Edward A Miao

Summary

Affiliation: Institute for Systems Biology
Country: USA

Publications

  1. pmc Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
    Edward A Miao
    Institute for Systems Biology, Seattle, Washington, USA
    Nat Immunol 11:1136-42. 2010
  2. pmc Innate immune detection of bacterial virulence factors via the NLRC4 inflammasome
    Edward A Miao
    Institute for Systems Biology, 1441 N 34th St, Seattle, WA 98103, USA
    J Clin Immunol 30:502-6. 2010
  3. pmc Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome
    Edward A Miao
    Institute for Systems Biology, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 107:3076-80. 2010
  4. pmc Pseudomonas aeruginosa activates caspase 1 through Ipaf
    Edward A Miao
    Institute for Systems Biology, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 105:2562-7. 2008
  5. pmc Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2
    Sarah E Warren
    Institute for Systems Biology, Seattle, WA 98103, USA
    J Immunol 185:818-21. 2010
  6. pmc Generation of a Listeria vaccine strain by enhanced caspase-1 activation
    Sarah E Warren
    Institute for Systems Biology, Seattle, WA 98109, USA
    Eur J Immunol 41:1934-40. 2011
  7. ncbi Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf
    Edward A Miao
    Institute for Systems Biology, Seattle, Washington 98103, USA
    Nat Immunol 7:569-75. 2006
  8. pmc Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo
    Nelson C Di Paolo
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Immunity 31:110-21. 2009
  9. pmc Activation of the NLRP3 inflammasome by intracellular poly I:C
    Jayant V Rajan
    Institute for Systems Biology, Seattle, WA 98103, USA
    FEBS Lett 584:4627-32. 2010
  10. pmc The NLRP3 inflammasome detects encephalomyocarditis virus and vesicular stomatitis virus infection
    Jayant V Rajan
    Institute for Systems Biology, 1441 34th Avenue N, Seattle, WA 98104, USA
    J Virol 85:4167-72. 2011

Collaborators

Detail Information

Publications13

  1. pmc Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
    Edward A Miao
    Institute for Systems Biology, Seattle, Washington, USA
    Nat Immunol 11:1136-42. 2010
    ..This demonstrates that activation of caspase-1 clears intracellular bacteria in vivo independently of IL-1β and IL-18 and establishes pyroptosis as an efficient mechanism of bacterial clearance by the innate immune system...
  2. pmc Innate immune detection of bacterial virulence factors via the NLRC4 inflammasome
    Edward A Miao
    Institute for Systems Biology, 1441 N 34th St, Seattle, WA 98103, USA
    J Clin Immunol 30:502-6. 2010
    ..Both flagellin and rod protein are unintentionally delivered to the mammalian cytosol by the bacterium through the T3SS...
  3. pmc Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome
    Edward A Miao
    Institute for Systems Biology, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 107:3076-80. 2010
    ..Furthermore, the specific detection of the virulence machinery permits the discrimination between pathogenic and nonpathogenic bacteria...
  4. pmc Pseudomonas aeruginosa activates caspase 1 through Ipaf
    Edward A Miao
    Institute for Systems Biology, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 105:2562-7. 2008
    ..Thus, Ipaf-dependent detection of cytosolic flagellin is a conserved mechanism by which macrophages detect the presence of pathogens that use T3SS...
  5. pmc Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2
    Sarah E Warren
    Institute for Systems Biology, Seattle, WA 98103, USA
    J Immunol 185:818-21. 2010
    ..We now use biochemical and genetic approaches to demonstrate that the third detector senses bacterial DNA and identify it as Aim2, a receptor that has previously been shown to detect viral DNA...
  6. pmc Generation of a Listeria vaccine strain by enhanced caspase-1 activation
    Sarah E Warren
    Institute for Systems Biology, Seattle, WA 98109, USA
    Eur J Immunol 41:1934-40. 2011
    ..monocytogenes-based vaccine. Moreover, the attenuated strains with embedded flagellin or PrgJ adjuvants represent attractive vectors for vaccines aimed at eliciting T-cell responses...
  7. ncbi Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf
    Edward A Miao
    Institute for Systems Biology, Seattle, Washington 98103, USA
    Nat Immunol 7:569-75. 2006
    ....
  8. pmc Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo
    Nelson C Di Paolo
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Immunity 31:110-21. 2009
    ..Thus, these data identify IL-1 alpha-IL-1RI as a key pathway allowing for the activation of proinflammatory responses to the virus, independently of its genomic nucleic acid recognition...
  9. pmc Activation of the NLRP3 inflammasome by intracellular poly I:C
    Jayant V Rajan
    Institute for Systems Biology, Seattle, WA 98103, USA
    FEBS Lett 584:4627-32. 2010
    ..This detection is independent of the other poly I:C sensors: TLR3 and MDA5. These results suggest a mechanism by which cytosolic dsRNA produced during viral infection could activate the NLRP3 inflammasome...
  10. pmc The NLRP3 inflammasome detects encephalomyocarditis virus and vesicular stomatitis virus infection
    Jayant V Rajan
    Institute for Systems Biology, 1441 34th Avenue N, Seattle, WA 98104, USA
    J Virol 85:4167-72. 2011
    ..These findings indicate that the NLRP3 inflammasome may be a common pathway for RNA virus detection, but its precise role in the host response may be variable...
  11. ncbi TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system
    Edward A Miao
    Institute for Systems Biology, Seattle, WA 98103, USA
    Semin Immunopathol 29:275-88. 2007
    ..Thus, TLR5 responds more generally to flagellated bacteria, while Ipaf responds to bacteria that express both flagellin and virulence factors...
  12. ncbi Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton
    Edward A Miao
    Department of Microbiology, University of Washington, HSB K 140, Box 357710, Seattle, WA 98195 7710, USA
    Mol Microbiol 48:401-15. 2003
    ..However, a third intracellular virulence factor, spvB, which ADP-ribosylates actin, strongly inhibited VAP formation in HeLa cells, suggesting a more subtle effect for SspH2 and SseI on the actin cytoskeleton...
  13. pmc Transcription of the SsrAB regulon is repressed by alkaline pH and is independent of PhoPQ and magnesium concentration
    Edward A Miao
    Department of Microbiology, Health Sciences Building, University of Washington, Seattle, WA 98195, USA
    J Bacteriol 184:1493-7. 2002
    ..0 or at a lower pH, suggesting that alkaline pH represses SsrAB activation. In addition, the PhoPQ two-component system, which is also activated intracellularly, was not required for activation of SsrAB...