Min You

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice
    Min You
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Hepatology 42:568-77. 2005
  2. ncbi Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP)
    Min You
    Department of Medicine, Indiana University School of Medicine and Richard Roudebush Veteran s Affairs Medical Center, Indianapolis, Indiana 46202, USA
    J Biol Chem 277:29342-7. 2002
  3. ncbi Molecular mechanisms of alcoholic fatty liver: role of sterol regulatory element-binding proteins
    Min You
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Alcohol 34:39-43. 2004
  4. ncbi The role of AMP-activated protein kinase in the action of ethanol in the liver
    Min You
    Depatment of Medicine, Indiana University School of Medicine, Richard Roudebush Veteran s Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Gastroenterology 127:1798-808. 2004
  5. ncbi Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice
    Monika Fischer
    Department of Medicine, Indiana University School of Medicine and Richard Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    J Biol Chem 278:27997-8004. 2003
  6. ncbi Transcriptional control of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: inhibition by cyclic AMP and COUP transcription factors
    Min You
    Department of Medicine, Indiana University School of Medicine and Richard Roudebush Veteran s Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Arch Biochem Biophys 398:79-86. 2002
  7. ncbi Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver
    Min You
    Department of Medicine, Indiana University School of Medicine, Emerson Hall Rm 317, 545 Barnhill Drive, Indianapolis, IN 46202, USA
    Am J Physiol Gastrointest Liver Physiol 287:G1-6. 2004
  8. ncbi Molecular mechanisms of alcoholic fatty liver: role of peroxisome proliferator-activated receptor alpha
    David W Crabb
    Department of Medicine, Indiana University, Emerson Hall, Room 317, 545 Barnhill Drive, Indianapolis, IN 46202, USA
    Alcohol 34:35-8. 2004
  9. ncbi Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology
    David W Crabb
    Indiana University School of Medicine and Roudebush VA Medical Center, Emerson Hall Room 317, 545 Barnhill Drive, Indianapolis, IN 46202, USA
    Proc Nutr Soc 63:49-63. 2004
  10. ncbi Association of the aldehyde dehydrogenase 2 promoter polymorphism with alcohol consumption and reactions in an American Jewish population
    Monika Fischer
    Department of Medicine, Indiana University School of Medicine and the Richard Roudebush Veteran s Affairs Medical Center, Indianapolis, Indiana, USA
    Alcohol Clin Exp Res 31:1654-9. 2007

