Karam El-Bayoumy

Summary

Affiliation: Institute for Cancer Prevention
Country: USA

Publications

  1. ncbi request reprint Elucidation of molecular targets of mammary cancer chemoprevention in the rat by organoselenium compounds using cDNA microarray
    Karam El-Bayoumy
    American Health Foundation Cancer Center, Institute for Cancer Prevention, 1 Dana Road, Valhalla, NY 10595, USA
    Carcinogenesis 24:1505-14. 2003
  2. ncbi request reprint Mechanisms of mammary cancer chemoprevention by organoselenium compounds
    Karam El-Bayoumy
    Institute for Cancer Prevention, American Health Foundation Cancer Center, 1 Dana Road, Valhalla, NY 10595, USA
    Mutat Res 551:181-97. 2004
  3. ncbi request reprint Comparative action of 1,4-phenylenebis(methylene)selenocyanate and its metabolites against 7,12-dimethylbenz[a]anthracene-DNA adduct formation in the rat and cell proliferation in rat mammary tumor cells
    Karam El-Bayoumy
    American Health Foundation Cancer Center, Institute for Cancer Prevention, 1 Dana Road, Valhalla, NY 10595, USA
    Chem Biol Interact 146:179-90. 2003
  4. ncbi request reprint Mammary carcinogenesis and molecular analysis of in vivo cII gene mutations in the mammary tissue of female transgenic rats treated with the environmental pollutant 6-nitrochrysene
    Telih Boyiri
    American Health Foundation Cancer Center, Institute for Cancer Prevention, Valhalla, NY 10595, USA
    Carcinogenesis 25:637-43. 2004
  5. ncbi request reprint Synthesis, in vitro metabolism, cell transformation, mutagenicity, and DNA adduction of dibenzo[c,mno]chrysene
    Dhimant Desai
    American Health Foundation, 1 Dana Road, Valhalla, New York 10595, USA
    Chem Res Toxicol 15:964-71. 2002
  6. ncbi request reprint Comparison of the chemopreventive efficacies of 1,4-phenylenebis(methylene)selenocyanate and selenium-enriched yeast on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mouse
    Arunangshu Das
    Institute for Cancer Prevention formerly American Health Foundation, 1 Dana Road, Valhalla, NY 10595, USA
    Nutr Cancer 46:179-85. 2003
  7. ncbi request reprint Human cytochromes P450 1A1 and 1B1 catalyze ring oxidation but not nitroreduction of environmental pollutant mononitropyrene isomers in primary cultures of human breast cells and cultured MCF-10A and MCF-7 cell lines
    Yuan Wan Sun
    Division of Cancer Etiology and Prevention, Institute for Cancer Prevention, Valhalla, New York 10595, USA
    Chem Res Toxicol 17:1077-85. 2004
  8. ncbi request reprint Chemopreventive efficacy of suberoylanilide hydroxamic acid (SAHA) against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in female A/J mice
    Dhimant Desai
    Institute for Cancer Prevention, American Helath Foundation Cancer Center, 1 Dana Road, Valhalla, NY 10595, USA
    Anticancer Res 23:499-503. 2003
  9. ncbi request reprint Metabolism of benzo[c]chrysene and comparative mammary gland tumorigenesis of benzo[c]chrysene bay and fjord region diol epoxides in female CD rats
    Shantu Amin
    American Health Foundation Cancer Center, Institute for Cancer Prevention, 1 Dana Road, Valhalla, New York 10595, USA
    Chem Res Toxicol 16:227-31. 2003
  10. ncbi request reprint Comparative tumorigenicity of the environmental pollutant 6-nitrochrysene and its metabolites in the rat mammary gland
    Karam El-Bayoumy
    American Health Foundation, 1 Dana Road, Valhalla, New York 10595, USA
    Chem Res Toxicol 15:972-8. 2002

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Elucidation of molecular targets of mammary cancer chemoprevention in the rat by organoselenium compounds using cDNA microarray
    Karam El-Bayoumy
    American Health Foundation Cancer Center, Institute for Cancer Prevention, 1 Dana Road, Valhalla, NY 10595, USA
    Carcinogenesis 24:1505-14. 2003
    ..To our knowledge, this is the first report that provides insights into the effects of p-XSC and p-XSeSG at the molecular level that may account for mammary cancer chemoprevention in vivo in the rat...
  2. ncbi request reprint Mechanisms of mammary cancer chemoprevention by organoselenium compounds
    Karam El-Bayoumy
    Institute for Cancer Prevention, American Health Foundation Cancer Center, 1 Dana Road, Valhalla, NY 10595, USA
    Mutat Res 551:181-97. 2004
    ..Collectively, the results described here, suggest that the molecular targets modulated by organoselenium compounds are highly useful indicators of success in clinical cancer chemoprevention trials...
