Feng Chun Yang

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Erk1 positively regulates osteoclast differentiation and bone resorptive activity
    Yongzheng He
    Departments of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 6:e24780. 2011
  2. pmc The haploinsufficient hematopoietic microenvironment is critical to the pathological fracture repair in murine models of neurofibromatosis type 1
    Xiaohua Wu
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 6:e24917. 2011
  3. pmc c-Fms signaling mediates neurofibromatosis Type-1 osteoclast gain-in-functions
    Yongzheng He
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 7:e46900. 2012
  4. pmc The plexiform neurofibroma microenvironment
    Feng Chun Yang
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA
    Cancer Microenviron 5:307-10. 2012
  5. pmc Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions
    Feng Chun Yang
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Invest 116:2880-91. 2006
  6. pmc Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signaling
    Feng Chun Yang
    Department of Pediatrics, and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut Street, Indianapolis, IN 46202, USA
    Hum Mol Genet 15:2421-37. 2006
  7. ncbi request reprint Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1
    Jincheng Yan
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Mol Genet 17:936-48. 2008
  8. ncbi request reprint Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells
    Amy M Munchhof
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut Street, Indianapolis, IN 46202, USA
    Hum Mol Genet 15:1858-69. 2006
  9. pmc Genetic reduction of class IA PI-3 kinase activity alters fetal hematopoiesis and competitive repopulating ability of hematopoietic stem cells in vivo
    Laura S Haneline
    Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, Indianapolis, IN 46202, USA
    Blood 107:1375-82. 2006
  10. ncbi request reprint Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cells
    Xiaohua Wu
    Department of Pediatrics, Herman B Wells Center for Pediatric Research and Indiana University School of Medicine, Cancer Research Institute, Indianapolis 46202, USA
    Hum Mol Genet 15:2837-45. 2006

Collaborators

Detail Information

Publications47

  1. pmc Erk1 positively regulates osteoclast differentiation and bone resorptive activity
    Yongzheng He
    Departments of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 6:e24780. 2011
    ....
  2. pmc The haploinsufficient hematopoietic microenvironment is critical to the pathological fracture repair in murine models of neurofibromatosis type 1
    Xiaohua Wu
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 6:e24917. 2011
    ..Collectively, these data provide evidence of a combinatory effect between nullizygous loss of Nf1 in osteoblast progenitors and haploinsufficiency in hematopoietic cells in the development of non-malignant NF1 manifestations...
  3. pmc c-Fms signaling mediates neurofibromatosis Type-1 osteoclast gain-in-functions
    Yongzheng He
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 7:e46900. 2012
    ....
  4. pmc The plexiform neurofibroma microenvironment
    Feng Chun Yang
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA
    Cancer Microenviron 5:307-10. 2012
    ....
  5. pmc Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions
    Feng Chun Yang
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Invest 116:2880-91. 2006
    ..Collectively, our results identify a what we believe to be a novel cellular and biochemical NF1-haploinsufficient phenotype in osteoclasts that has potential implications for the pathogenesis of NF1 bone disease...
  6. pmc Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signaling
    Feng Chun Yang
    Department of Pediatrics, and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut Street, Indianapolis, IN 46202, USA
    Hum Mol Genet 15:2421-37. 2006
    ..Genetic or pharmacological inhibition of c-abl reverses fibroblast proliferation and collagen synthesis to wild-type levels. These studies identify a novel molecular target to inhibit neurofibroma formation...
  7. ncbi request reprint Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1
    Jincheng Yan
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Hum Mol Genet 17:936-48. 2008
    ..Collectively, these data demonstrate that Rac1 critically contributes to increased osteoclast function induced by haploinsufficiency of Nf1 and implicate Rac1 as a rational therapeutic target for osteoporosis...
  8. ncbi request reprint Neurofibroma-associated growth factors activate a distinct signaling network to alter the function of neurofibromin-deficient endothelial cells
    Amy M Munchhof
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut Street, Indianapolis, IN 46202, USA
    Hum Mol Genet 15:1858-69. 2006
    ..Thus, these studies identify a unique biochemical pathway in Nf1+/- ECs as a potential therapeutic target in the neurofibroma microenvironment...
