Research Topics
Genomes and GenesSpecies | Karam El-BayoumySummaryAffiliation: Institute for Cancer Prevention Country: USA Publications
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Detail Information
Publications
Elucidation of molecular targets of mammary cancer chemoprevention in the rat by organoselenium compounds using cDNA microarrayKaram El-Bayoumy
American Health Foundation Cancer Center, Institute for Cancer Prevention, 1 Dana Road, Valhalla, NY 10595, USA
Carcinogenesis 24:1505-14. 2003..To our knowledge, this is the first report that provides insights into the effects of p-XSC and p-XSeSG at the molecular level that may account for mammary cancer chemoprevention in vivo in the rat...- Mechanisms of mammary cancer chemoprevention by organoselenium compoundsKaram El-Bayoumy
Institute for Cancer Prevention, American Health Foundation Cancer Center, 1 Dana Road, Valhalla, NY 10595, USA
Mutat Res 551:181-97. 2004..Collectively, the results described here, suggest that the molecular targets modulated by organoselenium compounds are highly useful indicators of success in clinical cancer chemoprevention trials... - Comparative action of 1,4-phenylenebis(methylene)selenocyanate and its metabolites against 7,12-dimethylbenz[a]anthracene-DNA adduct formation in the rat and cell proliferation in rat mammary tumor cellsKaram El-Bayoumy
American Health Foundation Cancer Center, Institute for Cancer Prevention, 1 Dana Road, Valhalla, NY 10595, USA
Chem Biol Interact 146:179-90. 2003..Collectively, our in vivo and in vitro results indicate that p-XSC and its conjugate are better candidates than TSC for future studies on mammary cancer chemoprevention... - Mammary carcinogenesis and molecular analysis of in vivo cII gene mutations in the mammary tissue of female transgenic rats treated with the environmental pollutant 6-nitrochryseneTelih Boyiri
American Health Foundation Cancer Center, Institute for Cancer Prevention, Valhalla, NY 10595, USA
Carcinogenesis 25:637-43. 2004..This is the first report that defines the relationship between carcinogenesis and mutagenesis, as well as between structures of 6-NC-DNA adducts and mutation characteristics in the target organ in vivo... - Synthesis, in vitro metabolism, cell transformation, mutagenicity, and DNA adduction of dibenzo[c,mno]chryseneDhimant Desai
American Health Foundation, 1 Dana Road, Valhalla, New York 10595, USA
Chem Res Toxicol 15:964-71. 2002..This hypothesis is currently being tested in our laboratory... - Comparison of the chemopreventive efficacies of 1,4-phenylenebis(methylene)selenocyanate and selenium-enriched yeast on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mouseArunangshu Das
Institute for Cancer Prevention (formerly American Health Foundation, 1 Dana Road, Valhalla, NY 10595, USA
Nutr Cancer 46:179-85. 2003..The inhibition of DNA methylation and the significantly higher retention of selenium from p-XSC as compared with selenium-enriched yeast in the target organ may in part account for the inhibition of lung tumorigenesis... - Human cytochromes P450 1A1 and 1B1 catalyze ring oxidation but not nitroreduction of environmental pollutant mononitropyrene isomers in primary cultures of human breast cells and cultured MCF-10A and MCF-7 cell linesYuan-Wan Sun
Division of Cancer Etiology and Prevention, Institute for Cancer Prevention, Valhalla, New York 10595, USA
Chem Res Toxicol 17:1077-85. 2004.... - Chemopreventive efficacy of suberoylanilide hydroxamic acid (SAHA) against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in female A/J miceDhimant Desai
Institute for Cancer Prevention, American Helath Foundation Cancer Center, 1 Dana Road, Valhalla, NY 10595, USA
Anticancer Res 23:499-503. 2003..The results of this model study indicate that SAHA holds promise as a potential chemopreventive agent against lung cancer... - Metabolism of benzo[c]chrysene and comparative mammary gland tumorigenesis of benzo[c]chrysene bay and fjord region diol epoxides in female CD ratsShantu Amin
American Health Foundation Cancer Center, Institute for Cancer Prevention, 1 Dana Road, Valhalla, New York 10595, USA
Chem Res Toxicol 16:227-31. 2003..It further supports previous observations that fjord region diol epoxides are more carcinogenic than structurally related bay region diol epoxides... - Comparative tumorigenicity of the environmental pollutant 6-nitrochrysene and its metabolites in the rat mammary glandKaram El-Bayoumy
