Sebastian Gagneux

Summary

Affiliation: Institute for Systems Biology
Country: USA

Publications

  1. ncbi request reprint Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development
    Sebastien Gagneux
    Institute for Systems Biology, Seattle, WA, USA
    Lancet Infect Dis 7:328-37. 2007
  2. ncbi request reprint Genomic interrogation of ancestral Mycobacterium tuberculosis from south India
    Sujatha Narayanan
    Tuberculosis Research Centre, Mayor VR Ramanathan Road, Chetput, Chennai, India
    Infect Genet Evol 8:474-83. 2008
  3. pmc Impact of bacterial genetics on the transmission of isoniazid-resistant Mycobacterium tuberculosis
    Sebastian Gagneux
    Division of Infectious Diseases and Geographic Medicine, Stanford University Medical Center, Stanford, California, USA
    PLoS Pathog 2:e61. 2006
  4. ncbi request reprint The competitive cost of antibiotic resistance in Mycobacterium tuberculosis
    Sebastien Gagneux
    Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA 94305, USA
    Science 312:1944-6. 2006
  5. pmc Variable host-pathogen compatibility in Mycobacterium tuberculosis
    Sebastien Gagneux
    Institute for Systems Biology, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 103:2869-73. 2006
  6. pmc Progression to active tuberculosis, but not transmission, varies by Mycobacterium tuberculosis lineage in The Gambia
    Bouke C de Jong
    Medical Research Council Laboratories, Banjul, The Gambia
    J Infect Dis 198:1037-43. 2008
  7. ncbi request reprint Mycobacterium africanum elicits an attenuated T cell response to early secreted antigenic target, 6 kDa, in patients with tuberculosis and their household contacts
    Bouke C de Jong
    Medical Research Council Laboratories, The Gambia
    J Infect Dis 193:1279-86. 2006
  8. pmc Relationship between Mycobacterium tuberculosis genotype and the clinical phenotype of pulmonary and meningeal tuberculosis
    Guy Thwaites
    Centre for Molecular Microbiology and Infection, Imperial College, Exhibition Rd, South Kensington, London, United Kingdom
    J Clin Microbiol 46:1363-8. 2008
  9. pmc The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis
    Maxine Caws
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam
    PLoS Pathog 4:e1000034. 2008
  10. pmc Large sequence polymorphisms classify Mycobacterium tuberculosis strains with ancestral spoligotyping patterns
    Laura Flores
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, USA
    J Clin Microbiol 45:3393-5. 2007

