Mervin Yoder

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi request reprint The homeoprotein Hex is required for hemangioblast differentiation
    Ying Guo
    Department of Medicine, Indiana University Cancer Center, Indianapolis, IN, USA
    Blood 102:2428-35. 2003
  2. ncbi request reprint Embryonic hematopoiesis in mice and humans
    M C Yoder
    Acta Paediatr Suppl 91:5-8. 2002
  3. ncbi request reprint Generation of HSCs in the embryo and assays to detect them
    Mervin C Yoder
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut Street, R4 402e, Indianapolis 46202, USA
    Oncogene 23:7161-3. 2004
  4. ncbi request reprint Clonogenic endothelial progenitor cells are sensitive to oxidative stress
    David A Ingram
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indianapolis, Indiana 46202, USA
    Stem Cells 25:297-304. 2007
  5. pmc Human endothelial progenitor cells
    Mervin C Yoder
    Department of Pediatrics, Herman B Wells Center for Pediatrics Research, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cold Spring Harb Perspect Med 2:a006692. 2012
  6. pmc Endothelial progenitor cell: a blood cell by many other names may serve similar functions
    Mervin C Yoder
    Hermann B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Mol Med (Berl) 91:285-95. 2013
  7. doi request reprint Endothelial progenitor cell: ongoing controversy for defining these cells and their role in neoangiogenesis in the murine system
    Mervin C Yoder
    Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, IN 46202, USA
    Curr Opin Hematol 16:269-73. 2009
  8. ncbi request reprint Blood cell progenitors: insights into the properties of stem cells
    Mervin C Yoder
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Anat Rec A Discov Mol Cell Evol Biol 276:66-74. 2004
  9. pmc The definition of EPCs and other bone marrow cells contributing to neoangiogenesis and tumor growth: is there common ground for understanding the roles of numerous marrow-derived cells in the neoangiogenic process?
    Mervin C Yoder
    Biochemistry and Molecular Biology, Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA Pediatrics and of Biochemistry and Molecular Biology, Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA
    Biochim Biophys Acta 1796:50-4. 2009
  10. doi request reprint Defining human endothelial progenitor cells
    M C Yoder
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Thromb Haemost 7:49-52. 2009

Detail Information

Publications83

  1. ncbi request reprint The homeoprotein Hex is required for hemangioblast differentiation
    Ying Guo
    Department of Medicine, Indiana University Cancer Center, Indianapolis, IN, USA
    Blood 102:2428-35. 2003
    ..Therefore, Hex is a novel regulator of hemangioblast differentiation to hematopoietic and endothelial cells...
  2. ncbi request reprint Embryonic hematopoiesis in mice and humans
    M C Yoder
    Acta Paediatr Suppl 91:5-8. 2002
    ..The aim of this report is to review briefly the ontogeny of hematopoiesis in mice and humans and to discuss recent evidence for an intraembryonic source of hematopoietic stem cells...
  3. ncbi request reprint Generation of HSCs in the embryo and assays to detect them
    Mervin C Yoder
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut Street, R4 402e, Indianapolis 46202, USA
    Oncogene 23:7161-3. 2004
    ..This review will highlight some of the various transplantation assays used to identify HSC from embryonic tissues...
  4. ncbi request reprint Clonogenic endothelial progenitor cells are sensitive to oxidative stress
    David A Ingram
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indianapolis, Indiana 46202, USA
    Stem Cells 25:297-304. 2007
    ....
  5. pmc Human endothelial progenitor cells
    Mervin C Yoder
    Department of Pediatrics, Herman B Wells Center for Pediatrics Research, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cold Spring Harb Perspect Med 2:a006692. 2012
    ....
  6. pmc Endothelial progenitor cell: a blood cell by many other names may serve similar functions
    Mervin C Yoder
    Hermann B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Mol Med (Berl) 91:285-95. 2013
    ..The review will conclude with identification of some roadblocks to progress in the field of identification of circulating cells that participate in vascular repair and regeneration...
  7. doi request reprint Endothelial progenitor cell: ongoing controversy for defining these cells and their role in neoangiogenesis in the murine system
    Mervin C Yoder
    Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, IN 46202, USA
    Curr Opin Hematol 16:269-73. 2009
    ....
