J T Zhang

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc A novel two mode-acting inhibitor of ABCG2-mediated multidrug transport and resistance in cancer chemotherapy
    Hui Peng
    Department of Pharmacology and Toxicology, University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 4:e5676. 2009
  2. pmc Role of eIF3a in regulating cisplatin sensitivity and in translational control of nucleotide excision repair of nasopharyngeal carcinoma
    R Y Liu
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, USA
    Oncogene 30:4814-23. 2011
  3. pmc Dynamic vs static ABCG2 inhibitors to sensitize drug resistant cancer cells
    Hui Peng
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 5:e15276. 2010
  4. pmc Regulation of expression by promoters versus internal ribosome entry site in the 5'-untranslated sequence of the human cyclin-dependent kinase inhibitor p27kip1
    Zhaoqian Liu
    Department of Pharmacology and Toxicology, Indiana University Cancer Center, Walther Oncology Center Walther Cancer Institute, Indiana University School of Medicine 1044 W Walnut Street, Indianapolis, IN 46202, USA
    Nucleic Acids Res 33:3763-71. 2005
  5. pmc Regulation of ribonucleotide reductase M2 expression by the upstream AUGs
    Zizheng Dong
    Department of Pharmacology and Toxicology, Indiana University Cancer Center, Walther Oncology Center, Walther Cancer Institute, Indiana University School of Medicine 1044 W Walnut Street, R4 166, Indianapolis, IN 46202, USA
    Nucleic Acids Res 33:2715-25. 2005
  6. pmc Overexpression of asparagine synthetase and matrix metalloproteinase 19 confers cisplatin sensitivity in nasopharyngeal carcinoma cells
    Ran yi Liu
    Corresponding Authors Jian Ting Zhang, Indiana University School of Medicine, 980 W Walnut St, Walther Hall C510, Indianapolis, IN 46202 5424
    Mol Cancer Ther 12:2157-66. 2013
  7. ncbi request reprint Use of arrays to investigate the contribution of ATP-binding cassette transporters to drug resistance in cancer chemotherapy and prediction of chemosensitivity
    Jian Ting Zhang
    Department of Pharmacology and Toxicology, Walther Oncology Center Walther Cancer Institute and IU Cancer Center, Indiana University School of Medicine, 1044 W Walnut Street, R4 166, Indianapolis, IN 46202, USA
    Cell Res 17:311-23. 2007
  8. ncbi request reprint Biochemistry and pharmacology of the human multidrug resistance gene product, ABCG2
    Jian Ting Zhang
    Department of Pharmacology and Toxicology, Walther Oncology Center Walther Cancer Institute and IU Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 32:531-41. 2007
  9. pmc Use of comparative proteomics to identify potential resistance mechanisms in cancer treatment
    Jian Ting Zhang
    Department of Pharmacology and Toxicology, Walther Oncology Center Walther Cancer Institute and IU Cancer Center, Indiana University School of Medicine, 1044 W Walnut Street, R4 166, IN 46202, United States
    Cancer Treat Rev 33:741-56. 2007
  10. pmc Role of 14-3-3σ in poor prognosis and in radiation and drug resistance of human pancreatic cancers
    Zhaomin Li
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    BMC Cancer 10:598. 2010

Research Grants

  1. MOLECULAR BASES OF MULTIDRUG RESISTANCE IN CANCERS
    Jian Ting Zhang; Fiscal Year: 2001
  2. Targeting the amino terminal gate of human MRP1
    Jian Ting Zhang; Fiscal Year: 2010
  3. MECHANISM OF DRUG BINDING TO P-GLYCOPROTEIN
    Jian Ting Zhang; Fiscal Year: 2000
  4. MECHANISM OF DRUG BINDING TO P-GLYCOPROTEIN
    Jian Ting Zhang; Fiscal Year: 2001
  5. Role of p170 in lung tumorigenesis
    Jian Ting Zhang; Fiscal Year: 2007
  6. Role of p170 in lung tumorigenesis
    Jian Ting Zhang; Fiscal Year: 2006
  7. Targeting the oligomerization of human ABCG2
    Jian Ting Zhang; Fiscal Year: 2009
  8. MECHANISM OF DRUG BINDING TO P-GLYCOPROTEIN
    Jian Ting Zhang; Fiscal Year: 1999
  9. Targeting the amino terminal gate of human MRP1
    Jian Ting Zhang; Fiscal Year: 2007
  10. Role of p170 in lung tumorigenesis
    Jian Ting Zhang; Fiscal Year: 2003

