Feng Zhou

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc DNA methylation program in developing hippocampus and its alteration by alcohol
    Yuanyuan Chen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 8:e60503. 2013
  2. pmc Ethanol exposure alters protein expression in a mouse model of fetal alcohol spectrum disorders
    Stephen Mason
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Int J Proteomics 2012:867141. 2012
  3. pmc Proceedings of the 2009 annual meeting of the Fetal Alcohol Spectrum Disorders Study Group
    Feng C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46032, USA
    Alcohol 46:101-5. 2012
  4. pmc Identification of transcription factor and microRNA binding sites in responsible to fetal alcohol syndrome
    Guohua Wang
    Division of Biostatistics Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    BMC Genomics 9:S19. 2008
  5. ncbi request reprint Special issue on stem cells: an introduction from the guest editor
    Feng C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, 46202, USA
    Curr Neurovasc Res 1:195-6. 2004
  6. ncbi request reprint Glutamate and dopamine synaptic terminals in extended amygdala after 14-week chronic alcohol drinking in inbred alcohol-preferring rats
    Feng C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Alcohol 39:39-49. 2006
  7. pmc Chronic alcohol drinking alters neuronal dendritic spines in the brain reward center nucleus accumbens
    Feng C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Brain Res 1134:148-61. 2007
  8. pmc Peptidergic agonists of activity-dependent neurotrophic factor protect against prenatal alcohol-induced neural tube defects and serotonin neuron loss
    Feng C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Alcohol Clin Exp Res 32:1361-71. 2008
  9. pmc Alcohol alters DNA methylation patterns and inhibits neural stem cell differentiation
    Feng C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 508, Indianapolis, Indiana 46202, USA
    Alcohol Clin Exp Res 35:735-46. 2011
  10. pmc Alteration of gene expression by alcohol exposure at early neurulation
    Feng C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    BMC Genomics 12:124. 2011