  8. ncbi request reprint Blood cell progenitors: insights into the properties of stem cells
    Mervin C Yoder
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Anat Rec A Discov Mol Cell Evol Biol 276:66-74. 2004
    ..Further work will be required to understand the molecular mechanisms that regulate commitment of stem and progenitor cells to each stage of progenitor cell development and ultimately into the mature blood cells...
  9. pmc The definition of EPCs and other bone marrow cells contributing to neoangiogenesis and tumor growth: is there common ground for understanding the roles of numerous marrow-derived cells in the neoangiogenic process?
    Mervin C Yoder
    Biochemistry and Molecular Biology, Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA Pediatrics and of Biochemistry and Molecular Biology, Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA
    Biochim Biophys Acta 1796:50-4. 2009
    ....
  10. doi request reprint Defining human endothelial progenitor cells
    M C Yoder
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Thromb Haemost 7:49-52. 2009
    ..Future studies must focus on defining the specific hematopoietic subsets that are involved in activating, recruiting, and remodeling the vascular networks formed by the endothelial colony forming cells...
  11. doi request reprint Is endothelium the origin of endothelial progenitor cells?
    Mervin C Yoder
    Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 West Walnut Street, R4 402e, Indianapolis, IN 46202, USA
    Arterioscler Thromb Vasc Biol 30:1094-103. 2010
    ..The article also discusses the current gaps in our knowledge to prove whether the colony-forming cells are in fact derived from vascular endothelium...
  12. doi request reprint Progenitor cells in the pulmonary circulation
    Mervin C Yoder
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Proc Am Thorac Soc 8:466-70. 2011
    ....
  13. doi request reprint Developing reagents and conditions to induce mesoderm subsets from ES cells
    Mervin C Yoder
    Department of Pediatrics, Indiana University School of Medicine, 1044 West Walnut Street, R4 402e, Indianapolis, IN 46202, USA
    Cell Stem Cell 1:603-4. 2007
    ..Nishikawa and colleagues, in a recent issue of Stem Cells (Era et al., 2007), have used selectable markers to detect lineage-specific gene expression and dissect the induction of mesoderm subsets in ES cell cultures...
  14. ncbi request reprint Roles of spleen and liver in development of the murine hematopoietic system
    Frances M Wolber
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Hematol 30:1010-9. 2002
    ..To investigate these issues we quantitated CFC and HSC activity in the spleen, BM, peripheral blood, and liver of the mouse during ontogeny...
  15. ncbi request reprint Hematopoietic stem cell repopulating ability can be maintained in vitro by some primary endothelial cells
    Weiming Li
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Hematol 32:1226-37. 2004
    ..The mechanisms maintaining HSC potential during systemic circulation remain elusive. We hypothesized that vascular endothelial cells (EC) play an important role in maintaining circulating HSC repopulating ability...
  16. ncbi request reprint Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs
    Xiaodong Xie
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 101:1329-35. 2003
    ..Thus, under certain growth factor conditions, Tpo directly inhibits early yolk sac erythroid CFU growth but facilitates megakaryocyte and mixed lineage colony formation...
  17. ncbi request reprint Donor chimerism and stem cell function in a murine congenic transplantation model after low-dose radiation conditioning: effects of a retroviral-mediated gene transfer protocol and implications for gene therapy
    W Scott Goebel
    Herman B Wells Center for Pediatric Research and Department of Pediatrics, Hematology Oncology, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA
    Exp Hematol 30:1324-32. 2002
    ..We investigated low-dose radiation conditioning for the transplantation of retrovirus-transduced cells in a C57Bl6/J murine model...
  18. doi request reprint Isolation and characterization of endothelial progenitor cells from human blood
    Laura E Mead
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Curr Protoc Stem Cell Biol . 2008
    ..In this unit, we describe detailed methodologies for isolation and characterization of ECFCs from both human peripheral and umbilical cord blood...