Collaborators

Detail Information

Publications27

  1. pmc A novel two mode-acting inhibitor of ABCG2-mediated multidrug transport and resistance in cancer chemotherapy
    Hui Peng
    Department of Pharmacology and Toxicology, University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 4:e5676. 2009
    ..Knockout of ABCG2 had no apparent adverse effect on the mice. Thus, ABCG2 is an ideal target for development of chemo-sensitizing agents for better treatment of drug resistant cancers and helping eradicate cancer stem cells...
  2. pmc Role of eIF3a in regulating cisplatin sensitivity and in translational control of nucleotide excision repair of nasopharyngeal carcinoma
    R Y Liu
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, USA
    Oncogene 30:4814-23. 2011
    ..Taken together, we conclude that eIF3a has an important role in the CDDP response and in NER activity of NPCs by suppressing the synthesis of NER proteins...
  3. pmc Dynamic vs static ABCG2 inhibitors to sensitize drug resistant cancer cells
    Hui Peng
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 5:e15276. 2010
    ....
  4. pmc Regulation of expression by promoters versus internal ribosome entry site in the 5'-untranslated sequence of the human cyclin-dependent kinase inhibitor p27kip1
    Zhaoqian Liu
    Department of Pharmacology and Toxicology, Indiana University Cancer Center, Walther Oncology Center Walther Cancer Institute, Indiana University School of Medicine 1044 W Walnut Street, Indianapolis, IN 46202, USA
    Nucleic Acids Res 33:3763-71. 2005
    ..The findings in this study also further enforce the importance that more stringent studies, such as promoterless dicistronic and monocistronic DNA and dicistronic RNA tests, are required to safeguard any future claims of cellular IRES...
  5. pmc Regulation of ribonucleotide reductase M2 expression by the upstream AUGs
    Zizheng Dong
    Department of Pharmacology and Toxicology, Indiana University Cancer Center, Walther Oncology Center, Walther Cancer Institute, Indiana University School of Medicine 1044 W Walnut Street, R4 166, Indianapolis, IN 46202, USA
    Nucleic Acids Res 33:2715-25. 2005
    ....
  6. pmc Overexpression of asparagine synthetase and matrix metalloproteinase 19 confers cisplatin sensitivity in nasopharyngeal carcinoma cells
    Ran yi Liu
    Corresponding Authors Jian Ting Zhang, Indiana University School of Medicine, 980 W Walnut St, Walther Hall C510, Indianapolis, IN 46202 5424
    Mol Cancer Ther 12:2157-66. 2013
    ..Thus, ASNS and MMP19, along with eIF3a, are the sensitivity factors for cisplatin treatment and may serve as potential candidate molecular markers for predicting cisplatin sensitivity of advanced nasopharyngeal carcinoma...
  7. ncbi request reprint Use of arrays to investigate the contribution of ATP-binding cassette transporters to drug resistance in cancer chemotherapy and prediction of chemosensitivity
    Jian Ting Zhang
    Department of Pharmacology and Toxicology, Walther Oncology Center Walther Cancer Institute and IU Cancer Center, Indiana University School of Medicine, 1044 W Walnut Street, R4 166, Indianapolis, IN 46202, USA
    Cell Res 17:311-23. 2007
    ..In this article, various arrays with limited or full list of ABC transporter genes and their use in identifying ABC transporter genes in drug resistance and chemo-sensitivity prediction will be reviewed...
  8. ncbi request reprint Biochemistry and pharmacology of the human multidrug resistance gene product, ABCG2
    Jian Ting Zhang
    Department of Pharmacology and Toxicology, Walther Oncology Center Walther Cancer Institute and IU Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 32:531-41. 2007
    ..In this paper, the recent progress on understanding the structure, function, and pharmacology of ABCG2 and its role in drug resistance and cancer stem cells will be reviewed...
  9. pmc Use of comparative proteomics to identify potential resistance mechanisms in cancer treatment
    Jian Ting Zhang
