Martin D Chapman

Summary

Affiliation: INDOOR Biotechnologies
Country: USA

Publications

  1. ncbi Recombinant major urinary proteins of the mouse in specific IgE and IgG testing
    Esmeralda J M Krop
    Department of Pulmonology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Int Arch Allergy Immunol 144:296-304. 2007
  2. ncbi Specific IgE and IgG antibody-binding patterns to recombinant cockroach allergens
    Shama M Satinover
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 115:803-9. 2005
  3. ncbi Asthma in the third world: can environmental intervention improve childhood asthma in U.S. inner cities?
    Martin D Chapman
    Ann Allergy Asthma Immunol 95:496-7. 2005
  4. doi Molecular approaches to allergen standardization
    Martin D Chapman
    INDOOR Biotechnologies Inc, 1216 Harris Street, Charlottesville, VA 22903, USA
    Curr Allergy Asthma Rep 12:478-84. 2012
  5. ncbi Nomenclature and structural biology of allergens
    Martin D Chapman
    INDOOR Biotechnologies, Inc, Charlottesville, VA 22903, USA
    J Allergy Clin Immunol 119:414-20. 2007
  6. ncbi Proteases as Th2 adjuvants
    Martin D Chapman
    INDOOR Biotechnologies, Inc, 1216 Harris Street, Charlottesville, VA 22903, USA
    Curr Allergy Asthma Rep 7:363-7. 2007
  7. doi The European Union CREATE project: a model for international standardization of allergy diagnostics and vaccines
    Martin D Chapman
    INDOOR Biotechnologies, Inc, Charlottesville, VA 22903, USA
    J Allergy Clin Immunol 122:882-889.e2. 2008
  8. pmc Targeting allergen to FcgammaRI reveals a novel T(H)2 regulatory pathway linked to thymic stromal lymphopoietin receptor
    Kathryn E Hulse
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 125:247-56.e1-8. 2010
  9. pmc Molecular determinants for antibody binding on group 1 house dust mite allergens
    Maksymilian Chruszcz
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 287:7388-98. 2012
  10. pmc Alternaria alternata allergen Alt a 1: a unique β-barrel protein dimer found exclusively in fungi
    Maksymilian Chruszcz
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    J Allergy Clin Immunol 130:241-7.e9. 2012