  19. pmc A hierarchy of endothelial colony-forming cell activity displayed by bovine corneal endothelial cells
    Lan Huang
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Invest Ophthalmol Vis Sci 51:3943-9. 2010
    ..To test the hypothesis that the robust expansion of bovine corneal endothelial cells (BCECs) in vitro is due to the presence of individual endothelial cells with various levels of proliferative potential...
  20. ncbi request reprint Muscle-derived CD45-SCA-1+c-kit- progenitor cells give rise to skeletal muscle myotubes in vitro
    Cassandre L Royer
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    In Vitro Cell Dev Biol Anim 38:512-7. 2002
    ..Both populations possess the ability to differentiate into skeletal muscle cells in vitro...
  21. pmc Overcoming obstacles in the search for the site of hematopoietic stem cell emergence
    Momoko Yoshimoto
    Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Cell Stem Cell 3:583-6. 2008
    ..However, the onset of the systemic circulation has long been a confounding developmental variable that may mask the site of blood cell emergence. This Minireview examines some approaches that have been applied to overcome this obstacle...
  22. doi request reprint Endothelial progenitor cells and cardiovascular cell-based therapies
    Julie A Mund
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, 46202, USA
    Cytotherapy 11:103-13. 2009
    ....
  23. ncbi request reprint CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo
    Michael J Ferkowicz
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Development 130:4393-403. 2003
    ....
  24. ncbi request reprint A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis
    Rebecca J Chan
    Department of Pediatrics, Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA
    Blood 102:2074-80. 2003
    ....
  25. doi request reprint Endothelial colony forming cells and mesenchymal stem cells are enriched at different gestational ages in human umbilical cord blood
    M Jawad Javed
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Pediatr Res 64:68-73. 2008
    ..These studies demonstrate that circulating MSCs and ECFCs appear at different GA in the human UCB, and that 24-28 wk GA UCB may be a novel source of MSCs for therapeutic use in human diseases...
  26. pmc Sonic hedgehog and retinoic acid synergistically promote sensory fate specification from bone marrow-derived pluripotent stem cells
    Takako Kondo
    Department of Otolaryngology Head and Neck Surgery, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Proc Natl Acad Sci U S A 102:4789-94. 2005
    ..These results identify Shh and RA as sensory competence factors for adult pluripotent cells and establish the importance of interactions between adult pluripotent cells and the host microenvironment in neuronal subtype specification...
  27. ncbi request reprint Endothelial cells in the early murine yolk sac give rise to CD41-expressing hematopoietic cells
    Weiming Li
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Stem Cells Dev 14:44-54. 2005
    ..These results demonstrate that CD41-expressing definitive hematopoietic cells appear to arise from endothelial cells lining nascent capillaries in vivo...
  28. ncbi request reprint Pluripotent stem cells identified in multiple murine tissues
    Jonathan C Howell
    Division of Hematology Oncology and Indiana Elks Cancer Research Center, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Ann N Y Acad Sci 996:158-73. 2003
    ..These studies suggest that a phenotypically common, multipotent cell can be identified in different tissues and that this cell may represent a universal pluripotent stem cell residing at different levels in multiple murine tissues...
  29. pmc Suppressed hindlimb perfusion in Rac2-/- and Nox2-/- mice does not result from impaired collateral growth
    Matthew R Distasi
    Department of Cellular and Integrative Physiology, Indiana Univ School of Medicine, 1001 W 10th St, WD OPW 425 E, Indianapolis, IN 46202, USA
    Am J Physiol Heart Circ Physiol 296:H877-86. 2009
    ..These novel results indicate that collateral luminal expansion and intimal cell recruitment/proliferation are not mediated by Rac2 and Nox2...
  30. pmc Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals
    Mervin C Yoder
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 109:1801-9. 2007
    ..Thus, these studies establish that CFU-ECs are not EPCs and the role of these cells in angiogenesis must be re-examined prior to further clinical trials, whereas ECFCs may serve as a potential therapy for vascular regeneration...
  31. ncbi request reprint Human CD34+AC133+VEGFR-2+ cells are not endothelial progenitor cells but distinct, primitive hematopoietic progenitors
    Jamie Case
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Hematol 35:1109-18. 2007
    ....
