Constantin T Yiannoutsos
Affiliation: Indiana University
- Sampling-based approaches to improve estimation of mortality among patient dropouts: experience from a large PEPFAR-funded program in Western KenyaConstantin T Yiannoutsos
Indiana University Division of Biostatistics, Indianapolis, IN, USA
PLoS ONE 3:e3843. 2008..Sampling-based approaches and statistical adjustment are the only scaleable methods permitting accurate estimation of M&E indices...
- Cerebrospinal fluid neopterin decay characteristics after initiation of antiretroviral therapyAylin Yilmaz
Department of Infectious Diseases, University of Gothenburg, Journalvagen 10, Gothenburg, 416 50, Sweden
J Neuroinflammation 10:62. 2013..We studied decay characteristics of neopterin in CSF and blood after commencement of ART in HIV-infected subjects and estimated the set-point levels of CSF neopterin after ART-mediated viral suppression...
- Estimated mortality of adult HIV-infected patients starting treatment with combination antiretroviral therapyCONSTANTIN THEODORE YIANNOUTSOS
Department of Biostatistics, Indiana University School of Medicine, 410 West 10th Street, Suite 3000, Indianapolis, IN 46202, USA
Sex Transm Infect 88:i33-43. 2012..To provide estimates of mortality among HIV-infected patients starting combination antiretroviral therapy...
- Trends in the clinical characteristics of HIV-infected patients initiating antiretroviral therapy in Kenya, Uganda and Tanzania between 2002 and 2009Elvin H Geng
Department of Medicine, San Francisco General Hospital, University of California at San Francisco, 995 Potrero Avenue, San Francisco, CA, USA
J Int AIDS Soc 14:46. 2011..Regionally representative socio-demographic, laboratory and clinical characteristics of patients accessing ART over time and across sites have not been well described...
- Alternative antiretroviral monitoring strategies for HIV-infected patients in east Africa: opportunities to save more lives?R Scott Braithwaite
Section on Value and Comparative Effectiveness, Department of Medicine, New York University School of Medicine, USA
J Int AIDS Soc 14:38. 2011..We estimated the incremental benefit and cost effectiveness of alternative monitoring strategies for east Africans with known HIV infection...
- Assessing multiple-group diagnostic problems with multi-dimensional receiver operating characteristic surfaces: application to proton MR Spectroscopy (MRS) in HIV-related neurological injuryConstantin T Yiannoutsos
Indiana University School of Medicine, 410 West 10th Street, Indianapolis, IN 46202, USA
Neuroimage 40:248-55. 2008..The three-dimensional ROC surface and its associated VUS are useful for assessing marker accuracy, detecting data trends and offering insight in disease processes affecting multiple groups...
- Modeling AIDS survival after initiation of antiretroviral treatment by Weibull models with changepointsConstantin T Yiannoutsos
Division of Biostatistics, Indiana University School of Medicine, 401 W, 10th Street, Suite 3000, Indianapolis, USA
J Int AIDS Soc 12:9. 2009..abstract:..
- Regional patterns of brain metabolites in AIDS dementia complexConstantin T Yiannoutsos
Division of Biostatistics, Indiana University School of Medicine, 1050 Wishard Boulevard, RG 4101, Indianapolis, IN 46202, USA
Neuroimage 23:928-35. 2004..We conclude that by using factor analysis, we are able to combine multiple metabolites across brain regions in a biologically plausible manner and construct a predictive model of ADC adjusting for relevant factors such as age...
- The impact of the President's Emergency Plan for AIDS Relief on expansion of HIV care services for adult patients in western KenyaKara Wools-Kaloustian
Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202 5124, USA
AIDS 23:195-201. 2009..The President's Emergency Plan for AIDS Relief committed $15 billion to addressing HIV in resource-poor settings...
- Survival after resection for invasive intraductal papillary mucinous neoplasm and for pancreatic adenocarcinoma: a multi-institutional comparison according to American Joint Committee on Cancer StageJoshua A Waters
Department of Surgery, Indiana University, Indianapolis, IN 46202, USA
J Am Coll Surg 213:275-83. 2011..This difference may be explained by earlier presentation of inv-IPMN. We hypothesized that inv-IPMN has survival comparable with PDAC after resection when matched by stage...
- A pilot trial of serial 18F-fluorodeoxyglucose positron emission tomography in patients with medically inoperable stage I non-small-cell lung cancer treated with hypofractionated stereotactic body radiotherapyMark A Henderson
Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Int J Radiat Oncol Biol Phys 76:789-95. 2010..This report describes PET correlates prospectively collected after stereotactic body radiotherapy (SBRT) for patients with medically inoperable NSCLC...