Research Grants

Detail Information

Publications37

  1. ncbi Recombinant major urinary proteins of the mouse in specific IgE and IgG testing
    Esmeralda J M Krop
    Department of Pulmonology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Int Arch Allergy Immunol 144:296-304. 2007
    ..We tested the use of recombinant variants of the major mouse allergen Mus m 1 in detection of mouse-specific antibodies in sera of laboratory animal workers and children...
  2. ncbi Specific IgE and IgG antibody-binding patterns to recombinant cockroach allergens
    Shama M Satinover
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 115:803-9. 2005
    ..The specificity of serum antibody responses to different cockroach allergens has not been studied...
  3. ncbi Asthma in the third world: can environmental intervention improve childhood asthma in U.S. inner cities?
    Martin D Chapman
    Ann Allergy Asthma Immunol 95:496-7. 2005
  4. doi Molecular approaches to allergen standardization
    Martin D Chapman
    INDOOR Biotechnologies Inc, 1216 Harris Street, Charlottesville, VA 22903, USA
    Curr Allergy Asthma Rep 12:478-84. 2012
    ..Molecular standardization will form the basis of new allergy diagnostics and therapeutics, as well as assessment of environmental exposure, and will improve the quality of treatment options for allergic patients...
  5. ncbi Nomenclature and structural biology of allergens
    Martin D Chapman
    INDOOR Biotechnologies, Inc, Charlottesville, VA 22903, USA
    J Allergy Clin Immunol 119:414-20. 2007
    ..Structural biology and proteomics define recombinant allergen targets for diagnostic and therapeutic purposes and identify motifs, patterns, and structures of immunologic significance...
  6. ncbi Proteases as Th2 adjuvants
    Martin D Chapman
    INDOOR Biotechnologies, Inc, 1216 Harris Street, Charlottesville, VA 22903, USA
    Curr Allergy Asthma Rep 7:363-7. 2007
    ..Thus although mite proteases allergens may act as Th2 adjuvants, a paradoxical effect is that other allergens may elicit strong Th2 responses in the absence of enzyme activity...
  7. doi The European Union CREATE project: a model for international standardization of allergy diagnostics and vaccines
    Martin D Chapman
    INDOOR Biotechnologies, Inc, Charlottesville, VA 22903, USA
    J Allergy Clin Immunol 122:882-889.e2. 2008
    ....
  8. pmc Targeting allergen to FcgammaRI reveals a novel T(H)2 regulatory pathway linked to thymic stromal lymphopoietin receptor
    Kathryn E Hulse
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 125:247-56.e1-8. 2010
    ..The molecule H22-Fel d 1, which targets cat allergen to FcgammaRI on dendritic cells (DCs), has the potential to treat cat allergy because of its T-cell modulatory properties...
  9. pmc Molecular determinants for antibody binding on group 1 house dust mite allergens
    Maksymilian Chruszcz
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 287:7388-98. 2012
    ..Mutations of the contact residues abrogate mAb 4C1 binding and reduce IgE antibody binding. These surface-exposed residues are molecular targets that can be exploited for development of recombinant allergen vaccines...
  10. pmc Alternaria alternata allergen Alt a 1: a unique β-barrel protein dimer found exclusively in fungi
    Maksymilian Chruszcz
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    J Allergy Clin Immunol 130:241-7.e9. 2012
    ..The structure and function of Alt a 1 is unknown...
  11. doi A multi-center ring trial of allergen analysis using fluorescent multiplex array technology
    Eva M King
    INDOOR Biotechnologies Inc, Charlottesville, VA 22903, USA
    J Immunol Methods 387:89-95. 2013
    ..This study evaluated intra- and inter-laboratory reproducibility of a fluorescent multiplex array, which simultaneously measures eight indoor allergens in a single reaction well...
  12. ncbi Targeting Fel d 1 to FcgammaRI induces a novel variation of the T(H)2 response in subjects with cat allergy
    Kathryn E Hulse
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 121:756-762.e4. 2008
    ..Induction of CD4+ T cells that produce IL-10 or IFN-gamma is central to the protective effects of conventional allergen immunotherapy...
  13. pmc Mechanisms of allergen-antibody interaction of cockroach allergen Bla g 2 with monoclonal antibodies that inhibit IgE antibody binding
    Jill Glesner
    INDOOR Biotechnologies, Inc, Charlottesville, Virginia, United States of America
    PLoS ONE 6:e22223. 2011
    ..The conformational epitopes for two specific monoclonal antibodies (mAb) that interfere with IgE antibody binding were identified by X-ray crystallography on opposite sites of the quasi-symmetrical cockroach allergen Bla g 2...
  14. ncbi Bla g 6: a troponin C allergen from Blattella germanica with IgE binding calcium dependence
    James Hindley
    School of Biosciences, Cardiff University, VA 22903, USA
    J Allergy Clin Immunol 117:1389-95. 2006