  32. pmc Rac1 is essential for intraembryonic hematopoiesis and for the initial seeding of fetal liver with definitive hematopoietic progenitor cells
    Gabriel Ghiaur
    Department of Pediatrics, Cincinnati Children s Research Foundation and Cincinnati Children s Hospital Medical Center, and Hoxworth Blood Center, University of Cincinnati College of Medicine, OH, USA
    Blood 111:3313-21. 2008
    ..These data suggest that Rac1 plays an important role in HSC/P migration during embryonic development and is essential for the emergence of intraembryonic hematopoiesis...
  33. ncbi request reprint Reduction of Shp-2 expression by small interfering RNA reduces murine embryonic stem cell-derived in vitro hematopoietic differentiation
    Gang Ming Zou
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 West Walnut St, R4 402e, Indianapolis, Indiana 46202, USA
    Stem Cells 24:587-94. 2006
    ....
  34. doi request reprint Recombinant self-complementary adeno-associated virus serotype vector-mediated hematopoietic stem cell transduction and lineage-restricted, long-term transgene expression in a murine serial bone marrow transplantation model
    Njeri Maina
    Division of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Hum Gene Ther 19:376-83. 2008
    ....
  35. pmc Bone marrow-derived angiogenic cells restore lung alveolar and vascular structure after neonatal hyperoxia in infant mice
    Vivek Balasubramaniam
    Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado Denver, 12800 E 19th Ave, Aurora, CO 80045, USA
    Am J Physiol Lung Cell Mol Physiol 298:L315-23. 2010
    ..We conclude that treatment with BMDAC after neonatal hyperoxia restores lung structure in this model of bronchopulmonary dysplasia...
  36. doi request reprint Assessing identity, phenotype, and fate of endothelial progenitor cells
    Karen K Hirschi
    Department of Pediatrics, Center for Cell and Gene Therapy and Children s Nutrition Research Center, Baylor College of Medicine, Houston, TX 77030, USA
    Arterioscler Thromb Vasc Biol 28:1584-95. 2008
  37. ncbi request reprint Flow cytometric analysis of hematopoietic development
    Edward F Srour
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA
    Methods Mol Med 105:65-80. 2005
    ..This plasticity of the HSCs demonstrates hemangioblast activity, proven by both single cell and serial HSC transplants, and is the focus of this chapter...
  38. ncbi request reprint Primary endothelial cells isolated from the yolk sac and para-aortic splanchnopleura support the expansion of adult marrow stem cells in vitro
    Weiming Li
    Herman B Wells Center for Pediatric Research, Cancer Research Institute, 1044 W Walnut St, R4 419, Indianapolis, IN 46202, USA
    Blood 102:4345-53. 2003
    ..These data suggest that 9.5-dpc yolk sac- and P-Sp-derived primary Tie2-GFP+Flk-1+CD41- endothelial cells possess the capacity to expand adult bone marrow hematopoietic progenitor cell and HSC repopulating ability ex vivo...
  39. ncbi request reprint A murine model of antimetabolite-based, submyeloablative conditioning for bone marrow transplantation: biologic insights and potential applications
    W Scott Goebel
    Herman B Wells Center for Pediatric Research and Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Ind, USA
    Exp Hematol 32:1255-64. 2004
    ....
  40. pmc Expression of RAC2 in endothelial cells is required for the postnatal neovascular response
    Pradip De
    Department of Pediatrics, Aflac Cancer Center and Blood Disorders Service, Emory University School of Medicine, Atlanta, GA 30322, USA
    Exp Cell Res 315:248-63. 2009
    ..These findings identify a novel signaling axis for the induction and potential modulation of postnatal angiogenesis...
  41. ncbi request reprint Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cells
    Xiaohua Wu
    Department of Pediatrics, Herman B Wells Center for Pediatric Research and Indiana University School of Medicine, Cancer Research Institute, Indianapolis 46202, USA
    Hum Mol Genet 15:2837-45. 2006
    ....
