Jin Zhong

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint Lithium: a novel treatment for Alzheimer's disease?
    Jin Zhong
    Indiana University School of Medicine, Department of Pediatrics, IU Medical Center, Indianapolis, IN 46202, USA
    Expert Opin Drug Saf 6:375-83. 2007
  2. ncbi request reprint Cesium chloride protects cerebellar granule neurons from apoptosis induced by low potassium
    Jin Zhong
    Department of Pediatrics, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN 46202, USA
    Int J Dev Neurosci 25:359-65. 2007
  3. ncbi request reprint Lithium protects ethanol-induced neuronal apoptosis
    Jin Zhong
    Department of Pediatrics, Riley Hospital for Children, 702 Barnhill Drive, Room 2641, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Biochem Biophys Res Commun 350:905-10. 2006
  4. ncbi request reprint High K+ and IGF-1 protect cerebellar granule neurons via distinct signaling pathways
    Jin Zhong
    Departments of Pediatrics and Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Neurosci Res 75:794-806. 2004
  5. ncbi request reprint Hydrogen peroxide attenuates insulin-like growth factor-1 neuroprotective effect, prevented by minocycline
    Jin Zhong
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202 5225, United States
    Neurochem Int 51:398-404. 2007
  6. ncbi request reprint Insulin-like growth factor-I protects granule neurons from apoptosis and improves ataxia in weaver mice
    Jin Zhong
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Neurosci Res 80:481-90. 2005
  7. pmc IGF-I improved bone mineral density and body composition of weaver mutant mice
    Weiguo Yao
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Growth Horm IGF Res 18:517-25. 2008
  8. ncbi request reprint Delayed IGF-1 treatment reduced long-term hypoxia-ischemia-induced brain damage and improved behavior recovery of immature rats
    Jin Zhong
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Neurol Res 31:483-9. 2009
  9. ncbi request reprint Role of the GH/IGF-I axis in the growth retardation of weaver mice
    Weiguo Yao
    Department of Pediatrics, Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA
    Endocrine 32:227-34. 2007
  10. ncbi request reprint Igf-I and postnatal growth of weaver mutant mice
    Weiguo Yao
    Department of Anatomy, Indiana University, IN 46202, USA
    Endocrine 26:117-25. 2005

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Lithium: a novel treatment for Alzheimer's disease?
    Jin Zhong
    Indiana University School of Medicine, Department of Pediatrics, IU Medical Center, Indianapolis, IN 46202, USA
    Expert Opin Drug Saf 6:375-83. 2007
    ..This review summarizes the supporting evidence and safety profiles of lithium's use in the treatment of neurological diseases, especially Alzheimer's disease...
  2. ncbi request reprint Cesium chloride protects cerebellar granule neurons from apoptosis induced by low potassium
    Jin Zhong
    Department of Pediatrics, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN 46202, USA
    Int J Dev Neurosci 25:359-65. 2007
    ..Given its relative safety and good penetration of the brain blood barrier, our findings support the potential therapeutic use of cesium in neurodegenerative diseases...
  3. ncbi request reprint Lithium protects ethanol-induced neuronal apoptosis
    Jin Zhong
    Department of Pediatrics, Riley Hospital for Children, 702 Barnhill Drive, Room 2641, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Biochem Biophys Res Commun 350:905-10. 2006
    ..In addition, the selective GSK-3beta inhibitor SB-415286 was unable to prevent ethanol-induced apoptosis. These data suggest lithium may be used as a potential preventive measure for ethanol-induced neurological deficits...
  4. ncbi request reprint High K+ and IGF-1 protect cerebellar granule neurons via distinct signaling pathways
    Jin Zhong
    Departments of Pediatrics and Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Neurosci Res 75:794-806. 2004
    ....
  5. ncbi request reprint Hydrogen peroxide attenuates insulin-like growth factor-1 neuroprotective effect, prevented by minocycline
    Jin Zhong
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202 5225, United States
    Neurochem Int 51:398-404. 2007
    ..More importantly, combining minocycline and IGF-1 could be an effective treatment in neurological diseases associated with both oxidative stress and deficiency of IGF-1...
  6. ncbi request reprint Insulin-like growth factor-I protects granule neurons from apoptosis and improves ataxia in weaver mice
    Jin Zhong
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Neurosci Res 80:481-90. 2005
    ..These results confirm our previous suggestion that a lack of IGF-I activity contributes to apoptosis of weaver granule neurons in vivo and supports IGF-I's potential therapeutic use in neurodegenerative disease...
  7. pmc IGF-I improved bone mineral density and body composition of weaver mutant mice
    Weiguo Yao
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Growth Horm IGF Res 18:517-25. 2008
    ..In summary, our results demonstrated that normal circulating IGF-I levels are important in maintaining BMD, BMC, and body composition in neurodegenerative diseases, such as hereditary cerebellar ataxia...
  8. ncbi request reprint Delayed IGF-1 treatment reduced long-term hypoxia-ischemia-induced brain damage and improved behavior recovery of immature rats
    Jin Zhong
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Neurol Res 31:483-9. 2009
    ..Overall, evidence from this investigation strongly supports IGF-1's potential therapeutic use in the treatment of hypoxic-ischemic encephalopathy in newborn patients...
  9. ncbi request reprint Role of the GH/IGF-I axis in the growth retardation of weaver mice
    Weiguo Yao
    Department of Pediatrics, Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA
    Endocrine 32:227-34. 2007
    ..This deficiency may occur at the level of the pituitary and/or hypothalamus and can be improved with GH administration...
  10. ncbi request reprint Igf-I and postnatal growth of weaver mutant mice
    Weiguo Yao
    Department of Anatomy, Indiana University, IN 46202, USA
    Endocrine 26:117-25. 2005
    ..In addition, IGF-I's regulation of systemic growth during and after puberty is likely modulated by androgen in male wv mice...
  11. ncbi request reprint Lack of spontaneous ocular neovascularization and attenuated laser-induced choroidal neovascularization in IGF-I overexpression transgenic mice
    Wenzheng Hu
    Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Vision Res 47:776-82. 2007
    ..The transgene was also associated with an attenuated laser-induced choroidal neovascularization. Differential expression levels and pattern of IGF-I gene may underlie the different retinal phenotypes in different transgenic lines...
  12. ncbi request reprint Potential role of IGF-I in hypoxia tolerance using a rat hypoxic-ischemic model: activation of hypoxia-inducible factor 1alpha
    Xinghe Wang
    Riley Research, Rm 208, 699 West Indiana University Medical Center, Indianapolis, IN 46202, USA
    Pediatr Res 55:385-94. 2004
    ..Overall, our results suggest that IGF-I transcriptional activation is one of the metabolic adaptive responses to hypoxia, which is likely mediated by a direct activation of HIF-1alpha...
  13. ncbi request reprint Inhibition of insulin-like growth factor I activity contributes to the premature apoptosis of cerebellar granule neuron in weaver mutant mice: in vitro analysis
    Jin Zhong
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Neurosci Res 70:36-45. 2002
    ..These results indicate that IGF-I's actions on wv granule neurons are normally inhibited by excess IGFBP5, and sufficient IGF-I receptor activation rescues wv granule neurons via stimulating the Akt signaling pathway...
  14. ncbi request reprint Pluripotent stem cells identified in multiple murine tissues
    Jonathan C Howell
    Division of Hematology Oncology and Indiana Elks Cancer Research Center, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Ann N Y Acad Sci 996:158-73. 2003
    ..These studies suggest that a phenotypically common, multipotent cell can be identified in different tissues and that this cell may represent a universal pluripotent stem cell residing at different levels in multiple murine tissues...