  9. pmc Genetic reduction of class IA PI-3 kinase activity alters fetal hematopoiesis and competitive repopulating ability of hematopoietic stem cells in vivo
    Laura S Haneline
    Indiana University School of Medicine, Herman B Wells Center for Pediatric Research, Indianapolis, IN 46202, USA
    Blood 107:1375-82. 2006
    ..Collectively, these data identify PI-3K as an important regulator of HSC function and potential therapeutic target in treating leukemic stem cells...
  10. ncbi request reprint Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cells
    Xiaohua Wu
    Department of Pediatrics, Herman B Wells Center for Pediatric Research and Indiana University School of Medicine, Cancer Research Institute, Indianapolis 46202, USA
    Hum Mol Genet 15:2837-45. 2006
    ....
  11. ncbi request reprint Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration-implications for increased neurofibroma formation during pregnancy
    Todd D Nebesio
    Department of Pediatrics, Herman B Wells Center for Pediatric Cancer Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Glia 55:527-36. 2007
    ....
  12. pmc Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/- mast cells
    Feng Chun Yang
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Invest 112:1851-61. 2003
    ..Thus, these studies identify a novel interaction between Nf1-/- Schwann cells and Nf1+/- mast cells that is likely to be important in neurofibroma formation...
  13. pmc Nf1-/- Schwann cell-conditioned medium modulates mast cell degranulation by c-Kit-mediated hyperactivation of phosphatidylinositol 3-kinase
    Shi Chen
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Pathol 177:3125-32. 2010
    ..Collectively, these studies identify both c-Kit and PI3K as molecular targets that modulate mast cell functions in cases of NF1...
  14. ncbi request reprint Hyperactive transforming growth factor-β1 signaling potentiates skeletal defects in a neurofibromatosis type 1 mouse model
    Steven D Rhodes
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    J Bone Miner Res 28:2476-89. 2013
    ....
  15. pmc Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia
    Anna C Pulliam-Leath
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA
    Blood 116:2915-20. 2010
    ..Importantly, this model closely recapitulates the phenotypes found in FA patients and may be useful as a preclinical platform to evaluate the molecular pathogenesis of spontaneous bone marrow failure, MDS and AML in FA...
  16. pmc Multiple increased osteoclast functions in individuals with neurofibromatosis type 1
    David A Stevenson
    Department of Pediatrics, Division of Medical Genetics, University of Utah, Salt Lake City, USA
    Am J Med Genet A 155:1050-9. 2011
    ....
  17. doi request reprint Ras dependent paracrine secretion of osteopontin by Nf1+/- osteoblasts promote osteoclast activation in a neurofibromatosis type I murine model
    Huijie Li
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Pediatr Res 65:613-8. 2009
    ..Our study identifies an important paracrine loop whereby elevated secretion of OPN by osteoblasts activate Nf1+/- OCLs that already have an intrinsic propensity for bone resorption leading to osteopenia and osteoporosis...
  18. ncbi request reprint K-ras is critical for modulating multiple c-kit-mediated cellular functions in wild-type and Nf1+/- mast cells
    Waleed F Khalaf
    Department Microbiology and Immunology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 178:2527-34. 2007
    ..These findings identify K-ras as a key effector in multiple mast cell functions and identify neurofibromin as a GAP for K-ras in mast cells...
  19. pmc Loss of SIMPL compromises TNF-alpha-dependent survival of hematopoietic progenitors
    Eric A Benson
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202 5122, USA
    Exp Hematol 38:71-81. 2010
    ..To address the role of SIMPL in TNF-alpha-dependent signaling in hematopoiesis, endothelial cells and hematopoietic progenitors expressing SIMPL short hairpin RNA were characterized...
  20. pmc The p85alpha subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration
    Veerendra Munugalavadla
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, 2 Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Mol Cell Biol 28:7182-98. 2008
    ..These results highlight the importance of the full-length version of the p85alpha subunit of class I(A) PI3-K in controlling multiple aspects of osteoclast functions...
  21. pmc p85alpha regulates osteoblast differentiation by cross-talking with the MAPK pathway
    Xiaohua Wu
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 286:13512-21. 2011
    ..These results suggest that p85α plays an essential role in osteoblast differentiation from MSCs by repressing the activation of MAPK pathway...