  42. ncbi request reprint Granulocyte colony-stimulating factor prior to nonmyeloablative irradiation decreases murine host hematopoietic stem cell function and increases engraftment of donor marrow cells
    Cecilia Barese
    Cancer Research Institute R4 402C, Indiana University School of Medicine, 1044 West Walnut Street, Indianapolis, Indiana 46202, USA
    Stem Cells 25:1578-85. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  43. ncbi request reprint Evaluation of primitive murine hematopoietic stem and progenitor cell transduction in vitro and in vivo by recombinant adeno-associated virus vector serotypes 1 through 5
    Li Zhong
    Division of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Hum Gene Ther 17:321-33. 2006
    ....
  44. ncbi request reprint Thrombopoietin acts synergistically with LIF to maintain an undifferentiated state of embryonic stem cells homozygous for a Shp-2 deletion mutation
    Xiaodong Xie
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut Street, Indianapolis, IN 46202, USA
    FEBS Lett 529:361-4. 2002
    ..Collectively, these data suggest that Tpo can play a role in preventing ES cell differentiation via Jak-STAT3 activation and perhaps via novel pathways that are enhanced in the absence of functional Shp-2...
  45. doi request reprint Deficiency of Src family kinases compromises the repopulating ability of hematopoietic stem cells
    Christie M Orschell
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Hematol 36:655-66. 2008
    ..However, little is known about the role of these kinases in the growth, homing, and engraftment potential of hematopoietic stem and progenitor cells...
  46. pmc Bone marrow engraftment but limited expansion of hematopoietic cells from multipotent germline stem cells derived from neonatal mouse testis
    Momoko Yoshimoto
    Department of Pediatrics, Kyoto University, Kyoto
    Exp Hematol 37:1400-10. 2009
    ..In the present work, we examined mGS cells for hematopoietic progenitor potential in vitro and in vivo...
  47. pmc Endothelial colony-forming cell role in neoangiogenesis and tissue repair
    Paul J Critser
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Curr Opin Organ Transplant 15:68-72. 2010
    ..This review will discuss the ability of endothelial progenitor cells (EPCs), which have been reported to contribute to neoangiogenesis in both physiological and pathological conditions, to contribute to neoangiogenesis in tissue repair...
  48. doi request reprint RNAi knockdown of transcription factor Pu.1 in the differentiation of mouse embryonic stem cells
    Gang Ming Zou
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, USA
    Methods Mol Biol 407:127-36. 2007
    ..This method will be useful to test the function of a wide variety of gene products using the ES cell differentiation system...
  49. ncbi request reprint Acute myocardial infarction in swine rapidly and selectively releases highly proliferative endothelial colony forming cells (ECFCs) into circulation
    Lan Huang
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Cell Transplant 16:887-97. 2007
    ..Because circulating ECFC are also altered in human subjects with severe coronary artery disease, the pig model of AMI may be an excellent preclinical model to test the role of ECFC in the pathophysiology of AMI...
  50. pmc Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotpic instability
    Charlie Mantel
    Department of Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine, and the Walther Cancer Institute, Indianapolis, IN 46202, USA
    Blood 109:4518-27. 2007
    ..This natural behavior of ESCs to tolerate/survive varying degrees of ploidy change could complicate genome-reprogramming studies and stem-cell plasticity studies, but could also reveal clues about the mechanisms of CIN in human tumors...
  51. ncbi request reprint Injury of the renal microvascular endothelium alters barrier function after ischemia
    Timothy A Sutton
    Division of Nephrology, Department of Medicine, Indiana Center for Biological Microscopy, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Physiol Renal Physiol 285:F191-8. 2003
    ..Taken together, these findings indicate that renal vascular endothelial injury occurs in ischemic ARF and may play an important role in the pathophysiology of ischemic ARF...
  52. ncbi request reprint Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood
    David A Ingram
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 104:2752-60. 2004
    ....
  53. ncbi request reprint Reconstitution of hematopoiesis following transplantation into neonatal mice
    Scott A Johnson
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA
    Methods Mol Med 105:95-106. 2005
    ....
