D S Wilkes

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. pmc IL-17 induces type V collagen overexpression and EMT via TGF-β-dependent pathways in obliterative bronchiolitis
    Ragini Vittal
    Center for Immunobiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Physiol Lung Cell Mol Physiol 304:L401-14. 2013
  2. pmc The role of autoimmunity in obliterative bronchiolitis after lung transplantation
    Daniel J Weber
    Center for Immunobiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Physiol Lung Cell Mol Physiol 304:L307-11. 2013
  3. pmc Humoral immunity and the development of obliterative bronchiolitis after lung transplantation: is there a link?
    Amir M Emtiazjoo
    Division of Pulmonary and Critical Care, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Respir Cell Mol Biol 48:145-9. 2013
  4. pmc Donor lung derived myeloid and plasmacytoid dendritic cells differentially regulate T cell proliferation and cytokine production
    Heather L Benson
    Department of Medicine, Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Respir Res 13:25. 2012
  5. doi request reprint Autoantibody formation in human and rat studies of chronic rejection and primary graft dysfunction
    David S Wilkes
    Center for Immunobiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Semin Immunol 24:131-5. 2012
  6. doi request reprint A breath of fresh air for lung transplant recipients
    David S Wilkes
    Center for Immunobiology, Departments of Medicine, Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Sci Transl Med 1:4ps5. 2009
  7. pmc Chronic lung allograft rejection and airway microvasculature: is HIF-1 the missing link?
    David S Wilkes
    Center for Immunobiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Invest 121:2155-7. 2011
  8. ncbi request reprint B-lymphocytes in the lung: a topic to be revisited
    D S Wilkes
    Division of Pulmonary, Critical Care, and Occupational Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
    Sarcoidosis Vasc Diffuse Lung Dis 18:34-49. 2001
  9. ncbi request reprint Allogeneic bronchoalveolar lavage cells induce the histology and immunology of lung allograft rejection in recipient murine lungs: role of intercellular adhesion molecule-1 on donor cells
    D S Wilkes
    Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
    Transplantation 67:890-6. 1999
  10. ncbi request reprint The role of autoimmunity in the pathogenesis of lung allograft rejection
    David S Wilkes
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Arch Immunol Ther Exp (Warsz) 51:227-30. 2003

Research Grants

Collaborators

  • S Yoshida
  • John Reynolds
  • T Fujisawa
  • D D Brand
  • I Petrache
  • Wei Li
  • WILLIAM BURLINGHAM
  • J Lee
  • Ruedi K Braun
  • P Y Kwo
  • Jason Christie
  • Lynn D Haynes
  • Mary S Hayney
  • T M Egan
  • RANDY BRUTKIEWICZ
  • Tonya J Webb
  • W M Baldwin
  • GILLES A BENICHOU
  • Heather L Benson
  • Oscar W Cummings
  • Takekazu Iwata
  • Gerald N Smith
  • Kathleen M Heidler
  • Kazuhiro Yasufuku
  • Teruaki Mizobuchi
  • Rebecca A Shilling
  • Daniel S Greenspan
  • Tricia L Humphreys
  • Janice S Blum
  • Daniel J Weber
  • Amir M Emtiazjoo
  • Ragini Vittal
  • Elizabeth A Mickler
  • Bagavathi Gopalakrishnan
  • Yan Zheng
  • Yoshito Yamada
  • Peng Qu
  • M Azizul Haque
  • Amanda J Fisher
  • Kazunori Murata
  • Joseph L Bobadilla
  • Babar A Khan
  • Masako Chiyo
  • Robert Presson
  • M Chiyo
  • Stanley M Spinola
  • Keith E Banks
  • Barry P Katz
  • G N Smith
  • Yasuo Sekine
  • David W Roe
  • Michael D Duncan
  • Kena A Swanson
  • Tina L Sumpter
  • K M Heidler
  • O W Cummings
  • Kena Woods
  • Kenneth S Knox
  • Lin Fan
  • Hongmei Gu
  • Chen Zhang
  • Hidemi Suzuki
  • Crystal Walline
  • Jeremy Lott
  • Amanda Jo Fisher
  • Jeong Soo Hong
  • Mayland Chang
  • Farrah Kheradmand
  • Shahriar Mobashery
  • Y Sekine
  • Cong Yan
  • Hong Du
  • Ichiro Yoshino
  • Karen Fox-Talbot
  • Shinji Nakashima
  • Robert B Love
  • Jose Torrealba
  • Ewa Jankowska-Gan
  • E L Thompson
  • M R Vasko
  • Robert G Presson
  • Alejandro Munoz del Rio
  • T Iwata
  • Zhiping Qian
  • Qingyong Xu
  • Michael Duncan
  • Elizabeth Mickler
  • Keith Meyer
  • H L Twigg
  • Alexander Philipovskiy

