Research Topics
| David J ReissSummaryAffiliation: Institute for Systems Biology Country: USA Publications
| Collaborators
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Detail Information
Publications
CTCF physically links cohesin to chromatinEric D Rubio
Department of Radiation Oncology, University of Washington School of Medicine, Seattle WA 98195, USA
Proc Natl Acad Sci U S A 105:8309-14. 2008..These results have implications for the functional role of cohesin subunits in the pathogenesis of Cornelia de Lange syndrome and Roberts syndromes...
The Inferelator: an algorithm for learning parsimonious regulatory networks from systems-biology data sets de novoRichard Bonneau
New York University, Biology Department, Center for Comparative Functional Genomics, New York, NY 10003, USA
Genome Biol 7:R36. 2006..Several specific regulatory predictions were experimentally tested and verified...
Multi-species integrative biclusteringPeter Waltman
Computer Science Department, Warren Weaver Hall Room 305, 251 Mercer Street, New York, NY 10012, USA
Genome Biol 11:R96. 2010....
Predicting protein-peptide interactions via a network-based motif samplerDavid J Reiss
Institute for Systems Biology, Seattle, WA 98103 8904, USA
Bioinformatics 20:i274-82. 2004..Such a question was recently posed by the use of random peptide screens to characterize the ligands of one such PRM, the SH3 domain...
Model-based deconvolution of genome-wide DNA bindingDavid J Reiss
Institute for Systems Biology, 1441 N 34th St Seattle, WA 98103 8904, USA
Bioinformatics 24:396-403. 2008....
Integrated biclustering of heterogeneous genome-wide datasets for the inference of global regulatory networksDavid J Reiss
Institute for Systems Biology, 1441 N, 34th St, Seattle, WA 98103 8904, USA
BMC Bioinformatics 7:280. 2006..In organisms where these motifs are not known, their de novo detection, integrated into the clustering algorithm, can help to guide the process towards more biologically parsimonious solutions...
Tools enabling the elucidation of molecular pathways active in human disease: application to Hepatitis C virus infectionDavid J Reiss
Institute for Systems Biology, 1441 N, 34th Street, Seattle, WA 98103, USA
BMC Bioinformatics 6:154. 2005....
Large scale physiological readjustment during growth enables rapid, comprehensive and inexpensive systems analysisMarc T Facciotti
Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103, USA
BMC Syst Biol 4:64. 2010..Therefore, a relatively quick and inexpensive strategy for observing changes in large fractions of the genetic elements is highly desirable...
Coordination of frontline defense mechanisms under severe oxidative stressAmardeep Kaur
Institute for Systems Biology, Seattle, WA 98103, USA
Mol Syst Biol 6:393. 2010....
Prevalence of transcription promoters within archaeal operons and coding sequencesTie Koide
Institute for Systems Biology, Seattle, WA 98103, USA
Mol Syst Biol 5:285. 2009..Using experimental validation, we illustrate the prevalence of overlapping genomic signals in archaeal transcription, casting doubt on the general perception of rigid boundaries between coding sequences and regulatory elements...
A single transcription factor regulates evolutionarily diverse but functionally linked metabolic pathways in response to nutrient availabilityAmy K Schmid
Institute for Systems Biology, Seattle, WA 98103 8904, USA
Mol Syst Biol 5:282. 2009..Simultaneous analysis of metabolic and gene regulatory network architectures suggests an ongoing process of co-evolution in which TrmB integrates the expression of metabolic enzyme-coding genes of diverse origins...
The anatomy of microbial cell state transitions in response to oxygenAmy K Schmid
Institute for Systems Biology, Seattle, Washington 98103, USA
Genome Res 17:1399-413. 2007..Dynamic temporal analysis of relationships between transcription and translation of key genes suggests several important mechanisms for cellular sustenance under anoxia as well as specific instances of post-transcriptional regulation...
Parallel evolution of transcriptome architecture during genome reorganizationSung Ho Yoon
Institute for Systems Biology, Seattle, Washington 98109, USA
Genome Res 21:1892-904. 2011..Importantly, our integrated analysis has revealed that organisms adapted to higher growth temperatures have lower tolerance for genome reorganization events that disrupt operon structures...
Integration and visualization of systems biology data in context of the genomeJ Christopher Bare
Institute for Systems Biology, 1441 N 34th Street, Seattle, WA 98103, USA
BMC Bioinformatics 11:382. 2010..Visualization and exploration of this data is critical to understanding the regulatory logic encoded in the genome by which the cell dynamically affects its physiology and interacts with its environment...
General transcription factor specified global gene regulation in archaeaMarc T Facciotti
Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98121, USA
Proc Natl Acad Sci U S A 104:4630-5. 2007....
Halobacterium salinarum NRC-1 PeptideAtlas: toward strategies for targeted proteomics and improved proteome coveragePhu T Van
Institute for Systems Biology, 1441 North 34th Street, Seattle, Washington 98103, USA
J Proteome Res 7:3755-64. 2008..Therefore, despite identifying at least one proteotypic peptide for almost all proteins in the PA, a context-dependent selection of proteotypic peptides appears to be the most effective approach for targeted proteomics...
Niche adaptation by expansion and reprogramming of general transcription factorsSerdar Turkarslan
Baliga Lab, Institute for Systems Biology, Seattle, WA 98109, USA
Mol Syst Biol 7:554. 2011..Based on these insights, we have introduced a synthetically redesigned TFB and altered the regulation of existing TFBs to illustrate how archaea can rapidly generate novel phenotypes by simply reprogramming their TFB regulatory network...
The Gaggle: an open-source software system for integrating bioinformatics software and data sourcesPaul T Shannon
Institute for Systems Biology, Seattle, WA 98103, USA
BMC Bioinformatics 7:176. 2006..A solution to this problem should recognize that data types, formats and software in this high throughput age of biology are constantly changing...
An integrated systems approach for understanding cellular responses to gamma radiationKenia Whitehead
Institute for Systems Biology, Seattle, WA 98103-8904, USA
Mol Syst Biol 2:47. 2006....
Global analysis of mRNA stability in Mycobacterium tuberculosisTige R Rustad
Seattle Biomedical Research Institute, 307 Westlake Avenue North, Seattle, WA 98109, USA
Nucleic Acids Res 41:509-17. 2013..The generally stable transcriptome described here, and the additional stabilization in response to physiologically relevant stresses, has far-ranging implications for how this pathogen is able to adapt in its human host...
BioNetBuilder: automatic integration of biological networksIliana Avila-Campillo
Department of Biology, New York University, New York, NY, USA
Bioinformatics 23:392-3. 2007..The BioNetBuilder plugin client is available as a Java Webstart, providing a platform-independent network interface to these public databases. Availability: http://err.bio.nyu.edu/cytoscape/bionetbuilder/..
A predictive model for transcriptional control of physiology in a free living cellRichard Bonneau
Center for Genomics and Systems Biology, New York University, New York, NY 10003, USA Courant Institute of Mathematical Sciences, Department of Computer Science, New York University, New York, NY 10003, USA
Cell 131:1354-65. 2007..This study supports the claim that the high degree of connectivity within biological and EF networks will enable the construction of similar models for any organism from relatively modest numbers of experiments...