    Department of Pharmacology and Toxicology, Walther Oncology Center Walther Cancer Institute and IU Cancer Center, Indiana University School of Medicine, 1044 W Walnut Street, R4 166, IN 46202, United States
    Cancer Treat Rev 33:741-56. 2007
    ..These observations suggest that combination therapies targeting multiple mechanisms to sensitize drug resistant cancers may be necessary to eradicate cancers in the future...
  10. pmc Role of 14-3-3σ in poor prognosis and in radiation and drug resistance of human pancreatic cancers
    Zhaomin Li
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    BMC Cancer 10:598. 2010
    ..Recently, the level of 14-3-3σ mRNA was found to be increased in pancreatic cancers and this increased expression may contribute to the failure in treatment of pancreatic cancers. In the present study, we tested this hypothesis...
  11. pmc Determinant of the extracellular location of the N-terminus of human multidrug-resistance-associated protein
    J T Zhang
    Department of Pharmacology and Toxicology, IU Cancer Center, R4 Room 166, Indiana University School of Medicine, 1044 W Walnut St, Indianapolis, IN 46202, USA
    Biochem J 348:597-606. 2000
    ..These findings suggest that TM2 in a polytopic membrane protein with an extracellular N-terminus may play a critical role in controlling correct membrane translocation and folding of the protein in general...
  12. ncbi request reprint Role of the ribosome in sequence-specific regulation of membrane targeting and translocation of P-glycoprotein signal-anchor transmembrane segments
    J T Zhang
    Department of Pharmacology and Toxicology, IU Cancer Center and Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Cell Sci 113:2545-55. 2000
    ..Based on this and previous studies, we propose a mechanism by which ribosomes dynamically dictate the membrane targeting and translocation of nascent polytopic membrane proteins...
  13. ncbi request reprint The multi-structural feature of the multidrug resistance gene product P-glycoprotein: implications for its mechanism of action (hypothesis)
    J T Zhang
    Department of Pharmacology and Toxicology, Indiana University Cancer Center and Walther Oncology Institute, Indiana University School of Medicine, Indianapolis 46202, USA
    Mol Membr Biol 18:145-52. 2001
    ..A model mechanism of P-glycoprotein action is proposed as a hypothesis that is based on recent progress in studying the topological folding of P-glycoprotein...
  14. ncbi request reprint Multidrug resistance in cancer chemotherapy and xenobiotic protection mediated by the half ATP-binding cassette transporter ABCG2
    B Han
    Department of Pharmacology and Toxicology, Walther Oncology Center Walther Cancer Institute and I U Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Curr Med Chem Anticancer Agents 4:31-42. 2004
    ..Interestingly, ABCG2 is also expressed highly in hematopoietic stem cells. However, the function of ABCG2 in stem cells is currently unknown, although it may provide protection to stem cells from a variety of xenobiotics...
  15. ncbi request reprint Sensitizing hormone-refractory prostate cancer cells to drug treatment by targeting 14-3-3sigma
    Baoguang Han
    Department of Pharmacology and Toxicology, Indiana University Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mol Cancer Ther 5:903-12. 2006
    ..Based on these studies, we propose that therapeutic intervention targeting 14-3-3sigma may be useful for sensitizing hormone-refractory prostate cancers to chemotherapy by both G2-M checkpoint abrogation and apoptosis enhancement...
  16. doi request reprint Preparation and evaluation of a high-strength biocompatible glass-ionomer cement for improved dental restoratives
    D Xie
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    Biomed Mater 3:025012. 2008
    ....
  17. ncbi request reprint A novel comonomer-free light-cured glass-ionomer cement for reduced cytotoxicity and enhanced mechanical strength
    Dong Xie
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA
    Dent Mater 23:994-1003. 2007