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development
    Sebastien Gagneux
    Institute for Systems Biology, Seattle, WA, USA
    Lancet Infect Dis 7:328-37. 2007
    ..We propose a strain selection framework, based on robust phylogenetic markers, which will allow for systematic and comprehensive evaluation of new tools for tuberculosis control...
  2. ncbi request reprint Genomic interrogation of ancestral Mycobacterium tuberculosis from south India
    Sujatha Narayanan
    Tuberculosis Research Centre, Mayor VR Ramanathan Road, Chetput, Chennai, India
    Infect Genet Evol 8:474-83. 2008
    ..2% belonged to the ancestral lineage of M. tuberculosis. Comparative whole-genome hybridization identified six new genomic regions within this lineage that were variably deleted...
  3. pmc Impact of bacterial genetics on the transmission of isoniazid-resistant Mycobacterium tuberculosis
    Sebastian Gagneux
    Division of Infectious Diseases and Geographic Medicine, Stanford University Medical Center, Stanford, California, USA
    PLoS Pathog 2:e61. 2006
    ..tuberculosis lineages. Our results show that in addition to host and environmental factors, strain genetic diversity can influence the transmission dynamics of drug-resistant bacteria...
  4. ncbi request reprint The competitive cost of antibiotic resistance in Mycobacterium tuberculosis
    Sebastien Gagneux
    Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA 94305, USA
    Science 312:1944-6. 2006
    ..In contrast, we demonstrate that prolonged patient treatment can result in multidrug-resistant strains with no fitness defect and that strains with low- or no-cost resistance mutations are also the most frequent among clinical isolates...
  5. pmc Variable host-pathogen compatibility in Mycobacterium tuberculosis
    Sebastien Gagneux
    Institute for Systems Biology, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 103:2869-73. 2006
    ..These observations suggest that mycobacterial lineages are adapted to particular human populations. If confirmed, our findings have important implications for tuberculosis control and vaccine development...
  6. pmc Progression to active tuberculosis, but not transmission, varies by Mycobacterium tuberculosis lineage in The Gambia
    Bouke C de Jong
    Medical Research Council Laboratories, Banjul, The Gambia
    J Infect Dis 198:1037-43. 2008
    ..There is considerable variability in the outcome of Mycobacterium tuberculosis infection. We hypothesized that Mycobacterium africanum was less likely than M. tuberculosis to transmit and progress to tuberculosis disease...
  7. ncbi request reprint Mycobacterium africanum elicits an attenuated T cell response to early secreted antigenic target, 6 kDa, in patients with tuberculosis and their household contacts
    Bouke C de Jong
    Medical Research Council Laboratories, The Gambia
    J Infect Dis 193:1279-86. 2006
    ..Mycobacterium africanum, a member of the M. tuberculosis complex that is infrequently found outside of western Africa, is the cause of up to half of the tuberculosis cases there...
  8. pmc Relationship between Mycobacterium tuberculosis genotype and the clinical phenotype of pulmonary and meningeal tuberculosis
    Guy Thwaites
    Centre for Molecular Microbiology and Infection, Imperial College, Exhibition Rd, South Kensington, London, United Kingdom
    J Clin Microbiol 46:1363-8. 2008
    ..In addition, increased drug resistance among bacteria of the East Asian/Beijing lineage might influence the response to treatment. This study suggests the genetic diversity of M. tuberculosis has important clinical consequences...
  9. pmc The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis
    Maxine Caws
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam
    PLoS Pathog 4:e1000034. 2008
    ..The study provides evidence that M. tuberculosis genotype influences clinical disease phenotype and demonstrates, for the first time, a significant interaction between host and bacterial genotypes and the development of tuberculosis...
  10. pmc Large sequence polymorphisms classify Mycobacterium tuberculosis strains with ancestral spoligotyping patterns
    Laura Flores
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, USA
    J Clin Microbiol 45:3393-5. 2007
    ..tuberculosis...
  11. ncbi request reprint Genetic diversification of Neisseria meningitidis during waves of colonization and disease in the meningitis belt of sub-Saharan Africa
    Julia Leimkugel
    Swiss Tropical Institute, Socinstr 57, 4051 Basel, Switzerland
    Vaccine 25:A18-23. 2007
    ....
  12. pmc The W-Beijing lineage of Mycobacterium tuberculosis overproduces triglycerides and has the DosR dormancy regulon constitutively upregulated
    Michael B Reed
    The Research Institute of the McGill University Health Centre, Montreal General Hospital, 1650 Cedar Ave, Montreal, Quebec, Canada H3G 1A4
    J Bacteriol 189:2583-9. 2007
    ....
  13. pmc Does resistance to pyrazinamide accurately indicate the presence of Mycobacterium bovis?
    Bouke C de Jong
    Division of Infectious Diseases, Stanford University, Stanford, California, USA
    J Clin Microbiol 43:3530-2. 2005
    ..The sensitivity for detection of M. bovis is lowered to 82% when only PZA-monoresistant isolates are screened...
  14. pmc Genomic deletions classify the Beijing/W strains as a distinct genetic lineage of Mycobacterium tuberculosis
    Anthony G Tsolaki
    Division of Infectious Diseases and Geographic Medicine, Stanford University Medical Center, Stanford, California 94305, USA
    J Clin Microbiol 43:3185-91. 2005
    ..tuberculosis...
  15. pmc Genomic analysis distinguishes Mycobacterium africanum
    Serge Mostowy
    McGill University Health Centre, Montreal, Canada
    J Clin Microbiol 42:3594-9. 2004
    ..tuberculosis complex speciation. Furthermore, the genomic results suggest a rational framework for defining M. africanum and provide tools to accurately assess its prevalence in clinical specimens...