Collaborators

Detail Information

Publications17

  1. pmc Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice
    Min You
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Hepatology 42:568-77. 2005
    ....
  2. ncbi Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP)
    Min You
    Department of Medicine, Indiana University School of Medicine and Richard Roudebush Veteran s Affairs Medical Center, Indianapolis, Indiana 46202, USA
    J Biol Chem 277:29342-7. 2002
    ..These finding suggest that metabolism of ethanol increased hepatic lipogenesis by activating SREBP-1 and that this effect of ethanol may contribute to the development of alcoholic fatty liver...
  3. ncbi Molecular mechanisms of alcoholic fatty liver: role of sterol regulatory element-binding proteins
    Min You
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Alcohol 34:39-43. 2004
    ..Consistent with this hypothesis, chronic ethanol feeding (4 weeks) resulted in a significantly reduced activity and protein level of AMP-activated protein kinase and increased acetyl coenzyme A carboxylase activity in the mouse livers...
  4. ncbi The role of AMP-activated protein kinase in the action of ethanol in the liver
    Min You
    Depatment of Medicine, Indiana University School of Medicine, Richard Roudebush Veteran s Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Gastroenterology 127:1798-808. 2004
    ..In the present study, we studied the mechanisms of this activation by identifying a new target of ethanol, AMP-activated protein kinase (AMPK)...
  5. ncbi Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice
    Monika Fischer
    Department of Medicine, Indiana University School of Medicine and Richard Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    J Biol Chem 278:27997-8004. 2003
    ..Impairment of PPARalpha function during ethanol consumption contributes to the development of alcoholic fatty liver, which can be overcome by Wy14,643...
  6. ncbi Transcriptional control of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: inhibition by cyclic AMP and COUP transcription factors
    Min You
    Department of Medicine, Indiana University School of Medicine and Richard Roudebush Veteran s Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Arch Biochem Biophys 398:79-86. 2002
    ..These data suggest that ALDH2 expression can be suppressed by cAMP, most likely through phosphorylation of HNF4 by PKA, and this may account for the reduction in enzyme protein during fasting...
  7. ncbi Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver
    Min You
    Department of Medicine, Indiana University School of Medicine, Emerson Hall Rm 317, 545 Barnhill Drive, Indianapolis, IN 46202, USA
    Am J Physiol Gastrointest Liver Physiol 287:G1-6. 2004
    ..The understanding of these ethanol effects provides new therapeutic targets to reverse alcoholic fatty liver...
  8. ncbi Molecular mechanisms of alcoholic fatty liver: role of peroxisome proliferator-activated receptor alpha
    David W Crabb
    Department of Medicine, Indiana University, Emerson Hall, Room 317, 545 Barnhill Drive, Indianapolis, IN 46202, USA
    Alcohol 34:35-8. 2004
    ..Blockade of PPARalpha function during ethanol consumption contributes to the development of alcoholic fatty liver, which can be overcome by WY14,643...
  9. ncbi Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology
    David W Crabb
    Indiana University School of Medicine and Roudebush VA Medical Center, Emerson Hall Room 317, 545 Barnhill Drive, Indianapolis, IN 46202, USA
    Proc Nutr Soc 63:49-63. 2004
    ..It will be important to replicate other interesting associations between these variants and other cancers and heart disease, and to determine the biochemical mechanisms underlying the associations...
  10. ncbi Association of the aldehyde dehydrogenase 2 promoter polymorphism with alcohol consumption and reactions in an American Jewish population
    Monika Fischer
    Department of Medicine, Indiana University School of Medicine and the Richard Roudebush Veteran s Affairs Medical Center, Indianapolis, Indiana, USA
    Alcohol Clin Exp Res 31:1654-9. 2007
    ..The A allele is predicted to be less active transcriptionally than the G allele. Therefore, we hypothesized that individuals with 1 or 2 A alleles would have exaggerated reactions to alcohol...
  11. ncbi Identification of trans-acting factors by electrophoretic mobility shift assay
    Rebecca J Chan
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indiana, Indianapolis, USA
    Methods Mol Biol 249:7-20. 2004
  12. ncbi Identification of a retinoid receptor response element in the human aldehyde dehydrogenase-2 promoter
    Jane Pinaire
    Department of Medicine, Indiana University School of Medicine and Veterans Affairs Medical Center, Indianapolis, USA
    Alcohol Clin Exp Res 27:1860-6. 2003
    ..The human aldehyde dehydrogenase-2 promoter contains sites that bind members of the nuclear receptor family, and one (designated FP330-3') is predicted to bind retinoic acid receptors...
  13. ncbi Mammalian sirtuin 1 is involved in the protective action of dietary saturated fat against alcoholic fatty liver in mice
    Min You
    Department of Molecular Pharmacology and Physiology, University of South Florida Health Sciences Center, Tampa, FL 33612, USA
    J Nutr 138:497-501. 2008
    ....
  14. doi Involvement of mammalian sirtuin 1 in the action of ethanol in the liver
    Min You
    Dept of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, College of Medicine, Box 8, Univ of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Am J Physiol Gastrointest Liver Physiol 294:G892-8. 2008
    ..Hence, SIRT1 may represent a novel therapeutic target for treatment of human alcoholic fatty liver disease...
  15. ncbi S-adenosylmethionine attenuates hepatic lipid synthesis in micropigs fed ethanol with a folate-deficient diet
    Farah Esfandiari
    Department of Internal Medicine, University of California Davis, Davis, CA 95616, USA
    Alcohol Clin Exp Res 31:1231-9. 2007
    ....
  16. ncbi Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta
    XiaoQing Lu
    Departments of Medicine and Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, Florida 33101, USA
    J Biol Chem 277:24340-5. 2002
    ..These results establish that the interaction of PCNA with DNA polymerase delta is mediated through the small subunit of the enzyme...
  17. pmc Inhibition of mTOR restores cisplatin sensitivity through down-regulation of growth and anti-apoptotic proteins
    Medhi Wangpaichitr
    Department of Molecular Cell and Developmental Biology, University of Miami School of Medicine, Miami, FL, USA
    Eur J Pharmacol 591:124-7. 2008
    ....