Pierre Yves Bochud

Summary

Affiliation: Institute for Systems Biology
Country: USA

Publications

  1. pmc Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy
    Pierre Yves Bochud
    Institute for Systems Biology, Seattle, WA 98103 8904, USA
    J Infect Dis 197:253-61. 2008
  2. ncbi Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection
    Pierre Yves Bochud
    Institute for Systems Biology, Seattle, Washington State, USA
    AIDS 21:441-6. 2007
  3. ncbi Polymorphisms in TLR2 are associated with increased viral shedding and lesional rate in patients with genital herpes simplex virus Type 2 infection
    Pierre Yves Bochud
    Institute for Systems Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98103, USA
    J Infect Dis 196:505-9. 2007
  4. pmc Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation
    Pierre Yves Bochud
    Institute for Systems Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    N Engl J Med 359:1766-77. 2008
  5. pmc Polymorphisms in toll-like receptor 4 and toll-like receptor 9 influence viral load in a seroincident cohort of HIV-1-infected individuals
    Samuel O Pine
    Program in Pathobiology, Department of Global Health, University of Washington, Seattle, Washington, USA
    AIDS 23:2387-95. 2009
  6. pmc Pathogenesis of sepsis: new concepts and implications for future treatment
    Pierre Yves Bochud
    Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103 8904, USA
    BMJ 326:262-6. 2003
  7. ncbi Cutting edge: a Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling
    Pierre Yves Bochud
    Institute for Systems Biology, Seattle, WA 98103 8904, USA
    J Immunol 170:3451-4. 2003
  8. ncbi Innate immunogenetics: a tool for exploring new frontiers of host defence
    Pierre Yves Bochud
    Institute for Systems Biology, Seattle, WA, USA
    Lancet Infect Dis 7:531-42. 2007
  9. ncbi Antimicrobial therapy for patients with severe sepsis and septic shock: an evidence-based review
    Pierre Yves Bochud
    The Institute for Systems Biology, Seattle, WA, USA
    Crit Care Med 32:S495-512. 2004
  10. ncbi Reverse transcriptase activity for quantitation of HIV-1 subtype C in plasma: relation to RNA copy number and CD4 T-cell count
    Elizabeth Seyoum
    Ethio Netherlands AIDS Research Project ENARP, Ethiopian Health and Nutrition Research Institute EHNRI, Addis Ababa, Ethiopia
    J Med Virol 78:161-8. 2006