  3. ncbi request reprint Comparative action of 1,4-phenylenebis(methylene)selenocyanate and its metabolites against 7,12-dimethylbenz[a]anthracene-DNA adduct formation in the rat and cell proliferation in rat mammary tumor cells
    Karam El-Bayoumy
    American Health Foundation Cancer Center, Institute for Cancer Prevention, 1 Dana Road, Valhalla, NY 10595, USA
    Chem Biol Interact 146:179-90. 2003
    ..Collectively, our in vivo and in vitro results indicate that p-XSC and its conjugate are better candidates than TSC for future studies on mammary cancer chemoprevention...
  4. ncbi request reprint Mammary carcinogenesis and molecular analysis of in vivo cII gene mutations in the mammary tissue of female transgenic rats treated with the environmental pollutant 6-nitrochrysene
    Telih Boyiri
    American Health Foundation Cancer Center, Institute for Cancer Prevention, Valhalla, NY 10595, USA
    Carcinogenesis 25:637-43. 2004
    ..This is the first report that defines the relationship between carcinogenesis and mutagenesis, as well as between structures of 6-NC-DNA adducts and mutation characteristics in the target organ in vivo...
  5. ncbi request reprint Synthesis, in vitro metabolism, cell transformation, mutagenicity, and DNA adduction of dibenzo[c,mno]chrysene
    Dhimant Desai
    American Health Foundation, 1 Dana Road, Valhalla, New York 10595, USA
    Chem Res Toxicol 15:964-71. 2002
    ..This hypothesis is currently being tested in our laboratory...
  6. ncbi request reprint Comparison of the chemopreventive efficacies of 1,4-phenylenebis(methylene)selenocyanate and selenium-enriched yeast on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mouse
    Arunangshu Das
    Institute for Cancer Prevention formerly American Health Foundation, 1 Dana Road, Valhalla, NY 10595, USA
    Nutr Cancer 46:179-85. 2003
    ..The inhibition of DNA methylation and the significantly higher retention of selenium from p-XSC as compared with selenium-enriched yeast in the target organ may in part account for the inhibition of lung tumorigenesis...
  7. ncbi request reprint Human cytochromes P450 1A1 and 1B1 catalyze ring oxidation but not nitroreduction of environmental pollutant mononitropyrene isomers in primary cultures of human breast cells and cultured MCF-10A and MCF-7 cell lines
    Yuan Wan Sun
    Division of Cancer Etiology and Prevention, Institute for Cancer Prevention, Valhalla, New York 10595, USA
    Chem Res Toxicol 17:1077-85. 2004
    ....
  8. ncbi request reprint Chemopreventive efficacy of suberoylanilide hydroxamic acid (SAHA) against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in female A/J mice
    Dhimant Desai
    Institute for Cancer Prevention, American Helath Foundation Cancer Center, 1 Dana Road, Valhalla, NY 10595, USA
    Anticancer Res 23:499-503. 2003
    ..The results of this model study indicate that SAHA holds promise as a potential chemopreventive agent against lung cancer...
  9. ncbi request reprint Metabolism of benzo[c]chrysene and comparative mammary gland tumorigenesis of benzo[c]chrysene bay and fjord region diol epoxides in female CD rats
    Shantu Amin
    American Health Foundation Cancer Center, Institute for Cancer Prevention, 1 Dana Road, Valhalla, New York 10595, USA
    Chem Res Toxicol 16:227-31. 2003
    ..It further supports previous observations that fjord region diol epoxides are more carcinogenic than structurally related bay region diol epoxides...
  10. ncbi request reprint Comparative tumorigenicity of the environmental pollutant 6-nitrochrysene and its metabolites in the rat mammary gland
    Karam El-Bayoumy
    American Health Foundation, 1 Dana Road, Valhalla, New York 10595, USA
    Chem Res Toxicol 15:972-8. 2002
    ..Collectively, these results suggest that metabolites derived from both ring-oxidation and nitroreduction contribute to the overall carcinogenicity of 6-NC in the rat mammary gland...
  11. ncbi request reprint Identification of tobacco-derived compounds in human pancreatic juice
    Bogdan Prokopczyk
    American Health Foundation, Division of Cancer Etiology and Prevention, Valhalla, New York 10595, USA
    Chem Res Toxicol 15:677-85. 2002
    ..This research presents preliminary data that supports the hypothesis that pancreatic tissue is exposed to TSNA and that they may be important contributors to pancreatic carcinogenesis in humans...