Detail Information

Publications41

  1. pmc IL-17 induces type V collagen overexpression and EMT via TGF-β-dependent pathways in obliterative bronchiolitis
    Ragini Vittal
    Center for Immunobiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Physiol Lung Cell Mol Physiol 304:L401-14. 2013
    ..Our findings highlight a feed-forward loop between IL-17 and TGF-β, leading to induction of col(V) and associated epithelial repair, thus providing one possible link between autoimmunity and OB after lung transplantation...
  2. pmc The role of autoimmunity in obliterative bronchiolitis after lung transplantation
    Daniel J Weber
    Center for Immunobiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Physiol Lung Cell Mol Physiol 304:L307-11. 2013
    ..Ultimately, this translational review discusses the role that autoimmunity plays in the development of OB and lung transplant rejection and then discusses options for therapeutic intervention...
  3. pmc Humoral immunity and the development of obliterative bronchiolitis after lung transplantation: is there a link?
    Amir M Emtiazjoo
    Division of Pulmonary and Critical Care, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Respir Cell Mol Biol 48:145-9. 2013
    ..This review highlights the current understanding of humoral immunity in the development of OB after lung transplantation...
  4. pmc Donor lung derived myeloid and plasmacytoid dendritic cells differentially regulate T cell proliferation and cytokine production
    Heather L Benson
    Department of Medicine, Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Respir Res 13:25. 2012
    ..Myeloid (cDCs) and plasmacytoid (pDCs) are believed to have differential effects on T cell activation. However, the roles of each DC type on T cell activation and rejection pathology post lung transplantation are unknown...
  5. doi request reprint Autoantibody formation in human and rat studies of chronic rejection and primary graft dysfunction
    David S Wilkes
    Center for Immunobiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Semin Immunol 24:131-5. 2012
    ..Similarly, the pathogenesis of OB has been linked recently to autoimmunity. This review will highlight the current understanding of autoantibodies in PGD and OB post lung transplantation...
  6. doi request reprint A breath of fresh air for lung transplant recipients
    David S Wilkes
    Center for Immunobiology, Departments of Medicine, Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Sci Transl Med 1:4ps5. 2009
    ....
  7. pmc Chronic lung allograft rejection and airway microvasculature: is HIF-1 the missing link?
    David S Wilkes
    Center for Immunobiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Invest 121:2155-7. 2011
    ..Data showing that overexpressing HIF-1α restores the microvascular airway normoxia and prevents airway fibrosis highlight a novel role for vascular biology in OB pathogenesis...
  8. ncbi request reprint B-lymphocytes in the lung: a topic to be revisited
    D S Wilkes
    Division of Pulmonary, Critical Care, and Occupational Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
    Sarcoidosis Vasc Diffuse Lung Dis 18:34-49. 2001
    ..This review discusses B-lymphocyte function and immunoglogulin production in general, as well as the regulation and function of humoral immunity as it relates to the lung in health and disease...
  9. ncbi request reprint Allogeneic bronchoalveolar lavage cells induce the histology and immunology of lung allograft rejection in recipient murine lungs: role of intercellular adhesion molecule-1 on donor cells
    D S Wilkes
    Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
    Transplantation 67:890-6. 1999
    ..Using this model, the purpose of the current study was to determine the role of ICAM-1 on donor lung cells in lung allograft rejection...
  10. ncbi request reprint The role of autoimmunity in the pathogenesis of lung allograft rejection
    David S Wilkes
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Arch Immunol Ther Exp (Warsz) 51:227-30. 2003
    ....
  11. doi request reprint Silencing S1P1 receptors regulates collagen-V reactive lymphocyte-mediated immunobiology in the transplanted lung
    M Chiyo
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Transplant 8:537-46. 2008
    ..These data demonstrate novel roles of S1P(1R,) which include regulating emigration and modulating lymphocyte activation...
  12. ncbi request reprint Anti-type V collagen lymphocytes that express IL-17 and IL-23 induce rejection pathology in fresh and well-healed lung transplants
    S Yoshida
    Center for Immunobiology, Indiana University of School of Medicine, Indianapolis, IN, USA
    Am J Transplant 6:724-35. 2006
    ..Finally, because of similar histologic patterns, the pathology of clinical rejection may reflect the activity of autoimmunity to col(V) and/or alloimmunity...
  13. ncbi request reprint Instillation of allogeneic lung macrophages and dendritic cells cause differential effects on local IFN-gamma production, lymphocytic bronchitis, and vasculitis in recipient murine lungs
    D S Wilkes
    Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
    J Leukoc Biol 64:578-86. 1998
    ..In addition, the rejection response was dependent on interactions between donor I-a-negative macrophages and DC...
  14. ncbi request reprint Lung transplant metalloproteinase levels are elevated prior to bronchiolitis obliterans syndrome
    G N Smith
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Transplant 7:1856-61. 2007
    ..These data suggest that ongoing and clinically silent MMP activity could perpetuate progressive disease in the allograft lung...
  15. ncbi request reprint Monocyte chemoattractant protein-1 and RANTES are chemotactic for graft infiltrating lymphocytes during acute lung allograft rejection
    Y Sekine