  54. ncbi request reprint Vessel wall-derived endothelial cells rapidly proliferate because they contain a complete hierarchy of endothelial progenitor cells
    David A Ingram
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut St R4 470, Indianapolis, IN 46202, USA
    Blood 105:2783-6. 2005
    ..This study provides evidence that a diversity of EPCs exists in human vessels and provides a conceptual framework for determining both the origin and function of EPCs in maintaining vessel integrity...
  55. ncbi request reprint Application of RNA interference to study stem cell function: current status and future perspectives
    Gang Ming Zou
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Biol Cell 97:211-9. 2005
    ....
  56. ncbi request reprint Unresolved questions, changing definitions, and novel paradigms for defining endothelial progenitor cells
    David A Ingram
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut St, R4 402e, Indianapolis, IN 46202, USA
    Blood 106:1525-31. 2005
    ..The potential implications of this view in relation to current EPC definitions are discussed...
  57. ncbi request reprint Clonal multilineage differentiation of murine common pluripotent stem cells isolated from skeletal muscle and adipose stromal cells
    Jamie Case
    Indiana University School of Medicine, Cancer Research Institute, 1044 West Walnut Street, R4 202, Indianapolis, IN 46202, USA
    Ann N Y Acad Sci 1044:183-200. 2005
    ..Taken together, these data demonstrate that a common PSC can be identified in different murine tissues and suggest that a small fraction of these cells are capable of clonal differentiation into multiple cell types...
  58. ncbi request reprint Blood island formation: longstanding observations and modern interpretations
    Michael J Ferkowicz
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Ind 46202, USA
    Exp Hematol 33:1041-7. 2005
    ....
  59. ncbi request reprint Shp-2 heterozygous hematopoietic stem cells have deficient repopulating ability due to diminished self-renewal
    Rebecca J Chan
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Hematol 34:1230-9. 2006
    ..Shp-2 is a widely expressed nonreceptor protein tyrosine phosphatase that participates early in hematopoietic development. The following study was performed to examine the role of Shp-2 in HSC function...
  60. ncbi request reprint Hematopoietic potential of murine skeletal muscle-derived CD45(-)Sca-1(+)c-kit(-) cells
    Jonathan C Howell
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis 46202, USA
    Exp Hematol 30:915-24. 2002
    ..Our goal was to determine the identity of neonatal muscle-derived cells that contain hematopoietic potential and to explore the status of CD45 expression on these cells...
  61. pmc Critical roles of lysosomal acid lipase in myelopoiesis
    Peng Qu
    Center for Immunobiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Pathol 176:2394-404. 2010
    ..These results provide evidence that LAL is an important regulator of myelopoiesis during hematopoietic development, differentiation, and homeostasis...
  62. ncbi request reprint Impaired nuclear transport and uncoating limit recombinant adeno-associated virus 2 vector-mediated transduction of primary murine hematopoietic cells
    Li Zhong
    Department of Microbiology and Immunology, Walther Oncology Center, Walther Cancer Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Gene Ther 15:1207-18. 2004
    ..A better understanding of the underlying mechanism of viral uncoating has implications in the optimal use of recombinant AAV vectors in hematopoietic stem cell gene therapy...
  63. ncbi request reprint Vascular cell adhesion molecule-1 expression and hematopoietic supportive capacity of immortalized murine stromal cell lines derived from fetal liver and adult bone marrow
    Joyce M Koenig
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    In Vitro Cell Dev Biol Anim 38:538-43. 2002
    ..Our studies suggest that cellular interactions other than those mediated by VCAM-1 are involved in the increased adhesive capacity of immortalized murine stroma derived from fetal liver...
  64. ncbi request reprint Self-complementary adeno-associated virus 2 (AAV)-T cell protein tyrosine phosphatase vectors as helper viruses to improve transduction efficiency of conventional single-stranded AAV vectors in vitro and in vivo
    Li Zhong
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis 46202, USA
    Mol Ther 10:950-7. 2004
    ..Thus, this novel co-infection strategy should be useful in circumventing one of the major obstacles in the optimal use of recombinant AAV vectors in human gene therapy...
  65. doi request reprint Stable integration of recombinant adeno-associated virus vector genomes after transduction of murine hematopoietic stem cells
    Zongchao Han
    Division of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Hum Gene Ther 19:267-78. 2008
    ....
