Xiao Ming Xu

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc Chondroitin sulfate proteoglycans regulate the growth, differentiation and migration of multipotent neural precursor cells through the integrin signaling pathway
    Wen Li Gu
    Department of Neurobiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China
    BMC Neurosci 10:128. 2009
  2. pmc Transplantation-mediated strategies to promote axonal regeneration following spinal cord injury
    Xiao Ming Xu
    Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, United States
    Respir Physiol Neurobiol 169:171-82. 2009
  3. pmc A novel growth-promoting pathway formed by GDNF-overexpressing Schwann cells promotes propriospinal axonal regeneration, synapse formation, and partial recovery of function after spinal cord injury
    Ling Xiao Deng
    Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, and Department of Neurological Surgery, Goodman and Campbell Brain and Spine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Neurosci 33:5655-67. 2013
  4. ncbi request reprint Cytosolic phospholipase A2 protein as a novel therapeutic target for spinal cord injury
    Nai Kui Liu
    Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Department of Neurological Surgery, and Goodman Campbell Brain and Spine, Indiana University School of Medicine, Indianapolis, IN
    Ann Neurol 75:644-58. 2014
  5. ncbi request reprint A semicircular controlled cortical impact produces long-term motor and cognitive dysfunction that correlates well with damage to both the sensorimotor cortex and hippocampus
    Nai Kui Liu
    Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Department of Neurological Surgery, Department of Anatomy and Cell Biology, Goodman Campbell Brain and Spine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Brain Res 1576:18-26. 2014
  6. pmc GDNF modifies reactive astrogliosis allowing robust axonal regeneration through Schwann cell-seeded guidance channels after spinal cord injury
    Ling Xiao Deng
    Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Neurol 229:238-50. 2011
  7. doi request reprint Cotransplantation of glial restricted precursor cells and schwann cells promotes functional recovery after spinal cord injury
    Jian Guo Hu
    Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Cell Transplant 22:2219-36. 2013
  8. doi request reprint A bilateral head injury that shows graded brain damage and behavioral deficits in adultmice
    Nai Kui Liu
    Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Department of Neurological Surgery and Goodman Campbell Brain and Spine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Brain Res 1499:121-8. 2013
  9. pmc Systemic bisperoxovanadium activates Akt/mTOR, reduces autophagy, and enhances recovery following cervical spinal cord injury
    Chandler L Walker
    Department of Anatomy and Cell Biology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 7:e30012. 2012
  10. pmc Preferential and bidirectional labeling of the rubrospinal tract with adenovirus-GFP for monitoring normal and injured axons
    Xiaofei Wang
    Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, and Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Neurotrauma 28:635-47. 2011