    Departments of Medicine, Microbiology and Immunology, Pathology, and Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Respir Cell Mol Biol 23:719-26. 2000
    ..These data show that chemotaxis for GILs is upregulated locally during lung allograft rejection, and that MCP-1 and RANTES contribute to GIL recruitment during the rejection response...
  16. doi request reprint Role of Th17 cells and IL-17 in lung transplant rejection
    Rebecca A Shilling
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Semin Immunopathol 33:129-34. 2011
    ..In this review, we will discuss the current data on Th17 and the prospects for the future for lung transplantation...
  17. ncbi request reprint Evidence for immune responses to a self-antigen in lung transplantation: role of type V collagen-specific T cells in the pathogenesis of lung allograft rejection
    M Azizul Haque
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 169:1542-9. 2002
    ....
  18. ncbi request reprint Metalloproteinase inhibition has differential effects on alloimmunity, autoimmunity, and histopathology in the transplanted lung
    Shigetoshi Yoshida
    Center for Immunobiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Transplantation 83:799-808. 2007
    ..It has been suggested that MMP inhibition could prevent the rejection response. However, the effect of MMP inhibition on lung allograft rejection has not been reported...
  19. ncbi request reprint Role of autoimmunity in organ allograft rejection: a focus on immunity to type V collagen in the pathogenesis of lung transplant rejection
    Tina L Sumpter
    Department of Medicine, Indiana University School of Medicine, Richard L Roudebush Veterans Affairs Medicine Center, 1481 W 10th St 111P, Indianapolis, IN 46202, USA
    Am J Physiol Lung Cell Mol Physiol 286:L1129-39. 2004
    ..The role of col(V) in lung transplant rejection is described in this review article. In addition, the potential role of regulatory T cells that are crucial to modulating autoimmunity and alloimmunity is also discussed...
  20. pmc Lung transplantation: opportunities for research and clinical advancement
    David S Wilkes
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Respir Crit Care Med 172:944-55. 2005
    ..This workshop provides a framework to identify critical issues related to clinical lung transplantation, and to delineate important areas for productive scientific investigation...
  21. pmc Type V collagen-induced oral tolerance plus low-dose cyclosporine prevents rejection of MHC class I and II incompatible lung allografts
    Yoshito Yamada
    Department of Medicine, Center for Immunobiology, Indiana University School of Medicine, Indianapolis, 46202, USA
    J Immunol 183:237-45. 2009
    ..These data demonstrate that col(V) enhances low-dose CsA-mediated immune suppression, and suggest a role for oral col(V) in immune modulation in lung transplantation...
  22. pmc Anti-type V collagen humoral immunity in lung transplant primary graft dysfunction
    Takekazu Iwata
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 181:5738-47. 2008
    ..This study demonstrates a major role for anti-col(V) humoral immunity in PGD, and identifies the airway epithelium as a target in PGD...
  23. ncbi request reprint Production of interferon-gamma by lung lymphocytes in HIV-infected individuals
    H L Twigg
    Divisions of Pulmonary Critical Care Medicine and Infectious Diseases, Department of Medicine, Indiana University Medical Center, Indianapolis, Indiana 46202, USA
    Am J Physiol 276:L256-62. 1999
    ..These data suggest that lung levels of IFN-gamma are high until late in HIV disease. These findings support the concept of administering exogenous IFN-gamma to patients with late-stage HIV disease and opportunistic infections...
  24. pmc Th-17, monokines, collagen type V, and primary graft dysfunction in lung transplantation
    Joseph L Bobadilla
    Microbiology and Immunology, Director, Center for Immunobiology, Indiana University School of Medicine, Van Nuys Medical Sciences Building MS224, 635 Barnhill Drive, Indianapolis, IN 46202 5120, USA
    Am J Respir Crit Care Med 177:660-8. 2008
    ..Human studies and rodent models have shown that collagen type V (col[V]), stimulates IL-17-dependent cellular immunity after lung transplantation...
  25. doi request reprint Lung transplant ischemia reperfusion injury: metalloprotease inhibition down-regulates exposure of type V collagen, growth-related oncogene-induced neutrophil chemotaxis, and tumor necrosis factor-alpha expression
    Takekazu Iwata
    Center for Immunobiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Transplantation 85:417-26. 2008
    ..Matrix metalloproteases (MMPs), which are induced by transplant-related ischemia-reperfusion injury (IRI), could expose col(V) and regulate local IRI-induced inflammation...
  26. pmc Endogenous matrix metalloproteinases 2 and 9 regulate activation of CD4+ and CD8+ T cells
    Heather L Benson
    Department of Biochemistry, Indiana University School of Medicine, Indianapolis, 46202, USA
    Am J Respir Cell Mol Biol 44:700-8. 2011
    ..MMPs, particularly MMP9, may function intracellularly to regulate T-cell activation. T cell-targeted MMP inhibition may provide a novel approach of immune regulation in the treatment of T cell-mediated diseases...
  27. ncbi request reprint Acute graft-versus-host disease of the lung after liver transplantation
    Kenneth S Knox
    Department of Medicine, Pulmonary Division, Indiana University School of Medicine, Indianapolis, IN, USA
    Liver Transpl 8:968-71. 2002
    ..High-dose corticosteroids were given with a return to baseline pulmonary function. The current case should alert clinicians to investigate pulmonary GVHD as a potential cause of postoperative dyspnea in liver transplant recipients...
