Recent studies have improved our understanding of the various mechanisms by which pathogenic organisms manipulate the TLR recognition system... - Macrophage recognition of zymosan particlesDavid M Underhill
Institute for Systems Biology, 1441 N 34th Street, Seattle, WA 98103, USA
J Endotoxin Res 9:176-80. 2003..Further, ablation of the Toll-like receptor-stimulating activity of zymosan does not affect the ability of phagocytic receptors to internalise the particle... - Toll-like receptors: networking for successDavid M Underhill
Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98105, USA
Eur J Immunol 33:1767-75. 2003..Useful models for these interacting signaling pathways are now emerging and should pave the way for understanding the molecular mechanisms that drive the rich diversity of inflammatory responses... - Phagocytosis of microbes: complexity in actionDavid M Underhill
Institute for Systems Biology, 1441 North 34 Street, Seattle, Washington 98103, USA
Annu Rev Immunol 20:825-52. 2002..Indeed, pathogenic microorganisms target many of these molecules in their attempts to evade destruction... - Toll-like receptors: key mediators of microbe detectionDavid M Underhill
Institute for Systems Biology, 4225 Roosevelt Way NE, Seattle, WA 98105, USA
Curr Opin Immunol 14:103-10. 2002..There has also been greater recognition of the importance of specific Toll-like receptors in host defense... - Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2Benjamin N Gantner
Department of Immunology, University of Washington, Seattle, 98103, USA
J Exp Med 197:1107-17. 2003..The data demonstrate that collaborative recognition of distinct microbial components by different classes of innate immune receptors is crucial in orchestrating inflammatory responses... - Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filamentsBenjamin N Gantner
The Department of Immunology, University of Washington, Seattle, WA, USA
EMBO J 24:1277-86. 2005..The data demonstrate a mechanism by which C. albicans shape alone directly contributes to the method by which phagocytes recognize the fungus... - Dectin-1 and TLRs permit macrophages to distinguish between different Aspergillus fumigatus cellular statesGeoffrey M Gersuk
Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Avenue North, Seattle, WA 98109, USA
J Immunol 176:3717-24. 2006..These data demonstrate one mechanism by which the pulmonary inflammatory response is tailored toward metabolically active cells, thereby avoiding unnecessary tissue damage with frequent inhalation of ubiquitous spores... - Leishmania major activates IL-1 alpha expression in macrophages through a MyD88-dependent pathwayThomas R Hawn
Division of Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98195, USA
Microbes Infect 4:763-71. 2002..Examination of promoter activation is a powerful tool for understanding the early events in macrophage activation for anti-inflammatory pathogens such as Leishmania that have mechanisms to downregulate transcription and translation... - Paired Ig-like receptors bind to bacteria and shape TLR-mediated cytokine productionMasafumi Nakayama
Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103, USA
J Immunol 178:4250-9. 2007..aureus and enhanced TLR-mediated inflammatory responses to the bacteria. These data suggest a novel mechanism for innate immune regulation by paired Ig-like receptor family members... - Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cellsHelen S Goodridge
Immunobiology Research Institute, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
J Immunol 178:3107-15. 2007..These data establish NFAT activation in myeloid cells as a novel mechanism of regulation of the innate antimicrobial response... - Generation of diversity in the innate immune system: macrophage heterogeneity arises from gene-autonomous transcriptional probability of individual inducible genesTimothy Ravasi
Institute for Molecular Bioscience, and Cooperative Research Center for Chronic Inflammatory Diseases, University of Queensland, Brisbane, Queensland 4072, Australia
J Immunol 168:44-50. 2002..The results indicate that each LPS-inducible gene has its own inherent probability of activation in response to LPS... - Collaboration between the innate immune receptors dectin-1, TLRs, and NodsDavid M Underhill
Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Immunol Rev 219:75-87. 2007..Studies on the molecular mechanisms of cross-talk and synergy between these receptors provide a framework in which to understand the importance of having multiple receptors recognize individual microbes... - Phagosome maturation: steady as she goesDavid M Underhill
Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
Immunity 23:343-4. 2005..However, in this issue of Immunity, Yates and Russell use carefully defined particles and quantitative methodology to measure phagosome maturation and find no effect of TLR signaling on the process...