Affiliation: Institute for Systems Biology
- Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product developmentSebastien Gagneux
Institute for Systems Biology, Seattle, WA, USA
Lancet Infect Dis 7:328-37. 2007..We propose a strain selection framework, based on robust phylogenetic markers, which will allow for systematic and comprehensive evaluation of new tools for tuberculosis control...
- Genomic interrogation of ancestral Mycobacterium tuberculosis from south IndiaSujatha Narayanan
Tuberculosis Research Centre, Mayor VR Ramanathan Road, Chetput, Chennai, India
Infect Genet Evol 8:474-83. 2008..2% belonged to the ancestral lineage of M. tuberculosis. Comparative whole-genome hybridization identified six new genomic regions within this lineage that were variably deleted...
- Impact of bacterial genetics on the transmission of isoniazid-resistant Mycobacterium tuberculosisSebastian Gagneux
Division of Infectious Diseases and Geographic Medicine, Stanford University Medical Center, Stanford, California, USA
PLoS Pathog 2:e61. 2006..tuberculosis lineages. Our results show that in addition to host and environmental factors, strain genetic diversity can influence the transmission dynamics of drug-resistant bacteria...
- The competitive cost of antibiotic resistance in Mycobacterium tuberculosisSebastien Gagneux
Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA 94305, USA
Science 312:1944-6. 2006..In contrast, we demonstrate that prolonged patient treatment can result in multidrug-resistant strains with no fitness defect and that strains with low- or no-cost resistance mutations are also the most frequent among clinical isolates...
- Variable host-pathogen compatibility in Mycobacterium tuberculosisSebastien Gagneux
Institute for Systems Biology, Seattle, WA 98103, USA
Proc Natl Acad Sci U S A 103:2869-73. 2006..These observations suggest that mycobacterial lineages are adapted to particular human populations. If confirmed, our findings have important implications for tuberculosis control and vaccine development...
- Progression to active tuberculosis, but not transmission, varies by Mycobacterium tuberculosis lineage in The GambiaBouke C de Jong
Medical Research Council Laboratories, Banjul, The Gambia
J Infect Dis 198:1037-43. 2008..There is considerable variability in the outcome of Mycobacterium tuberculosis infection. We hypothesized that Mycobacterium africanum was less likely than M. tuberculosis to transmit and progress to tuberculosis disease...
- Mycobacterium africanum elicits an attenuated T cell response to early secreted antigenic target, 6 kDa, in patients with tuberculosis and their household contactsBouke C de Jong
Medical Research Council Laboratories, The Gambia
J Infect Dis 193:1279-86. 2006..Mycobacterium africanum, a member of the M. tuberculosis complex that is infrequently found outside of western Africa, is the cause of up to half of the tuberculosis cases there...
- Relationship between Mycobacterium tuberculosis genotype and the clinical phenotype of pulmonary and meningeal tuberculosisGuy Thwaites
Centre for Molecular Microbiology and Infection, Imperial College, Exhibition Rd, South Kensington, London, United Kingdom
J Clin Microbiol 46:1363-8. 2008..In addition, increased drug resistance among bacteria of the East Asian/Beijing lineage might influence the response to treatment. This study suggests the genetic diversity of M. tuberculosis has important clinical consequences...
- The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosisMaxine Caws
Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam
PLoS Pathog 4:e1000034. 2008..The study provides evidence that M. tuberculosis genotype influences clinical disease phenotype and demonstrates, for the first time, a significant interaction between host and bacterial genotypes and the development of tuberculosis...
- Large sequence polymorphisms classify Mycobacterium tuberculosis strains with ancestral spoligotyping patternsLaura Flores
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, USA
J Clin Microbiol 45:3393-5. 2007..tuberculosis...
- Genetic diversification of Neisseria meningitidis during waves of colonization and disease in the meningitis belt of sub-Saharan AfricaJulia Leimkugel
Swiss Tropical Institute, Socinstr 57, 4051 Basel, Switzerland
Vaccine 25:A18-23. 2007....
- The W-Beijing lineage of Mycobacterium tuberculosis overproduces triglycerides and has the DosR dormancy regulon constitutively upregulatedMichael B Reed
The Research Institute of the McGill University Health Centre, Montreal General Hospital, 1650 Cedar Ave, Montreal, Quebec, Canada H3G 1A4
J Bacteriol 189:2583-9. 2007....
- Does resistance to pyrazinamide accurately indicate the presence of Mycobacterium bovis?Bouke C de Jong
Division of Infectious Diseases, Stanford University, Stanford, California, USA
J Clin Microbiol 43:3530-2. 2005..The sensitivity for detection of M. bovis is lowered to 82% when only PZA-monoresistant isolates are screened...
- Genomic deletions classify the Beijing/W strains as a distinct genetic lineage of Mycobacterium tuberculosisAnthony G Tsolaki
Division of Infectious Diseases and Geographic Medicine, Stanford University Medical Center, Stanford, California 94305, USA
J Clin Microbiol 43:3185-91. 2005..tuberculosis...
- Genomic analysis distinguishes Mycobacterium africanumSerge Mostowy
McGill University Health Centre, Montreal, Canada
J Clin Microbiol 42:3594-9. 2004..tuberculosis complex speciation. Furthermore, the genomic results suggest a rational framework for defining M. africanum and provide tools to accurately assess its prevalence in clinical specimens...