Gustavo Glusman

Summary

Affiliation: Institute for Systems Biology
Country: USA

Publications

  1. pmc Optimal scaling of digital transcriptomes
    Gustavo Glusman
    Institute for Systems Biology, Seattle, Washington, United States of America
    PLoS ONE 8:e77885. 2013
  2. pmc Kaviar: an accessible system for testing SNV novelty
    Gustavo Glusman
    Institute for Systems Biology, Seattle, WA 98109, USA
    Bioinformatics 27:3216-7. 2011
  3. pmc Genomic complexity of the variable region-containing chitin-binding proteins in amphioxus
    Larry J Dishaw
    All Children s Hospital, Department of Molecular Genetics, 801 Sixth Street South, St, Petersburg, FL 33701, USA
    BMC Genet 9:78. 2008
  4. pmc A third approach to gene prediction suggests thousands of additional human transcribed regions
    Gustavo Glusman
    Institute for Systems Biology, Seattle, Washington, USA
    PLoS Comput Biol 2:e18. 2006
  5. pmc The evolution of vertebrate Toll-like receptors
    Jared C Roach
    Institute for Systems Biology, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 102:9577-82. 2005
  6. pmc Relationship estimation from whole-genome sequence data
    Hong Li
    Institute for Systems Biology, Seattle, Washington, United States of America
    PLoS Genet 10:e1004144. 2014
  7. pmc Chromosomal haplotypes by genetic phasing of human families
    Jared C Roach
    Institute for Systems Biology, Seattle, WA 98109, USA
    Am J Hum Genet 89:382-97. 2011
  8. pmc Analysis of genetic inheritance in a family quartet by whole-genome sequencing
    Jared C Roach
    Institute for Systems Biology, Seattle, WA 98103, USA
    Science 328:636-9. 2010
  9. pmc Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden
    Jared C Roach
    Institute for Systems Biology, Seattle, WA 98103, USA
    Am J Hum Genet 79:614-27. 2006
  10. pmc An enigmatic fourth runt domain gene in the fugu genome: ancestral gene loss versus accelerated evolution
    Gustavo Glusman
    Institute for Systems Biology, 1441 N 34th St, Seattle, WA 98103, USA
    BMC Evol Biol 4:43. 2004