  28. ncbi request reprint CDllc+ cells modulate pulmonary immune responses by production of indoleamine 2,3-dioxygenase
    Kena A Swanson
    Department of Microbiology and Immunology, Indiana University School of Medicine, 1001 West Tenth Street, OPW 425, Indianapolis, IN 46202, USA
    Am J Respir Cell Mol Biol 30:311-8. 2004
    ..Collectively these data show that lung iAPCs contribute to local regulation of cellular immune responses by production of IDO...
  29. pmc Critical roles of lysosomal acid lipase in T cell development and function
    Peng Qu
    The Center for Immunobiology, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 635 Barnhill Dr, Indianapolis, IN 46202, USA
    Am J Pathol 174:944-56. 2009
    ..The altered development and function of lal(-/-) T cells contributes to disease formation in various organs during LAL deficiency...
  30. ncbi request reprint Lung preservation: pulmonary flush route affects bronchial mucosal temperature and expression of IFN-gamma and Gro in regional lymph nodes
    David W Roe
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Transplant 5:995-1001. 2005
    ..These data suggest that pulmonary flush via AG/BA during donor harvest may be optimal to decrease the risk of early graft failure...
  31. ncbi request reprint The phenotype and function of lung dendritic cells
    Tonya J Webb
    Center for Immunobiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202 5120, USA
    Crit Rev Immunol 25:465-91. 2005
    ....
  32. pmc Dysregulated immune profiles for skin and dendritic cells are associated with increased host susceptibility to Haemophilus ducreyi infection in human volunteers
    Tricia L Humphreys
    Department of Medicine, Indiana University, Indianapolis, IN 46202, USA
    Infect Immun 75:5686-97. 2007
    ..ducreyi. PP DC may promote a dysregulated T-cell response that contributes to phagocytic failure, while RR DC may promote a Th1 response that facilitates bacterial clearance...
  33. pmc Haemophilus ducreyi partially activates human myeloid dendritic cells
    Keith E Banks
    Department of Medicine, Center for Immunobiology, Indiana University, School of Medicine, Indianapolis, IN 46202, USA
    Infect Immun 75:5678-85. 2007
    ..The survival of H. ducreyi in DC may provide a mechanism by which the organism traffics to lymph nodes. Partial activation of DC may abrogate the establishment of a full Th1 response and an environment that promotes phagocytosis...
  34. pmc Transplant-related immunosuppression: a review of immunosuppression and pulmonary infections
    Michael D Duncan
    Department of Medicine, Indiana University School of Medicine, Van Nuys Medical Sciences Building MS224, 635 Barnhill Dr, Indianapolis, IN 46202 5120, USA
    Proc Am Thorac Soc 2:449-55. 2005
    ..The immunosuppressants involve many classes of drugs, including antibody therapies that eliminate specific groups of cells or alter signaling pathways used by effector cells. The article reviews the agents and associated infections...
  35. pmc Nocardia infection in lung transplant recipients
    Babar A Khan
    Department of Medicine, Indiana University School of Medicine, Medical Science Building 224C, Indianapolis, IN, USA
    Clin Transplant 22:562-6. 2008
    ..Nocardia infection is an under-recognized entity in lung transplant recipients, and the optimal duration of therapy and prophylaxis are unclear...
  36. pmc IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants
    William J Burlingham
    Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
    J Clin Invest 117:3498-506. 2007
    ..These data suggest that while alloimmunity initiates lung transplant rejection, de novo autoimmunity mediated by col(V)-specific Th17 cells and monocyte/macrophage accessory cells ultimately causes progressive airway obliteration...
  37. ncbi request reprint Induction of autoimmunity after allotransplantation
    Gilles Benichou
    Department of Surgery, Transplantation Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Front Biosci 12:4362-9. 2007
    ..This suggests that, after transplantation, the inflammatory alloresponse to donor MHC triggers a cascade of events including autoimmunity to tissue antigens, a phenomenon that is essential to the actual rejection...
  38. ncbi request reprint Differential expression of Smad7 transcripts identifies the CD4+CD45RChigh regulatory T cells that mediate type V collagen-induced tolerance to lung allografts
    Teruaki Mizobuchi
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Immunol 171:1140-7. 2003
    ..Collectively, these data show that the Tregs that mediate col(V)-induced tolerance to lung allografts do not express SMAD7 and, therefore, are permissive to TGF-beta-mediated signaling...
  39. ncbi request reprint Comparison of surgical procedures for vascular and airway anastomoses that utilize a modified non-suture external cuff technique for experimental lung transplantation in rats
    Teruaki Mizobuchi
    Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Heart Lung Transplant 23:889-93. 2004
    ..We developed a "modified" NS technique that uses a larger and longer cuff for anastomoses and compared the efficacy of this procedure to the BS technique for lung transplantation...
  40. ncbi request reprint Prevention of bronchiolitis obliterans in rat lung allografts by type V collagen-induced oral tolerance
    Kazuhiro Yasufuku
    Department of Surgery, Institute of Pulmonary Cancer Research, Chiba University School of Medicine, Chiba, Japan
    Transplantation 73:500-5. 2002
    ..The current study examines if col(V)-induced oral tolerance prevents BO...
  41. pmc C4d deposition and cellular infiltrates as markers of acute rejection in rat models of orthotopic lung transplantation
    Kazunori Murata
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Transplantation 86:123-9. 2008
    ....