  66. pmc VEGF and IHH rescue definitive hematopoiesis in Gata-4 and Gata-6-deficient murine embryoid bodies
    Monique Pierre
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Hematol 37:1038-53. 2009
    ..Therefore, we compared Gata-4 null (G4N) and Gata-6 null (G6N) EBs with wild-type EBs to assess their ability to commit to hematopoietic cells...
  67. ncbi request reprint The multiple facets of hematopoietic stem cells
    Rebecca J Chan
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, 46202, USA
    Curr Neurovasc Res 1:197-206. 2004
    ..The application of these studies to improved therapies for human disease, from leukemia to myocardial infarction, will be discussed...
  68. ncbi request reprint Functional p85alpha gene is required for normal murine fetal erythropoiesis
    Hannah Huddleston
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut St, R4 470, Indianapolis, IN 46202, USA
    Blood 102:142-5. 2003
    ..Taken together, these data establish an important role for p85alpha and class IA PI-3 kinase in regulating the development of both early and late erythroid progenitors in fetal liver...
  69. pmc Venous and arterial endothelial proteomics: mining for markers and mechanisms of endothelial diversity
    Matthew R Richardson
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Expert Rev Proteomics 7:823-31. 2010
    ..It is the purpose of this article to account for the diversity of vascular EC proteomic investigations and comment on the issues that have been and should be addressed in future work...
  70. ncbi request reprint The role of Hex in hemangioblast and hematopoietic development
    Rebecca J Chan
    Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, USA
    Methods Mol Biol 330:123-33. 2006
    ..Contained here are the methods needed to conduct embryonic stem cell-derived in vitro hematopoietic assays...
  71. ncbi request reprint Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain
    Gang Ming Zou
    Department of Pediatrics Section of Hematology Oncology, Indiana University School of Medicine, Indianapolis 46202, USA
    Blood 109:1917-22. 2007
    ..In summary, these data indicate Ape1 is required in normal embryonic hematopoiesis and that the redox function, but not the repair endonuclease activity, of Ape1 is critical in normal embryonic hematopoietic development...
  72. pmc Adeno-associated virus type 2-mediated gene transfer: role of cellular T-cell protein tyrosine phosphatase in transgene expression in established cell lines in vitro and transgenic mice in vivo
    Keyun Qing
    Department of Microbiology and Immunology, Walther Oncology Center, Walther Cancer Institute, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    J Virol 77:2741-6. 2003
    ....
  73. ncbi request reprint PECAM-1 is expressed on hematopoietic stem cells throughout ontogeny and identifies a population of erythroid progenitors
    Christina I Baumann
    Center for Hematologic Malignancies, Division of Hematology and Medical Oncology, Department of Medicine, Oregon Health and Sciences University UHN73C 3181 SW Sam Jackson Park Rd, 97239, USA
    Blood 104:1010-6. 2004
    ..These results demonstrate CD31 expression on hematopoietic stem cells throughout ontogeny and identify a population of CD31+ short-term erythroid progenitors cells that confer protection from lethal doses of radiation...
  74. pmc Production of the endocannabinoids anandamide and 2-arachidonoylglycerol by endothelial progenitor cells
    Christiane A Opitz
    Krannert Institute of Cardiology, Indiana University School of Medicine, 1800 North Capitol Avenue, Room E310, Indianapolis, IN, United States
    FEBS Lett 581:4927-31. 2007
    ..Treatment of mature endothelial cells with endocannabinoids significantly reduced the induction of the pro-inflammatory adhesion molecule CD106 (VCAM-1) by TNF-alpha...
  75. ncbi request reprint Endothelial-monocyte-activating polypeptide II induces migration of endothelial progenitor cells via the chemokine receptor CXCR3
    Yonghao Hou
    Department of Cellular and Integrative Physiology and Indiana Center for Vascular Biology and Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Hematol 34:1125-32. 2006
    ..Here we address the hypothesis that the hypoxia-inducible full-length endothelial-monocyte-activating polypeptide II (EMAP II) provides a mechanism to recruit late outgrowth highly proliferating endothelial progenitor cells (EPCs)...