Collaborators

Detail Information

Publications25

  1. pmc Optimal scaling of digital transcriptomes
    Gustavo Glusman
    Institute for Systems Biology, Seattle, Washington, United States of America
    PLoS ONE 8:e77885. 2013
    ..The new methods yield robustly normalized expression values, which is a prerequisite for the identification of differentially expressed and tissue-specific genes as potential biomarkers. ..
  2. pmc Kaviar: an accessible system for testing SNV novelty
    Gustavo Glusman
    Institute for Systems Biology, Seattle, WA 98109, USA
    Bioinformatics 27:3216-7. 2011
    ....
  3. pmc Genomic complexity of the variable region-containing chitin-binding proteins in amphioxus
    Larry J Dishaw
    All Children s Hospital, Department of Molecular Genetics, 801 Sixth Street South, St, Petersburg, FL 33701, USA
    BMC Genet 9:78. 2008
    ..In this report, we describe VCBP genomic organization and characterize adjacent and intervening genetic features which may influence both their polymorphism and complex transcriptional repertoire...
  4. pmc A third approach to gene prediction suggests thousands of additional human transcribed regions
    Gustavo Glusman
    Institute for Systems Biology, Seattle, Washington, USA
    PLoS Comput Biol 2:e18. 2006
    ..They therefore complement existing gene prediction methods and will help identify functional transcripts within many apparent "genomic deserts."..
  5. pmc The evolution of vertebrate Toll-like receptors
    Jared C Roach
    Institute for Systems Biology, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 102:9577-82. 2005
    ..In addition, we have produced >70 gene models, including sequences from the opossum, chicken, frog, dog, sea urchin, and sea squirt...
  6. pmc Relationship estimation from whole-genome sequence data
    Hong Li
    Institute for Systems Biology, Seattle, Washington, United States of America
    PLoS Genet 10:e1004144. 2014
    ..Our results identify regions of the genome that are highly problematic for IBD mapping and introduce new software to accurately detect 1(st) through 9(th) degree relationships from whole-genome sequence data. ..
  7. pmc Chromosomal haplotypes by genetic phasing of human families
    Jared C Roach
    Institute for Systems Biology, Seattle, WA 98109, USA
    Am J Hum Genet 89:382-97. 2011
    ..We implement our algorithm in a suite of software scripts (Haploscribe). Haplotypes and family genome sequences will become increasingly important for personalized medicine and for fundamental biology...
  8. pmc Analysis of genetic inheritance in a family quartet by whole-genome sequencing
    Jared C Roach
    Institute for Systems Biology, Seattle, WA 98103, USA
    Science 328:636-9. 2010
    ..Family-based genome analysis enabled us to narrow the candidate genes for both of these Mendelian disorders to only four. Our results demonstrate the value of complete genome sequencing in families...
  9. pmc Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden
    Jared C Roach
    Institute for Systems Biology, Seattle, WA 98103, USA
    Am J Hum Genet 79:614-27. 2006
    ..0%-31.0%) suggests that variation within ITPR3 reflects an important contribution to T1D in Sweden. Two-locus regression analysis supports an influence of ITPR3 variation on T1D that is distinct from that of any MHC class II gene...
  10. pmc An enigmatic fourth runt domain gene in the fugu genome: ancestral gene loss versus accelerated evolution
    Gustavo Glusman
    Institute for Systems Biology, 1441 N 34th St, Seattle, WA 98103, USA
    BMC Evol Biol 4:43. 2004
    ..Three runt domain genes have been described in each vertebrate genome (the RUNX gene family), but only one in other chordates. Therefore, the common ancestor of vertebrates has been thought to have had a single runt domain gene...
  11. pmc Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea
    Nitin S Baliga
    Institute for Systems Biology, Seattle, Washington 98103, USA
    Genome Res 14:2221-34. 2004
    ..Finally, as expected from the larger genome, H. marismortui encodes many more functions and seems to have fewer nutritional requirements for survival than does Halobacterium sp. NRC-1...
  12. pmc Accurate and robust prediction of genetic relationship from whole-genome sequences
    Hong Li
    Institute for Systems Biology, Seattle, Washington, United States of America
    PLoS ONE 9:e85437. 2014
    ..The software is available at familygenomics.systemsbiology.net/grab. ..
  13. pmc Realistic artificial DNA sequences as negative controls for computational genomics
    Juan Caballero
    Institute for Systems Biology, 401 Terry Ave N, Seattle, WA 98109, USA
    Nucleic Acids Res 42:e99. 2014
    ..A web service, source code and the models for human and many other species are freely available at http://repeatmasker.org/garlic/. ..
  14. pmc Low-pass sequencing for microbial comparative genomics
    Young Ah Goo
    Institute for Systems Biology, Seattle, Washington 98103, USA
    BMC Genomics 5:3. 2004
    ..NRC-1 genome as a reference. Low-pass shotgun sequencing is a simple, inexpensive, and rapid approach that can readily be performed on any cultured microbe...
  15. ncbi request reprint KLK31P is a novel androgen regulated and transcribed pseudogene of kallikreins that is expressed at lower levels in prostate cancer cells than in normal prostate cells
    Wei Lu
    Institute for Systems Biology, Seattle, Washington 98103, USA
    Prostate 66:936-44. 2006
    ..KLK expression is associated with various human diseases including cancers. Noncoding RNAs such as PCA3/DD3 and PCGEM1 have been identified in prostate cancer cells...
  16. pmc Genetic divergence of the rhesus macaque major histocompatibility complex
    Riza Daza-Vamenta
    The Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genome Res 14:1501-15. 2004
    ..For the clinical model, these data and derivative genetic tools can be implemented in ongoing genetic and disease studies that involve the rhesus macaque...
  17. ncbi request reprint Interchromosomal segmental duplications explain the unusual structure of PRSS3, the gene for an inhibitor-resistant trypsinogen
    Lee Rowen
    Institute for Systems Biology, Seattle, Washington, USA
    Mol Biol Evol 22:1712-20. 2005
    ..These residues could be involved in interactions with inhibitors...
  18. pmc Structural and genetic diversity of group B streptococcus capsular polysaccharides
    Michael J Cieslewicz
    Division of Infectious Diseases, Children s Hospital, University of Washington, Seattle, WA 98109, USA
    Infect Immun 73:3096-103. 2005
    ....
  19. pmc T1DBase, a community web-based resource for type 1 diabetes research
    Luc J Smink
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Cambridge CB2 2XY, UK
    Nucleic Acids Res 33:D544-9. 2005
    ..All data are open access and all software is open source...
  20. ncbi request reprint Phylogenesis and regulated expression of the RUNT domain transcription factors RUNX1 and RUNX3
    Ditsa Levanon
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Blood Cells Mol Dis 30:161-3. 2003
    ..In the absence of Runx3, knockout mice develop severe ataxia due to the early death of the TrkC neurons. Other phenotypic defects of Runx3 KO mice including abnormalities in thymopoiesis are also being investigated...
  21. pmc Human Gene-Centric Databases at the Weizmann Institute of Science: GeneCards, UDB, CroW 21 and HORDE
    Marilyn Safran
    Department of Biological Services Bioinformatics Unit, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Nucleic Acids Res 31:142-6. 2003
    ..weizmann.ac.il/HORDE). The synergistic relationships amongst these efforts have positively impacted the quality, quantity and usefulness of the GeneCards gene compendium...
  22. ncbi request reprint Initial sequencing and comparative analysis of the mouse genome
    Robert H Waterston
    Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
    Nature 420:520-62. 2002
    ....
  23. ncbi request reprint Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes
    Samuel Aparicio
    Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609
    Science 297:1301-10. 2002
    ..Conserved linkages between Fugu and human genes indicate the preservation of chromosomal segments from the common vertebrate ancestor, but with considerable scrambling of gene order...
  24. pmc A comparison of the human and chimpanzee olfactory receptor gene repertoires
    Yoav Gilad
    Yale University School of Medicine, Department of Genetics, New Haven, Connecticut 06520, USA
    Genome Res 15:224-30. 2005
    ..Thus, although overall there is relaxed constraint on human olfaction relative to chimpanzee, species-specific sensory requirements appear to have shaped the evolution of the functional OR gene repertoires in both species...