    ..The known cockroach allergens do not appear to account for the full repertoire of IgE responses...
  15. ncbi Simultaneous detection of total and allergen-specific IgE by using purified allergens in a fluorescent multiplex array
    Eva Maria King
    INDOOR Biotechnologies Inc, Charlottesville, VA 22903, USA
    J Allergy Clin Immunol 120:1126-31. 2007
    ..Testing serum samples for total and allergen-specific IgE requires separate testing for each antibody and allergen specificity...
  16. pmc Crystal structures of mite allergens Der f 1 and Der p 1 reveal differences in surface-exposed residues that may influence antibody binding
    Maksymilian Chruszcz
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, 22908, USA
    J Mol Biol 386:520-30. 2009
    ..This uneven spatial arrangement of conserved versus altered residues could explain both the specificity and cross-reactivity of antibodies against Der f 1 and Der p 1...
  17. pmc Flow cytometry imaging identifies rare T(H)2 cells expressing thymic stromal lymphopoietin receptor in a "proallergic" milieu
    Amanda J Reefer
    Asthma and Allergic Diseases Center, University of Virginia Health System, Charlottesville, VA 22908 1355, USA
    J Allergy Clin Immunol 126:1049-58, 1058.e1-10. 2010
    ..Expression of TSLP receptor on the surface of activated T(H)2 cells could amplify T(H)2 responses at inflamed sites through the direct actions of TSLP...
  18. ncbi Monitoring peanut allergen in food products by measuring Ara h 1
    Anna Pomes
    INDOOR Biotechnologies, Inc, Charlottesville, VA 22903, USA
    J Allergy Clin Immunol 111:640-5. 2003
    ..Peanut allergy is an important health problem in the United States, affecting approximately 0.6% of children. Inadvertent exposure to peanut is a risk factor for life-threatening food-induced anaphylaxis...
  19. ncbi IgE reactivity of tandem repeats derived from cockroach allergen, Bla g 1
    Anna Pomes
    Asthma and Allergic Diseases Center, Department of Medicine, University of Virginia, Charlottesville, VA, USA
    Eur J Biochem 269:3086-92. 2002
    ..The rBla g 1 is suitable for structural studies and a candidate for clinical use in diagnosis of cockroach allergy and development of new forms of immunotherapy...
  20. ncbi High-level expression of immunoreactive recombinant cat allergen (Fel d 1): Targeting to antigen-presenting cells
    Lisa D Vailes
    INDOOR Biotechnologies Inc, Charlottesville, VA 22903, USA
    J Allergy Clin Immunol 110:757-62. 2002
    ..Cat allergen Fel d 1 is a heterodimer encoded by 2 separate genes that has been difficult to produce as a fully immunoreactive molecule...
  21. ncbi Cockroach allergen Bla g 2: an unusual aspartic proteinase
    Sabina Wunschmann
    INDOOR Biotechnologies, Inc, Charlottesville, VA 22903, USA
    J Allergy Clin Immunol 116:140-5. 2005
    ..Bla g 2 is a potent cockroach allergen, but despite sharing sequence homology with aspartic proteinases, it contains critical amino acid substitutions that impair proteolytic activity. The biologic function of Bla g 2 remains unclear...
  22. ncbi High-throughput fluorescent multiplex array for indoor allergen exposure assessment
    Christopher D Earle
    INDOOR Biotechnologies, Inc, Charlottesville, VA 22903, USA
    J Allergy Clin Immunol 119:428-33. 2007
    ..Current enzyme immunoassay methods for detection of common indoor allergens in environmental dust samples are labor-intensive and time consuming...
  23. ncbi Cockroach allergen Bla g 2: structure, function, and implications for allergic sensitization
    Anna Pomes
    Asthma and Allergic Diseases Center, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA, 22903, USA
    Am J Respir Crit Care Med 165:391-7. 2002
    ..The results show dissociation between enzymatic activity and allergenicity for Bla g 2 and suggest that other genetic and environmental factors are important determinants of sensitization...
  24. ncbi Allergen nomenclature
    Martin D Chapman
    INDOOR Biotechnologies, Inc, University of Virginia, Charlottesville, Virginia, USA
    Clin Allergy Immunol 18:51-64. 2004
  25. ncbi Recombinant allergens for immunotherapy
    Martin D Chapman
    Asthma and Allergic Diseases Center, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA
    Allergy Asthma Proc 23:5-8. 2002
    ..These include peptide-based vaccines, engineered hypoallergens with reduced reactivity for IgE antibodies, nucleotide-conjugated vaccines that promote Th1 responses, and the possibility of developing prophylactic allergen vaccines...
  26. ncbi Atopy, asthma, and antibodies to Ascaris among rural and urban children in Kenya
    Matthew S Perzanowski
    University of Virginia Asthma and Allergic Diseases Center, Health Sciences Center, Charlottesville, 22908 1355, USA
    J Pediatr 140:582-8. 2002
    ..The purpose of this study was to evaluate differences in the relationship between asthma and immune responses to allergens in children living in rural and urban areas of Kenya...