  12. ncbi request reprint Metabolism and DNA binding of the environmental pollutant 6-nitrochrysene in primary culture of human breast cells and in cultured MCF-10A, MCF-7 and MDA-MB-435s cell lines
    Telih Boyiri
    American Health Foundation, Valhalla, NY 10595, USA
    Int J Cancer 100:395-400. 2002
    ..This is the first report to demonstrate the ability of human breast cells, MCF-10A, and breast cancer cell lines to activate 6-NC to metabolites that can damage DNA...
  13. ncbi request reprint Cyclooxygenase-2 expression influences the growth of human large and small cell lung carcinoma lines in athymic mice: impact of an organoselenium compound on growth regulation
    Karam El-Bayoumy
    American Health Foundation, Valhalla, NY 10595, USA
    Int J Oncol 20:557-61. 2002
    ..Therefore, inhibition of COX-2 expression by agents such as p-XSC provides a strong rationale for the development of future clinical prevention trials...
  14. ncbi request reprint Influence of selenium-enriched yeast supplementation on biomarkers of oxidative damage and hormone status in healthy adult males: a clinical pilot study
    Karam El-Bayoumy
    American Health Foundation, Valhalla, New York 10595, USA
    Cancer Epidemiol Biomarkers Prev 11:1459-65. 2002
    ..001), and this difference disappeared after 12 months. Future trials will test the above hypothesis in prostate cancer patients and in subjects at high risk for prostate cancer...
  15. ncbi request reprint Induction of preneoplastic lung lesions in guinea pigs by cigarette smoke inhalation and their exacerbation by high dietary levels of vitamins C and E
    Emerich S Fiala
    Institute for Cancer Prevention, Valhalla, NY, USA
    Carcinogenesis 26:605-12. 2005
    ....
  16. ncbi request reprint Molecular targets of the chemopreventive agent 1,4-phenylenebis (methylene)-selenocyanate in human non-small cell lung cancer
    Karam El-Bayoumy
    Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Carcinogenesis 27:1369-76. 2006
    ....
  17. ncbi request reprint The organoselenium compound 1,4-phenylenebis(methylene)selenocyanate inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorgenesis and enhances glutathione-related antioxidant levels in A/J mouse lung
    John P Richie
    Department of Health Evaluation Sciences, Penn State Cancer Institute, Penn State University, Milton S Hershey Medical Center, PA 17033, USA
    Chem Biol Interact 161:93-103. 2006
    ....
  18. ncbi request reprint Differential effects of naturally occurring and synthetic organoselenium compounds on biomarkers in androgen responsive and androgen independent human prostate carcinoma cells
    John T Pinto
    Laboratory of Molecular Neurobiology, Cornell Burke Medical Research Institute, White Plains, NY 10605, USA
    Int J Cancer 120:1410-7. 2007
    ....
  19. pmc Effects of 1,4-phenylenebis(methylene)selenocyanate on mutagenesis and p53 protein expression in the tongue of lacI rats treated with 4-nitroquinoline-N-oxide
    Joseph Guttenplan
    Department of Basic Sciences, College of Dentistry, School of Medicine, New York University, New York, NY 10010, USA
    Mutat Res 634:146-55. 2007
    ..However, the fact that p-XSC is also effective when administered after 4-NQO, suggests additional mechanisms of inhibition exist...
  20. ncbi request reprint 4-Hydroxy-1-(3-pyridyl)-1-butanone, an indicator for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA damage, is not detected in human pancreatic tissue
    Bogdan Prokopczyk
    Department of Pharmacology, H078, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033 0805, USA
    Cancer Epidemiol Biomarkers Prev 14:540-1. 2005
  21. ncbi request reprint Comparative excretion and tissue distribution of selenium in mice and rats following treatment with the chemopreventive agent 1,4-phenylenebis(methylene)selenocyanate
    Ock Soon Sohn
    Department of Biochemistry and Molecular Biology, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033 0850, USA
    Chem Biol Interact 151:193-202. 2005
    ..It may be that the conversion of p-XSeSG to TSC is too facile, or the mere conjugation of p-XSC with glutathione does not occur in rats and mice...
  22. doi request reprint Effects of naturally occurring and synthetic organoselenium compounds on protein profiling in androgen responsive and androgen independent human prostate cancer cells
    Raghu Sinha
    Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Nutr Cancer 60:267-75. 2008
    ..This is the first report showing that SM and p-XSC are capable of altering these proteins; their roles in prostate cancer prevention warrant further investigations...