- Viability and effectiveness of large-scale HIV treatment initiatives in sub-Saharan Africa: experience from western KenyaKara Wools-Kaloustian
Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA
AIDS 20:41-8. 2006..To determine the clinical and immunological outcomes of a cohort of HIV-infected patients receiving antiretroviral therapy...
- Invasive intraductal papillary mucinous neoplasm: predictors of survival and role of adjuvant therapyOlivier Turrini
Department of Surgery, Indiana University, Indianapolis, IN, USA
HPB (Oxford) 12:447-55. 2010..It is unclear whether adjuvant treatment for invasive IPMN improves survival. This study aimed to determine the impact of adjuvant treatment in invasive IPMN...
- The need for double-sampling designs in survival studies: an application to monitor PEPFARMing Wen An
Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland 21205, USA
Biometrics 65:301-6. 2009..Moreover, we show the need for appropriate analysis methods coupled with double-sampling designs...
- Ordered multiple-class ROC analysis with continuous measurementsChristos T Nakas
Division of Biostatistics, Indiana University School of Medicine, 1050 Wishard Boulevard, RG 4101, Indianapolis, IN 46202 2872, USA
Stat Med 23:3437-49. 2004..A three-group classification example in the context of HIV neurological disease is presented and the results are discussed...
- Preoperative predictors of malignancy in pancreatic intraductal papillary mucinous neoplasmsChad A Wiesenauer
Department of Surgery, Indiana University School of Medicine, USA
Arch Surg 138:610-7; discussion 617-8. 2003..Malignant intraductal papillary mucinous neoplasms (IPMNs) can be predicted before surgery...
- Intraductal papillary mucinous neoplasms: predictors of malignant and invasive pathologyC Max Schmidt
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Ann Surg 246:644-51; discussion 651-4. 2007..Determine whether size and other preoperative parameters predict malignant or invasive intraductal papillary mucinous neoplasia (IPMN)...
- Modulation of in vitro proliferation kinetics and primitive hematopoietic potential of individual human CD34+CD38-/lo cells in G0Edward F Srour
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Blood 105:3109-16. 2005..These data suggest that although exit from quiescence and commitment to proliferation might be stochastic, kinetics of proliferation, and possibly fate of primitive HPCs, might be modulated by extrinsic factors...
- Pancreaticoduodenectomy: a 20-year experience in 516 patientsC Max Schmidt
Department of Surgery, University Hospital, Indiana University School of Medicine, Indianapolis, USA
Arch Surg 139:718-25; discussion 725-7. 2004..Pancreaticoduodenectomy (PD) is a safe procedure for a variety of periampullary conditions...
- Intraperitoneal radioactive phosphorus (32P) and vaginal brachytherapy as adjuvant treatment for uterine papillary serous carcinoma and clear cell carcinoma: a phase II Hoosier Oncology Group (HOG 97-01) studyAchilles J Fakiris
Indiana University School of Medicine, 535 Barnhill Drive, RT 041 Indianapolis, IN 46202 5289, USA
Gynecol Oncol 96:818-23. 2005....
- Safety of discontinuation of maintenance therapy for disseminated histoplasmosis after immunologic response to antiretroviral therapyMitchell Goldman
Division of Infectious Diseases, Indiana University School of Medicine, Wishard Memorial Hospital, Indianapolis, Indiana 46202, USA
Clin Infect Dis 38:1485-9. 2004....
- Pancreatic fistula following pancreaticoduodenectomy: clinical predictors and patient outcomesC Max Schmidt
Department of Surgery, School of Medicine, Indiana University, Indianapolis, IN 46202, USA
HPB Surg 2009:404520. 2009..Outcomes in patients with PF are remarkable for a higher rate of septic complications, longer hospital stays, but in this study, no increased mortality...
- Observational research on NCDs in HIV-positive populations: conceptual and methodological considerationsMaya Petersen
Division of Biostatistics, Berkeley School of Public Health, Berkeley, CA Department of Biostatistics, Indiana University R M Fairbanks School of Public Health, Indianapolis, IN Section of General Internal Medicine, Yale University Schools of Medicine and Public Health and Veterans Affairs VA Connecticut Healthcare System, West Haven, CT Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa and HIV AIDS Research Group Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
J Acquir Immune Defic Syndr 67:S8-16. 2014..We conclude with recommendations to improve the quality of data and analyses available to inform the response to HIV and NCD comorbidity in LMICs...
