Affiliation: Institute for Systems Biology
- Integrated genomic and proteomic analyses of a systematically perturbed metabolic networkT Ideker
The Institute for Systems Biology, 4225 Roosevelt Way NE, Suite 200, Seattle, WA 98105, USA
Science 292:929-34. 2001..We refine the model through further iterations of perturbation and global measurements, suggesting hypotheses about the regulation of galactose utilization and physical interactions between this and a variety of other metabolic pathways...
- Testing for differentially-expressed genes by maximum-likelihood analysis of microarray dataT Ideker
Department of Molecular Biotechnology, University of Washington, Seattle, WA 98195, USA
J Comput Biol 7:805-17. 2000..The effect of sample size on parameter optimization is also explored, as is the use of the error model to compare the within- and between-slide intensity variation intrinsic to an array experiment...
- A new approach to decoding life: systems biologyT Ideker
Institute for Systems Biology, Seattle, Washington 98105, USA
Annu Rev Genomics Hum Genet 2:343-72. 2001..The emergence of systems biology is described, as are several examples of specific systems approaches...
- Negative selection: a method for obtaining low-abundance cDNAs using high-density cDNA clone arraysP S Nelson
Department of Molecular Biotechnology, University of Washington, Seattle 98195, USA
Genet Anal 15:209-15. 1999....