    ..The mechanical strengths and in vitro cytotoxicity of the formed system were evaluated and compared with those of several representative commercial glass-ionomer cements...
  18. ncbi request reprint Loss of 14-3-3sigma in prostate cancer and its precursors
    Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Clin Cancer Res 10:3064-8. 2004
    ..The role of 14-3-3sigma in prostatic carcinogenesis is uncertain...
  19. ncbi request reprint Human multidrug transporter ABCG2, a target for sensitizing drug resistance in cancer chemotherapy
    Junkang Xu
    Department of Pharmacology and Toxicology, Indiana University Cancer Center, Walther Oncology Center Walther Cancer Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Curr Med Chem 14:689-701. 2007
    ..This review summarizes current knowledge on ABCG2, its relevance to multidrug resistance and drug disposition, and its ever-growing numbers of substrates and inhibitors...
  20. ncbi request reprint Characterization of oligomeric human half-ABC transporter ATP-binding cassette G2
    Junkang Xu
    Department of Pharmacology and Toxicology, Indiana University Cancer Center, Walther Oncology Center Walther Cancer Institute, Indiana University School of Medicine, 1044 W Walnut Street, Indianapolis, IN 46202, USA
    J Biol Chem 279:19781-9. 2004
    ..Further immunoprecipitation analysis showed that the oligomeric ABCG2 did not contain any other proteins. Taken together, we conclude that human ABCG2 likely exists and functions as a homotetramer...
  21. ncbi request reprint Two subcellular localizations of eIF3 p170 and its interaction with membrane-bound microfilaments: implications for alternative functions of p170
    R Pincheira
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis 46202, USA
    Eur J Cell Biol 80:410-8. 2001
    ..Phosphorylation may play an important regulatory role in the function of p170 in translation initiation and other alternative functions...
  22. ncbi request reprint Oligomerization domain of the multidrug resistance-associated transporter ABCG2 and its dominant inhibitory activity
    Junkang Xu
    Department of Pharmacology and Toxicology, Indiana University Cancer Center, Walther Oncology Center Walther Cancer Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Cancer Res 67:4373-81. 2007
    ....
  23. doi request reprint Oligomerization of human ATP-binding cassette transporters and its potential significance in human disease
    Wei Mo
    Indiana University School of Medicine, Indianapolis, 46202, USA
    Expert Opin Drug Metab Toxicol 5:1049-63. 2009
    ..In this review, we perform a critical analysis of the past studies on the oligomerization of ABC transporters...
  24. pmc Effect of cysteine mutagenesis on the function and disulfide bond formation of human ABCG2
    Yang Liu
    Department of Pharmacology and Toxicology, IU Simon Cancer Center, Walther Oncology Center Walther Cancer Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Pharmacol Exp Ther 326:33-40. 2008
    ....
  25. doi request reprint A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction
    Hailan Liu
    Department of Pharmacology and Toxicology, Walther Oncology Center Walther Cancer Institute and Indiana University Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mol Cancer Ther 7:263-70. 2008
    ....
  26. ncbi request reprint Initiation factor eIF3 and regulation of mRNA translation, cell growth, and cancer
    Zizheng Dong
    Department of Pharmacology and Toxicology, Indiana University Cancer Center, Indianapolis, IN 46202, USA
    Crit Rev Oncol Hematol 59:169-80. 2006
    ....
  27. ncbi request reprint Regulation of function by dimerization through the amino-terminal membrane-spanning domain of human ABCC1/MRP1
    Youyun Yang
    Department of Pharmacology and Toxicology, Indiana University Cancer Center, IN 46202, USA
    J Biol Chem 282:8821-30. 2007
    ..It is also tempting to propose that the MSD0L0-mediated dimerization may be targeted for therapeutic development to sensitize ABCC1/MRP1-mediated drug resistance in cancer chemotherapy...