American Health Foundation, 1 Dana Road, Valhalla, New York 10595, USA
Chem Res Toxicol 15:972-8. 2002..Collectively, these results suggest that metabolites derived from both ring-oxidation and nitroreduction contribute to the overall carcinogenicity of 6-NC in the rat mammary gland... - Identification of tobacco-derived compounds in human pancreatic juiceBogdan Prokopczyk
American Health Foundation, Division of Cancer Etiology and Prevention, Valhalla, New York 10595, USA
Chem Res Toxicol 15:677-85. 2002..This research presents preliminary data that supports the hypothesis that pancreatic tissue is exposed to TSNA and that they may be important contributors to pancreatic carcinogenesis in humans... - Metabolism and DNA binding of the environmental pollutant 6-nitrochrysene in primary culture of human breast cells and in cultured MCF-10A, MCF-7 and MDA-MB-435s cell linesTelih Boyiri
American Health Foundation, Valhalla, NY 10595, USA
Int J Cancer 100:395-400. 2002..This is the first report to demonstrate the ability of human breast cells, MCF-10A, and breast cancer cell lines to activate 6-NC to metabolites that can damage DNA... - Cyclooxygenase-2 expression influences the growth of human large and small cell lung carcinoma lines in athymic mice: impact of an organoselenium compound on growth regulationKaram El-Bayoumy
American Health Foundation, Valhalla, NY 10595, USA
Int J Oncol 20:557-61. 2002..Therefore, inhibition of COX-2 expression by agents such as p-XSC provides a strong rationale for the development of future clinical prevention trials... - Influence of selenium-enriched yeast supplementation on biomarkers of oxidative damage and hormone status in healthy adult males: a clinical pilot studyKaram El-Bayoumy
American Health Foundation, Valhalla, New York 10595, USA
Cancer Epidemiol Biomarkers Prev 11:1459-65. 2002..001), and this difference disappeared after 12 months. Future trials will test the above hypothesis in prostate cancer patients and in subjects at high risk for prostate cancer... - Induction of preneoplastic lung lesions in guinea pigs by cigarette smoke inhalation and their exacerbation by high dietary levels of vitamins C and EEmerich S Fiala
Institute for Cancer Prevention, Valhalla, NY, USA
Carcinogenesis 26:605-12. 2005.... - Molecular targets of the chemopreventive agent 1,4-phenylenebis (methylene)-selenocyanate in human non-small cell lung cancerKaram El-Bayoumy
Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Carcinogenesis 27:1369-76. 2006.... - The organoselenium compound 1,4-phenylenebis(methylene)selenocyanate inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorgenesis and enhances glutathione-related antioxidant levels in A/J mouse lungJohn P Richie
Department of Health Evaluation Sciences, Penn State Cancer Institute, Penn State University, Milton S. Hershey Medical Center, PA 17033, USA
Chem Biol Interact 161:93-103. 2006.... - Differential effects of naturally occurring and synthetic organoselenium compounds on biomarkers in androgen responsive and androgen independent human prostate carcinoma cellsJohn T Pinto
Laboratory of Molecular Neurobiology, Cornell Burke Medical Research Institute, White Plains, NY 10605, USA
Int J Cancer 120:1410-7. 2007.... 
Effects of 1,4-phenylenebis(methylene)selenocyanate on mutagenesis and p53 protein expression in the tongue of lacI rats treated with 4-nitroquinoline-N-oxideJoseph Guttenplan
Department of Basic Sciences, College of Dentistry, School of Medicine, New York University, New York, NY 10010, USA
Mutat Res 634:146-55. 2007..However, the fact that p-XSC is also effective when administered after 4-NQO, suggests additional mechanisms of inhibition exist...- 4-Hydroxy-1-(3-pyridyl)-1-butanone, an indicator for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA damage, is not detected in human pancreatic tissueBogdan Prokopczyk
Department of Pharmacology, H078, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033-0805, USA
Cancer Epidemiol Biomarkers Prev 14:540-1. 2005 - Comparative excretion and tissue distribution of selenium in mice and rats following treatment with the chemopreventive agent 1,4-phenylenebis(methylene)selenocyanateOck Soon Sohn
Department of Biochemistry and Molecular Biology, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033-0850, USA
Chem Biol Interact 151:193-202. 2005..It may be that the conversion of p-XSeSG to TSC is too facile, or the mere conjugation of p-XSC with glutathione does not occur in rats and mice... 