Collaborators

Detail Information

Publications38

  1. pmc DNA methylation program in developing hippocampus and its alteration by alcohol
    Yuanyuan Chen
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 8:e60503. 2013
    ..Alcohol hindered the acquisition and progression of methylation marks, and altered the chromatin translocation of these marks in the nucleus, which was correlated with developmental retardation...
  2. pmc Ethanol exposure alters protein expression in a mouse model of fetal alcohol spectrum disorders
    Stephen Mason
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Int J Proteomics 2012:867141. 2012
    ..Using a whole-embryo culture, we have identified misregulated proteins known to be involved in nervous system development and function...
  3. pmc Proceedings of the 2009 annual meeting of the Fetal Alcohol Spectrum Disorders Study Group
    Feng C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46032, USA
    Alcohol 46:101-5. 2012
    ..Scientific presentations were made by recipients of the Student Research Merit Award and Rosett Award...
  4. pmc Identification of transcription factor and microRNA binding sites in responsible to fetal alcohol syndrome
    Guohua Wang
    Division of Biostatistics Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    BMC Genomics 9:S19. 2008
    ..This suggests that disturbance of miRNA functions may contribute to the alcohol-induced developmental deficiencies...
  5. ncbi request reprint Special issue on stem cells: an introduction from the guest editor
    Feng C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, 46202, USA
    Curr Neurovasc Res 1:195-6. 2004
  6. ncbi request reprint Glutamate and dopamine synaptic terminals in extended amygdala after 14-week chronic alcohol drinking in inbred alcohol-preferring rats
    Feng C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Alcohol 39:39-49. 2006
    ..Our results further indicate that repeated deprivation of alcohol can change the ratio of GLU to DA innervation in the sNAc, a key region of the reward circuitry...
  7. pmc Chronic alcohol drinking alters neuronal dendritic spines in the brain reward center nucleus accumbens
    Feng C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Brain Res 1134:148-61. 2007
    ....
  8. pmc Peptidergic agonists of activity-dependent neurotrophic factor protect against prenatal alcohol-induced neural tube defects and serotonin neuron loss
    Feng C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Alcohol Clin Exp Res 32:1361-71. 2008
    ....
  9. pmc Alcohol alters DNA methylation patterns and inhibits neural stem cell differentiation
    Feng C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 508, Indianapolis, Indiana 46202, USA
    Alcohol Clin Exp Res 35:735-46. 2011
    ....
  10. pmc Alteration of gene expression by alcohol exposure at early neurulation
    Feng C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    BMC Genomics 12:124. 2011
    ..To explore the global gene expression changes which may underline these developmental defects, microarray analyses were performed in a whole embryo mouse culture model that allows control over alcohol and embryonic variables...
  11. ncbi request reprint Cellular DNA methylation program during neurulation and its alteration by alcohol exposure
    Feng C Zhou
    Department of Anatomy and Cell Biology, Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Birth Defects Res A Clin Mol Teratol 91:703-15. 2011
    ..We have demonstrated that DNA methylation is programmed when neural stem cells differentiate (Zhou et al.,2011). Here, we analyzed the DNA methylation events that occur during early neural tube development...
  12. ncbi request reprint Fetal alcohol exposure reduces serotonin innervation and compromises development of the forebrain along the serotonergic pathway
    Feng C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Alcohol Clin Exp Res 29:141-9. 2005
    ....
  13. ncbi request reprint A neuroprotective peptide antagonizes fetal alcohol exposure-compromised brain growth
    Feng C Zhou
    Indiana University School of Medicine, Department of Anatomy and Cell Biology and Program in Medical Neurobiology, and IUPUI, Indianapolis, IN 46202, USA
    J Mol Neurosci 24:189-99. 2004
    ....
  14. ncbi request reprint Production and characterization of an anti-serotonin 1A receptor antibody which detects functional 5-HT1A binding sites
    F C Zhou
    Department of Anatomy, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Brain Res Mol Brain Res 69:186-201. 1999
    ....
  15. ncbi request reprint Expression of serotonin transporter protein in developing rat brain
    F C Zhou
    Department of Anatomy, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Brain Res Dev Brain Res 119:33-45. 2000
    ..The early appearance of 5-HTT may also endow functionality as well as vulnerabilities of 5-HT, sensory thalamic, and cortical neurons to 5-HTT targeting drugs during pregnancy and after birth...
  16. ncbi request reprint Prenatal alcohol exposure retards the migration and development of serotonin neurons in fetal C57BL mice
    F C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Brain Res Dev Brain Res 126:147-55. 2001
    ..As 5-HT neurons have been implicated for signaling brain maturation, fewer 5-HT neurons may have lasting effects on the development of brain or, if persistent in the adult, profoundly affect adult brain function...
  17. ncbi request reprint DNA microarray analysis of differential gene expression of 6-year-old rat neural striatal progenitor cells during early differentiation
    F C Zhou
    Departments of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Restor Neurol Neurosci 18:95-104. 2001
    ..The six-year long-term neural stem cells are an excellent model for studying developmental neurobiological processes and aging...
  18. ncbi request reprint Serotonin uptake into dopamine neurons via dopamine transporters: a compensatory alternative
    Feng C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Brain Res 942:109-19. 2002
    ..This study also demonstrates that DA neurons can store 5-HT for possible "false neurotransmitter" or other usage...
  19. ncbi request reprint Moderate alcohol exposure compromises neural tube midline development in prenatal brain
    Feng C Zhou
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Brain Res Dev Brain Res 144:43-55. 2003
    ....
  20. ncbi request reprint Serotonin transporters are located on the axons beyond the synaptic junctions: anatomical and functional evidence
    F C Zhou
    Department of Anatomy and Medical Neurobiology Program, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Brain Res 805:241-54. 1998
    ..Our findings may also impact the understanding of the sites of action of selective serotonin reuptake inhibitors and drug entry into serotonin neurons via the numerous axonal sites...
  21. ncbi request reprint Selective serotonin reuptake inhibitor disrupts organization of thalamocortical somatosensory barrels during development