  22. pmc Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow
    Feng Chun Yang
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Cell 135:437-48. 2008
    ..Further, genetic or pharmacologic attenuation of c-kit signaling in Nf1+/- hematopoietic cells diminishes neurofibroma initiation and progression. Finally, these studies implicate mast cells as critical mediators of tumor initiation...
  23. pmc Pathogenesis of plexiform neurofibroma: tumor-stromal/hematopoietic interactions in tumor progression
    Karl Staser
    Department of Biochemistry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Annu Rev Pathol 7:469-95. 2012
    ..These observations parallel findings in other NF1 disease manifestations and are clearly relevant to medical management of these neurofibromas...
  24. pmc Normal hematopoiesis and neurofibromin-deficient myeloproliferative disease require Erk
    Karl Staser
    Herman Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA
    J Clin Invest 123:329-34. 2013
    ....
  25. pmc Nmp4/CIZ suppresses the parathyroid hormone anabolic window by restricting mesenchymal stem cell and osteoprogenitor frequency
    Yongzheng He
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA
    Stem Cells Dev 22:492-500. 2013
    ..6-fold increase in CFU-GM colonies (osteoclast progenitors). We propose that Nmp4/CIZ limits the PTH anabolic window by restricting the number of BM stem, progenitor, and blood cells that support anabolic bone remodeling...
  26. pmc Continuous in vivo infusion of interferon-gamma (IFN-gamma) enhances engraftment of syngeneic wild-type cells in Fanca-/- and Fancg-/- mice
    Yue Si
    Department of Microbiology and Immunology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, USA
    Blood 108:4283-7. 2006
    ..Given that FANCA, FANCC, and FANCG complementation groups account for more than 90% of all FA patients, these data provide evidence that IFN-gamma conditioning may be a useful nongenotoxic strategy for myelopreparation in FA patients...
  27. ncbi request reprint Functional p85alpha gene is required for normal murine fetal erythropoiesis
    Hannah Huddleston
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut St, R4 470, Indianapolis, IN 46202, USA
    Blood 102:142-5. 2003
    ..Taken together, these data establish an important role for p85alpha and class IA PI-3 kinase in regulating the development of both early and late erythroid progenitors in fetal liver...
  28. ncbi request reprint Neurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cells
    Fang Li
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut Street, Indianapolis, IN 46202, USA
    Hum Mol Genet 15:1921-30. 2006
    ....
  29. pmc Ex vivo culture of Fancc-/- stem/progenitor cells predisposes cells to undergo apoptosis, and surviving stem/progenitor cells display cytogenetic abnormalities and an increased risk of malignancy
    Xiaxin Li
    Cancer Research Institute, 1044 W Walnut Street, Rm 408, Indianapolis, IN 46202 5254, USA
    Blood 105:3465-71. 2005
    ..These studies could have implications for the design of genetic therapies for treatment of Fanconi anemia and potentially other genetic diseases with intrinsic defects in genome stability...
  30. pmc Mast cells and the neurofibroma microenvironment
    Karl Staser
    Department of Biochemistry, and Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA
    Blood 116:157-64. 2010
    ..Finally, we emphasize the importance of the tumor microenvironment hypothesis, asserting that tumorigenic cells in the neurofibroma do not arise and grow in isolation...
  31. ncbi request reprint Enforced expression of CUL-4A interferes with granulocytic differentiation and exit from the cell cycle
    Binghui Li
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202 USA
    Blood 101:1769-76. 2003
    ....
  32. pmc Primary osteopathy of vertebrae in a neurofibromatosis type 1 murine model
    Wei Zhang
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA
    Bone 48:1378-87. 2011
    ..This novel murine model provides a platform to understand the cellular and molecular mechanisms underlying the pathogenesis of spinal deficits in NF1 patients...
  33. pmc Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in Fancg-/- mice in vivo
    Yan Li
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Blood 113:2342-51. 2009
    ....
  34. ncbi request reprint Lymphoproliferative defects in mice lacking the expression of neurofibromin: functional and biochemical consequences of Nf1 deficiency in T-cell development and function
    David A Ingram
    Section of Neonatal Perinatal Medicine, Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indianapolis, IN 46202, USA
    Blood 100:3656-62. 2002
    ..Collectively, these results identify neurofibromin as a GAP for Ras in T cells for maintaining immune homeostasis in vivo...