Effects of naturally occurring and synthetic organoselenium compounds on protein profiling in androgen responsive and androgen independent human prostate cancer cellsRaghu Sinha
Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
Nutr Cancer 60:267-75. 2008..This is the first report showing that SM and p-XSC are capable of altering these proteins; their roles in prostate cancer prevention warrant further investigations...- Ploidy differences between hormone- and chemical carcinogen-induced rat mammary neoplasms: comparison to invasive human ductal breast cancerJonathan J Li
Hormonal Carcinogenesis Laboratory, Division of Etiology and Prevention of Hormonal Cancers, Kansas Cancer Institute, Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160-7417, USA
Mol Carcinog 33:56-65. 2002.... - Identification of 5-(deoxyguanosin-N2-yl)- 1,2-dihydroxy-1,2-dihydro-6-aminochrysene as the major DNA lesion in the mammary gland of rats treated with the environmental pollutant 6-nitrochryseneKaram El-Bayoumy
Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
Chem Res Toxicol 17:1591-9. 2004..We also report here for the first time that among those adducts identified in vitro, only 5-(dG-N2-yl)-1,2-DHD-6-AC is the major DNA lesion detected in the mammary glands of rats treated with 6-NC... - The role of nitric oxide on DNA damage induced by benzene metabolitesAssieh A Melikian
New York University, School of Medicine, Department of Environmental Medicine, Tuxedo, NY 10987, USA
Oncol Rep 19:1331-7. 2008..Phenol, the major benzene metabolite that does not induce DNA damage alone and is inactive in vivo, synergistically enhances DNA damage induced by potent benzene metabolite in the presence of nitric oxide... - Inhibition of nuclear factor-kappaB DNA binding by organoselenocyanates through covalent modification of the p50 subunitKun Ming Chen
Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, PA 17033, USA
Cancer Res 67:10475-83. 2007..This study shows for the first time that BSC and p-XSC may exert their chemopreventive activity, at least in part, by inhibiting NF-kappaB through covalent modification of Cys(62) of the p50 subunit of NF-kappaB... - Effects of 1,4-phenylenebis(methylene)selenocyanate (p-XSC) and vitamin E on 4-nitroquinoline-N-oxide (4-NQO)-induced mutagenesis in lacZ mouse upper aerodigestive tissueJoseph B Guttenplan
Division of Basic Sciences Biochemistry, New York University, Dental Center, 345 E 24th St, New York, NY 10100, USA
Mutat Res 518:85-93. 2002.... - Effects of the environmental mammary carcinogen 6-nitrochrysene on p53 and p21(Cip1) protein expression and cell cycle regulation in MCF-7 and MCF-10A cellsYuan Wan Sun
Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA
Chem Biol Interact 170:31-9. 2007..g. DNA repair machinery) after exposure to 6-NC and this may, in part, account for its remarkable carcinogenicity in the mammary tissue... - 4-(Methylnitrosamino)-I-(3-pyridyl)-1-butanone enhances the expression of apolipoprotein A-I and Clara cell 17-kDa protein in the lung proteomes of rats fed a corn oil diet but not a fish oil dietSung Il Chang
Department of Pharmacology, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Cancer Epidemiol Biomarkers Prev 16:228-35. 2007..Therefore, we propose that both proteins may serve as potential biomarkers in future molecular epidemiologic and clinical chemoprevention intervention studies... - Molecular chemoprevention by selenium: a genomic approachKaram El-Bayoumy
Department of Biochemistry and Molecular Biology, Pennsylvania State Cancer Institute, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Mutat Res 591:224-36. 2005..The molecular (genetic) biomarkers presented in this review will provide the foundation for future studies of the chemopreventive properties of structurally varied selenium compounds... - Benzene increases protein-bound 3-nitrotyrosine in bone marrow of B6C3F1 miceKun-ming Chen
Department of Biochemistry and Molecular Biology, College of Medicine, Penn State University, Hershey, PA 17033, USA
Chem Biol Interact 156:81-91. 2005.... - Cancer chemoprevention by garlic and garlic-containing sulfur and selenium compoundsKaram El-Bayoumy
Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, PA 17033, USA
J Nutr 136:864S-869S. 2006.... - Effects of 3H-1,2-dithiole-3-thione, 1,4-phenylenebis(methylene)selenocyanate, and selenium-enriched yeast individually and in combination on benzo[a]pyrene-induced mutagenesis in oral tissue and esophagus in lacZ miceJoseph B Guttenplan
Division of Basic Sciences Biochemistry, New York University, Dental Center, New York, NY 10100, USA
Mutat Res 559:199-210. 2004....