    Yanling Xu
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Brain Res Dev Brain Res 150:151-61. 2004
    ....
  22. ncbi request reprint Effects of chronic alcohol and repeated deprivations on dopamine D1 and D2 receptor levels in the extended amygdala of inbred alcohol-preferring rats
    Youssef Sari
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Alcohol Clin Exp Res 30:46-56. 2006
    ..Therefore, the current studies investigated the effects of chronic ethanol consumption, with or without deprivations, on D1 and D2 receptor densities within the EA...
  23. ncbi request reprint Serotonin and its transporter on proliferation of fetal heart cells
    Youssef Sari
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, MS508, Indianapolis, IN 46202, USA
    Int J Dev Neurosci 21:417-24. 2003
    ..These data indicate a role of 5-HT and 5-HTT on heart development. Abnormal 5-HT level or misuse of 5-HT uptake blocker may alter the heart development...
  24. pmc Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation
    Yunlong Liu
    Division of Biostatistics, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Epigenetics 4:500-11. 2009
    ....
  25. ncbi request reprint Effects of prenatal alcohol exposure on the development of the vibrissal somatosensory cortical barrel network
    Teresa A Powrozek
    Department of Psychology at Indiana University Purdue University, Indianapolis, IN 46202, USA
    Brain Res Dev Brain Res 155:135-46. 2005
    ....
  26. ncbi request reprint Prenatal alcohol exposure causes long-term serotonin neuron deficit in mice
    Youssef Sari
    Indiana University School of Medicine, Department of Anatomy and Cell Biology, Indianapolis, Indiana 46202, USA
    Alcohol Clin Exp Res 28:941-8. 2004
    ..In this study, we report that the deficit of 5-HT neurons found in midgestation persisted on E18 and into young adulthood...
  27. ncbi request reprint Differential teratogenic effect of alcohol on embryonic development between C57BL/6 and DBA/2 mice: a new view
    Tetsuo Ogawa
    From the Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Alcohol Clin Exp Res 29:855-63. 2005
    ..Whether genetic factors or conditions of alcohol exposure influence the susceptibility to alcohol-related developmental impairment remains a question...
  28. pmc Alcohol-induced facial dysmorphology in C57BL/6 mouse models of fetal alcohol spectrum disorder
    Bruce Anthony
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Alcohol 44:659-71. 2010
    ..Furthermore, these findings suggest that discriminant analysis may be useful in predicting alcohol exposure in either mouse substrains...
  29. pmc Cellular epigenetic modifications of neural stem cell differentiation
    Rabindra P Singh
    Departments of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Cell Transplant 18:1197-211. 2009
    ..These results indicate that chromatin is dynamically remodeled when NSCs transform from the quiescent state to active growth, and that DNA methylation modification is essential for neural stem cell differentiation...
  30. ncbi request reprint Alcohol teratogenesis: mechanisms of damage and strategies for intervention
    Charles R Goodlett
    Department of Psychology, Indiana University Purdue University at Indianapolis, 402 North Blackford Street, Indianapolis, Indiana 46202, USA
    Exp Biol Med (Maywood) 230:394-406. 2005
    ....
  31. ncbi request reprint General discussion at the fetal alcohol syndrome symposium
    Feng C Zhou
    Department of Anatomy, Indiana Univeristy School of Medicine, Indianapolis, Indiana 45202, USA
    Exp Biol Med (Maywood) 230:407-12. 2005
  32. pmc Alcohol exposure alters cell cycle and apoptotic events during early neurulation
    Bruce Anthony
    Department of Anatomy, Indiana University School of Medicine, Indiana University Purdue University, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Alcohol Alcohol 43:261-73. 2008
    ..In this study, we examined cell cycle proteins pertinent to the G1-S phase transition and apoptosis, to determine if cell cycle misregulation can be attributed to apoptotic induction and growth defects...
  33. ncbi request reprint Ontogeny of 5-HT1A receptor expression in the developing hippocampus
    Tushar D Patel
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Medical Science Research Building, Room 508, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Brain Res Dev Brain Res 157:42-57. 2005
    ..Furthermore, the temporal patterns of expression suggest a role for 5-HT1A in postmitotic events such as neuronal migration, neurite outgrowth, and phenotypic differentiation...
  34. ncbi request reprint Dopamine D1/5 receptor modulation of firing rate and bidirectional theta burst firing in medial septal/vertical limb of diagonal band neurons in vivo
    Thomas E Fitch
    Neuroscience Discovery, Eli Lilly and Co, Lilly Corporate Ctr, Indianapolis, IN 46285 0510, USA
    J Neurophysiol 95:2808-20. 2006
    ..Some of these MS/vDB neurons may be cholinergic or GABAergic that may indirectly regulate theta rhythm in the hippocampus...
  35. pmc Structural and functional modifications in glutamateric synapses following prolonged ethanol exposure
    L Judson Chandler
    Alcohol Research Center and Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Alcohol Clin Exp Res 30:368-76. 2006
    ..3) Presynaptic and Postsynaptic Alterations in the Nucleus Accumbens Following Chronic Alcohol Exposure, by Feng Zhou, Youssef Sari, and Richard Bell; and (4) An Active Role for Accumbens Homer2 Expression in Alcohol-Induced ..
  36. ncbi request reprint 4-1BB-like molecule is expressed in islet-infiltrating mononuclear cells and in the gray matter of the brain
    Ho Y Lim
    The Immunomodulation Research Center and Department of Biological Sciences, University of Ulsan, Ulsan, 680 749, Korea
    Cell Biol Int 26:271-8. 2002
    ..The staining pattern strongly resembled the receptor/nerve terminals in the brain and in the peripheral nervous system. Taken together, BBLP may be associated with the early phase of inflammation and with brain function...
  37. ncbi request reprint Bridging nigrostriatal pathway with fibroblast growth factor-primed peripheral nerves and fetal ventral mesencephalon transplant recuperates from deficits in parkinsonian rats
    Yung Hsiao Chiang
    Department of Neurological Surgery, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Cell Transplant 15:475-82. 2006
    ..Taken together, our data indicate that peripheral nerve, with the aid of bFGF, greatly facilitates the reconstitution of the TH pathway from nigra to striatum and improves motor function in hemiparkinsonian rats...
  38. ncbi request reprint Transplantation of fetal kidney cells: neuroprotection and neuroregeneration
    Yung Hsiao Chiang
    Tri Service General Hospital, National Defense Medical Center, Taiwan
    Cell Transplant 14:1-9. 2005
    ..In this review, we discuss preclinical evidence for the efficacy of fetal kidney cell transplantation in neuroprotection and regeneration models...