  76. ncbi request reprint Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4
    Yanjun Li
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Blood 105:635-7. 2005
    ..These findings verify the negative role of SOCS-3 on LIF signaling and provide a novel role for Klf4 in ES cell function...
  77. pmc All primitive and definitive hematopoietic progenitor cells emerging before E10 in the mouse embryo are products of the yolk sac
    Christopher T Lux
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis 46202 5254, USA
    Blood 111:3435-8. 2008
    ..Thus, primitive erythroblasts and essentially all definitive HPCs destined to initially seed the fetal liver after E9.5 are generated in the YS between E7.0-E9.5 and are redistributed into the EP via the systemic circulation...
  78. ncbi request reprint Lung microvascular endothelium is enriched with progenitor cells that exhibit vasculogenic capacity
    Diego F Alvarez
    Department of Pharmacology, Center for Lung Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA
    Am J Physiol Lung Cell Mol Physiol 294:L419-30. 2008
    ..Thus the pulmonary microcirculation is enriched with EPCs that display vasculogenic competence while maintaining functional endothelial microvascular specificity...
  79. ncbi request reprint NO role in EPC function
    Mervin C Yoder
    Indiana University School of Medicine, IN, USA
    Blood 105:1846-7. 2005
    ..The nitric oxide pathway plays an important role in modulating endothelial progenitor cell function, playing a critical role in blood vessel repair in response to injury...
  80. pmc Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension
    Kewal Asosingh
    Cleveland Clinic, Department of Pathobiology, NC22, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Pathol 172:615-27. 2008
    ..Thus, mobilization of high levels of proliferative bone marrow-derived proangiogenic precursors is a characteristic of IPAH and may participate in the pulmonary vascular remodeling process...
  81. pmc The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation
    Katrin E Rhodes
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Stem Cell 2:252-63. 2008
    ..These data suggest that, in addition to providing a niche for a large pool of HSCs prior to liver colonization, the placenta is a true site of HSC generation...
  82. pmc Knockdown of Pu.1 by small interfering RNA in CD34+ embryoid body cells derived from mouse ES cells turns cell fate determination to pro-B cells
    Gang Ming Zou
    Section of Hematology Oncology, Department of Medicine, University of Chicago Medical Center, 5841 South Maryland Avenue, MC2115, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 102:13236-41. 2005
    ..1 expression inhibits the earliest B cell development through repressing early B cell factor and paired box protein 5 expression, although lower levels of Pu.1 expression in HPC play a key role in promoting B cell fate determination...
  83. ncbi request reprint Definitive hematopoietic commitment within the embryonic vascular endothelial-cadherin(+) population
    Stuart T Fraser
    Department of Molecular Genetics, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Exp Hematol 30:1070-8. 2002
    ....

Research Grants14

  1. Lymphopoietic development in the extra-embryonic yolk sac
    Mervin C Yoder; Fiscal Year: 2010
    ....
  2. Lymphopoietic development in the extra-embryonic yolk sac
    Mervin Yoder; Fiscal Year: 2009
    ....
  3. ENDOTHELIAL CELL ROLE IN YOLK SAC STEM CELL DEVELOPMENT
    Mervin Yoder; Fiscal Year: 2007
    ..These studies will define molecular pathways required for blood island development and remodeling. ..
  4. Cord Blood Stem Cell Expansion Ex Vivo With Endothelial Progenitor Cells
    Mervin Yoder; Fiscal Year: 2005
    ..abstract_text> ..
  5. ENDOTHELIAL CELL ROLE IN YOLK SAC STEM CELL DEVELOPMENT
    Mervin Yoder; Fiscal Year: 2005
    ..We hypothesize that yolk sac and embryo proper endothelial cells will facilitate HSC engraftment upon transplantation in vivo ..
  6. ENDOTHELIAL CELL ROLE IN YOLK SAC STEM CELL DEVELOPMENT
    Mervin Yoder; Fiscal Year: 2002
    ..abstract_text> ..
  7. Lymphopoietic development in the extra-embryonic yolk sac
    Mervin C Yoder; Fiscal Year: 2011
    ....