Research Topics
Genomes and Genes | Gustavo GlusmanSummaryAffiliation: Institute for Systems Biology Country: USA Publications
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Detail Information
Publications
Kaviar: an accessible system for testing SNV noveltyGustavo Glusman
Institute for Systems Biology, Seattle, WA 98109, USA
Bioinformatics 27:3216-7. 2011....- Genomic complexity of the variable region-containing chitin-binding proteins in amphioxusLarry J Dishaw
All Children s Hospital, Department of Molecular Genetics, 801 Sixth Street South, St, Petersburg, FL 33701, USA
BMC Genet 9:78. 2008..In this report, we describe VCBP genomic organization and characterize adjacent and intervening genetic features which may influence both their polymorphism and complex transcriptional repertoire... - A third approach to gene prediction suggests thousands of additional human transcribed regionsGustavo Glusman
Institute for Systems Biology, Seattle, Washington, USA
PLoS Comput Biol 2:e18. 2006..They therefore complement existing gene prediction methods and will help identify functional transcripts within many apparent "genomic deserts.".. - The evolution of vertebrate Toll-like receptorsJared C Roach
Institute for Systems Biology, Seattle, WA 98103, USA
Proc Natl Acad Sci U S A 102:9577-82. 2005..In addition, we have produced >70 gene models, including sequences from the opossum, chicken, frog, dog, sea urchin, and sea squirt... - Chromosomal haplotypes by genetic phasing of human familiesJared C Roach
Institute for Systems Biology, Seattle, WA 98109, USA
Am J Hum Genet 89:382-97. 2011..We implement our algorithm in a suite of software scripts (Haploscribe). Haplotypes and family genome sequences will become increasingly important for personalized medicine and for fundamental biology... - Analysis of genetic inheritance in a family quartet by whole-genome sequencingJared C Roach
Institute for Systems Biology, Seattle, WA 98103, USA
Science 328:636-9. 2010..Family-based genome analysis enabled us to narrow the candidate genes for both of these Mendelian disorders to only four. Our results demonstrate the value of complete genome sequencing in families... - Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in SwedenJared C Roach
Institute for Systems Biology, Seattle, WA 98103, USA
Am J Hum Genet 79:614-27. 2006..0%-31.0%) suggests that variation within ITPR3 reflects an important contribution to T1D in Sweden. Two-locus regression analysis supports an influence of ITPR3 variation on T1D that is distinct from that of any MHC class II gene... - An enigmatic fourth runt domain gene in the fugu genome: ancestral gene loss versus accelerated evolutionGustavo Glusman
Institute for Systems Biology, 1441 N 34th St, Seattle, WA 98103, USA
BMC Evol Biol 4:43. 2004..Three runt domain genes have been described in each vertebrate genome (the RUNX gene family), but only one in other chordates. Therefore, the common ancestor of vertebrates has been thought to have had a single runt domain gene... - Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead SeaNitin S Baliga
Institute for Systems Biology, Seattle, Washington 98103, USA
Genome Res 14:2221-34. 2004..Finally, as expected from the larger genome, H. marismortui encodes many more functions and seems to have fewer nutritional requirements for survival than does Halobacterium sp. NRC-1... - Low-pass sequencing for microbial comparative genomicsYoung Ah Goo
Institute for Systems Biology, Seattle, Washington 98103, USA
BMC Genomics 5:3. 2004..NRC-1 genome as a reference. Low-pass shotgun sequencing is a simple, inexpensive, and rapid approach that can readily be performed on any cultured microbe... - Genetic divergence of the rhesus macaque major histocompatibility complexRiza Daza-Vamenta
The Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Genome Res 14:1501-15. 2004..For the clinical model, these data and derivative genetic tools can be implemented in ongoing genetic and disease studies that involve the rhesus macaque... 
KLK31P is a novel androgen regulated and transcribed pseudogene of kallikreins that is expressed at lower levels in prostate cancer cells than in normal prostate cellsWei Lu
Institute for Systems Biology, Seattle, Washington 98103, USA
Prostate 66:936-44. 2006..KLK expression is associated with various human diseases including cancers. Noncoding RNAs such as PCA3/DD3 and PCGEM1 have been identified in prostate cancer cells...- Interchromosomal segmental duplications explain the unusual structure of PRSS3, the gene for an inhibitor-resistant trypsinogenLee Rowen
Institute for Systems Biology, Seattle, Washington, USA
Mol Biol Evol 22:1712-20. 2005..These residues could be involved in interactions with inhibitors... - Structural and genetic diversity of group B streptococcus capsular polysaccharidesMichael J Cieslewicz
Division of Infectious Diseases, Children s Hospital, University of Washington, Seattle, WA 98109, USA
Infect Immun 73:3096-103. 2005.... - T1DBase, a community web-based resource for type 1 diabetes researchLuc J Smink
Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Cambridge CB2 2XY, UK
Nucleic Acids Res 33:D544-9. 2005..All data are open access and all software is open source... - Phylogenesis and regulated expression of the RUNT domain transcription factors RUNX1 and RUNX3Ditsa Levanon
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
Blood Cells Mol Dis 30:161-3. 2003..In the absence of Runx3, knockout mice develop severe ataxia due to the early death of the TrkC neurons. Other phenotypic defects of Runx3 KO mice including abnormalities in thymopoiesis are also being investigated... - Human Gene-Centric Databases at the Weizmann Institute of Science: GeneCards, UDB, CroW 21 and HORDEMarilyn Safran
Department of Biological Services Bioinformatics Unit, The Weizmann Institute of Science, 76100 Rehovot, Israel
Nucleic Acids Res 31:142-6. 2003..weizmann.ac.il/HORDE). The synergistic relationships amongst these efforts have positively impacted the quality, quantity and usefulness of the GeneCards gene compendium... - Initial sequencing and comparative analysis of the mouse genomeRobert H Waterston
Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
Nature 420:520-62. 2002.... - Whole-genome shotgun assembly and analysis of the genome of Fugu rubripesSamuel Aparicio
Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609
Science 297:1301-10. 2002..Conserved linkages between Fugu and human genes indicate the preservation of chromosomal segments from the common vertebrate ancestor, but with considerable scrambling of gene order... - A comparison of the human and chimpanzee olfactory receptor gene repertoiresYoav Gilad
Yale University School of Medicine, Department of Genetics, New Haven, Connecticut 06520, USA
Genome Res 15:224-30. 2005..Thus, although overall there is relaxed constraint on human olfaction relative to chimpanzee, species-specific sensory requirements appear to have shaped the evolution of the functional OR gene repertoires in both species...