Research Grants21

  1. MOLECULAR BASES OF MULTIDRUG RESISTANCE IN CANCERS
    Jian Ting Zhang; Fiscal Year: 2001
    ..Additionally, this study will increase our understanding of how specific protein topological structures are related to transport functions in general. ..
  2. Targeting the amino terminal gate of human MRP1
    Jian Ting Zhang; Fiscal Year: 2010
    ..This work may also lead us to the discovery of a new class of therapeutic agents that can help overcome drug-resistant cancers. ..
  3. MECHANISM OF DRUG BINDING TO P-GLYCOPROTEIN
    Jian Ting Zhang; Fiscal Year: 2000
    ..This work may lead us to the discovery of a new family of chaperone proteins associated with ribosomes that are important in determining the folding of membrane proteins co-translationally. ..
  4. MECHANISM OF DRUG BINDING TO P-GLYCOPROTEIN
    Jian Ting Zhang; Fiscal Year: 2001
    ..This work may lead us to the discovery of a new family of chaperone proteins associated with ribosomes that are important in determining the folding of membrane proteins co-translationally. ..
  5. Role of p170 in lung tumorigenesis
    Jian Ting Zhang; Fiscal Year: 2007
    ..This work will certainly add to our understanding of the functional mechanism of translation initiation of protein synthesis. ..
  6. Role of p170 in lung tumorigenesis
    Jian Ting Zhang; Fiscal Year: 2006
    ..This work will certainly add to our understanding of the functional mechanism of translation initiation of protein synthesis. ..
  7. Targeting the oligomerization of human ABCG2
    Jian Ting Zhang; Fiscal Year: 2009
    ..This work may also lead us to the discovery of a new class of therapeutic agents that can help overcome drug-resistant cancers. ..
  8. MECHANISM OF DRUG BINDING TO P-GLYCOPROTEIN
    Jian Ting Zhang; Fiscal Year: 1999
    ..This work may lead us to the discovery of a new family of chaperone proteins associated with ribosomes that are important in determining the folding of membrane proteins co-translationally. ..
  9. Targeting the amino terminal gate of human MRP1
    Jian Ting Zhang; Fiscal Year: 2007
    ..This work may also lead us to the discovery of a new class of therapeutic agents that can help overcome drug-resistant cancers. ..
  10. Role of p170 in lung tumorigenesis
    Jian Ting Zhang; Fiscal Year: 2003
    ..This work will certainly add to our understanding of the functional mechanism of translation initiation of protein synthesis. ..
  11. MOLECULAR BASES OF MULTIDRUG RESISTANCE IN CANCERS
    Jian Ting Zhang; Fiscal Year: 2000
    ..Additionally, this study will increase our understanding of how specific protein topological structures are related to transport functions in general. ..
  12. Targeting the oligomerization of human ABCG2
    Jian Ting Zhang; Fiscal Year: 2007
    ..This work may also lead us to the discovery of a new class of therapeutic agents that can help overcome drug-resistant cancers. ..
  13. Targeting the amino terminal gate of human MRP1
    Jian Ting Zhang; Fiscal Year: 2009
    ..This work may also lead us to the discovery of a new class of therapeutic agents that can help overcome drug-resistant cancers. ..
  14. Therapeutic targeting of stratifin structure and function
    Jian Ting Zhang; Fiscal Year: 2010
    ....
  15. Targeting the oligomerization of human ABCG2
    Jian Ting Zhang; Fiscal Year: 2006
    ..This work may also lead us to the discovery of a new class of therapeutic agents that can help overcome drug-resistant cancers. ..
  16. Role of p170 in lung tumorigenesis
    Jian Ting Zhang; Fiscal Year: 2005
    ..This work will certainly add to our understanding of the functional mechanism of translation initiation of protein synthesis. ..
  17. Role of p170 in lung tumorigenesis
    Jian Ting Zhang; Fiscal Year: 2004
    ..This work will certainly add to our understanding of the functional mechanism of translation initiation of protein synthesis. ..
  18. MOLECULAR BASES OF MULTIDRUG RESISTANCE IN CANCERS
    Jian Ting Zhang; Fiscal Year: 1999
    ..Additionally, this study will increase our understanding of how specific protein topological structures are related to transport functions in general. ..