Research Grants13

  1. Epigenetics of fetal alcohol syndrome
    Feng Zhou; Fiscal Year: 2009
    ..The effect of these epigenetic key genes will be confirmed in the in vivo model exposed to alcohol vapor chamber with alcohol exposure pattern and paradigms similar to the whole embryonic culture. ..
  2. Mouse Model Neuro-Facial Dysmorphology: Tanslational and Treatment Studies
    Feng Zhou; Fiscal Year: 2007
    ..The new studies will test whether the trophic peptides can prevent alcohol-induced brain and facial dysmorphology as well as behavioral impairment known to occur in FAS. ..
  3. Epigenetics of fetal alcohol syndrome
    Feng Zhou; Fiscal Year: 2007
    ..The effect of these epigenetic key genes will be confirmed in the in vivo model exposed to alcohol vapor chamber with alcohol exposure pattern and paradigms similar to the whole embryonic culture. ..
  4. Epigenetics of fetal alcohol syndrome
    Feng Zhou; Fiscal Year: 2006
    ..The effect of these epigenetic key genes will be confirmed in the in vivo model exposed to alcohol vapor chamber with alcohol exposure pattern and paradigms similar to the whole embryonic culture. ..
  5. Neuroanatomical adaptation at synaptic level to chronic
    Feng Zhou; Fiscal Year: 2003
    ..The setting of this threshold might be derailed when alcohol is cyclically deprived. Current and future study along this line will provide information enabling us to better understanding excess drinking behavior. ..
  6. ALCOHOL & BRAIN DEVELOPMENT: MIDLINE CASCADE HYPOTHESIS
    Feng Zhou; Fiscal Year: 2003
    ....
  7. ALCOHOL & BRAIN DEVELOPMENT: MIDLINE CASCADE HYPOTHESIS
    Feng Zhou; Fiscal Year: 2002
    ....
  8. ALCOHOL & BRAIN DEVELOPMENT: MIDLINE CASCADE HYPOTHESIS
    Feng Zhou; Fiscal Year: 2001
    ....
  9. ALCOHOL & BRAIN DEVELOPMENT: MIDLINE CASCADE HYPOTHESIS
    Feng Zhou; Fiscal Year: 2001
    ....
  10. ALCOHOL & BRAIN DEVELOPMENT: MIDLINE CASCADE HYPOTHESIS
    Feng Zhou; Fiscal Year: 2000
    ....