Collaborators

Detail Information

Publications22

  1. pmc Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy
    Pierre Yves Bochud
    Institute for Systems Biology, Seattle, WA 98103 8904, USA
    J Infect Dis 197:253-61. 2008
    ..The goal of the present study was to assess the effect of Toll-like receptor 2 (TLR2) polymorphisms on susceptibility to and clinical presentation of leprosy...
  2. ncbi Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection
    Pierre Yves Bochud
    Institute for Systems Biology, Seattle, Washington State, USA
    AIDS 21:441-6. 2007
    ..Toll-like receptors (TLRs) have a key role in innate immunity and mutations in the genes encoding these receptors have been associated with increased or decreased susceptibility to infections...
  3. ncbi Polymorphisms in TLR2 are associated with increased viral shedding and lesional rate in patients with genital herpes simplex virus Type 2 infection
    Pierre Yves Bochud
    Institute for Systems Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98103, USA
    J Infect Dis 196:505-9. 2007
    ..02 and P=.001) rates. An SNP in haplotype 2 (-15607A/G) was also associated with shedding (P=.01) and lesional (P=.008) rates. Polymorphisms in TLR2 may be in part responsible for differences in the severity of HSV-2 infection...
  4. pmc Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation
    Pierre Yves Bochud
    Institute for Systems Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    N Engl J Med 359:1766-77. 2008
    ..We examined the role of TLR polymorphisms in conferring a risk of invasive aspergillosis among recipients of allogeneic hematopoietic-cell transplants...
  5. pmc Polymorphisms in toll-like receptor 4 and toll-like receptor 9 influence viral load in a seroincident cohort of HIV-1-infected individuals
    Samuel O Pine
    Program in Pathobiology, Department of Global Health, University of Washington, Seattle, Washington, USA
    AIDS 23:2387-95. 2009
    ..We investigated the impact of TLR single nucleotide polymorphisms (SNPs) on clinical outcome in a seroincident cohort of HIV-1-infected volunteers...
  6. pmc Pathogenesis of sepsis: new concepts and implications for future treatment
    Pierre Yves Bochud
    Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103 8904, USA
    BMJ 326:262-6. 2003
  7. ncbi Cutting edge: a Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling
    Pierre Yves Bochud
    Institute for Systems Biology, Seattle, WA 98103 8904, USA
    J Immunol 170:3451-4. 2003
    ....
  8. ncbi Innate immunogenetics: a tool for exploring new frontiers of host defence
    Pierre Yves Bochud
    Institute for Systems Biology, Seattle, WA, USA
    Lancet Infect Dis 7:531-42. 2007
    ..This is likely to open new perspectives for the development of diagnostic, predictive, and preventive management strategies to combat infectious diseases...
  9. ncbi Antimicrobial therapy for patients with severe sepsis and septic shock: an evidence-based review
    Pierre Yves Bochud
    The Institute for Systems Biology, Seattle, WA, USA
    Crit Care Med 32:S495-512. 2004
    ....
  10. ncbi Reverse transcriptase activity for quantitation of HIV-1 subtype C in plasma: relation to RNA copy number and CD4 T-cell count
    Elizabeth Seyoum
    Ethio Netherlands AIDS Research Project ENARP, Ethiopian Health and Nutrition Research Institute EHNRI, Addis Ababa, Ethiopia
    J Med Virol 78:161-8. 2006
    ..It is based on a simple technique, can be run in any routine diagnostic laboratory, and is a competitive alternative for use in resource limited settings...
  11. ncbi Alternative approach to blood screening using the ExaVir reverse transcriptase activity assay
    Elizabeth Seyoum
    Ethio Netherlands AIDS Research Project ENARP, Ethiopian Health and Nutrition Research Institute EHNRI, Addis Ababa
    Curr HIV Res 3:371-6. 2005
    ..This sample was detectable in the fluorimetric version of the test. The detection of RT activity in addition to the currently used markers would seem to have a potential for use in blood screening...
  12. ncbi Diagnosis of tuberculous lymphadenitis in Butajira, rural Ethiopia
    Mohammed Ahmed Yassin
    Southern Region Health Bureau, Awassa, Ethiopia
    Scand J Infect Dis 35:240-3. 2003
    ..tuberculosis is needed for diagnosis in lymphadenitis cases of this kind. These findings could help to strengthen the diagnostic algorithm suggested by the National TB Control Program...
  13. ncbi Kinetics of sedimentation rate, viral load and TNF-alpha in relation to HIV co-infection in tuberculosis
    Thomas Schön
    Department of Medical Microbiology, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Trans R Soc Trop Med Hyg 100:483-8. 2006
    ..Additionally, TNF-alpha and HIV viral load remained elevated in HIV+/Tb+ patients following treatment despite clinical improvement comparable to HIV-/Tb+ patients...
  14. ncbi Evaluation of outpatients with suspected pulmonary tuberculosis in a high HIV prevalence setting in Ethiopia: clinical, diagnostic and epidemiological characteristics
    Judith Bruchfeld
    Division of Infectious Diseases, Institution of Medicine, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden
    Scand J Infect Dis 34:331-7. 2002
    ..Also, increased awareness of, and improved diagnostic tools for, HIV-related pulmonary infections other than PTB are required, together with algorithms for patients with suspected PTB...
  15. ncbi Local nerve damage in leprosy does not lead to an impaired cellular immune response or decreased wound healing in the skin
    M Ruby Siddiqui
    Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, New York, USA
    J Infect Dis 186:260-5. 2002
    ..Rather, chronic cutaneous ulceration in leprosy most likely results from repeated trauma associated with loss of sensation...
  16. ncbi [Burnout in Greene-land]
    Sven Britton
    Lakartidningen 104:2446-7. 2007
  17. ncbi [Needle exchange as bribery]
    Sven Britton
    Lakartidningen 104:2133. 2007
  18. ncbi Co-infection of Onchocerca volvulus and intestinal helminths in indigenous and migrant farmers in southwest Ethiopia
    Genene Mengistu
    Armauer Hansen Research Institute, P O Box 1005, Addis Ababa, Ethiopia
    Ethiop Med J 40:19-27. 2002
    ..The public health significance of coexistence of the two diseases, and the need for intensive control measures are discussed...
  19. ncbi Treatment of intestinal worms is associated with decreased HIV plasma viral load
    Dawit Wolday
    Armauer Hansen Research Institute, Addis Ababa, Ethiopia
    J Acquir Immune Defic Syndr 31:56-62. 2002
    ..We have previously suggested that helminthic infections make the host more susceptible to HIV infection and enhance its progression due to the chronic immune activation they cause...
  20. ncbi Chronic helminth infections may negatively influence immunity against tuberculosis and other diseases of public health importance
    Daniel Elias
    ACE BioSciences, Unsbjergvej 2A, 5220 Odense SOE, Denmark
    Expert Rev Anti Infect Ther 5:475-84. 2007
    ..Understanding such interactions could assist in the design of vaccines against these diseases...
  21. ncbi Are intestinal helminths risk factors for developing active tuberculosis?
    Daniel Elias
    Department of Microbiology and Parasitology, Gondar University, Gondar, Ethiopia
    Trop Med Int Health 11:551-8. 2006
    ..To determine the prevalence of intestinal helminth infections in active tuberculosis patients and their healthy household contacts and to assess its association with active TB in an area endemic for both types of infections...
  22. pmc Immune responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 signal subclinical infection among contacts of tuberculosis patients
    T Mark Doherty
    Department of Tuberculosis Immunology, Statens Serum Institute Hvidovre Hospital, Copenhagen, Denmark
    J Clin Microbiol 40:704-6. 2002
    ..We report that strong recognition of tuberculosis complex-specific antigen ESAT-6 by healthy household contacts of tuberculosis patients correlates with the subsequent development of active tuberculosis during a 2-year follow-up period...