Affiliation: Infinity Pharmaceuticals
- The antiproliferative activity of the heat shock protein 90 inhibitor IPI-504 is not dependent on NAD(P)H:quinone oxidoreductase 1 activity in vivoMark Douglas
Infinity Pharmaceuticals, 780 Memorial Drive, Cambridge, MA 02139, USA
Mol Cancer Ther 8:3369-78. 2009..Our results suggest that NQO1 activity is not a determinant of IPI-504 activity in vivo and, therefore, unlikely to become an important resistance mechanism to IPI-504 in the clinic...