  27. pmc Dust mite, cockroach, cat, and dog allergen concentrations in homes of asthmatic children in the northeastern United States: impact of socioeconomic factors and population density
    Brian P Leaderer
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520 8034, USA
    Environ Health Perspect 110:419-25. 2002
    ..Mite and cockroach allergens have distinct and opposite associations with socioeconomic factors and population density...
  28. ncbi Environmental detection of mouse allergen by means of immunoassay for recombinant Mus m 1
    Elena Ferrari
    Department of Experimental Medicine Section of Chemistry and Structural Biochemistry University of Parma, Italy
    J Allergy Clin Immunol 114:341-6. 2004
    ..Mouse urinary allergens are an important cause of occupational asthma in animal facilities. Domestic exposure to mouse allergens is a risk factor for asthma among inner-city residents...
  29. pmc Crystal structure of a dimerized cockroach allergen Bla g 2 complexed with a monoclonal antibody
    Mi Li
    Macromolecular Crystallography Laboratory, NCI Frederick, National Institutes of Health, Frederick, Maryland 21702, USA
    J Biol Chem 283:22806-14. 2008
    ..We have now identified key residues involved in IgE antibody binding; this information will be useful for the design of vaccines for immunotherapy...
  30. ncbi Risk factors for wheezing in a subtropical environment: role of respiratory viruses and allergen sensitization
    Ataide A Camara
    Department of Pediatrics, School of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    J Allergy Clin Immunol 113:551-7. 2004
    ..Risk factors for acute wheezing among children in subtropical areas are largely unknown...
  31. ncbi Exposure to indoor allergens in homes of patients with asthma and/or rhinitis in southeast Brazil: effect of mattress and pillow covers on mite allergen levels
    Kátia R C Tobias
    Department of Pediatrics, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Int Arch Allergy Immunol 133:365-70. 2004
    ..It is important to establish the degree of exposure, and to evaluate whether allergen control measures are effective in a particular area...
  32. pmc Prediction of residential pet and cockroach allergen levels using questionnaire information
    Ulrike Gehring
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Environ Health Perspect 112:834-9. 2004
    ..Knowledge of past pet ownership can improve pet allergen exposure assessment by means of questionnaire. However, for epidemiologic purposes, measured concentrations of allergens are necessary...
  33. ncbi Distribution of peanut allergen in the environment
    Tamara T Perry
    Department of Pediatrics, Division of Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Allergy Clin Immunol 113:973-6. 2004
    ..Patients with peanut allergy can have serious reactions to very small quantities of peanut allergen and often go to extreme measures to avoid potential contact with this allergen...
  34. doi Cross-reactive IgE antibody responses to tropomyosins from Ascaris lumbricoides and cockroach
    Ana Beatriz R Santos
    Department of Internal Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    J Allergy Clin Immunol 121:1040-6.e1. 2008
    ..Evidence indicates that infection with Ascaris lumbricoides may promote development of allergy and asthma...
  35. ncbi A prospective study of wheezing in young children: the independent effects of cockroach exposure, breast-feeding and allergic sensitization
    Jorgete M Silva
    Department of Pediatrics, School of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes 3900, Ribeirao Preto, Sao Paulo 14049 900, Brazil
    Pediatr Allergy Immunol 16:393-401. 2005
    ..Breast-feeding for at least 1 month was a protective factor. A strong association between allergic sensitization and persistence of wheezing was found in a group of very young children living in a subtropical area...
  36. ncbi Crystal structure of cockroach allergen Bla g 2, an unusual zinc binding aspartic protease with a novel mode of self-inhibition
    Alla Gustchina
    Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, MD 21702, USA
    J Mol Biol 348:433-44. 2005
    ..Five disulfide bridges and a Zn-binding site confer stability to the protein, which may contribute to sensitization at lower levels of exposure than other allergens...
  37. ncbi Peanut allergen exposure through saliva: assessment and interventions to reduce exposure
    Jennifer M Maloney
    Elliot and Roslyn Jaffe Food Allergy Institute, Division of Allergy and Immunology, Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA
    J Allergy Clin Immunol 118:719-24. 2006
    ..Exposure to food allergens through saliva (kissing, utensils) can cause local and systemic allergic reactions...

Research Grants1

  1. Rapid Test for Monitoring Dust Mite Avoidance in Homes
    Martin Chapman; Fiscal Year: 2004
    ..The Phase II project will result in the development of consumer based allergen tests that will improve asthma management using environmental control procedures. ..