- Stereotactic body radiation therapy for early-stage non-small-cell lung carcinoma: four-year results of a prospective phase II studyAchilles J Fakiris
Department of Radiation Oncology, Indiana University School of Medicine, 535 Barnhill Drive, Indianapolis, IN 46202, USA
Int J Radiat Oncol Biol Phys 75:677-82. 2009..The 50-month results of a prospective Phase II trial of stereotactic body radiation therapy (SBRT) in medically inoperable patients are reported...
- Antiretroviral treatment effect on immune activation reduces cerebrospinal fluid HIV-1 infectionElizabeth Sinclair
Department of Medicine, University of California at San Francisco, San Francisco, CA, USA
J Acquir Immune Defic Syndr 47:544-52. 2008..To define the effect of antiretroviral therapy (ART) on activation of T cells in cerebrospinal fluid (CSF) and blood, and interactions of this activation with CSF HIV-1 RNA concentrations...
- A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysisPatricia Lani Lee
NMR Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02111, USA
J Magn Reson Imaging 17:625-33. 2003....
- Severity of HIV-associated neuropathy is associated with plasma HIV-1 RNA levelsDavid M Simpson
Department of Neurology, Mount Sinai School of Medicine, 1 Gustave L Levy Place, Box 1052, New York, NY 10029, USA
AIDS 16:407-12. 2002..To determine if there is an association between plasma HIV-1 RNA levels and severity of HIV-associated distal symmetrical polyneuropathy (DSP)...
- Outcomes of HIV-infected orphaned and non-orphaned children on antiretroviral therapy in western KenyaWinstone M Nyandiko
Department of Child Health and Pediatrics, Moi University School of Medicine, PO Box 2582 30100, Eldoret, Kenya
J Acquir Immune Defic Syndr 43:418-25. 2006..Determine outcome differences between orphaned and non-orphaned children receiving antiretroviral therapy (ART)...
- Memantine and HIV-associated cognitive impairment: a neuropsychological and proton magnetic resonance spectroscopy studyGiovanni Schifitto
University of Rochester, Rochester, New York 14620, USA
AIDS 21:1877-86. 2007..To assess the safety and efficacy of memantine, an uncompetitive antagonist of the N-methyl-D-aspartate receptor as treatment of HIV-associated cognitive impairment...
- Proton MRS and neuropsychological correlates in AIDS dementia complex: evidence of subcortical specificityRobert H Paul
Department of Behavioral Neuroscience, University of Missouri, St Louis, St Louis, MO 63121, USA
J Neuropsychiatry Clin Neurosci 19:283-92. 2007..Prospective studies are needed to elucidate the evolution of these changes in the setting of antiretroviral therapy...
- Innovative approaches to application of information technology in disease surveillance and prevention in Western KenyaWilson Odero
Moi University, School of Public Health, Eldoret, Kenya
J Biomed Inform 40:390-7. 2007....
- Clinical validation of the NeuroScreenRonald J Ellis
Department of Neurosciences, UCSD AntiViral Research Center and HIV Neurobehavioral Research Center, University of California, San Diego, California 92103, USA
J Neurovirol 11:503-11. 2005..However, because it yields substantial numbers of false positives and negatives, the NeuroScreen may be less useful in evaluating individual patients...
- Assessment of diagnostic markers by goodness-of-fit testsChristos Nakas
Department of Mathematics, Statistics and OR Unit, Aristotle University, 54006 Thessaloniki, Greece
Stat Med 22:2503-13. 2003..The latter are a viable alternative and can be used as a 'black box' or as an exploratory first step in the evaluation of novel diagnostic markers...
- Association of the dopamine beta hydroxylase gene with attention deficit hyperactivity disorder: genetic analysis of the Milwaukee longitudinal studyKAREN MULLER SMITH
Genetics Program, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, USA
Am J Med Genet B Neuropsychiatr Genet 119:77-85. 2003..These results indicate that the DBH TaqI A allele, or another polymorphism in linkage disequilibrium with this allele, may confer increased susceptibility towards ADHD...
- A placebo-controlled study of memantine for the treatment of human immunodeficiency virus-associated sensory neuropathyGiovanni Schifitto
University of Rochester, Rochester, New York 14620, USA
J Neurovirol 12:328-31. 2006..Results were similar to those of other pilot studies of memantine for neuropathic pain unrelated to HIV, suggesting that memantine is ineffective for the symptomatic treatment of HIV-associated SDSP...