Research Grants23

  1. Innovative Methods for Immune Tolerance in Lung Transpl*
    David Wilkes; Fiscal Year: 2003
    ..MMP expression and activity will be examined in the transplanted lungs of naive and tolerant allograft recipients. Addtionally, systemic and local production of col(V) peptide during allograft rejection ..
  2. Type V Collagen Prevents Lung Allograft Rejection
    David Wilkes; Fiscal Year: 2005
    ....
  3. Type V Collagen Prevents Lung Allograft Rejection
    David Wilkes; Fiscal Year: 2009
    ..This application may also identify new areas that may allow for new treatments of this clinical problem. ..
  4. MMPs in Alloimmune and Autoimmune Lung Disease
    David Wilkes; Fiscal Year: 2007
    ..The ultimate goal of these studies is to identify novel targets for therapeutic intervention for patients suffering from lung allograft rejection and autoimmune lung disease. ..
  5. IMMUNE RESPONSES IN LUNG ALLOGRAFT REJECTION
    David Wilkes; Fiscal Year: 2006
    ..Gene therapy will also be utilized to over express IDO in allograft donor lungs prior to transplantation followed by an assessment of the rejection response. ..
  6. Type V Collagen Prevents Lung Allograft Rejection
    David S Wilkes; Fiscal Year: 2010
    ..This application may also identify new areas that may allow for new treatments of this clinical problem. ..
  7. Type V Collagen Prevents Lung Allograft Rejection
    David Wilkes; Fiscal Year: 2007
    ..This application may also identify new areas that may allow for new treatments of this clinical problem. ..
  8. IMMUNE RESPONSES IN LUNG ALLOGRAFT REJECTION
    David Wilkes; Fiscal Year: 2002
    ..The goal of these studies is to discern the immune mechanisms of lung allograft rejection at a molecular level so targets may be identified for therapeutic intervention to prolong the survival of lung allograft recipients. ..