  35. pmc AMD3100 synergizes with G-CSF to mobilize repopulating stem cells in Fanconi anemia knockout mice
    Anna C Pulliam
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA
    Exp Hematol 36:1084-90. 2008
    ....
  36. pmc Nmp4/CIZ closes the parathyroid hormone anabolic window
    Joseph P Bidwell
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Crit Rev Eukaryot Gene Expr 22:205-18. 2012
    ..Despite numerous remaining questions, Nmp4/CIZ provides insights into how the anabolic window is regulated, and itself may provide an adjuvant therapy target for the treatment of osteoporosis by extending PTH anabolic efficacy...
  37. pmc Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76K
    Zhenyun Yang
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Leuk Res 35:961-4. 2011
    ..Collectively, these studies suggest that cells expressing Shp2E76K have a greater dependence on KSR1 for GM-CSF hypersensitivity than cells expressing Shp2D61Y...
  38. pmc Plexiform neurofibroma genesis: questions of Nf1 gene dose and hyperactive mast cells
    Karl Staser
    Department of Biochemistry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Curr Opin Hematol 17:287-93. 2010
    ..Here, we discuss the importance of Nf1 gene dosage, delineate hematopoietic contributions to the plexiform neurofibroma microenvironment, and highlight applications to human treatment...
  39. doi request reprint Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: a phase 2 trial
    Kent A Robertson
    Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Lancet Oncol 13:1218-24. 2012
    ..We undertook an open-label phase 2 trial to test whether treatment with imatinib mesylate can decrease the volume burden of clinically significant plexiform neurofibromas in patients with NF1...
  40. pmc A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells
    Karl Staser
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA
    Exp Hematol 41:56-66.e2. 2013
    ..This heretofore unknown mechanism of mast cell degranulation provides novel therapeutic targets in allergy and asthma and may inform studies of kinase regulation of cytoskeletal dynamics in other cell lineages...
  41. pmc Cul4A is required for hematopoietic stem-cell engraftment and self-renewal
    Binghui Li
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Blood 110:2704-7. 2007
    ..These studies are the first to demonstrate that ubiquitin-mediated protein degradation is important for HSC function. Further, they indicate that a Cul4A ubiquitin ligase targets for degradation one or multiple HSC regulators...
  42. pmc The tumor suppressor CDKN3 controls mitosis
    Grzegorz Nalepa
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Cell Biol 201:997-1012. 2013
    ..Finally, we show that CDKN3 protein is down-regulated in brain tumors. Our findings indicate that CDKN3 controls mitosis through the CDC2 signaling axis. These results have implications for targeted anticancer therapeutics. ..
  43. doi request reprint Mechanical stimulation suppresses phosphorylation of eIF2alpha and PERK-mediated responses to stress to the endoplasmic reticulum
    Hideyuki Hirasawa
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    FEBS Lett 584:745-52. 2010
    ..Taken together, our observations suggest a pro-survival role of mechanical stimulation in Perk-mediated stress responses...
  44. pmc Novel method of murine embryonic stem cell-derived osteoclast development
    Michael L Goodman
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Stem Cells Dev 18:195-200. 2009
    ..We describe two simplified, novel methods of stromal cell-independent ES cell-derived osteoclast development...
  45. ncbi request reprint What accounts for the variable responses to progesterone on Schwann cells from mice and humans-the species-specific influence or the paracrine effects from the tumor microenvironment?
    Todd D Nebesio
    Cancer Biol Ther 10:1077-8. 2010
  46. pmc Collection, cryopreservation, and characterization of human dental pulp-derived mesenchymal stem cells for banking and clinical use
    Brandon C Perry
    General BioTechnology, LLC, Indianapolis, Indiana, USA
    Tissue Eng Part C Methods 14:149-56. 2008
    ..These initial studies will facilitate the development of future cGTP protocols for the clinical banking of MSC...
  47. doi request reprint Approaches to treating NF1 tibial pseudarthrosis: consensus from the Children's Tumor Foundation NF1 Bone Abnormalities Consortium
    David A Stevenson
    Department of Pediatrics, Division of Medical Genetics, University of Utah, Salt Lake City, UT 84132, USA
    J Pediatr Orthop 33:269-75. 2013
    ..On the basis of current knowledge, we propose a number of concepts to consider as a theoretical approach to the optimal management of tibial pseudarthrosis...