Collaborators

Detail Information

Publications14

  1. pmc Chondroitin sulfate proteoglycans regulate the growth, differentiation and migration of multipotent neural precursor cells through the integrin signaling pathway
    Wen Li Gu
    Department of Neurobiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China
    BMC Neurosci 10:128. 2009
    ..Chondroitin sulfate proteoglycans (CSPGs) are prominent components of the extracellular matrix (ECM) in the central nervous system (CNS) and are assumed to play important roles in controlling neuronal differentiation and development...
  2. pmc Transplantation-mediated strategies to promote axonal regeneration following spinal cord injury
    Xiao Ming Xu
    Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, United States
    Respir Physiol Neurobiol 169:171-82. 2009
    ..Combinatorial approaches and clinical research are also reviewed...
  3. pmc A novel growth-promoting pathway formed by GDNF-overexpressing Schwann cells promotes propriospinal axonal regeneration, synapse formation, and partial recovery of function after spinal cord injury
    Ling Xiao Deng
    Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, and Department of Neurological Surgery, Goodman and Campbell Brain and Spine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Neurosci 33:5655-67. 2013
    ..Within the distal host spinal cord, regenerated DPSN axons formed synapses with host neurons leading to the restoration of action potentials and partial recovery of function...
  4. ncbi request reprint Cytosolic phospholipase A2 protein as a novel therapeutic target for spinal cord injury
    Nai Kui Liu
    Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Department of Neurological Surgery, and Goodman Campbell Brain and Spine, Indiana University School of Medicine, Indianapolis, IN
    Ann Neurol 75:644-58. 2014
    ..The objective of this study was to investigate whether cytosolic phospholipase A2 (cPLA2 ), an important isoform of PLA2 that mediates the release of arachidonic acid, plays a role in the pathogenesis of spinal cord injury (SCI)...
  5. ncbi request reprint A semicircular controlled cortical impact produces long-term motor and cognitive dysfunction that correlates well with damage to both the sensorimotor cortex and hippocampus
    Nai Kui Liu
    Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Department of Neurological Surgery, Department of Anatomy and Cell Biology, Goodman Campbell Brain and Spine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Brain Res 1576:18-26. 2014
    ..These findings collectively suggest that the current model may offer sensitive, reliable, and clinically relevant outcomes for assessments of therapeutic strategies for TBI. ..
  6. pmc GDNF modifies reactive astrogliosis allowing robust axonal regeneration through Schwann cell-seeded guidance channels after spinal cord injury
    Ling Xiao Deng
    Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Neurol 229:238-50. 2011
    ..Thus, our study demonstrates a novel role of GDNF in modifying spinal cord injury (SCI)-induced astrogliosis resulting in robust axonal regeneration in adult rats...
  7. doi request reprint Cotransplantation of glial restricted precursor cells and schwann cells promotes functional recovery after spinal cord injury
    Jian Guo Hu
    Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Cell Transplant 22:2219-36. 2013
    ....
  8. doi request reprint A bilateral head injury that shows graded brain damage and behavioral deficits in adultmice
    Nai Kui Liu
    Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Department of Neurological Surgery and Goodman Campbell Brain and Spine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Brain Res 1499:121-8. 2013
    ..These findings collectively suggest that the current model may offer a sensitive, reliable and clinically-relevant model for assessments of therapeutic strategies forTBI...
  9. pmc Systemic bisperoxovanadium activates Akt/mTOR, reduces autophagy, and enhances recovery following cervical spinal cord injury
    Chandler L Walker
    Department of Anatomy and Cell Biology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
    PLoS ONE 7:e30012. 2012
    ..Overall, this study demonstrates the efficacy of a clinically applicable pharmacological therapy for rapid initiation of neuroprotection post-spinal cord injury, and sheds light on the signaling involved in its action...
  10. pmc Preferential and bidirectional labeling of the rubrospinal tract with adenovirus-GFP for monitoring normal and injured axons
    Xiaofei Wang
    Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, and Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Neurotrauma 28:635-47. 2011
    ..Thus Adv-GFP could be used as a novel tool for monitoring and evaluating strategies designed to maximize RST axonal regeneration and remodeling following SCI...
  11. pmc MicroRNA in central nervous system trauma and degenerative disorders
    Nai Kui Liu
    Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute and Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Physiol Genomics 43:571-80. 2011
    ..miRNAs may represent a new layer of regulators for neurobiology and a novel class of therapeutic targets for neurological diseases...
  12. ncbi request reprint Phospholipase A2 and its molecular mechanism after spinal cord injury
    Nai Kui Liu
    Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, 950 W Walnut St, R 2 Building, Room 402, Indianapolis, IN 46202, USA
    Mol Neurobiol 41:197-205. 2010
    ..This review outlines the current knowledge of the PLA(2) in the spinal cord with an emphasis being placed on the possible roles of PLA(2) in mediating the secondary SCI...
  13. pmc PTEN inhibitor bisperoxovanadium protects oligodendrocytes and myelin and prevents neuronal atrophy in adult rats following cervical hemicontusive spinal cord injury
    Chandler L Walker
    Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Department of Neurological Surgery, Indiana University School of Medicine, 950 W Walnut Street, R2 Building, Room 402, Indianapolis, IN 46202, USA Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Department of Anatomy and Cell Biology, Indiana University School of Medicine, 950 W Walnut Street, R2 Building, Room 402, Indianapolis, IN 46202, USA Electronic address
    Neurosci Lett 573:64-8. 2014
    ..0 ± 0.02 vs. Veh: 0.77 ± 0.02) relative to Sham neuron size. This study provides key insight into additional cell and tissue effects that could contribute to bpV-mediated functional recovery observed after contusive cervical SCI...
  14. pmc Altered microRNA expression following traumatic spinal cord injury
    Nai Kui Liu
    Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute and Department of Neurological Surgery, Indiana University School of Medicine, 950 W Walnut St, R 2 Building, Room 402, Indianapolis, IN 46202, USA
    Exp Neurol 219:424-9. 2009
    ..These findings suggest that abnormal expression of miRNAs may contribute to the pathogenesis of SCI and are potential targets for therapeutic interventions following SCI...

Research Grants11

  1. SCHWANN CELLS, NEUROTROPHINS AND SPINAL CORD REGROWTH
    Xiao Ming Xu; Fiscal Year: 2001
    ..Taken together the specific aims of this model could be described as one with a most comprehensive attempt to maximize regeneration into the host cord tissue caudal to a Schwann cell bridged lesion. ..
  2. PKC inhibition-mediated spinal cord regeneration
    Xiao Ming Xu; Fiscal Year: 2009
    ....
  3. Role of phospholipase A2 in spinal cord secondary injury
    Xiao Ming Xu; Fiscal Year: 2009
    ..We hope that, by completion of this application, we will identify a novel target for therapeutic intervention aimed at promoting greater anatomical and functional recoveries after SCI. ..
  4. PKC inhibition-mediated spinal cord regeneration
    Xiao Ming Xu; Fiscal Year: 2009
    ....
  5. PKC inhibition-mediated spinal cord regeneration
    Xiao Ming Xu; Fiscal Year: 2006
    ....
  6. PKC inhibition-mediated spinal cord regeneration
    Xiao Ming Xu; Fiscal Year: 2005
    ....
  7. SCHWANN CELLS, NEUROTROPHINS AND SPINAL CORD REGROWTH
    Xiao Ming Xu; Fiscal Year: 2005
    ..abstract_text> ..
  8. SCHWANN CELLS, NEUROTROPHINS AND SPINAL CORD REGROWTH
    Xiao Ming Xu; Fiscal Year: 2004
    ..abstract_text> ..
  9. SCHWANN CELLS, NEUROTROPHINS AND SPINAL CORD REGROWTH
    Xiao Ming Xu; Fiscal Year: 2003
    ..abstract_text> ..
  10. Role of phospholipase A2 in spinal cord secondary injury
    Xiao Ming Xu; Fiscal Year: 2010
    ..We hope that, by completion of this application, we will identify a novel target for therapeutic intervention aimed at promoting greater anatomical and functional recoveries after SCI. ..