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Genomes and Genes | Min YouSummaryAffiliation: Indiana University Country: USA Publications
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Publications
Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in miceMin You
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Hepatology 42:568-77. 2005....- Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP)Min You
Department of Medicine, Indiana University School of Medicine and Richard Roudebush Veteran s Affairs Medical Center, Indianapolis, Indiana 46202, USA
J Biol Chem 277:29342-7. 2002..These finding suggest that metabolism of ethanol increased hepatic lipogenesis by activating SREBP-1 and that this effect of ethanol may contribute to the development of alcoholic fatty liver... - Molecular mechanisms of alcoholic fatty liver: role of sterol regulatory element-binding proteinsMin You
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Alcohol 34:39-43. 2004..Consistent with this hypothesis, chronic ethanol feeding (4 weeks) resulted in a significantly reduced activity and protein level of AMP-activated protein kinase and increased acetyl coenzyme A carboxylase activity in the mouse livers... - The role of AMP-activated protein kinase in the action of ethanol in the liverMin You
Depatment of Medicine, Indiana University School of Medicine, Richard Roudebush Veteran's Affairs Medical Center, Indianapolis, Indiana 46202, USA
Gastroenterology 127:1798-808. 2004..CONCLUSIONS: Taken together, our findings suggest that AMPK may play a key role in regulating the effects of ethanol on SREBP-1 activation, fatty acid metabolism, and development of alcoholic fatty liver... - Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed miceMonika Fischer
Department of Medicine, Indiana University School of Medicine and Richard Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
J Biol Chem 278:27997-8004. 2003..Impairment of PPARalpha function during ethanol consumption contributes to the development of alcoholic fatty liver, which can be overcome by Wy14,643... - Transcriptional control of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: inhibition by cyclic AMP and COUP transcription factorsMin You
Department of Medicine, Indiana University School of Medicine and Richard Roudebush Veteran s Affairs Medical Center, Indianapolis, Indiana 46202, USA
Arch Biochem Biophys 398:79-86. 2002..These data suggest that ALDH2 expression can be suppressed by cAMP, most likely through phosphorylation of HNF4 by PKA, and this may account for the reduction in enzyme protein during fasting... - Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liverMin You
Department of Medicine, Indiana University School of Medicine, Emerson Hall Rm. 317, 545 Barnhill Drive, Indianapolis, IN 46202, USA
Am J Physiol Gastrointest Liver Physiol 287:G1-6. 2004..The understanding of these ethanol effects provides new therapeutic targets to reverse alcoholic fatty liver... - Molecular mechanisms of alcoholic fatty liver: role of peroxisome proliferator-activated receptor alphaDavid W Crabb
Department of Medicine, Indiana University, Emerson Hall, Room 317, 545 Barnhill Drive, Indianapolis, IN 46202, USA
Alcohol 34:35-8. 2004..Blockade of PPARalpha function during ethanol consumption contributes to the development of alcoholic fatty liver, which can be overcome by WY14,643... - Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathologyDavid W Crabb
Indiana University School of Medicine and Roudebush VA Medical Center, Emerson Hall Room 317, 545 Barnhill Drive, Indianapolis, IN 46202, USA
Proc Nutr Soc 63:49-63. 2004..It will be important to replicate other interesting associations between these variants and other cancers and heart disease, and to determine the biochemical mechanisms underlying the associations... - Association of the aldehyde dehydrogenase 2 promoter polymorphism with alcohol consumption and reactions in an American Jewish populationMonika Fischer
Department of Medicine, Indiana University School of Medicine and the Richard Roudebush Veteran s Affairs Medical Center, Indianapolis, Indiana, USA
Alcohol Clin Exp Res 31:1654-9. 2007..The A allele is predicted to be less active transcriptionally than the G allele. Therefore, we hypothesized that individuals with 1 or 2 A alleles would have exaggerated reactions to alcohol... - Identification of trans-acting factors by electrophoretic mobility shift assayRebecca J Chan
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indiana, Indianapolis, USA
Methods Mol Biol 249:7-20. 2004 - Identification of a retinoid receptor response element in the human aldehyde dehydrogenase-2 promoterJane Pinaire
Department of Medicine, Indiana University School of Medicine and Veterans Affairs Medical Center, Indianapolis, USA
Alcohol Clin Exp Res 27:1860-6. 2003..The human aldehyde dehydrogenase-2 promoter contains sites that bind members of the nuclear receptor family, and one (designated FP330-3') is predicted to bind retinoic acid receptors... - Mammalian sirtuin 1 is involved in the protective action of dietary saturated fat against alcoholic fatty liver in miceMin You
Department of Molecular Pharmacology and Physiology, University of South Florida Health Sciences Center, Tampa, FL 33612, USA
J Nutr 138:497-501. 2008.... - Involvement of mammalian sirtuin 1 in the action of ethanol in the liverMin You
Dept of Molecular Pharmacology and Physiology, School of Basic Biomedical Sciences, College of Medicine, Box 8, Univ of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
Am J Physiol Gastrointest Liver Physiol 294:G892-8. 2008..Hence, SIRT1 may represent a novel therapeutic target for treatment of human alcoholic fatty liver disease... - S-adenosylmethionine attenuates hepatic lipid synthesis in micropigs fed ethanol with a folate-deficient dietFarah Esfandiari
Department of Internal Medicine, University of California Davis, Davis, CA 95616, USA
Alcohol Clin Exp Res 31:1231-9. 2007.... - Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase deltaXiaoQing Lu
Departments of Medicine and Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, Florida 33101, USA
J Biol Chem 277:24340-5. 2002..These results establish that the interaction of PCNA with DNA polymerase delta is mediated through the small subunit of the enzyme... - Inhibition of mTOR restores cisplatin sensitivity through down-regulation of growth and anti-apoptotic proteinsMedhi Wangpaichitr
Department of Molecular Cell and Developmental Biology, University of Miami School of Medicine, Miami, FL, USA
Eur J Pharmacol 591:124-7. 2008....