  23. ncbi request reprint Ploidy differences between hormone- and chemical carcinogen-induced rat mammary neoplasms: comparison to invasive human ductal breast cancer
    Jonathan J Li
    Hormonal Carcinogenesis Laboratory, Division of Etiology and Prevention of Hormonal Cancers, Kansas Cancer Institute, Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160 7417, USA
    Mol Carcinog 33:56-65. 2002
    ....
  24. ncbi request reprint Identification of 5-(deoxyguanosin-N2-yl)- 1,2-dihydroxy-1,2-dihydro-6-aminochrysene as the major DNA lesion in the mammary gland of rats treated with the environmental pollutant 6-nitrochrysene
    Karam El-Bayoumy
    Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Chem Res Toxicol 17:1591-9. 2004
    ..We also report here for the first time that among those adducts identified in vitro, only 5-(dG-N2-yl)-1,2-DHD-6-AC is the major DNA lesion detected in the mammary glands of rats treated with 6-NC...
  25. pmc The role of nitric oxide on DNA damage induced by benzene metabolites
    Assieh A Melikian
    New York University, School of Medicine, Department of Environmental Medicine, Tuxedo, NY 10987, USA
    Oncol Rep 19:1331-7. 2008
    ..Phenol, the major benzene metabolite that does not induce DNA damage alone and is inactive in vivo, synergistically enhances DNA damage induced by potent benzene metabolite in the presence of nitric oxide...
  26. ncbi request reprint Inhibition of nuclear factor-kappaB DNA binding by organoselenocyanates through covalent modification of the p50 subunit
    Kun Ming Chen
    Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, PA 17033, USA
    Cancer Res 67:10475-83. 2007
    ..This study shows for the first time that BSC and p-XSC may exert their chemopreventive activity, at least in part, by inhibiting NF-kappaB through covalent modification of Cys(62) of the p50 subunit of NF-kappaB...
  27. ncbi request reprint Effects of 1,4-phenylenebis(methylene)selenocyanate (p-XSC) and vitamin E on 4-nitroquinoline-N-oxide (4-NQO)-induced mutagenesis in lacZ mouse upper aerodigestive tissue
    Joseph B Guttenplan
    Division of Basic Sciences Biochemistry, New York University, Dental Center, 345 E 24th St, New York, NY 10100, USA
    Mutat Res 518:85-93. 2002
    ....
  28. pmc Effects of the environmental mammary carcinogen 6-nitrochrysene on p53 and p21(Cip1) protein expression and cell cycle regulation in MCF-7 and MCF-10A cells
    Yuan Wan Sun
    Department of Biochemistry and Molecular Biology, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA
    Chem Biol Interact 170:31-9. 2007
    ..g. DNA repair machinery) after exposure to 6-NC and this may, in part, account for its remarkable carcinogenicity in the mammary tissue...
  29. ncbi request reprint 4-(Methylnitrosamino)-I-(3-pyridyl)-1-butanone enhances the expression of apolipoprotein A-I and Clara cell 17-kDa protein in the lung proteomes of rats fed a corn oil diet but not a fish oil diet
    Sung Il Chang
    Department of Pharmacology, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Cancer Epidemiol Biomarkers Prev 16:228-35. 2007
    ..Therefore, we propose that both proteins may serve as potential biomarkers in future molecular epidemiologic and clinical chemoprevention intervention studies...
  30. ncbi request reprint Molecular chemoprevention by selenium: a genomic approach
    Karam El-Bayoumy
    Department of Biochemistry and Molecular Biology, Pennsylvania State Cancer Institute, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Mutat Res 591:224-36. 2005
    ..The molecular (genetic) biomarkers presented in this review will provide the foundation for future studies of the chemopreventive properties of structurally varied selenium compounds...
  31. ncbi request reprint Benzene increases protein-bound 3-nitrotyrosine in bone marrow of B6C3F1 mice
    Kun Ming Chen
    Department of Biochemistry and Molecular Biology, College of Medicine, Penn State University, Hershey, PA 17033, USA
    Chem Biol Interact 156:81-91. 2005
    ....
  32. ncbi request reprint Cancer chemoprevention by garlic and garlic-containing sulfur and selenium compounds
    Karam El-Bayoumy
    Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, PA 17033, USA
    J Nutr 136:864S-869S. 2006
    ....
  33. ncbi request reprint Effects of 3H-1,2-dithiole-3-thione, 1,4-phenylenebis(methylene)selenocyanate, and selenium-enriched yeast individually and in combination on benzo[a]pyrene-induced mutagenesis in oral tissue and esophagus in lacZ mice
    Joseph B Guttenplan
    Division of Basic Sciences Biochemistry, New York University, Dental Center, New York, NY 10100, USA
    Mutat Res 559:199-210. 2004
    ....